JP2013526518A - Mciおよびアルツハイマー病の処置 - Google Patents

Mciおよびアルツハイマー病の処置 Download PDF

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Publication number
JP2013526518A
JP2013526518A JP2013510067A JP2013510067A JP2013526518A JP 2013526518 A JP2013526518 A JP 2013526518A JP 2013510067 A JP2013510067 A JP 2013510067A JP 2013510067 A JP2013510067 A JP 2013510067A JP 2013526518 A JP2013526518 A JP 2013526518A
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Japan
Prior art keywords
nifedipine
pharmaceutical composition
lactam
nitroso
therapeutically effective
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JP2013510067A
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Japanese (ja)
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JP2013526518A5 (enExample
Inventor
マーク ラベル,
バート リン,
Original Assignee
ザ ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション
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Priority claimed from PCT/US2010/034721 external-priority patent/WO2010132671A1/en
Application filed by ザ ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション filed Critical ザ ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション
Publication of JP2013526518A publication Critical patent/JP2013526518A/ja
Publication of JP2013526518A5 publication Critical patent/JP2013526518A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013510067A 2010-05-13 2010-11-18 Mciおよびアルツハイマー病の処置 Pending JP2013526518A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
USPCT/US2010/034721 2010-05-13
PCT/US2010/034721 WO2010132671A1 (en) 2009-05-15 2010-05-13 Treatment of mci and alzheimer's disease
PCT/US2010/057287 WO2011142778A1 (en) 2010-05-13 2010-11-18 Treatment of mci and alzheimer's disease

Publications (2)

Publication Number Publication Date
JP2013526518A true JP2013526518A (ja) 2013-06-24
JP2013526518A5 JP2013526518A5 (enExample) 2014-01-09

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Family Applications (1)

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JP2013510067A Pending JP2013526518A (ja) 2010-05-13 2010-11-18 Mciおよびアルツハイマー病の処置

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EP (1) EP2568811A4 (enExample)
JP (1) JP2013526518A (enExample)
CN (1) CN102984938A (enExample)
AU (1) AU2010353287A1 (enExample)
CA (1) CA2799162A1 (enExample)
WO (1) WO2011142778A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017504630A (ja) * 2014-01-29 2017-02-09 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company アリールラクタムキナーゼ阻害剤
JP2021017402A (ja) * 2019-07-17 2021-02-15 東海物産株式会社 軽度認知障害改善用組成物及びこの組成物を用いた軽度認知障害の改善方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2994160T3 (da) * 2013-05-06 2019-08-12 Baxalta Inc Behandling af alzheimers sygdom subpopulationer med poolet immunoglobulin g
CN105659093A (zh) 2013-06-28 2016-06-08 株式会社Mcbi 认知功能障碍疾病的生物标记物及使用该生物标记物的认知功能障碍疾病的检测方法
CN106177046A (zh) * 2016-08-29 2016-12-07 杨添福 一种基于普立宁钾开发的神经认知障碍治疗药物及其制备方法
CN106645505A (zh) * 2016-11-18 2017-05-10 中国医科大学 可实现glt‑1蛋白鉴定及绝对定量的试剂盒及测定方法
CN107022019B (zh) * 2016-11-24 2020-10-30 桂林医学院 一种用于脑内降铁除自由基的多肽、制备方法与应用
CN106636388A (zh) * 2016-12-15 2017-05-10 湖南中能荆卫生物科技有限公司 用于亨廷顿病诊断的基因及其应用以及由其编码的蛋白和蛋白的应用
CN108191966B (zh) * 2018-01-11 2020-10-27 桂林医学院 一种含导肽可穿越血脑屏障螯合脑内铁降自由基的多肽
CN114437173A (zh) * 2019-01-07 2022-05-06 森纳生物科学公司 新型肽及其用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8002A (en) * 1851-03-25 Upright pianoforte
WO2006109164A2 (en) * 2005-04-15 2006-10-19 Research & Innovation Soc. Coop. A R.L. A method for preventing, delaying or reverting abnormal amyloid deposition
JP2007512338A (ja) * 2003-11-21 2007-05-17 メモリー・ファーマシューティカルズ・コーポレイション L型カルシウムチャンネルブロッカーとコリンエステラーゼ阻害剤を用いた組成物及び処置方法
WO2007064010A1 (ja) * 2005-12-02 2007-06-07 Mochida Pharmaceutical Co., Ltd. アルツハイマー型認知症予防・治療剤
WO2008051291A2 (en) * 2006-04-11 2008-05-02 Ordway Research Institute Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof

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DE2126533A1 (de) * 1971-05-28 1972-12-14 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur Herstellung pharma zeutischer Zubereitungen
US6558650B1 (en) * 1998-04-08 2003-05-06 Oregon Health And Science University Enhancement of cellular gallium uptake
US6489319B2 (en) * 1999-08-16 2002-12-03 Revaax Pharmaceuticals, Llc Neurotherapeutic use of carboxypeptidase inhibitors
EP1343501A4 (en) * 2000-11-21 2004-12-15 Howard Zik USE OF 1,4-DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROLOGICAL INVOLVEMENTS ATTRIBUTABLE TO HERPES VIRUS
WO2007112288A2 (en) * 2006-03-23 2007-10-04 Mount Sinai School Of Medicine Cardiovascular composition and use the same for the treatment of alzheimers disease
US20080293712A1 (en) * 2007-03-05 2008-11-27 Wyeth Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof
AU2009295308A1 (en) * 2008-09-25 2010-04-01 Merck Canada Inc. Beta-carboline sulphonylurea derivatives as EP4 receptor antagonists
TW201103907A (en) * 2009-03-20 2011-02-01 Lundbeck & Co As H Amide derivatives as neuropeptide Y5 receptor ligands

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8002A (en) * 1851-03-25 Upright pianoforte
JP2007512338A (ja) * 2003-11-21 2007-05-17 メモリー・ファーマシューティカルズ・コーポレイション L型カルシウムチャンネルブロッカーとコリンエステラーゼ阻害剤を用いた組成物及び処置方法
WO2006109164A2 (en) * 2005-04-15 2006-10-19 Research & Innovation Soc. Coop. A R.L. A method for preventing, delaying or reverting abnormal amyloid deposition
WO2007064010A1 (ja) * 2005-12-02 2007-06-07 Mochida Pharmaceutical Co., Ltd. アルツハイマー型認知症予防・治療剤
WO2008051291A2 (en) * 2006-04-11 2008-05-02 Ordway Research Institute Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6014050249; Neurobiology of Aging 15(1), 1994, 55-61 *
JPN6014050251; Neurobiology of Aging 16(5), 1995, 791-796 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017504630A (ja) * 2014-01-29 2017-02-09 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company アリールラクタムキナーゼ阻害剤
JP2021017402A (ja) * 2019-07-17 2021-02-15 東海物産株式会社 軽度認知障害改善用組成物及びこの組成物を用いた軽度認知障害の改善方法
JP7321017B2 (ja) 2019-07-17 2023-08-04 東海物産株式会社 機能性食品

Also Published As

Publication number Publication date
CA2799162A1 (en) 2011-11-17
EP2568811A1 (en) 2013-03-20
CN102984938A (zh) 2013-03-20
AU2010353287A1 (en) 2012-11-29
WO2011142778A1 (en) 2011-11-17
EP2568811A4 (en) 2014-03-12

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