JP2013531973A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013531973A5 JP2013531973A5 JP2013508229A JP2013508229A JP2013531973A5 JP 2013531973 A5 JP2013531973 A5 JP 2013531973A5 JP 2013508229 A JP2013508229 A JP 2013508229A JP 2013508229 A JP2013508229 A JP 2013508229A JP 2013531973 A5 JP2013531973 A5 JP 2013531973A5
- Authority
- JP
- Japan
- Prior art keywords
- aars
- polypeptide
- item
- cell
- tables
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims description 215
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims description 215
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 97
- 229920001184 polypeptide Polymers 0.000 claims description 94
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 94
- 239000000203 mixture Substances 0.000 claims description 73
- 108090000623 proteins and genes Proteins 0.000 claims description 64
- 102000004169 proteins and genes Human genes 0.000 claims description 61
- 210000004027 cell Anatomy 0.000 claims description 56
- 230000027455 binding Effects 0.000 claims description 37
- 230000000694 effects Effects 0.000 claims description 36
- 108091033319 polynucleotide Proteins 0.000 claims description 36
- 102000040430 polynucleotide Human genes 0.000 claims description 36
- 239000002157 polynucleotide Substances 0.000 claims description 36
- 150000001875 compounds Chemical class 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 31
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 26
- 150000001413 amino acids Chemical class 0.000 claims description 21
- 230000001225 therapeutic effect Effects 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 239000011230 binding agent Substances 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 11
- 108010001857 Cell Surface Receptors Proteins 0.000 claims description 10
- 102000006240 membrane receptors Human genes 0.000 claims description 10
- 239000002773 nucleotide Substances 0.000 claims description 9
- 125000003729 nucleotide group Chemical group 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 239000002158 endotoxin Substances 0.000 claims description 7
- 238000012360 testing method Methods 0.000 claims description 7
- 108091034117 Oligonucleotide Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 230000002797 proteolythic effect Effects 0.000 claims description 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 4
- 230000001413 cellular effect Effects 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 230000008482 dysregulation Effects 0.000 claims description 4
- 208000027866 inflammatory disease Diseases 0.000 claims description 4
- 230000001404 mediated effect Effects 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
- 201000001119 neuropathy Diseases 0.000 claims description 3
- 230000007823 neuropathy Effects 0.000 claims description 3
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 3
- 102000005962 receptors Human genes 0.000 claims description 3
- 239000012679 serum free medium Substances 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 230000001766 physiological effect Effects 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 4
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 description 80
- 108020001507 fusion proteins Proteins 0.000 description 12
- 102000037865 fusion proteins Human genes 0.000 description 12
- 239000000523 sample Substances 0.000 description 12
- 230000004071 biological effect Effects 0.000 description 8
- 230000033228 biological regulation Effects 0.000 description 7
- 125000000266 alpha-aminoacyl group Chemical group 0.000 description 6
- 239000012528 membrane Substances 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- 238000005556 structure-activity relationship Methods 0.000 description 4
- 230000008685 targeting Effects 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 108010076504 Protein Sorting Signals Proteins 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 102000003675 cytokine receptors Human genes 0.000 description 3
- 108010057085 cytokine receptors Proteins 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000005945 translocation Effects 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- 102000040945 Transcription factor Human genes 0.000 description 2
- 108091023040 Transcription factor Proteins 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 238000000423 cell based assay Methods 0.000 description 2
- 230000024245 cell differentiation Effects 0.000 description 2
- 230000008622 extracellular signaling Effects 0.000 description 2
- 230000009368 gene silencing by RNA Effects 0.000 description 2
- 102000034356 gene-regulatory proteins Human genes 0.000 description 2
- 108091006104 gene-regulatory proteins Proteins 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 230000009703 regulation of cell differentiation Effects 0.000 description 2
- 230000025053 regulation of cell proliferation Effects 0.000 description 2
- 230000024833 regulation of cytokine production Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 208000029578 Muscle disease Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 239000000074 antisense oligonucleotide Substances 0.000 description 1
- 238000012230 antisense oligonucleotides Methods 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000011712 cell development Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 108091005573 modified proteins Proteins 0.000 description 1
- 102000035118 modified proteins Human genes 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 210000000229 preadipocyte Anatomy 0.000 description 1
- 239000013615 primer Substances 0.000 description 1
- 239000002987 primer (paints) Substances 0.000 description 1
- 238000010377 protein imaging Methods 0.000 description 1
- 230000037425 regulation of transcription Effects 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 210000002363 skeletal muscle cell Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32837110P | 2010-04-27 | 2010-04-27 | |
| US32836910P | 2010-04-27 | 2010-04-27 | |
| US32837310P | 2010-04-27 | 2010-04-27 | |
| US61/328,369 | 2010-04-27 | ||
| US61/328,371 | 2010-04-27 | ||
| US61/328,373 | 2010-04-27 | ||
| PCT/US2011/034207 WO2011139801A2 (en) | 2010-04-27 | 2011-04-27 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl trna synthetases |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015142866A Division JP2015186486A (ja) | 2010-04-27 | 2015-07-17 | スレオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP2017163371A Division JP2017201994A (ja) | 2010-04-27 | 2017-08-28 | スレオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013531973A JP2013531973A (ja) | 2013-08-15 |
| JP2013531973A5 true JP2013531973A5 (cg-RX-API-DMAC10.html) | 2014-05-22 |
| JP6240500B2 JP6240500B2 (ja) | 2017-11-29 |
Family
ID=44904372
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013508229A Active JP6240500B2 (ja) | 2010-04-27 | 2011-04-27 | スレオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP2015142866A Pending JP2015186486A (ja) | 2010-04-27 | 2015-07-17 | スレオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP2017163371A Withdrawn JP2017201994A (ja) | 2010-04-27 | 2017-08-28 | スレオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015142866A Pending JP2015186486A (ja) | 2010-04-27 | 2015-07-17 | スレオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP2017163371A Withdrawn JP2017201994A (ja) | 2010-04-27 | 2017-08-28 | スレオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8986681B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2563382B1 (cg-RX-API-DMAC10.html) |
| JP (3) | JP6240500B2 (cg-RX-API-DMAC10.html) |
| CN (2) | CN103096910A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2011248521B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2797259C (cg-RX-API-DMAC10.html) |
| ES (1) | ES2638311T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2011139801A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010099477A2 (en) | 2009-02-27 | 2010-09-02 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| WO2011139714A2 (en) | 2010-04-26 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
| CN103096910A (zh) | 2010-04-27 | 2013-05-08 | Atyr医药公司 | 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103096911B (zh) | 2010-04-27 | 2018-05-29 | Atyr 医药公司 | 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103097523B (zh) | 2010-04-29 | 2016-09-28 | Atyr医药公司 | 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| AU2011248457B2 (en) | 2010-04-29 | 2017-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases |
| US8946157B2 (en) | 2010-05-03 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases |
| WO2011140132A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
| CA2797978C (en) | 2010-05-03 | 2019-12-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
| EP2566515B1 (en) | 2010-05-03 | 2017-08-02 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases |
| CN102985103A (zh) | 2010-05-04 | 2013-03-20 | Atyr医药公司 | 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现 |
| JP6008843B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ， インコーポレイテッド | グルタミル−プロリルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US8945541B2 (en) | 2010-05-14 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases |
| WO2011146410A2 (en) | 2010-05-17 | 2011-11-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases |
| CA2800375C (en) | 2010-05-27 | 2021-03-09 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases |
| CN103118694B (zh) | 2010-06-01 | 2016-08-03 | Atyr医药公司 | 与赖氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| CA2804416C (en) | 2010-07-12 | 2020-04-28 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases |
| CA2804424C (en) | 2010-07-12 | 2021-03-30 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| KR102099730B1 (ko) | 2010-07-12 | 2020-04-16 | 에이티와이알 파마, 인코포레이티드 | 아스파르틸trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| CA2808539C (en) | 2010-08-25 | 2021-05-25 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases |
| CA2812795C (en) | 2010-10-06 | 2021-08-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases |
| WO2012158945A2 (en) * | 2011-05-19 | 2012-11-22 | The Scripps Research Institute | Compositions and methods for treating charcot-marie-tooth diseases and related neuronal diseases |
| US9714419B2 (en) | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
| US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
| US9822353B2 (en) | 2011-12-06 | 2017-11-21 | Atyr Pharma, Inc. | PEGylated aspartyl-tRNA synthetase polypeptides |
| CN104220461A (zh) | 2011-12-29 | 2014-12-17 | Atyr医药公司 | 天冬氨酰-tRNA合成酶-FC缀合物 |
| WO2014018619A1 (en) * | 2012-07-25 | 2014-01-30 | University Of Vermont And State Agricultural College | Methods and compounds for increasing threonyl-trna synthetase activity |
| US10087435B2 (en) * | 2012-07-25 | 2018-10-02 | University Of Vermont And State Agricultural College | Methods and compounds for reducing threonyl-tRNA synthetase activity |
| US10175237B2 (en) | 2012-07-25 | 2019-01-08 | University Of Vermont And State Agricultural College | Methods and compounds for diagnosing threonyl-tRNA synthetase-associated diseases and conditions |
| JP6397479B2 (ja) | 2013-03-15 | 2018-09-26 | エータイアー ファーマ， インコーポレイテッド | ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート |
| CN110536694A (zh) | 2017-04-20 | 2019-12-03 | Atyr 医药公司 | 用于治疗肺部炎症的组合物和方法 |
| WO2019055594A1 (en) | 2017-09-13 | 2019-03-21 | North Carolina State University | BRUSHING ADIPOSE TISSUE INDUCED LOCALLY BY MICRO-NEEDLE STAMPS FOR THE TREATMENT OF OBESITY |
| CN110317867A (zh) * | 2019-07-11 | 2019-10-11 | 德阳市人民医院 | Tars作为诊断男性骨质疏松症的分子标志物的应用 |
| CN110567861B (zh) * | 2019-09-09 | 2021-12-21 | 浙江普罗亭健康科技有限公司 | 基于质谱流式检测技术筛查具有免疫原性抗原肽的试剂盒及检测方法 |
| CN112067515B (zh) * | 2020-09-03 | 2023-04-25 | 南昌大学 | 一种均相检测大分子抗原的动态光散射免疫方法 |
Family Cites Families (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE9115660U1 (de) | 1991-12-18 | 1992-07-30 | Aventis Research & Technologies GmbH & Co KG, 65929 Frankfurt | L-Phenylalanyl-tRNA-Synthetase mit erweiterter Substratselektivität aus Mikroorganismen |
| US5759833A (en) | 1994-05-27 | 1998-06-02 | Cubist Pharmaceuticals, Inc. | Human isoleucyl-tRNA synthetase proteins, nucleic acids and tester strains comprising same |
| US5798240A (en) | 1994-09-13 | 1998-08-25 | Cubist Pharmaceuticals, Inc. | Recombinant mycobacterial methionyl-tRNA synthetase genes and methods of use therefore |
| US5756327A (en) | 1994-09-13 | 1998-05-26 | Cubist Pharmaceuticals, Inc. | Recombinant mycobacterial isoleucyl-tRNA synthetase genes, tester strains and assays |
| US5801013A (en) | 1995-05-26 | 1998-09-01 | Cubist Pharmaceuticals, Inc. | Helicobacter aminoacyl-tRNA synthetase proteins, nucleic acids and strains comprising same |
| EP1876241A3 (en) | 1996-01-11 | 2008-07-30 | Corixa Corporation | Compositions and methods for the treatment and diagnosis of breast cancer |
| EP0785271A1 (en) | 1996-01-19 | 1997-07-23 | Smithkline Beecham Plc | Threonyl-tRNA synthetase of Staphylococcus aureus |
| US5795757A (en) | 1997-01-17 | 1998-08-18 | Smithkline Beecham, P.L.C. | DNA encoding threonyl tRNA synthetase from staphylococcus aureus |
| US5756329A (en) | 1996-01-19 | 1998-05-26 | Smithkline Beecham P.L.C. | DNA encoding phenylalanyl tRNA synthetase from Staphylococcus aureus |
| GB9601067D0 (en) | 1996-01-19 | 1996-03-20 | Smithkline Beecham Plc | Novel compounds |
| GB9607993D0 (en) | 1996-04-18 | 1996-06-19 | Smithkline Beecham Plc | Novel compounds |
| GB9607991D0 (en) | 1996-04-18 | 1996-06-19 | Smithkline Beecham Plc | Novel compounds |
| US5795758A (en) | 1997-04-18 | 1998-08-18 | Smithkline Beecham Corporation | DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae |
| KR100203919B1 (ko) | 1996-10-04 | 1999-06-15 | 신동권 | 수용성 단백질을 생산하는 새로운 발현 플라스미드 |
| US5885815A (en) | 1996-11-01 | 1999-03-23 | Cubist Pharmaceuticals, Inc. | Candida isoleucyl-tRNA synthetase proteins, nucleic acids and strains comprising same |
| US5776749A (en) | 1997-01-17 | 1998-07-07 | Smithkline Beecham P.L.C. | DNA encoding cysteinyl tRNA synthetase from Staphylococcus aureus |
| JP2002516571A (ja) | 1997-05-06 | 2002-06-04 | ヒューマン ジノーム サイエンシーズ，インコーポレイテッド | Ｅｎｔｅｒｏｃｏｃｃｕｓ ｆａｅｃａｌｉｓポリヌクレオチドおよびポリペプチド |
| US5939298A (en) | 1997-07-23 | 1999-08-17 | Smithkline Beecham Corporation | DNA encoding phenylalanyl tRNA synthetase alpha sub-unit from chlamydi a trachomatis |
| US5858720A (en) | 1997-07-23 | 1999-01-12 | Smithkline Beecham Corporation | Hiss |
| US5882892A (en) | 1997-07-23 | 1999-03-16 | Smithkline Beecham Corporation | Asps |
| US6428960B1 (en) | 1998-03-04 | 2002-08-06 | Onyx Pharmaceuticals, Inc. | Selection method for producing recombinant baculovirus |
| CN1292033A (zh) | 1998-03-04 | 2001-04-18 | 昂尼克斯药物公司 | 用于遗传物质高通量表达的杆状病毒表达系统和方法 |
| US6255090B1 (en) | 1998-07-15 | 2001-07-03 | E. I. Du Pont De Nemours & Company | Plant aminoacyl-tRNA synthetase |
| US6271441B1 (en) | 1998-07-21 | 2001-08-07 | E. I. Du Pont De Nemours & Company | Plant aminoacyl-tRNA synthetase |
| US6696619B1 (en) * | 1998-11-05 | 2004-02-24 | Omolayo O. Famodu | Plant aminoacyl-tRNA synthetases |
| AU6364700A (en) | 1999-07-22 | 2001-02-13 | Incyte Genomics, Inc. | Human synthetases |
| WO2001019999A1 (en) | 1999-09-14 | 2001-03-22 | Shanghai Biorigin Gene Development Co. Ltd. | A GENE ENCODING A NOVEL THREONYL-tRNA SYNTHETASE, ITS USES AND THE PREPARING METHODS |
| CN1375007A (zh) * | 1999-09-14 | 2002-10-16 | 上海生元基因开发有限公司 | 编码一种新的苏氨酰转移核糖核酸合成酶的基因及其应用和制备方法 |
| US6548060B1 (en) | 1999-11-18 | 2003-04-15 | Sunghoon Kim | Anti-apoptotic use of human glutaminyl-tRNA synthetase with two consecutive pro-apoptotic mediators |
| CN1311300A (zh) | 2000-03-02 | 2001-09-05 | 上海博德基因开发有限公司 | 一种新的多肽－人苏氨酰－tRNA合成酶14和编码这种多肽的多核苷酸 |
| US7067126B2 (en) | 2000-03-31 | 2006-06-27 | The Scripps Research Institute | Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| US7144984B2 (en) | 2000-03-31 | 2006-12-05 | The Scripps Research Institute | Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis |
| US7273844B2 (en) | 2000-03-31 | 2007-09-25 | The Scripps Research Institute | Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis |
| CN1322818A (zh) | 2000-05-09 | 2001-11-21 | 上海博德基因开发有限公司 | 一种新的多肽——人II类氨酰基－tRNA合成酶10和编码这种多肽的多核苷酸 |
| US20040181830A1 (en) | 2001-05-07 | 2004-09-16 | Kovalic David K. | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| WO2001088188A2 (en) | 2000-05-18 | 2001-11-22 | Nihon University, School Juridical Person | Method for examining ischemic conditions |
| JP2004510407A (ja) | 2000-05-25 | 2004-04-08 | インサイト・ゲノミックス・インコーポレイテッド | アミノアシルｔＲＮＡ合成酵素 |
| CN1341725A (zh) * | 2000-09-07 | 2002-03-27 | 上海博德基因开发有限公司 | 一种新的多肽——人苏氨酰－tRNA合成酶48.73和编码这种多肽的多核苷酸 |
| CN1341727A (zh) | 2000-09-07 | 2002-03-27 | 上海博德基因开发有限公司 | 一种新的多肽——甲硫氨酰tRNA合成酶35.09和编码这种多肽的多核苷酸 |
| CN1352242A (zh) | 2000-11-02 | 2002-06-05 | 上海博德基因开发有限公司 | 一种新的多肽——人谷氨酰tRNA合成酶12.65和编码这种多肽的多核苷酸 |
| CN1352252A (zh) | 2000-11-06 | 2002-06-05 | 上海博德基因开发有限公司 | 一种新的多肽——人II类氨酰基－tRNA合成酶11.77和编码这种多肽的多核苷酸 |
| AU2002223349A1 (en) | 2000-11-28 | 2002-06-11 | Mcgill University | Incorporation and priming function of trnalys in hiv and related viruses |
| EP1349939A2 (en) | 2000-12-15 | 2003-10-08 | Incyte Genomics, Inc. | Aminoacyl trna synthetases |
| AU2002306558B2 (en) | 2001-02-23 | 2007-06-28 | The Scripps Research Institute | Tryptophanyl-tRNA synthetase derived polypeptides useful for the regulation of angiogenesis |
| US6903189B2 (en) | 2001-03-21 | 2005-06-07 | The Scripps Research Institute | Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis |
| EP2128246B1 (en) | 2001-04-19 | 2014-03-12 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-Aminoacyl-tRNA synthetase pairs |
| US20030215827A1 (en) | 2001-05-22 | 2003-11-20 | Henry Yue | Aminoacyl trna synthetases |
| KR100405919B1 (ko) | 2001-06-05 | 2003-11-14 | 주식회사 이매진 | ｐ43의 Ｎ-말단 펩타이드를 유효성분으로 하는 면역증강용 약학조성물 |
| US20040018505A1 (en) | 2001-06-29 | 2004-01-29 | Lee Ernestine A. | Aminoacyl trna synthetases |
| AU2002332430A1 (en) | 2001-07-26 | 2003-02-17 | Novartis Ag | Methods of treating neuropilin-mediated diseases |
| US7785827B2 (en) | 2001-09-20 | 2010-08-31 | University Of Houston System | Method and composition for leucyl-tRNA synthetases and derivatives thereof that activate and aminoacylate non-leucine amino acid to tRNA adaptor molecules |
| US20040048290A1 (en) | 2001-12-13 | 2004-03-11 | Lee Ernestine A | Aminoacyl trna synthetases |
| EP2388265A1 (en) | 2002-02-22 | 2011-11-23 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| US6940080B2 (en) | 2002-03-28 | 2005-09-06 | Kabushiki Kaisha Toshiba | Charged particle beam lithography system, lithography method using charged particle beam, method of controlling charged particle beam, and method of manufacturing semiconductor device |
| AU2003234600A1 (en) | 2002-05-13 | 2003-11-11 | Rigel Pharmaceuticals, Inc. | tRNA SYNTHASE: MODULATORS OF ANGIOGENESIS |
| CA2497338A1 (en) | 2002-08-30 | 2004-03-18 | Japan Science And Technology Corporation | Method of targeted gene disruption, genome of hyperthermostable bacterium and genome chip using the same |
| WO2004022746A1 (en) | 2002-09-06 | 2004-03-18 | Isogenica Limited | In vitro peptide expression libraray |
| JP2006516089A (ja) * | 2002-10-02 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| WO2004060262A2 (en) | 2003-01-07 | 2004-07-22 | Lorantis Limited | Modulators of notch signalling for use in immunotherpapy |
| KR100575251B1 (ko) | 2003-03-03 | 2006-05-02 | 재단법인서울대학교산학협력재단 | ｐ38／ＪＴＶ－1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법 |
| WO2004087875A2 (en) | 2003-03-25 | 2004-10-14 | Incyte Corporation | Nucleic acid-associated proteins |
| AU2004258821A1 (en) | 2003-05-01 | 2005-02-03 | Replidyne, Inc. | Antibacterial methods and compositions |
| ATE386133T1 (de) | 2003-07-07 | 2008-03-15 | Scripps Research Inst | Zusammensetzungen der orthogonalen lysyl-trna und aminoacyl-trna synthetase paaren und ihre verwendungen |
| WO2005007870A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF |
| CA2549830A1 (en) | 2003-12-18 | 2006-01-05 | The Scripps Research Institute | Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells |
| KR100599454B1 (ko) | 2004-04-27 | 2006-07-12 | 재단법인서울대학교산학협력재단 | 종양 억제자로 작용하는 ａｉｍ3의 신규 용도 |
| PT2484365E (pt) | 2004-06-04 | 2013-12-12 | Scripps Research Inst | Composições e métodos para o tratamento de doenças neovasculares |
| US20060078553A1 (en) | 2004-10-07 | 2006-04-13 | Paul Glidden | Diverse multi-unit complexes including a tRNA synthetase fragment |
| US20060079673A1 (en) | 2004-08-02 | 2006-04-13 | Paul Glidden | Polynucleotides encoding tRNA synthetase fragments and uses thereof |
| US8282921B2 (en) | 2004-08-02 | 2012-10-09 | Paul Glidden | tRNA synthetase fragments |
| US20060024288A1 (en) | 2004-08-02 | 2006-02-02 | Pfizer Inc. | tRNA synthetase fragments |
| US8003780B2 (en) | 2004-11-24 | 2011-08-23 | Neomics Co., Ltd. | AIMP2-DX2 gene and SiRNA targeting AIMP2-DX2 |
| US7459529B2 (en) | 2004-11-24 | 2008-12-02 | Seoul National University Industry Foundation | AIMP2-DX2 and its uses |
| KR20070090023A (ko) | 2004-12-22 | 2007-09-04 | 암브룩스, 인코포레이티드 | 변형 인간 성장 호르몬 |
| CN102732588B (zh) | 2004-12-22 | 2015-01-07 | Ambrx公司 | 氨酰基-tRNA合成酶的组合物及其用途 |
| CN103103238B (zh) | 2005-08-18 | 2016-08-10 | Ambrx公司 | 一种在细胞中制造在特定位置处具有所选氨基酸的抗体或抗体片段多肽的方法 |
| US7514229B2 (en) | 2005-09-29 | 2009-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosing and evaluating treatment of blood disorders |
| EP1977004B1 (en) | 2005-12-02 | 2014-10-29 | The Scripps Research Institute | Angiogenic tyrosyl trna synthetase compositions and methods |
| PL1999259T3 (pl) | 2006-03-03 | 2015-01-30 | California Inst Of Techn | Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek |
| NZ573407A (en) | 2006-05-26 | 2012-09-28 | Obodies Ltd | Ob fold domains |
| US20100120627A1 (en) | 2006-08-02 | 2010-05-13 | Abdelmajid Belouchi | Genemap of the human genes associated with psoriasis |
| CA2660286A1 (en) | 2006-08-09 | 2008-02-21 | Homestead Clinical Corporation | Organ-specific proteins and methods of their use |
| EP2064316B1 (en) | 2006-09-08 | 2012-01-25 | Ambrx, Inc. | Site specific incorporation of non-natural amino acids by vertebrate cells |
| ATE502960T1 (de) | 2006-11-17 | 2011-04-15 | Novartis Ag | Lingo bindende moleküle und pharmazeutische verwendung davon |
| WO2008133359A1 (en) | 2007-04-27 | 2008-11-06 | Imagene Co., Ltd. | Method for screening immune modulator |
| JP2009017840A (ja) | 2007-07-13 | 2009-01-29 | Japan Agengy For Marine-Earth Science & Technology | 外来遺伝子を細胞に安定に保持する方法 |
| WO2009059056A2 (en) | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
| JP5585904B2 (ja) | 2008-02-08 | 2014-09-10 | 独立行政法人理化学研究所 | アミノアシルｔＲＮＡ合成酵素活性を有するポリペプチド及びその利用 |
| CA2718153A1 (en) | 2008-03-11 | 2009-09-17 | University Of North Carolina At Chapel Hill | Angiostatic compositions comprising truncated tyrosyl-trna synthetase polypeptides and methods of using same |
| MX2010013632A (es) | 2008-06-11 | 2011-06-16 | Atyr Pharma Inc | Actividad trombopoyetica de polipeptidos de tirosil-arnt sintetasa. |
| CN102159708B (zh) | 2008-06-26 | 2016-08-31 | Atyr医药公司 | 包含具有非常规生物活性的甘氨酰-tRNA合成酶的组合物和方法 |
| JP5628807B2 (ja) | 2008-08-18 | 2014-11-19 | ソウル ナショナル ユニバーシティー インダストリー ファウンデーション | リジルｔＲＮＡ合成酵素の細胞内水準を調節して癌転移又は癌細胞の移動を調節する方法 |
| KR101102485B1 (ko) | 2008-10-10 | 2012-01-05 | 서울대학교산학협력단 | Ｇｒｓ단백질 또는 이의 단편의 신규한 용도 |
| KR101067817B1 (ko) | 2008-10-10 | 2011-09-27 | 서울대학교산학협력단 | Ａｉｍｐ1 폴리펩티드에 대한 항체를 포함하는 관절염 진단용 조성물 |
| KR101067815B1 (ko) | 2009-02-05 | 2011-09-27 | 서울대학교산학협력단 | 제1형 당뇨병의 신규한 진단 마커 |
| US20120058133A1 (en) | 2009-02-19 | 2012-03-08 | President And Fellows Of Harvard College | Inhibition of trna synthetases and therapeutic applications thereof |
| WO2010099477A2 (en) | 2009-02-27 | 2010-09-02 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| EP3255146B1 (en) | 2009-03-16 | 2019-05-15 | Pangu Biopharma Limited | Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities |
| JP5848236B2 (ja) | 2009-03-31 | 2016-01-27 | エータイアー ファーマ， インコーポレイテッド | 非標準的な生物活性を有するアスパルチルｔＲＮＡ合成酵素を含む組成物および方法 |
| EP2509625B1 (en) | 2009-12-11 | 2015-01-28 | Atyr Pharma, Inc. | Histidyl trna synthetases for reducing inflammation |
| US20110150885A1 (en) | 2009-12-11 | 2011-06-23 | Atyr Pharma, Inc. | Aminoacyl trna synthetases for modulating hematopoiesis |
| US8828395B2 (en) | 2009-12-11 | 2014-09-09 | Atyr Pharma, Inc. | Antibodies that bind tyrosyl-tRNA synthetases |
| US8828685B2 (en) | 2010-02-04 | 2014-09-09 | The Scripps Research Institute | Monomeric forms of human aminoacyl-t-RNA synthetases having non-canonical biological activities |
| WO2011139714A2 (en) | 2010-04-26 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
| CN103096910A (zh) | 2010-04-27 | 2013-05-08 | Atyr医药公司 | 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103096911B (zh) | 2010-04-27 | 2018-05-29 | Atyr 医药公司 | 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| AU2011248457B2 (en) | 2010-04-29 | 2017-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases |
| CN103097523B (zh) | 2010-04-29 | 2016-09-28 | Atyr医药公司 | 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| WO2011140132A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
| CA2797978C (en) | 2010-05-03 | 2019-12-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
| US8946157B2 (en) | 2010-05-03 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases |
| EP2566515B1 (en) | 2010-05-03 | 2017-08-02 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases |
| JP6008843B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ， インコーポレイテッド | グルタミル−プロリルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| CN102985103A (zh) | 2010-05-04 | 2013-03-20 | Atyr医药公司 | 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现 |
| US8945541B2 (en) | 2010-05-14 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases |
| WO2011146410A2 (en) | 2010-05-17 | 2011-11-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases |
| CA2800375C (en) | 2010-05-27 | 2021-03-09 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases |
| CN103118694B (zh) | 2010-06-01 | 2016-08-03 | Atyr医药公司 | 与赖氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| CA2804416C (en) | 2010-07-12 | 2020-04-28 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| CA2804424C (en) | 2010-07-12 | 2021-03-30 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| KR102099730B1 (ko) | 2010-07-12 | 2020-04-16 | 에이티와이알 파마, 인코포레이티드 | 아스파르틸trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
| CA2808539C (en) | 2010-08-25 | 2021-05-25 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases |
| CA2812795C (en) | 2010-10-06 | 2021-08-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases |
| WO2012158945A2 (en) | 2011-05-19 | 2012-11-22 | The Scripps Research Institute | Compositions and methods for treating charcot-marie-tooth diseases and related neuronal diseases |
| US9714419B2 (en) | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
| US9822353B2 (en) | 2011-12-06 | 2017-11-21 | Atyr Pharma, Inc. | PEGylated aspartyl-tRNA synthetase polypeptides |
| US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
| CN104220461A (zh) | 2011-12-29 | 2014-12-17 | Atyr医药公司 | 天冬氨酰-tRNA合成酶-FC缀合物 |
| CN104334196B (zh) | 2012-02-16 | 2018-04-10 | Atyr 医药公司 | 用于治疗自身免疫疾病和炎性疾病的组氨酰‑tRNA合成酶 |
| US20140066321A1 (en) | 2012-07-23 | 2014-03-06 | Pangu Biopharma Limited | Structures of human histidyl-trna synthetase and methods of use |
| JP6397479B2 (ja) | 2013-03-15 | 2018-09-26 | エータイアー ファーマ， インコーポレイテッド | ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート |
-
2011
- 2011-04-27 CN CN2011800303013A patent/CN103096910A/zh active Pending
- 2011-04-27 CN CN201711430252.8A patent/CN108165537A/zh active Pending
- 2011-04-27 ES ES11777984.3T patent/ES2638311T3/es active Active
- 2011-04-27 AU AU2011248521A patent/AU2011248521B2/en active Active
- 2011-04-27 JP JP2013508229A patent/JP6240500B2/ja active Active
- 2011-04-27 WO PCT/US2011/034207 patent/WO2011139801A2/en not_active Ceased
- 2011-04-27 US US13/643,750 patent/US8986681B2/en active Active
- 2011-04-27 CA CA2797259A patent/CA2797259C/en active Active
- 2011-04-27 EP EP11777984.3A patent/EP2563382B1/en active Active
-
2015
- 2015-02-11 US US14/619,722 patent/US9580706B2/en active Active
- 2015-07-17 JP JP2015142866A patent/JP2015186486A/ja active Pending
-
2017
- 2017-01-12 US US15/404,682 patent/US10150958B2/en active Active
- 2017-08-28 JP JP2017163371A patent/JP2017201994A/ja not_active Withdrawn
-
2018
- 2018-10-25 US US16/171,087 patent/US10563192B2/en active Active