JP2013522350A - 中耳炎の処置において使用するためのソラフェニブもしくはバタラニブなどのｖｅｇｆおよび／またはｈｉｆ経路を標的とする化合物 - Google Patents
中耳炎の処置において使用するためのソラフェニブもしくはバタラニブなどのｖｅｇｆおよび／またはｈｉｆ経路を標的とする化合物 Download PDFInfo
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- ATEBXHFBFRCZMA-VXTBVIBXSA-N rifabutin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC(=C2N3)C(=O)C=4C(O)=C5C)C)OC)C5=C1C=4C2=NC13CCN(CC(C)C)CC1 ATEBXHFBFRCZMA-VXTBVIBXSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
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- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- HVXKQKFEHMGHSL-QKDCVEJESA-N tesevatinib Chemical compound N1=CN=C2C=C(OC[C@@H]3C[C@@H]4CN(C)C[C@@H]4C3)C(OC)=CC2=C1NC1=CC=C(Cl)C(Cl)=C1F HVXKQKFEHMGHSL-QKDCVEJESA-N 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 230000006663 ubiquitin-proteasome pathway Effects 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
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- 229960000241 vandetanib Drugs 0.000 description 1
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1004761.1A GB201004761D0 (en) | 2010-03-22 | 2010-03-22 | Method |
| GB1004761.1 | 2010-03-22 | ||
| PCT/GB2011/000382 WO2011117568A1 (en) | 2010-03-22 | 2011-03-18 | Compounds targeting the vegf and/or hif pathway such as sorafenib or vatalanib for use in the treatment of otitis media |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013522350A true JP2013522350A (ja) | 2013-06-13 |
| JP2013522350A5 JP2013522350A5 (OSRAM) | 2014-03-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500572A Pending JP2013522350A (ja) | 2010-03-22 | 2011-03-18 | 中耳炎の処置において使用するためのソラフェニブもしくはバタラニブなどのｖｅｇｆおよび／またはｈｉｆ経路を標的とする化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20130078260A1 (OSRAM) |
| EP (1) | EP2549989A1 (OSRAM) |
| JP (1) | JP2013522350A (OSRAM) |
| CN (1) | CN102905697A (OSRAM) |
| AU (1) | AU2011231405A1 (OSRAM) |
| CA (1) | CA2793643A1 (OSRAM) |
| GB (1) | GB201004761D0 (OSRAM) |
| WO (1) | WO2011117568A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3215186A4 (en) * | 2014-11-04 | 2018-10-24 | University of Southern California | COMPOSITIONS AND METHODS FOR TREATING HIF-1alpha OVER-EXPRESSING CANCERS |
| EA202091509A1 (ru) | 2017-12-19 | 2020-09-22 | Акуос, Инк. | Aav-опосредованная доставка терапевтических антител во внутреннее ухо |
| PH12023551518A1 (en) | 2020-12-01 | 2024-05-13 | Akouos Inc | Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms |
| CN112807293B (zh) * | 2021-03-01 | 2023-06-02 | 青岛大学 | 甲磺酸去铁胺在制备治疗中耳炎药物中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006083458A2 (en) * | 2004-12-30 | 2006-08-10 | Bioresponse Llc | Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions |
| US20070249550A1 (en) * | 2004-09-01 | 2007-10-25 | Sitkovsky Michail V | Modulation of immune response and inflammation by targeting hypoxia inducible factors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008094208A2 (en) * | 2006-08-02 | 2008-08-07 | Northwestern University | Protein kinase targeted therapeutics |
-
2010
- 2010-03-22 GB GBGB1004761.1A patent/GB201004761D0/en not_active Ceased
-
2011
- 2011-03-18 CA CA2793643A patent/CA2793643A1/en not_active Abandoned
- 2011-03-18 WO PCT/GB2011/000382 patent/WO2011117568A1/en not_active Ceased
- 2011-03-18 US US13/636,097 patent/US20130078260A1/en not_active Abandoned
- 2011-03-18 CN CN2011800254426A patent/CN102905697A/zh active Pending
- 2011-03-18 JP JP2013500572A patent/JP2013522350A/ja active Pending
- 2011-03-18 EP EP11710237A patent/EP2549989A1/en not_active Withdrawn
- 2011-03-18 AU AU2011231405A patent/AU2011231405A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070249550A1 (en) * | 2004-09-01 | 2007-10-25 | Sitkovsky Michail V | Modulation of immune response and inflammation by targeting hypoxia inducible factors |
| WO2006083458A2 (en) * | 2004-12-30 | 2006-08-10 | Bioresponse Llc | Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions |
Non-Patent Citations (8)
| Title |
|---|
| JPN5013004662; ＪＵＮＧ Ｈ Ｈ: 'ＥＸＰＲＥＳＳＩＯＮ ＯＦ ＶＡＳＣＵＬＡＲ ＥＮＤＯＴＨＥＬＩＡＬ ＧＲＯＷＴＨ ＦＡＣＴＯＲ ＩＮ ＯＴＩＴＩＳ ＭＥＤＩＡ' ＡＣＴＡ ＯＴＯ-ＬＡＲＹＮＧＯＬＯＧＩＣＡ Ｖ１１９ Ｎ７, 19990101, Ｐ８０１-８０８, ＳＣＡＮＤＩＮＡＶＩＡＮ ＵＮＩＶＥＲＳＩＴＹ ＰＲＥＳＳ * |
| JPN6015002527; Ｋｉｄ Ｉｎｔ．， １９９７， Ｖｏｌ．５１ ｐ．５５３-５５５ * |
| JPN6015002529; Ａｒｃｈ Ｂｉｏｃｈｅｍ Ｂｉｏｐｈｙｓ．， １９９６， Ｖｏｌ．３３４ Ｎｏ．２ ｐ．３８９-３９４ * |
| JPN6015002531; Ｊ Ｂｉｏｌ Ｃｈｅｍ．， ２０００， Ｖｏｌ．２７５ Ｎｏ．３８ ｐ．２９６４３-２９６４７ * |
| JPN6015002534; Ｂｉｏｃｈｅｍ Ｊ．， ２００７， Ｖｏｌ．４０６ Ｎｏ．２ ｐ．３１７-３２３ * |
| JPN6015002536; 耳鼻咽喉科免疫アレルギー．， ２００４， Ｖｏｌ．２２ Ｎｏ．２ ＣＤ-ＲＯＭ ｐ．３７-３８ * |
| JPN6015002538; Ｏｔｏｌ Ｊｐｎ．， ２００４， Ｖｏｌ．１４ ｐ．６１８ * |
| JPN6015002542; ＰＬｏＳ Ｇｅｎｅｔ．， ２０１１ Ｏｃｔ， Ｖｏｌ．７ Ｎｏ．１０ ｐ．ｅ１００２３３６． * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2793643A1 (en) | 2011-09-29 |
| GB201004761D0 (en) | 2010-05-05 |
| EP2549989A1 (en) | 2013-01-30 |
| AU2011231405A1 (en) | 2012-10-04 |
| CN102905697A (zh) | 2013-01-30 |
| US20130078260A1 (en) | 2013-03-28 |
| WO2011117568A1 (en) | 2011-09-29 |
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