CA2804210A1 - Methods and compositions for the specific inhibition of androgen receptor by double-stranded rna - Google Patents
Methods and compositions for the specific inhibition of androgen receptor by double-stranded rna Download PDFInfo
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- CA2804210A1 CA2804210A1 CA2804210A CA2804210A CA2804210A1 CA 2804210 A1 CA2804210 A1 CA 2804210A1 CA 2804210 A CA2804210 A CA 2804210A CA 2804210 A CA2804210 A CA 2804210A CA 2804210 A1 CA2804210 A1 CA 2804210A1
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| US20100048914A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| WO2009128936A2 (en) | 2008-04-16 | 2009-10-22 | The Johns Hopkins University | Compositions and methods for treating or preventing prostate cancer and for detecting androgen receptor variants |
| US9175291B2 (en) | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
| JP2016501533A (ja) * | 2012-12-14 | 2016-01-21 | ダイセルナ ファーマシューティカルズ， インコーポレイテッドＤｉｃｅｒｎａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 二本鎖ｒｎａによるｃｋａｐ５の特異的阻害に関する方法および組成物 |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
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| WO2015023710A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| US10774387B2 (en) | 2014-05-19 | 2020-09-15 | The Johns Hopkins University | Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer |
| CA2959336A1 (en) * | 2014-08-25 | 2016-03-03 | The Johns Hopkins University | Methods and compositions related to prostate cancer therapeutics |
| DK3234134T3 (da) | 2014-12-17 | 2020-07-27 | Proqr Therapeutics Ii Bv | Målrettet rna-redigering |
| CA2989384A1 (en) * | 2015-07-30 | 2017-02-02 | Bayer Cropscience Aktiengesellschaft | Methods and compositions for the control of rust fungi by inhibiting expression of the hxt1 gene |
| MA45340A (fr) * | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Acides nucléiques du récepteur des androgènes et leurs utilisations |
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| ES2837076T3 (es) | 2016-09-01 | 2021-06-29 | Proqr Therapeutics Ii Bv | Oligonucleótidos para la edición de ARN de cadena sencilla modificados químicamente |
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
| US11274300B2 (en) | 2017-01-19 | 2022-03-15 | Proqr Therapeutics Ii B.V. | Oligonucleotide complexes for use in RNA editing |
| KR102321426B1 (ko) * | 2017-02-21 | 2021-11-05 | 올릭스 주식회사 | 남성형 탈모 표적 유전자의 발현을 억제하는 비대칭 siRNA |
| EP3755814B1 (en) * | 2018-02-23 | 2025-04-09 | Cornell University | Assay for detection of androgen receptor variants |
| AU2019243946B2 (en) | 2018-03-27 | 2025-03-06 | Proqr Therapeutics Ii B.V. | Nucleic acid molecules for pseudouridylation |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| KR102473989B1 (ko) * | 2018-11-28 | 2022-12-07 | (주)바이오니아 | 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물 |
| WO2025160224A1 (en) * | 2024-01-24 | 2025-07-31 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of androgen receptor (ar), compositions thereof, and methods of use |
| WO2025226946A1 (en) * | 2024-04-24 | 2025-10-30 | Cedric Francois | Methods and compositions for the treatment of androgenic alopecia |
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| US20050170371A1 (en) * | 2001-05-18 | 2005-08-04 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA) |
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| US20060257851A1 (en) * | 2002-11-26 | 2006-11-16 | Itzhak Bentwich | Bioinformatically detectable group of novel viral regulatory genes and uses thereof |
| US20050164970A1 (en) * | 2003-12-22 | 2005-07-28 | University Of Kansas Medical Center | Method for treating prostate cancer using siRNA duplex for androgen receptor |
| JP5243789B2 (ja) * | 2004-03-15 | 2013-07-24 | シティ・オブ・ホープ | 二本鎖ｒｎａによる遺伝子発現の特異的阻害のための方法及び組成物 |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| JP4961549B2 (ja) * | 2006-02-16 | 2012-06-27 | 国立大学法人愛媛大学 | アンドロゲン受容体遺伝子に特異的なｓｉＲＮＡ |
| US20080014584A1 (en) * | 2006-06-01 | 2008-01-17 | Mayo Foundation For Medical Education And Research | Modulating androgen receptor activity |
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- 2011-07-01 WO PCT/US2011/042810 patent/WO2012006241A2/en not_active Ceased
- 2011-07-01 CA CA2804210A patent/CA2804210A1/en not_active Abandoned
- 2011-07-01 AU AU2011276363A patent/AU2011276363A1/en not_active Abandoned
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| US8927515B2 (en) | 2015-01-06 |
| WO2012006241A2 (en) | 2012-01-12 |
| AU2011276363A1 (en) | 2013-01-10 |
| EP2591104A2 (en) | 2013-05-15 |
| US20130131149A1 (en) | 2013-05-23 |
| EP2591104A4 (en) | 2014-09-03 |
| JP2013534424A (ja) | 2013-09-05 |
| US20150197756A1 (en) | 2015-07-16 |
| WO2012006241A3 (en) | 2012-04-19 |
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