JP2013522295A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013522295A5 JP2013522295A5 JP2013500079A JP2013500079A JP2013522295A5 JP 2013522295 A5 JP2013522295 A5 JP 2013522295A5 JP 2013500079 A JP2013500079 A JP 2013500079A JP 2013500079 A JP2013500079 A JP 2013500079A JP 2013522295 A5 JP2013522295 A5 JP 2013522295A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- body weight
- dosage
- weight per
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 230000037396 body weight Effects 0.000 claims 7
- 206010061218 Inflammation Diseases 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000001684 chronic Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000006673 Asthma Diseases 0.000 claims 1
- 206010006448 Bronchiolitis Diseases 0.000 claims 1
- 206010006451 Bronchitis Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 208000007451 Chronic Bronchitis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 229960000860 Dapsone Drugs 0.000 claims 1
- MQJKPEGWNLWLTK-UHFFFAOYSA-N Di(p-aminophenyl)sulphone Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 MQJKPEGWNLWLTK-UHFFFAOYSA-N 0.000 claims 1
- 229940112141 Dry Powder Inhaler Drugs 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 206010022114 Injury Diseases 0.000 claims 1
- 229940071648 Metered Dose Inhaler Drugs 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 238000000889 atomisation Methods 0.000 claims 1
- 201000009267 bronchiectasis Diseases 0.000 claims 1
- 201000003883 cystic fibrosis Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000009794 idiopathic pulmonary fibrosis Diseases 0.000 claims 1
- 230000000414 obstructive Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
Claims (11)
- 薬学的有効量のダプソンと、
吸入使用に適した薬学的に受容可能なキャリアを含有する、気道炎症の予防又は治療を必要とする患者の気道炎症を予防又は治療するための吸入投与用医薬組成物。 - 前記組成物は、定量吸入器又はドライパウダー吸入器での使用に適した乾燥粉末組成物である請求項１に記載の医薬組成物。
- 前記組成物は、水溶液である請求項１に記載の医薬組成物。
- 前記患者は、嚢胞性線維症、気管支拡張症、閉塞性細気管支炎、肺気腫、慢性気管支炎、慢性鼻副鼻腔炎、吸引毒性傷害、慢性閉塞性肺疾患、特発性肺線維症、喘息及び慢性気道炎症からなる群から選ばれる疾病又は疾患を患っている請求項１〜３のいずれか１項に記載の医薬組成物。
- 前記水溶液は、前記水溶液のエアロゾルの噴霧化により投与される請求項３に記載の医薬組成物。
- 前記医薬組成物は、１日１回投与される請求項１〜５のいずれか１項に記載の医薬組成物。
- 前記医薬組成物は、ほぼ均等な時限的投薬量で１日に２〜１２回投与される請求項１〜５のいずれか１項に記載の医薬組成物。
- 前記医薬組成物の投与量は、１回の投与につき体重１ｋｇあたり約０．５ｍｇから体重１ｋｇあたり約５．０ｍｇである請求項１〜６のいずれか１項に記載の医薬組成物。
- 前記医薬組成物の投与量は、１回の投与につき体重１ｋｇあたり約１．０ｍｇから体重１ｋｇあたり約４．０ｍｇである請求項８に記載の医薬組成物。
- 前記医薬組成物の投与量は、１回の投与につき体重１ｋｇあたり約１．５ｍｇから体重１ｋｇあたり約３．０ｍｇである請求項９に記載の医薬組成物。
- 前記医薬組成物の投与量は、１回の投与につき体重１ｋｇあたり約２．０ｍｇである請求項１０に記載の方法。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31387710P | 2010-03-15 | 2010-03-15 | |
| US61/313,877 | 2010-03-15 | ||
| US41635310P | 2010-11-23 | 2010-11-23 | |
| US61/416,353 | 2010-11-23 | ||
| PCT/US2011/027494 WO2011115778A2 (en) | 2010-03-15 | 2011-03-08 | Aerosolized dapsone as a therapy for inflammation of the airway and abnormal mucociliary transport |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013522295A JP2013522295A (ja) | 2013-06-13 |
| JP2013522295A5 true JP2013522295A5 (ja) | 2014-05-01 |
| JP5908884B2 JP5908884B2 (ja) | 2016-04-26 |
Family
ID=44649767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500079A Active JP5908884B2 (ja) | 2010-03-15 | 2011-03-08 | 気道炎症及び粘液線毛輸送機能異常治療用のエアロゾル化したダプソン |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20130005822A1 (ja) |
| EP (1) | EP2547335A4 (ja) |
| JP (1) | JP5908884B2 (ja) |
| KR (1) | KR101924162B1 (ja) |
| AU (1) | AU2011227613B2 (ja) |
| BR (1) | BR112012023877A2 (ja) |
| CA (1) | CA2793170C (ja) |
| WO (1) | WO2011115778A2 (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104619321A (zh) * | 2012-04-06 | 2015-05-13 | Uab研究基金会 | 用于增加cftr活性的方法 |
| JP6944701B2 (ja) * | 2016-10-21 | 2021-10-06 | 国立大学法人山口大学 | ＣＤ１１ｂアンタゴニストを含む劇症型急性肺炎治療用組成物 |
| CA3126367A1 (en) | 2020-03-30 | 2021-09-30 | Pulmonem Inc. | Dapsone formulations and methods of using same |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2099415T3 (es) | 1991-12-18 | 1997-05-16 | Minnesota Mining & Mfg | Formulaciones de aerosol en suspension. |
| MX9704550A (es) | 1994-12-22 | 1997-10-31 | Astra Ab | Formulaciones de medicamentos en aerosol. |
| US20030082107A1 (en) * | 1997-10-01 | 2003-05-01 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer |
| GB9820886D0 (en) | 1998-09-26 | 1998-11-18 | Glaxo Group Ltd | Inhalation device |
| DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| JP2002543122A (ja) * | 1999-04-30 | 2002-12-17 | エイピーティー ファーマスーティカルズ エルエルスィー | 抗マラリア治療剤についての新規使用 |
| AU2001257022B2 (en) * | 2000-04-13 | 2005-02-03 | Mayo Foundation For Medical Education And Research | Abeta 42 lowering agents |
| GB2362101A (en) * | 2000-05-12 | 2001-11-14 | Astrazeneca Ab | Treatment of chronic obstructive pulmonary disease |
| US7077130B2 (en) | 2000-12-22 | 2006-07-18 | Chrysalis Technologies Incorporated | Disposable inhaler system |
| US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| US7090830B2 (en) * | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| AUPS017702A0 (en) * | 2002-01-25 | 2002-02-14 | Atopic Pty Ltd | Methods and compositions for the treatment of asthma and related disorders |
| US7040314B2 (en) | 2002-09-06 | 2006-05-09 | Philip Morris Usa Inc. | Aerosol generating devices and methods for generating aerosols suitable for forming propellant-free aerosols |
| US7497214B2 (en) | 2002-09-16 | 2009-03-03 | 3M Innovative Properties Company | Aerosol dispensers and adaptors therefor |
| ATE389034T1 (de) * | 2002-09-30 | 2008-03-15 | Novartis Pharma Gmbh | Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie |
| US20040086469A1 (en) * | 2002-10-30 | 2004-05-06 | Osborne David W. | Protectant for UV-induced skin damage |
| US7683029B2 (en) | 2003-05-07 | 2010-03-23 | Philip Morris Usa Inc. | Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin |
| AU2004270733B2 (en) * | 2003-09-11 | 2011-05-19 | Itherx Pharma, Inc. | Cytokine inhibitors |
| BRPI0415753A (pt) * | 2003-10-21 | 2006-12-19 | Pharmacia Corp | método para tratamento e prevenção da inflamação respiratória com um inibidor de ciclooxigenase-2 em associação com um inibidor de fosfodiesterase 4 e composições que os contêm |
| WO2007059905A2 (en) * | 2005-11-25 | 2007-05-31 | Develogen Aktiengesellschaft | Thienopyrimidines treating inflammatory diseases |
| US20080066739A1 (en) * | 2006-09-20 | 2008-03-20 | Lemahieu Edward | Methods and systems of delivering medication via inhalation |
| US8586010B2 (en) * | 2008-02-27 | 2013-11-19 | Allergan, Inc. | Dapsone to treat rosascea |
| US20120093947A1 (en) * | 2009-02-27 | 2012-04-19 | United States Department Of Veterans Affairs | Method of treating reactive airway disease |
-
2011
- 2011-03-08 US US13/583,434 patent/US20130005822A1/en not_active Abandoned
- 2011-03-08 CA CA2793170A patent/CA2793170C/en not_active Expired - Fee Related
- 2011-03-08 KR KR1020127026909A patent/KR101924162B1/ko active IP Right Grant
- 2011-03-08 WO PCT/US2011/027494 patent/WO2011115778A2/en active Application Filing
- 2011-03-08 EP EP11756734.7A patent/EP2547335A4/en not_active Withdrawn
- 2011-03-08 AU AU2011227613A patent/AU2011227613B2/en not_active Ceased
- 2011-03-08 BR BR112012023877A patent/BR112012023877A2/pt not_active IP Right Cessation
- 2011-03-08 JP JP2013500079A patent/JP5908884B2/ja active Active
-
2014
- 2014-10-22 US US14/520,976 patent/US20150040894A1/en not_active Abandoned
-
2018
- 2018-02-20 US US15/899,539 patent/US20180243213A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011520911A5 (ja) | ||
| RU2019100425A (ru) | Новая доза и препаративная форма | |
| JP2013224331A5 (ja) | ||
| JP2016040316A5 (ja) | ||
| NZ585856A (en) | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease | |
| JP2015508780A5 (ja) | ||
| JP2014518268A5 (ja) | ||
| JP2007106777A5 (ja) | ||
| RU2013142268A (ru) | Фармацевтическая композиция | |
| JP2009269923A5 (ja) | ||
| JP2013531056A5 (ja) | ||
| RU2008124825A (ru) | Органические соединения, включающие соль гликопиррония | |
| RU2017144619A (ru) | Катионы одновалентных металлов сухих порошков для ингаляций | |
| JP2013542940A5 (ja) | ||
| MD4369C1 (ro) | Utilizarea glicopirolatului pentru tratarea tahicardiei, doză unică, dispozitiv de administrare, metodă de tratament şi profilaxie a tahicardiei | |
| PH12014502662A1 (en) | Novel dosage form and formulation of abediterol | |
| JP2015519356A5 (ja) | ||
| RU2011140239A (ru) | Фармацевтическая композиция, содержащая стероидное производное (3,2-с)пиразола и второе фармацевтически активное соединение | |
| JP2013522295A5 (ja) | ||
| JP2011500731A5 (ja) | ||
| JP2013518061A5 (ja) | ||
| HRP20221034T1 (hr) | Aklidinij za upotrebu u povećanju fizičke aktivnosti u dnevnom životu kod pacijenta koji pati od kronične opstruktivne bolesti pluća | |
| Das et al. | Understanding the Respiratory Delivery of High Dose Anti‐Tubercular Drugs | |
| JP2017511307A5 (ja) | ||
| Takizawa | Recent development of drug delivery systems for the treatment of asthma and related disorders |