JP2013523842A5 - - Google Patents
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- Publication number
- JP2013523842A5 JP2013523842A5 JP2013504020A JP2013504020A JP2013523842A5 JP 2013523842 A5 JP2013523842 A5 JP 2013523842A5 JP 2013504020 A JP2013504020 A JP 2013504020A JP 2013504020 A JP2013504020 A JP 2013504020A JP 2013523842 A5 JP2013523842 A5 JP 2013523842A5
- Authority
- JP
- Japan
- Prior art keywords
- pool
- cord blood
- patient
- stem cell
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004700 fetal blood Anatomy 0.000 claims 82
- 210000000130 stem cell Anatomy 0.000 claims 75
- 238000000034 method Methods 0.000 claims 52
- 239000000523 sample Substances 0.000 claims 32
- 239000000427 antigen Substances 0.000 claims 20
- 108091007433 antigens Proteins 0.000 claims 20
- 102000036639 antigens Human genes 0.000 claims 20
- 230000003394 haemopoietic effect Effects 0.000 claims 20
- 108700028369 Alleles Proteins 0.000 claims 19
- 230000002062 proliferating effect Effects 0.000 claims 16
- 210000004369 blood Anatomy 0.000 claims 15
- 239000008280 blood Substances 0.000 claims 15
- 230000003169 placental effect Effects 0.000 claims 14
- 230000006870 function Effects 0.000 claims 13
- 238000004590 computer program Methods 0.000 claims 12
- 239000012520 frozen sample Substances 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 9
- 230000035755 proliferation Effects 0.000 claims 8
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 7
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 7
- 241000282412 Homo Species 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 4
- 238000011176 pooling Methods 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 3
- 238000010257 thawing Methods 0.000 claims 3
- 206010033661 Pancytopenia Diseases 0.000 claims 2
- 238000007710 freezing Methods 0.000 claims 2
- 230000008014 freezing Effects 0.000 claims 2
- 208000004235 neutropenia Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 238000005138 cryopreservation Methods 0.000 claims 1
- 230000005865 ionizing radiation Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32257510P | 2010-04-09 | 2010-04-09 | |
| US61/322,575 | 2010-04-09 | ||
| PCT/US2011/031957 WO2011127472A1 (en) | 2010-04-09 | 2011-04-11 | Compositions and methods for providing hematopoietic function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017079812A Division JP2017149752A (ja) | 2010-04-09 | 2017-04-13 | 臍帯血移植体を補うための方法、造血機能を提供するための方法および増殖臍帯血幹細胞の採取物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013523842A JP2013523842A (ja) | 2013-06-17 |
| JP2013523842A5 true JP2013523842A5 (enExample) | 2015-05-07 |
Family
ID=44120971
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013504020A Pending JP2013523842A (ja) | 2010-04-09 | 2011-04-11 | 造血機能を提供するための組成物および方法 |
| JP2017079812A Pending JP2017149752A (ja) | 2010-04-09 | 2017-04-13 | 臍帯血移植体を補うための方法、造血機能を提供するための方法および増殖臍帯血幹細胞の採取物 |
| JP2020020612A Active JP7041179B2 (ja) | 2010-04-09 | 2020-02-10 | 造血機能を提供するための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017079812A Pending JP2017149752A (ja) | 2010-04-09 | 2017-04-13 | 臍帯血移植体を補うための方法、造血機能を提供するための方法および増殖臍帯血幹細胞の採取物 |
| JP2020020612A Active JP7041179B2 (ja) | 2010-04-09 | 2020-02-10 | 造血機能を提供するための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20130095080A1 (enExample) |
| EP (2) | EP2555781A1 (enExample) |
| JP (3) | JP2013523842A (enExample) |
| CA (2) | CA2795938C (enExample) |
| WO (1) | WO2011127472A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2788476B1 (en) | 2011-12-08 | 2019-05-22 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| EP2864476A4 (en) * | 2012-06-14 | 2016-04-06 | Hutchinson Fred Cancer Res | EX-VIVO EXPANSION OF MYOGENIC STEM CELLS THROUGH NOTCH ACTIVATION |
| CA2897499A1 (en) * | 2013-01-08 | 2014-07-17 | Fred Hutchinson Cancer Research Center | Compositions and methods for expansion of embryonic hematopoietic stem cells |
| KR20160079854A (ko) | 2013-10-31 | 2016-07-06 | 프레드 헛친슨 켄서 리서치 센터 | 변형된 조혈 줄기/선조 및 비-t 효과기 세포 및 이의 용도 |
| US20150342165A1 (en) * | 2014-05-29 | 2015-12-03 | City Of Hope | Humanized mouse and methods of using the same |
| CN106459919B (zh) * | 2014-06-04 | 2021-03-23 | 弗莱德哈钦森癌症研究中心 | 使用notch 1和/或notch 2激动剂扩增和植入干细胞 |
| JP2016104711A (ja) * | 2014-11-21 | 2016-06-09 | 国立大学法人 東京大学 | 造血幹細胞移植を補助することに用いるための医薬組成物およびその製造方法 |
| EP3247808B1 (en) | 2015-01-21 | 2021-05-05 | Fred Hutchinson Cancer Research Center | Point-of-care and/or portable platform for gene therapy |
| JP6985934B2 (ja) | 2015-04-29 | 2021-12-22 | フレッド ハッチンソン キャンサー リサーチ センター | 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用 |
| US11827904B2 (en) | 2015-04-29 | 2023-11-28 | Fred Hutchinson Cancer Center | Modified stem cells and uses thereof |
| CA3005767A1 (en) * | 2015-12-04 | 2017-06-08 | Fred Hutchinson Cancer Research Center | Uses of expanded populations of hematopoietic stem/progenitor cells |
| CA2968946A1 (en) * | 2016-05-30 | 2017-11-30 | Ottawa Heart Institute Research Corporation | Serum-free and xenogen-free human cardiac explant-derived stem cells and uses and methods for the production thereof |
| AU2018212634A1 (en) * | 2017-01-24 | 2019-08-08 | Fred Hutchinson Cancer Research Center | Systems and methods for hematopoietic cell expansion utilizing hydrogels |
| EP4268831A3 (en) | 2018-09-12 | 2024-05-22 | Fred Hutchinson Cancer Center | Reducing cd33 expression to selectively protect therapeutic cells |
| JP2022533191A (ja) * | 2019-05-17 | 2022-07-21 | デヴェラ セラピューティクス インコーポレイテッド | 拡大した幹細胞生成物を使用して、血液悪性腫瘍を有する患者の処置転帰を改善するための組成物および方法 |
| WO2023150393A2 (en) | 2022-02-07 | 2023-08-10 | Ensoma, Inc. | Inhibitor-resistant mgmt modifications and modification of mgmt-encoding nucleic acids |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| DK0861261T3 (da) | 1995-06-28 | 2009-12-14 | Imp Cancer Res Tech | Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| WO2002059285A1 (en) * | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| AU2003219966A1 (en) * | 2002-03-05 | 2003-09-22 | Daniel D. Richard | Dual blood donation plus method |
| US20040219136A1 (en) * | 2003-02-13 | 2004-11-04 | Hariri Robert J | Use of umbilical cord blood to treat individuals having a disease, disorder or condition |
| US7569385B2 (en) * | 2003-08-14 | 2009-08-04 | The Regents Of The University Of California | Multipotent amniotic fetal stem cells |
| JP2005102656A (ja) * | 2003-10-02 | 2005-04-21 | Toray Ind Inc | 細胞培養器具およびそれを用いた細胞製剤の製造方法 |
| US20050276792A1 (en) * | 2004-03-26 | 2005-12-15 | Kaminski Joseph K | Systems and methods for providing a stem cell bank |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| ZA200704252B (en) | 2004-10-25 | 2009-09-30 | Cellerant Therapeutics Inc | Methods of expanding myeloid cell populations and uses thereof |
| CA2609266A1 (en) * | 2005-06-02 | 2006-12-07 | Stemcyte, Inc. | Plasma-depleted, non-red blood cell-depleted cord blood compositions and methods of use |
| EP1984491B1 (en) | 2006-02-14 | 2016-12-07 | Cellerant Therapeutics, Inc. | Compositions for enhancing engraftment of hematopoietic stem cells |
-
2011
- 2011-04-11 US US13/640,298 patent/US20130095080A1/en not_active Abandoned
- 2011-04-11 CA CA2795938A patent/CA2795938C/en active Active
- 2011-04-11 WO PCT/US2011/031957 patent/WO2011127472A1/en not_active Ceased
- 2011-04-11 CA CA3090548A patent/CA3090548C/en active Active
- 2011-04-11 EP EP11717077A patent/EP2555781A1/en not_active Withdrawn
- 2011-04-11 JP JP2013504020A patent/JP2013523842A/ja active Pending
- 2011-04-11 EP EP16162911.8A patent/EP3097916B1/en active Active
-
2015
- 2015-07-16 US US14/801,771 patent/US20160199418A1/en not_active Abandoned
-
2017
- 2017-04-13 JP JP2017079812A patent/JP2017149752A/ja active Pending
-
2019
- 2019-10-01 US US16/590,255 patent/US20200030384A1/en not_active Abandoned
-
2020
- 2020-02-10 JP JP2020020612A patent/JP7041179B2/ja active Active
-
2024
- 2024-08-30 US US18/820,648 patent/US20250235488A1/en active Pending
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