JP2013525348A - 酵素切断可能なオピオイドプロドラッグとそのインヒビターとを含んでなる組成物 - Google Patents

酵素切断可能なオピオイドプロドラッグとそのインヒビターとを含んでなる組成物 Download PDF

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Publication number
JP2013525348A
JP2013525348A JP2013506120A JP2013506120A JP2013525348A JP 2013525348 A JP2013525348 A JP 2013525348A JP 2013506120 A JP2013506120 A JP 2013506120A JP 2013506120 A JP2013506120 A JP 2013506120A JP 2013525348 A JP2013525348 A JP 2013525348A
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Japan
Prior art keywords
substituted
aryl
alkyl
hydrogen
arylalkyl
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JP2013506120A
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English (en)
Japanese (ja)
Inventor
イー． ジェンキンス，トーマス
オー． フスフェルド，クレイグ
ディー． セローギー，ジュリー
ダブリュー． レイ，ジョナサン
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Signature Therapeutics Inc
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Signature Therapeutics Inc
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Application filed by Signature Therapeutics Inc filed Critical Signature Therapeutics Inc
Publication of JP2013525348A publication Critical patent/JP2013525348A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2013506120A 2010-04-21 2010-04-21 酵素切断可能なオピオイドプロドラッグとそのインヒビターとを含んでなる組成物 Pending JP2013525348A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/031953 WO2011133149A1 (fr) 2010-04-21 2010-04-21 Compositions comprenant des promédicaments opiacés clivables par enzyme et leurs inhibiteurs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015127573A Division JP2015199772A (ja) 2015-06-25 2015-06-25 酵素切断可能なオピオイドプロドラッグとそのインヒビターとを含んでなる組成物

Publications (1)

Publication Number Publication Date
JP2013525348A true JP2013525348A (ja) 2013-06-20

Family

ID=44834413

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013506120A Pending JP2013525348A (ja) 2010-04-21 2010-04-21 酵素切断可能なオピオイドプロドラッグとそのインヒビターとを含んでなる組成物

Country Status (9)

Country Link
EP (1) EP2560489A4 (fr)
JP (1) JP2013525348A (fr)
CN (1) CN102917589A (fr)
AU (1) AU2010351605C1 (fr)
BR (1) BR112012026768A2 (fr)
CA (1) CA2795222A1 (fr)
IL (1) IL222354A0 (fr)
RU (1) RU2012149438A (fr)
WO (1) WO2011133149A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013503862A (ja) * 2009-09-08 2013-02-04 シグネーチャー セラピューティクス，インク． 酵素切断可能なケトン修飾オピオイドプロドラッグとその任意選択のインヒビターとを含んでなる組成物
JP2014502972A (ja) * 2011-01-11 2014-02-06 シグネーチャー セラピューティクス，インク． 酵素切断可能なオキシコドンプロドラッグを含んでなる組成物
US12011427B2 (en) 2019-12-11 2024-06-18 Inspirna, Inc. Methods of treating cancer

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11634384B2 (en) 2014-11-25 2023-04-25 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
US20170056352A1 (en) 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
US10821105B2 (en) 2016-05-25 2020-11-03 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
WO2018160178A1 (fr) 2017-03-01 2018-09-07 Rgenix, Inc. Sels pharmaceutiquement acceptables d'acide bêta-guanidinopropionique ayant des propriétés améliorées et utilisations de ceux-ci
WO2019058367A1 (fr) * 2017-09-19 2019-03-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Promédicaments lipophiles à base de peptides
WO2019058374A1 (fr) 2017-09-19 2019-03-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Peptides cycliques n-méthylés et promédicaments de ceux-ci
JP2021532183A (ja) 2018-07-27 2021-11-25 コンセントリック アナルジェジクス，インク． フェノール性ｔｒｐｖ１アゴニストのｐｅｇ化プロドラッグ
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070123468A1 (en) * 2005-08-19 2007-05-31 Pharmacofore, Inc. Prodrugs of active agents
JP2012509846A (ja) * 2008-10-17 2012-04-26 ファーマコフォア，インク． フェノール性オピオイドの放出が減弱された医薬組成物

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* Cited by examiner, † Cited by third party
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DE69941367D1 (de) * 1998-12-15 2009-10-15 Applera Corp Multienzym-nachweisverfahren
US7060708B2 (en) * 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7598273B2 (en) * 2005-10-06 2009-10-06 Auspex Pharmaceuticals, Inc Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties
SG172633A1 (en) * 2006-05-26 2011-07-28 Pharmacofore Inc Controlled release of phenolic opioids
CN101528264B (zh) * 2006-05-26 2014-02-26 特色疗法股份有限公司 酚类阿片样物质的受控释放
WO2008101187A2 (fr) * 2007-02-16 2008-08-21 Pharmacofore, Inc. Pro-médicaments d'antagonistes opioïdes phénoliques périphériques
JP2013503862A (ja) * 2009-09-08 2013-02-04 シグネーチャー セラピューティクス，インク． 酵素切断可能なケトン修飾オピオイドプロドラッグとその任意選択のインヒビターとを含んでなる組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070123468A1 (en) * 2005-08-19 2007-05-31 Pharmacofore, Inc. Prodrugs of active agents
JP2012509846A (ja) * 2008-10-17 2012-04-26 ファーマコフォア，インク． フェノール性オピオイドの放出が減弱された医薬組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6014017363; Ｂｉｏｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ ３０, 2002, ｐ．２８５-３０１ *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013503862A (ja) * 2009-09-08 2013-02-04 シグネーチャー セラピューティクス，インク． 酵素切断可能なケトン修飾オピオイドプロドラッグとその任意選択のインヒビターとを含んでなる組成物
JP2016041698A (ja) * 2009-09-08 2016-03-31 シグネーチャー セラピューティクス, インク.Signature Therapeutics, Inc. 酵素切断可能なケトン修飾オピオイドプロドラッグとその任意選択のインヒビターとを含んでなる組成物
JP2018172387A (ja) * 2009-09-08 2018-11-08 シグネーチャー セラピューティクス, インク.Signature Therapeutics, Inc. 酵素切断可能なケトン修飾オピオイドプロドラッグとその任意選択のインヒビターとを含んでなる組成物
JP2014502972A (ja) * 2011-01-11 2014-02-06 シグネーチャー セラピューティクス，インク． 酵素切断可能なオキシコドンプロドラッグを含んでなる組成物
US12011427B2 (en) 2019-12-11 2024-06-18 Inspirna, Inc. Methods of treating cancer

Also Published As

Publication number Publication date
CN102917589A (zh) 2013-02-06
BR112012026768A2 (pt) 2015-09-29
CA2795222A1 (fr) 2011-10-27
AU2010351605A1 (en) 2012-11-22
EP2560489A4 (fr) 2014-01-22
WO2011133149A1 (fr) 2011-10-27
AU2010351605B2 (en) 2015-01-29
RU2012149438A (ru) 2014-05-27
EP2560489A1 (fr) 2013-02-27
IL222354A0 (en) 2012-12-31
AU2010351605C1 (en) 2015-08-06

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