JP2013523656A5 - - Google Patents
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- JP2013523656A5 JP2013523656A5 JP2013501523A JP2013501523A JP2013523656A5 JP 2013523656 A5 JP2013523656 A5 JP 2013523656A5 JP 2013501523 A JP2013501523 A JP 2013501523A JP 2013501523 A JP2013501523 A JP 2013501523A JP 2013523656 A5 JP2013523656 A5 JP 2013523656A5
- Authority
- JP
- Japan
- Prior art keywords
- hcc
- combination
- composition
- nanoparticles
- taxane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 43
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims description 37
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 37
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 239000002105 nanoparticle Substances 0.000 claims description 16
- 102100001249 ALB Human genes 0.000 claims description 10
- 101710027066 ALB Proteins 0.000 claims description 10
- 229940050528 albumin Drugs 0.000 claims description 10
- 108091022031 Microtubules Proteins 0.000 claims description 6
- 102000028664 Microtubules Human genes 0.000 claims description 6
- 210000004688 Microtubules Anatomy 0.000 claims description 6
- 102100006455 STMN1 Human genes 0.000 claims description 6
- 101700082977 STMN1 Proteins 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drugs Drugs 0.000 claims description 5
- 230000015556 catabolic process Effects 0.000 claims description 4
- 230000004059 degradation Effects 0.000 claims description 4
- 238000006731 degradation reaction Methods 0.000 claims description 4
- 101700074435 ABI1 Proteins 0.000 claims description 2
- 102100017838 ABI1 Human genes 0.000 claims description 2
- 108060000078 ABP1 Proteins 0.000 claims description 2
- 108060000215 ADF1 Proteins 0.000 claims description 2
- 102100000245 ARHGAP4 Human genes 0.000 claims description 2
- 101710031656 ARHGAP4 Proteins 0.000 claims description 2
- 101710003347 BQ2027_MB2006C Proteins 0.000 claims description 2
- 102000001765 Bcl-2-Like Protein 11 Human genes 0.000 claims description 2
- 108010040168 Bcl-2-Like Protein 11 Proteins 0.000 claims description 2
- 101710041907 CCP1 Proteins 0.000 claims description 2
- 108050001278 CDC42 Proteins 0.000 claims description 2
- 102000017925 CHRM3 Human genes 0.000 claims description 2
- 108060003367 CHRM3 Proteins 0.000 claims description 2
- 102100018392 CNN3 Human genes 0.000 claims description 2
- 101700083893 CNN3 Proteins 0.000 claims description 2
- 102100001963 CSMD1 Human genes 0.000 claims description 2
- 101700074512 CSMD1 Proteins 0.000 claims description 2
- 102100002208 DBNL Human genes 0.000 claims description 2
- 102100003802 DDOST Human genes 0.000 claims description 2
- 101710024407 DDOST Proteins 0.000 claims description 2
- 102100015624 DOCK7 Human genes 0.000 claims description 2
- 101700055164 DOCK7 Proteins 0.000 claims description 2
- 102100016354 EHMT2 Human genes 0.000 claims description 2
- 101700009373 EHMT2 Proteins 0.000 claims description 2
- 101700060492 ENAH Proteins 0.000 claims description 2
- 102100011013 ENAH Human genes 0.000 claims description 2
- -1 ERLF1 Proteins 0.000 claims description 2
- 102100001368 ERMAP Human genes 0.000 claims description 2
- 101700029521 ERMAP Proteins 0.000 claims description 2
- 101700054126 HDAC5 Proteins 0.000 claims description 2
- 102100007188 HDAC5 Human genes 0.000 claims description 2
- 101710006482 HSPA8 Proteins 0.000 claims description 2
- 102100003586 HSPA8 Human genes 0.000 claims description 2
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 2
- 102100004336 LCP1 Human genes 0.000 claims description 2
- 101700057588 LCP1 Proteins 0.000 claims description 2
- 102100011884 LDLRAP1 Human genes 0.000 claims description 2
- 101710006701 LDLRAP1 Proteins 0.000 claims description 2
- 102100010689 MCF2 Human genes 0.000 claims description 2
- 108060004652 MCF2 Proteins 0.000 claims description 2
- 206010061289 Metastatic neoplasm Diseases 0.000 claims description 2
- 102100019469 OLA1 Human genes 0.000 claims description 2
- 101700010436 OLA1 Proteins 0.000 claims description 2
- 102100019910 PACSIN2 Human genes 0.000 claims description 2
- 101710044887 PACSIN2 Proteins 0.000 claims description 2
- 229960001592 Paclitaxel Drugs 0.000 claims description 2
- 102100012819 RASA1 Human genes 0.000 claims description 2
- 101700073537 RASA1 Proteins 0.000 claims description 2
- 108010041021 RUNX1 Translocation Partner 1 Protein Proteins 0.000 claims description 2
- 102100009178 RUNX1T1 Human genes 0.000 claims description 2
- 102100006457 STMN2 Human genes 0.000 claims description 2
- 101700017834 STMN2 Proteins 0.000 claims description 2
- 108020004459 Small Interfering RNA Proteins 0.000 claims description 2
- 101700035155 TOX4 Proteins 0.000 claims description 2
- 102100000138 TRIP10 Human genes 0.000 claims description 2
- 101710015216 TRIP10 Proteins 0.000 claims description 2
- 101710025594 TUBB3 Proteins 0.000 claims description 2
- 102100008054 TUBB3 Human genes 0.000 claims description 2
- 101710025656 TUBB4 Proteins 0.000 claims description 2
- 101710034464 TUBB4A Proteins 0.000 claims description 2
- 108010040632 Transforming Protein 2 Src Homology 2 Domain-Containing Proteins 0.000 claims description 2
- 102000002016 Transforming Protein 2 Src Homology 2 Domain-Containing Human genes 0.000 claims description 2
- 108090000704 Tubulin Proteins 0.000 claims description 2
- 102000004243 Tubulin Human genes 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000001394 metastastic Effects 0.000 claims description 2
- 238000009099 neoadjuvant therapy Methods 0.000 claims description 2
- 230000000683 nonmetastatic Effects 0.000 claims description 2
- 230000000306 recurrent Effects 0.000 claims description 2
- 239000002924 silencing RNA Substances 0.000 claims description 2
- 229930003347 taxol Natural products 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 210000004185 Liver Anatomy 0.000 claims 1
- 206010027761 Mixed hepatocellular cholangiocarcinoma Diseases 0.000 claims 1
- 210000003240 Portal Vein Anatomy 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 description 1
- 210000003494 Hepatocytes Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31815310P | 2010-03-26 | 2010-03-26 | |
US61/318,153 | 2010-03-26 | ||
PCT/US2011/030037 WO2011119988A1 (en) | 2010-03-26 | 2011-03-25 | Methods of treatment of hepatocellular carcinoma |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015091142A Division JP2015134825A (ja) | 2010-03-26 | 2015-04-28 | 肝細胞がんの処置方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013523656A JP2013523656A (ja) | 2013-06-17 |
JP2013523656A5 true JP2013523656A5 (US20070167479A1-20070719-C00034.png) | 2014-05-08 |
JP5847156B2 JP5847156B2 (ja) | 2016-01-20 |
Family
ID=44673662
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013501523A Active JP5847156B2 (ja) | 2010-03-26 | 2011-03-25 | 肝細胞がんの処置方法 |
JP2015091142A Pending JP2015134825A (ja) | 2010-03-26 | 2015-04-28 | 肝細胞がんの処置方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015091142A Pending JP2015134825A (ja) | 2010-03-26 | 2015-04-28 | 肝細胞がんの処置方法 |
Country Status (21)
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
TR200502189T1 (tr) | 2002-12-09 | 2007-01-22 | American Bioscience, Inc. | Kompozisyonlar ve farmakolojik etken maddelerin aktarımı için yöntemler. |
HUE038768T2 (hu) | 2005-02-18 | 2018-11-28 | Abraxis Bioscience Llc | Terápiás szerek kombinációi, valamint beadásukra szolgáló módszerek, és kombinációs terápia |
US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
TWI417114B (zh) * | 2005-08-31 | 2013-12-01 | Abraxis Bioscience Llc | 具有增強穩定性之弱水溶性藥物之組合物及其製備方法 |
SI2117520T1 (sl) | 2006-12-14 | 2019-01-31 | Abraxis Bioscience, Llc | Zdravljenje raka dojk glede na status hormonskih receptorjev z nano delci, ki zajemajo taksan |
MX2009009537A (es) * | 2007-03-07 | 2009-09-16 | Abraxis Bioscience Llc | Nanoparticula que comprende rapamicina y albumina como agente anticancer. |
WO2008150532A1 (en) * | 2007-06-01 | 2008-12-11 | Abraxis Bioscience, Llc | Methods and compositions for treating recurrent cancer |
DK2419732T3 (da) | 2009-04-15 | 2019-12-16 | Abraxis Bioscience Llc | Prionfrie nanopartikelsammensætninger og fremgangsmåder |
HUE027749T2 (en) | 2010-03-26 | 2016-10-28 | Abraxis Bioscience Llc | Methods of treating hepatocellular carcinoma |
NZ602635A (en) | 2010-03-29 | 2014-12-24 | Abraxis Bioscience Llc | Methods of enhancing drug delivery and effectiveness of therapeutic agents |
RU2016119999A (ru) | 2010-03-29 | 2018-11-08 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Способы лечения онкологических заболеваний |
US9399071B2 (en) | 2010-06-04 | 2016-07-26 | Abraxis Bioscience, Llc | Methods of treatment of pancreatic cancer |
BR112013027674A2 (pt) | 2011-04-28 | 2016-09-06 | Abraxis Bioscience Llc | "usos de composições de nanopartículas, composições compreendendo as referidas nanopartículas e cateter com uma agulha". |
PL2790675T3 (pl) | 2011-12-14 | 2019-12-31 | Abraxis Bioscience, Llc | Zastosowanie polimerowych rozczynników do liofilizacji lub zamrażania cząstek |
US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
US20140186447A1 (en) * | 2012-12-28 | 2014-07-03 | Abraxis Bioscience, Llc | Nanoparticle compositions of albumin and paclitaxel |
US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
CN105228612A (zh) | 2013-03-12 | 2016-01-06 | 阿布拉科斯生物科学有限公司 | 治疗肺癌的方法 |
ES2881851T3 (es) | 2013-03-14 | 2021-11-30 | Abraxis Bioscience Llc | Métodos para tratar el cáncer de vejiga |
CA2913023C (en) | 2013-05-30 | 2021-06-08 | Nanobiotix | Pharmaceutical composition, preparation and uses thereof |
WO2015120273A1 (en) * | 2014-02-07 | 2015-08-13 | The General Hospital Corporation | Differential diagnosis of hepatic neoplasms |
SG11201704219UA (en) | 2014-11-25 | 2017-06-29 | Nanobiotix | Pharmaceutical composition, preparation and uses thereof |
HUE062561T2 (hu) | 2014-11-25 | 2023-11-28 | Curadigm Sas | Legalább két eltérõ nanorészecskéket és egy gyógyászati vegyületet kombináló gyógyászati készítmény, annak elõállítása és alkalmazásai |
PL3223796T3 (pl) | 2014-11-25 | 2021-12-20 | Curadigm Sas | Kompozycje farmaceutyczne, ich wytwarzanie i zastosowania |
EP3229843B1 (en) * | 2014-11-25 | 2020-01-01 | Curadigm Sas | Pharmaceutical composition, preparation and uses thereof |
US10705070B1 (en) | 2015-03-05 | 2020-07-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
US10527604B1 (en) | 2015-03-05 | 2020-01-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel |
AU2016269146B2 (en) | 2015-05-28 | 2021-01-28 | Nanobiotix | Nanoparticles for use as a therapeutic vaccine |
PL3313401T3 (pl) | 2015-06-29 | 2022-02-07 | Abraxis Bioscience, Llc | Nanocząsteczki zawierające sirolimus i albuminę do stosowania w leczeniu nowotworów z komórek epitelioidnych |
MX2019003694A (es) * | 2016-10-07 | 2019-06-24 | Abraxis Bioscience Llc | Metodos para tratar cancer del tracto biliar. |
US11419842B2 (en) * | 2016-10-27 | 2022-08-23 | Zhuhai Beihai Biotech Co., Ltd. | Neutral pH compositions of Docetaxel and human serum albumin |
US10896749B2 (en) * | 2017-01-27 | 2021-01-19 | Shire Human Genetic Therapies, Inc. | Drug monitoring tool |
CN107828887A (zh) * | 2017-10-12 | 2018-03-23 | 上海市东方医院 | Stmn1基因的用途 |
CN112188892A (zh) | 2018-03-20 | 2021-01-05 | 阿布拉科斯生物科学有限公司 | 通过mTOR抑制剂和白蛋白的纳米颗粒的施用治疗中枢神经系统障碍的方法 |
MX2022004989A (es) | 2019-10-28 | 2022-07-21 | Abraxis Bioscience Llc | Composiciones farmaceuticas de albumina y rapamicina. |
WO2023072755A1 (en) * | 2021-10-26 | 2023-05-04 | Lipogems International S.P.A. | Microfragmented fat tissue as drug delivery system in liver cancer therapy |
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US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
TWI417114B (zh) | 2005-08-31 | 2013-12-01 | Abraxis Bioscience Llc | 具有增強穩定性之弱水溶性藥物之組合物及其製備方法 |
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MX2009009537A (es) | 2007-03-07 | 2009-09-16 | Abraxis Bioscience Llc | Nanoparticula que comprende rapamicina y albumina como agente anticancer. |
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WO2008150532A1 (en) | 2007-06-01 | 2008-12-11 | Abraxis Bioscience, Llc | Methods and compositions for treating recurrent cancer |
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CA2721153C (en) | 2008-04-10 | 2018-10-02 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
WO2010118365A1 (en) | 2009-04-10 | 2010-10-14 | Abraxis Bioscience, Llc | Nanoparticle formulations and uses therof |
NZ593343A (en) | 2008-12-11 | 2013-04-26 | Abraxis Bioscience Llc | Combination cancer treatment conprising Abraxane and an inflamatory inhibitor |
MX2011009452A (es) | 2009-03-13 | 2011-11-29 | Abraxis Bioscience Llc | Terapia de combinacion con derivados tiocolchicina. |
DK2419732T3 (da) | 2009-04-15 | 2019-12-16 | Abraxis Bioscience Llc | Prionfrie nanopartikelsammensætninger og fremgangsmåder |
MX340670B (es) | 2009-08-25 | 2016-07-20 | Abraxis Bioscience Llc * | Terapia combinada con composiciones de nanoparticulas de taxano e inhibidores de hedgehog. |
HUE027749T2 (en) | 2010-03-26 | 2016-10-28 | Abraxis Bioscience Llc | Methods of treating hepatocellular carcinoma |
RU2016119999A (ru) | 2010-03-29 | 2018-11-08 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Способы лечения онкологических заболеваний |
NZ602635A (en) | 2010-03-29 | 2014-12-24 | Abraxis Bioscience Llc | Methods of enhancing drug delivery and effectiveness of therapeutic agents |
NZ708506A (en) | 2010-06-02 | 2016-08-26 | Abraxis Bioscience Llc | Methods of treating bladder cancer |
US9399071B2 (en) | 2010-06-04 | 2016-07-26 | Abraxis Bioscience, Llc | Methods of treatment of pancreatic cancer |
RU2577278C2 (ru) | 2010-06-07 | 2016-03-10 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Способы комбинированной терапии для лечения пролиферативных заболеваний |
BR112013027674A2 (pt) | 2011-04-28 | 2016-09-06 | Abraxis Bioscience Llc | "usos de composições de nanopartículas, composições compreendendo as referidas nanopartículas e cateter com uma agulha". |
PL2790675T3 (pl) | 2011-12-14 | 2019-12-31 | Abraxis Bioscience, Llc | Zastosowanie polimerowych rozczynników do liofilizacji lub zamrażania cząstek |
US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
US20140186447A1 (en) | 2012-12-28 | 2014-07-03 | Abraxis Bioscience, Llc | Nanoparticle compositions of albumin and paclitaxel |
US20140199404A1 (en) | 2013-01-11 | 2014-07-17 | Abraxis Bioscience, Llc | Method for treating cancer based on level of a nucleoside transporter |
US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
US20140199405A1 (en) | 2013-01-11 | 2014-07-17 | Abraxis Bioscience, Llc | Method for treating cancer based on mutation status of k-ras |
-
2011
- 2011-03-25 HU HUE11760333A patent/HUE027749T2/en unknown
- 2011-03-25 KR KR1020127027815A patent/KR101786142B1/ko active IP Right Grant
- 2011-03-25 CA CA2793536A patent/CA2793536C/en active Active
- 2011-03-25 CA CA3051495A patent/CA3051495A1/en not_active Abandoned
- 2011-03-25 NZ NZ602382A patent/NZ602382A/en unknown
- 2011-03-25 JP JP2013501523A patent/JP5847156B2/ja active Active
- 2011-03-25 EP EP11760333.2A patent/EP2552438B1/en active Active
- 2011-03-25 LT LTEP11760333.2T patent/LT2552438T/lt unknown
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