JP2013530931A5 - - Google Patents
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- Publication number
- JP2013530931A5 JP2013530931A5 JP2013505286A JP2013505286A JP2013530931A5 JP 2013530931 A5 JP2013530931 A5 JP 2013530931A5 JP 2013505286 A JP2013505286 A JP 2013505286A JP 2013505286 A JP2013505286 A JP 2013505286A JP 2013530931 A5 JP2013530931 A5 JP 2013530931A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- poly
- active ingredient
- biologically active
- form according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002552 dosage form Substances 0.000 claims 48
- 239000004480 active ingredient Substances 0.000 claims 15
- 239000007788 liquid Substances 0.000 claims 11
- 239000003381 stabilizer Substances 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 6
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 5
- 229920001577 copolymer Polymers 0.000 claims 4
- -1 poly (2-ethyl- Chemical group 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 3
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 239000007909 solid dosage form Substances 0.000 claims 3
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- RFKMCNOHBTXSMU-UHFFFAOYSA-N methoxyflurane Chemical compound COC(F)(F)C(Cl)Cl RFKMCNOHBTXSMU-UHFFFAOYSA-N 0.000 claims 2
- 229960002455 methoxyflurane Drugs 0.000 claims 2
- 239000000693 micelle Substances 0.000 claims 2
- 239000004584 polyacrylic acid Substances 0.000 claims 2
- SMUQFGGVLNAIOZ-UHFFFAOYSA-N quinaldine Chemical compound C1=CC=CC2=NC(C)=CC=C21 SMUQFGGVLNAIOZ-UHFFFAOYSA-N 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 1
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 1
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 1
- WDRZVZVXHZNSFG-UHFFFAOYSA-N 1-ethenylpyridin-1-ium Chemical compound C=C[N+]1=CC=CC=C1 WDRZVZVXHZNSFG-UHFFFAOYSA-N 0.000 claims 1
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 claims 1
- ABYGSZMCWVXFCQ-UHFFFAOYSA-N 4-propylheptane Chemical compound CCCC(CCC)CCC ABYGSZMCWVXFCQ-UHFFFAOYSA-N 0.000 claims 1
- 229920001685 Amylomaize Polymers 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 229960004280 dinoprost tromethamine Drugs 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims 1
- 229940043264 dodecyl sulfate Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 claims 1
- 235000019175 phylloquinone Nutrition 0.000 claims 1
- 239000011772 phylloquinone Substances 0.000 claims 1
- 229960001898 phytomenadione Drugs 0.000 claims 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229940065514 poly(lactide) Drugs 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920002187 poly[N-2-(hydroxypropyl) methacrylamide] polymer Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920002557 polyglycidol polymer Polymers 0.000 claims 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229920000909 polytetrahydrofuran Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 claims 1
- 229960004134 propofol Drugs 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32734810P | 2010-04-23 | 2010-04-23 | |
| US61/327,348 | 2010-04-23 | ||
| PCT/CA2011/000447 WO2011130834A1 (en) | 2010-04-23 | 2011-04-21 | Non-intravenous dosage form comprising solid formulation of liquid biologically active agent and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017094186A Division JP6572256B2 (ja) | 2010-04-23 | 2017-05-10 | 液状生物学的活性成分の固形製剤を含む非静脈内剤型およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013530931A JP2013530931A (ja) | 2013-08-01 |
| JP2013530931A5 true JP2013530931A5 (cg-RX-API-DMAC7.html) | 2014-05-29 |
Family
ID=44833585
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505286A Pending JP2013530931A (ja) | 2010-04-23 | 2011-04-21 | 液状生物学的活性成分の固形製剤を含む非静脈内剤型およびその使用 |
| JP2017094186A Active JP6572256B2 (ja) | 2010-04-23 | 2017-05-10 | 液状生物学的活性成分の固形製剤を含む非静脈内剤型およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017094186A Active JP6572256B2 (ja) | 2010-04-23 | 2017-05-10 | 液状生物学的活性成分の固形製剤を含む非静脈内剤型およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130039864A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2563349A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2013530931A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2797098C (cg-RX-API-DMAC7.html) |
| IL (1) | IL222568A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011130834A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060198891A1 (en) | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
| WO2011130834A1 (en) * | 2010-04-23 | 2011-10-27 | Labopharm Inc. | Non-intravenous dosage form comprising solid formulation of liquid biologically active agent and uses thereof |
| WO2017205632A1 (en) * | 2016-05-27 | 2017-11-30 | The Johns Hopkins University | Buccal, sublingual and intranasal delivery of fospropofol |
| JP6912876B2 (ja) * | 2016-10-06 | 2021-08-04 | 三洋化成工業株式会社 | アクリル系医薬固形製剤用添加剤 |
| GB2561009B (en) * | 2017-03-31 | 2020-05-13 | Altus Formulation Inc | Non-ionic PVP-PLA block copolymers and pharmaceutical compositions derived therefrom |
| WO2021247463A1 (en) * | 2020-06-02 | 2021-12-09 | Purdue Research Foundation | Formulation of monodisperse kinetically frozen polymer micelles via equilibration-nanoprecipitation |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1120109A3 (en) * | 2000-01-24 | 2002-07-10 | Pfizer Products Inc. | Rapidly disintegrating and fast dissolving solid dosage form |
| US6338859B1 (en) * | 2000-06-29 | 2002-01-15 | Labopharm Inc. | Polymeric micelle compositions |
| US6623765B1 (en) * | 2000-08-01 | 2003-09-23 | University Of Florida, Research Foundation, Incorporated | Microemulsion and micelle systems for solubilizing drugs |
| US6780324B2 (en) * | 2002-03-18 | 2004-08-24 | Labopharm, Inc. | Preparation of sterile stabilized nanodispersions |
| AU2003275854B9 (en) * | 2002-10-25 | 2009-08-27 | Paladin Labs (Barbados) Inc. | Controlled-release compositions |
| EP2444069B1 (en) * | 2003-07-23 | 2019-06-05 | Evonik Corporation | Controlled release compositions |
| WO2005058250A2 (en) * | 2003-12-17 | 2005-06-30 | Mgi Gp, Inc. | Methods of administering water-soluble prodrugs of propofol for extended sedation |
| US20060198891A1 (en) * | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
| BRPI0716890A2 (pt) * | 2006-09-22 | 2013-10-22 | Labopharm Inc | Composição, e, método de produção de uma composição, de administração de um agente farmaceuticamente ativo insolúvel em água a um mamífero, e de tratamento de câncer em um mamífero |
| CA2694089A1 (en) * | 2007-07-16 | 2009-01-22 | Northeastern University | Therapeutic stable nanoparticles |
| PL2200588T3 (pl) * | 2007-09-25 | 2019-09-30 | Solubest Ltd. | Kompozycje zawierające lipofilowe związki aktywne i sposób ich wytwarzania |
| FR2930444B1 (fr) * | 2008-04-29 | 2010-06-04 | Servier Lab | Micelles polymerisees |
| WO2011130834A1 (en) * | 2010-04-23 | 2011-10-27 | Labopharm Inc. | Non-intravenous dosage form comprising solid formulation of liquid biologically active agent and uses thereof |
-
2011
- 2011-04-21 WO PCT/CA2011/000447 patent/WO2011130834A1/en not_active Ceased
- 2011-04-21 JP JP2013505286A patent/JP2013530931A/ja active Pending
- 2011-04-21 US US13/643,038 patent/US20130039864A1/en not_active Abandoned
- 2011-04-21 EP EP11771439.4A patent/EP2563349A4/en not_active Withdrawn
- 2011-04-21 CA CA2797098A patent/CA2797098C/en active Active
-
2012
- 2012-10-21 IL IL222568A patent/IL222568A/en active IP Right Grant
-
2017
- 2017-05-10 JP JP2017094186A patent/JP6572256B2/ja active Active
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