JP2013533868A5 - - Google Patents
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- Publication number
- JP2013533868A5 JP2013533868A5 JP2013517018A JP2013517018A JP2013533868A5 JP 2013533868 A5 JP2013533868 A5 JP 2013533868A5 JP 2013517018 A JP2013517018 A JP 2013517018A JP 2013517018 A JP2013517018 A JP 2013517018A JP 2013533868 A5 JP2013533868 A5 JP 2013533868A5
- Authority
- JP
- Japan
- Prior art keywords
- diazaspiro
- pyrrolo
- pyrimidin
- nonan
- methanone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 **(CN(*)C1(CC1)CC1)CN1c1c(cc[n]2)c2nc(I)n1 Chemical compound **(CN(*)C1(CC1)CC1)CN1c1c(cc[n]2)c2nc(I)n1 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36309510P | 2010-07-09 | 2010-07-09 | |
| US61/363,095 | 2010-07-09 | ||
| PCT/DK2011/000080 WO2012003829A1 (en) | 2010-07-09 | 2011-07-08 | Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013533868A JP2013533868A (ja) | 2013-08-29 |
| JP2013533868A5 true JP2013533868A5 (enExample) | 2014-08-28 |
Family
ID=44513700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013517018A Pending JP2013533868A (ja) | 2010-07-09 | 2011-07-08 | タンパク質チロシンキナーゼ阻害剤としての新規ホモピペラジン誘導体およびそれらの医薬使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9586961B2 (enExample) |
| EP (1) | EP2590981B1 (enExample) |
| JP (1) | JP2013533868A (enExample) |
| CN (1) | CN102985425A (enExample) |
| RU (1) | RU2013105450A (enExample) |
| TW (1) | TW201204732A (enExample) |
| WO (1) | WO2012003829A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104072499A (zh) * | 2013-03-29 | 2014-10-01 | 黄传满 | 哌嗪取代嘧啶类化合物及其用途 |
| CN103242321A (zh) * | 2013-05-21 | 2013-08-14 | 苏州科捷生物医药有限公司 | 苄基哌嗪类化合物及其抗肿瘤用途 |
| CN103396414B (zh) * | 2013-07-16 | 2015-06-03 | 浙江医药高等专科学校 | 咪唑取代的噻唑并环己烷类化合物、及其抗肿瘤用途 |
| MA39092B1 (fr) * | 2013-12-05 | 2018-09-28 | Pfizer | Pyrrolo[2,3-d]pyrimidinyle, pyrrolo[2,3-b]pyrazinyle et pyrollo[2,3-d]pyridinyle acrylamides |
| AR101214A1 (es) * | 2014-07-22 | 2016-11-30 | Bayer Cropscience Ag | Ciano-cicloalquilpenta-2,4-dienos, ciano-cicloalquilpent-2-en-4-inas, ciano-heterociclilpenta-2,4-dienos y ciano-heterociclilpent-2-en-4-inas sustituidos como principios activos contra el estrés abiótico de plantas |
| CN105712998B (zh) * | 2014-12-05 | 2019-12-13 | 上海润诺生物科技有限公司 | 氮杂吲哚类衍生物、其制备方法及其在医药上的应用 |
| AU2017326487B2 (en) * | 2016-09-14 | 2021-08-05 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-MLL interaction |
| WO2018134352A1 (en) * | 2017-01-20 | 2018-07-26 | Leo Pharma A/S | Bicyclic amines as novel jak kinase inhibitors |
| JP7101176B2 (ja) * | 2017-02-03 | 2022-07-14 | レオ ファーマ アクティーゼルスカブ | 新規ＪＡＫキナーゼ阻害剤としての５－（７Ｈ－ピロロ［２，３－ｄ］ピリミジン－４－イル）－５－アザスピロ［２．５］オクタン－８－カルボン酸誘導体 |
| CN108069986B (zh) * | 2017-12-08 | 2018-10-02 | 牡丹江医学院 | 一种治疗角膜炎的活性药物及其制备方法 |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| WO2021046350A1 (en) | 2019-09-05 | 2021-03-11 | Incyte Corporation | Ruxolitinib formulation for reduction of itch in atopic dermatitis |
| US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
| IL293965A (en) | 2019-12-19 | 2022-08-01 | Janssen Pharmaceutica Nv | History of Spiro straight chain transformed |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20004727A3 (cs) * | 1998-06-19 | 2002-03-13 | Pfizer Products Inc. | Deriváty pyrrolo[2,3-d] pyrimidinu |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| AU2005249380C1 (en) | 2004-04-23 | 2012-09-20 | Exelixis, Inc. | Kinase modulators and methods of use |
| EP2049529B1 (en) | 2006-07-14 | 2010-08-11 | Merck Sharp & Dohme Corp. | Substituted diazepan orexin receptor antagonists |
| AU2008234822A1 (en) * | 2007-04-02 | 2008-10-09 | Palau Pharma, S. A. | Pyrrolopyrimidine derivatives as JAK3 inhibitors |
| WO2009017838A2 (en) | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
| WO2009021169A2 (en) * | 2007-08-08 | 2009-02-12 | Lexicon Pharmaceuticals, Inc. | (7h-pyrr0l0 [2, 3-d] pyrimidin-4-yl) -piperazines as kinase inhibitors for the treatment of cancer and inflammation |
| MX2010008719A (es) | 2008-02-06 | 2010-09-24 | Novartis Ag | Pirrolo [2,-d] piridinas y usos de las mismas como inhibidores de cinasa de tirosina. |
| WO2009131687A2 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
-
2011
- 2011-07-08 JP JP2013517018A patent/JP2013533868A/ja active Pending
- 2011-07-08 TW TW100124316A patent/TW201204732A/zh unknown
- 2011-07-08 CN CN2011800339890A patent/CN102985425A/zh active Pending
- 2011-07-08 EP EP11738151.7A patent/EP2590981B1/en not_active Not-in-force
- 2011-07-08 WO PCT/DK2011/000080 patent/WO2012003829A1/en not_active Ceased
- 2011-07-08 US US13/809,059 patent/US9586961B2/en not_active Expired - Fee Related
- 2011-07-08 RU RU2013105450/04A patent/RU2013105450A/ru not_active Application Discontinuation
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