JP2013531659A5 - - Google Patents
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- Publication number
- JP2013531659A5 JP2013531659A5 JP2013516595A JP2013516595A JP2013531659A5 JP 2013531659 A5 JP2013531659 A5 JP 2013531659A5 JP 2013516595 A JP2013516595 A JP 2013516595A JP 2013516595 A JP2013516595 A JP 2013516595A JP 2013531659 A5 JP2013531659 A5 JP 2013531659A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- hydrogen
- prodrug
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims description 74
- 239000001257 hydrogen Substances 0.000 claims description 70
- 125000000217 alkyl group Chemical group 0.000 claims description 65
- 150000001412 amines Chemical class 0.000 claims description 6
- 230000004962 physiological condition Effects 0.000 claims description 3
- 239000008177 pharmaceutical agent Substances 0.000 claims description 2
- 229940002612 prodrug Drugs 0.000 claims 13
- 239000000651 prodrug Substances 0.000 claims 13
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 12
- 239000004471 Glycine Substances 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 description 39
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 29
- 125000003118 aryl group Chemical group 0.000 description 20
- 125000004429 atom Chemical group 0.000 description 13
- 125000000623 heterocyclic group Chemical group 0.000 description 9
- 125000003342 alkenyl group Chemical group 0.000 description 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 4
- 125000005843 halogen group Chemical group 0.000 description 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 4
- 108010016626 Dipeptides Proteins 0.000 description 2
- 0 CC*C(*)(*)C(N(*)C(C)(*)C(C)=*)=O Chemical compound CC*C(*)(*)C(N(*)C(C)(*)C(C)=*)=O 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35819410P | 2010-06-24 | 2010-06-24 | |
| US61/358,194 | 2010-06-24 | ||
| PCT/US2011/039755 WO2011162968A1 (en) | 2010-06-24 | 2011-06-09 | Dipeptide linked medicinal agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013531659A JP2013531659A (ja) | 2013-08-08 |
| JP2013531659A5 true JP2013531659A5 (https=) | 2017-02-09 |
| JP6101202B2 JP6101202B2 (ja) | 2017-03-22 |
Family
ID=45371760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516595A Active JP6101202B2 (ja) | 2010-06-24 | 2011-06-09 | ジペプチド結合医薬剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130137849A1 (https=) |
| EP (1) | EP2588127A4 (https=) |
| JP (1) | JP6101202B2 (https=) |
| KR (1) | KR20130083843A (https=) |
| CN (1) | CN102958533B (https=) |
| AR (1) | AR081984A1 (https=) |
| CA (1) | CA2796879A1 (https=) |
| MX (1) | MX2012014573A (https=) |
| RU (1) | RU2013102991A (https=) |
| TW (1) | TW201204392A (https=) |
| WO (1) | WO2011162968A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
| AR072160A1 (es) | 2008-06-17 | 2010-08-11 | Univ Indiana Res & Tech Corp | Co-agonistas del receptor de glucagon/glp-1 |
| EP2443146B1 (en) | 2009-06-16 | 2016-10-05 | Indiana University Research And Technology Corporation | Gip receptor-active glucagon compounds |
| ES2711526T3 (es) | 2010-08-13 | 2019-05-06 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
| RS56173B1 (sr) | 2011-06-22 | 2017-11-30 | Univ Indiana Res & Tech Corp | Koagonisti receptora za glukagon/glp-1 receptora |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| BR112014020103A2 (pt) | 2012-02-15 | 2018-10-09 | Aileron Therapeutics, Inc. | macrociclos peptidomiméticos |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| JP2020528082A (ja) | 2017-07-17 | 2020-09-17 | ロイズマン，キース | 加齢黄斑変性と他の眼疾患の治療用の細胞透過性ペプチドを使用する治療薬の局所送達 |
| EP4185607A1 (en) | 2020-07-22 | 2023-05-31 | Novo Nordisk A/S | Co-agonists at glp-1 and gip receptors suitable for oral delivery |
| TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5786335A (en) * | 1995-11-06 | 1998-07-28 | Warner-Lambert Company | Sulfhydryl containing peptides for treating vascular disease |
| EP1243276A1 (en) * | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US20050187147A1 (en) * | 2003-09-22 | 2005-08-25 | Newman Michael J. | Compositions and methods for increasing drug efficiency |
| US8263545B2 (en) * | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| CA2621847A1 (en) * | 2005-09-08 | 2007-03-15 | Shire Llc | Prodrugs of t3 and t4 with enhanced bioavailability |
| MX2010005317A (es) * | 2007-11-20 | 2010-06-02 | Ambrx Inc | Polipeptidos de insulina modificados y sus usos. |
| EP2249853A4 (en) * | 2008-01-30 | 2012-12-26 | Univ Indiana Res & Tech Corp | ESTER BASED PEPTIDE PRODRUGS |
| AU2009335715B2 (en) * | 2008-12-19 | 2016-09-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| WO2010080605A1 (en) * | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Dipeptide linked medicinal agents |
| PE20120332A1 (es) * | 2008-12-19 | 2012-04-14 | Univ Indiana Res & Tech Corp | Profarmacos de peptido de la superfamilia de glucagon basado en amida |
-
2011
- 2011-06-09 MX MX2012014573A patent/MX2012014573A/es not_active Application Discontinuation
- 2011-06-09 US US13/697,050 patent/US20130137849A1/en not_active Abandoned
- 2011-06-09 CA CA2796879A patent/CA2796879A1/en not_active Abandoned
- 2011-06-09 KR KR1020127033201A patent/KR20130083843A/ko not_active Withdrawn
- 2011-06-09 JP JP2013516595A patent/JP6101202B2/ja active Active
- 2011-06-09 RU RU2013102991/04A patent/RU2013102991A/ru not_active Application Discontinuation
- 2011-06-09 WO PCT/US2011/039755 patent/WO2011162968A1/en not_active Ceased
- 2011-06-09 CN CN201180031396.0A patent/CN102958533B/zh not_active Expired - Fee Related
- 2011-06-09 EP EP11798607.5A patent/EP2588127A4/en not_active Withdrawn
- 2011-06-23 TW TW100121932A patent/TW201204392A/zh unknown
- 2011-06-23 AR ARP110102185A patent/AR081984A1/es unknown
-
2016
- 2016-02-05 US US15/016,959 patent/US20160158375A1/en not_active Abandoned
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