JP2013521271A5 - - Google Patents
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- Publication number
- JP2013521271A5 JP2013521271A5 JP2012555529A JP2012555529A JP2013521271A5 JP 2013521271 A5 JP2013521271 A5 JP 2013521271A5 JP 2012555529 A JP2012555529 A JP 2012555529A JP 2012555529 A JP2012555529 A JP 2012555529A JP 2013521271 A5 JP2013521271 A5 JP 2013521271A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- dye
- diagnostic evaluation
- cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 27
- 239000000049 pigment Substances 0.000 claims description 2
- 238000007435 diagnostic evaluation Methods 0.000 claims 7
- 239000001913 cellulose Substances 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 4
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 230000003902 lesion Effects 0.000 claims 4
- 239000011159 matrix material Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 2
- 208000037062 Polyps Diseases 0.000 claims 2
- 206010056626 Pseudopolyp Diseases 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 208000025865 Ulcer Diseases 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 229940106189 ceramide Drugs 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- -1 glycol alkyl ethers Chemical class 0.000 claims 2
- 150000002433 hydrophilic molecules Chemical class 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 150000002634 lipophilic molecules Chemical class 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 230000001855 preneoplastic effect Effects 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 239000008247 solid mixture Substances 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical compound COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 claims 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
- 244000043261 Hevea brasiliensis Species 0.000 claims 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 1
- 229920001800 Shellac Polymers 0.000 claims 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- 229920013820 alkyl cellulose Polymers 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000008051 alkyl sulfates Chemical class 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 235000012730 carminic acid Nutrition 0.000 claims 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 1
- 150000001783 ceramides Chemical class 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 150000001841 cholesterols Chemical class 0.000 claims 1
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims 1
- 229940097275 indigo Drugs 0.000 claims 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical group [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 claims 1
- 229960000907 methylthioninium chloride Drugs 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 1
- 235000019960 monoglycerides of fatty acid Nutrition 0.000 claims 1
- 229920003052 natural elastomer Polymers 0.000 claims 1
- 229920001194 natural rubber Polymers 0.000 claims 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000004208 shellac Substances 0.000 claims 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 1
- 229940113147 shellac Drugs 0.000 claims 1
- 235000013874 shellac Nutrition 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 229920003051 synthetic elastomer Polymers 0.000 claims 1
- 239000005061 synthetic rubber Substances 0.000 claims 1
- 229950003937 tolonium Drugs 0.000 claims 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
- 210000001072 colon Anatomy 0.000 description 2
- 238000001839 endoscopy Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000037406 food intake Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2010A000345 | 2010-03-04 | ||
| ITMI2010A000345A IT1398643B1 (it) | 2010-03-04 | 2010-03-04 | Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa |
| US32755710P | 2010-04-23 | 2010-04-23 | |
| US61/327,557 | 2010-04-23 | ||
| PCT/IB2011/050881 WO2011107945A1 (en) | 2010-03-04 | 2011-03-02 | Solid composition for the oral administration of dyes and diagnostic use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521271A JP2013521271A (ja) | 2013-06-10 |
| JP2013521271A5 true JP2013521271A5 (https=) | 2014-01-30 |
| JP5770752B2 JP5770752B2 (ja) | 2015-08-26 |
Family
ID=42647312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555529A Active JP5770752B2 (ja) | 2010-03-04 | 2011-03-02 | 色素を経口投与するための固体組成物およびその診断使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US8545811B2 (https=) |
| EP (2) | EP2542268B1 (https=) |
| JP (1) | JP5770752B2 (https=) |
| KR (1) | KR101763700B1 (https=) |
| CN (1) | CN102811747B (https=) |
| AU (1) | AU2011222496B2 (https=) |
| BR (1) | BR112012022373B1 (https=) |
| CA (1) | CA2790143C (https=) |
| CY (1) | CY1123967T1 (https=) |
| DK (2) | DK3011975T3 (https=) |
| ES (2) | ES2602157T3 (https=) |
| FR (1) | FR21C1009I1 (https=) |
| HR (2) | HRP20161366T1 (https=) |
| HU (3) | HUE053977T2 (https=) |
| IL (1) | IL221541A (https=) |
| IT (1) | IT1398643B1 (https=) |
| LT (2) | LT3011975T (https=) |
| MX (1) | MX342323B (https=) |
| NZ (1) | NZ602130A (https=) |
| PL (2) | PL3011975T3 (https=) |
| PT (2) | PT2542268T (https=) |
| RS (2) | RS61641B1 (https=) |
| RU (1) | RU2561034C2 (https=) |
| SI (1) | SI3011975T1 (https=) |
| WO (1) | WO2011107945A1 (https=) |
| ZA (1) | ZA201206360B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8895064B2 (en) | 1999-06-14 | 2014-11-25 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
| EP1183014B1 (en) | 1999-06-14 | 2003-10-08 | Cosmo S.p.A. | Controlled release and taste masking oral pharmaceutical compositions |
| WO2010045477A2 (en) | 2008-10-16 | 2010-04-22 | Obalon Therapeutics, Inc. | Intragastric volume-occupying device and method for fabricating same |
| US10154964B2 (en) | 2011-09-07 | 2018-12-18 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
| EP2722058A1 (en) * | 2012-10-19 | 2014-04-23 | Cosmo Technologies Ltd | Solid oral composition containing dyes for use in endoscopic diagnosis |
| AU2015212418B2 (en) * | 2014-01-29 | 2020-01-23 | Cosmo Technologies Limited | Liquid composition in the form of emulsion or microemulsion for rectal administration containing at least one dye, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum |
| US10124074B2 (en) * | 2014-02-26 | 2018-11-13 | Toufic Kachaamy | Indirect chromoendoscopy with an oral indigo carmine base preparation |
| CN106999618A (zh) | 2014-12-08 | 2017-08-01 | 金诺斯公司 | 用于颜料消毒的添加剂组合物及其方法 |
| HK1250902A1 (zh) * | 2015-04-23 | 2019-01-18 | Obalon Therapeutics, Inc. | 用於确定内部装置故障的系统和方法 |
| CN114258912A (zh) | 2016-02-12 | 2022-04-01 | 金诺斯公司 | 用于表面净化的组合物和方法 |
| EA201892365A1 (ru) | 2016-04-19 | 2019-03-29 | Конарис Рисерч Инститьют Аг | Составы и композиции шеллачных микрокапсул |
| US11185605B2 (en) | 2016-07-25 | 2021-11-30 | Kinnos Inc. | Device and related compositions and methods for use in surface decontamination |
| EP3544638A1 (en) | 2016-11-28 | 2019-10-02 | Cosmo Technologies Ltd. | Solid oral composition containing dyes |
| FR3059664B1 (fr) | 2016-12-01 | 2019-01-25 | Provepharm Life Solutions | Procede de preparation du carmin d’indigo |
| CA3104884A1 (en) | 2018-07-12 | 2020-01-16 | Kinnos Inc. | Devices, compositions, and methods for use in surface decontamination |
| CN108888765B (zh) * | 2018-07-16 | 2021-02-26 | 山东理工大学 | 一种释放亚甲基蓝聚集体的含亚甲基蓝的二氧化硅/虫胶复合颗粒的制备方法 |
| CN111184876B (zh) * | 2020-02-20 | 2022-03-04 | 沈伟 | 一种消化道黏膜染色剂、制备方法及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3361632A (en) * | 1964-05-08 | 1968-01-02 | Hoechst Ag | Medicinal preparations having a protracted activity and method of making them |
| DK0565668T3 (da) * | 1991-10-31 | 2000-01-31 | Zila Inc | Biologisk farvemiddelsammensætning, fremgangsmåde til fremstilling deraf og til anvendelse til aftegning af epitelcancer |
| US6405070B1 (en) * | 1998-06-16 | 2002-06-11 | Bhaskar Banerjee | Detection of cancer using cellular autofluorescence |
| EP1183014B1 (en) | 1999-06-14 | 2003-10-08 | Cosmo S.p.A. | Controlled release and taste masking oral pharmaceutical compositions |
| ITMI991316A1 (it) | 1999-06-14 | 2000-12-14 | Cip Ninety Two 92 S A | Composizioni farmaceutiche orali a rilascio modificato di mesalazina |
| US8895064B2 (en) | 1999-06-14 | 2014-11-25 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
| US6584630B1 (en) | 2000-04-06 | 2003-07-01 | Ohio Medical Instrument Company, Inc. | Radiolucent surgical table extension assembly and method |
| WO2001076478A1 (en) | 2000-04-10 | 2001-10-18 | Nordisk Terapi As | System for testing and exercising sensorimotoric control of the neck |
| FR2829933B3 (fr) * | 2001-09-21 | 2004-03-12 | Ellipse Pharmaceuticals | Procede de fabrication d'un produit pharmaceutique administrable par voie orale avec des agents detrompeurs notamment de gout et produit obtenu |
| US7217410B2 (en) | 2003-06-17 | 2007-05-15 | The Board Of Trustees Of The Universtiy Of Illinois | Surface modified protein microparticles |
| US20070077202A1 (en) * | 2005-06-12 | 2007-04-05 | Pentax Corporation | Histostain composition for endoscope |
| US20070116757A1 (en) * | 2005-11-08 | 2007-05-24 | Collegium Pharmaceutical, Inc. | Methylene Blue Derivatives |
-
2010
- 2010-03-04 IT ITMI2010A000345A patent/IT1398643B1/it active
-
2011
- 2011-03-02 RU RU2012142192/15A patent/RU2561034C2/ru active
- 2011-03-02 SI SI201131964T patent/SI3011975T1/sl unknown
- 2011-03-02 RS RS20210391A patent/RS61641B1/sr unknown
- 2011-03-02 DK DK15186682.9T patent/DK3011975T3/da active
- 2011-03-02 WO PCT/IB2011/050881 patent/WO2011107945A1/en not_active Ceased
- 2011-03-02 CA CA2790143A patent/CA2790143C/en active Active
- 2011-03-02 BR BR112012022373-9A patent/BR112012022373B1/pt active IP Right Grant
- 2011-03-02 JP JP2012555529A patent/JP5770752B2/ja active Active
- 2011-03-02 AU AU2011222496A patent/AU2011222496B2/en active Active
- 2011-03-02 DK DK11714409.7T patent/DK2542268T3/en active
- 2011-03-02 KR KR1020127026021A patent/KR101763700B1/ko active Active
- 2011-03-02 NZ NZ602130A patent/NZ602130A/en unknown
- 2011-03-02 EP EP11714409.7A patent/EP2542268B1/en active Active
- 2011-03-02 HU HUE15186682A patent/HUE053977T2/hu unknown
- 2011-03-02 MX MX2012010125A patent/MX342323B/es active IP Right Grant
- 2011-03-02 LT LTEP15186682.9T patent/LT3011975T/lt unknown
- 2011-03-02 EP EP15186682.9A patent/EP3011975B1/en active Active
- 2011-03-02 HU HUE11714409A patent/HUE030246T2/en unknown
- 2011-03-02 LT LTEP11714409.7T patent/LT2542268T/lt unknown
- 2011-03-02 PT PT117144097T patent/PT2542268T/pt unknown
- 2011-03-02 PT PT151866829T patent/PT3011975T/pt unknown
- 2011-03-02 ES ES11714409.7T patent/ES2602157T3/es active Active
- 2011-03-02 PL PL15186682T patent/PL3011975T3/pl unknown
- 2011-03-02 PL PL11714409T patent/PL2542268T3/pl unknown
- 2011-03-02 ES ES15186682T patent/ES2863986T3/es active Active
- 2011-03-02 RS RS20160959A patent/RS55414B1/sr unknown
- 2011-03-02 CN CN201180012333.0A patent/CN102811747B/zh active Active
- 2011-03-02 HR HRP20161366TT patent/HRP20161366T1/hr unknown
-
2012
- 2012-08-20 IL IL221541A patent/IL221541A/en active IP Right Grant
- 2012-08-23 ZA ZA2012/06360A patent/ZA201206360B/en unknown
- 2012-09-04 US US13/602,875 patent/US8545811B2/en active Active
-
2013
- 2013-07-01 US US13/932,321 patent/US9402922B2/en active Active
- 2013-07-01 US US13/932,328 patent/US9402923B2/en active Active
-
2016
- 2016-03-04 US US15/061,232 patent/US10265420B2/en active Active
-
2018
- 2018-01-23 US US15/877,591 patent/US20180214580A1/en not_active Abandoned
-
2019
- 2019-09-27 US US16/585,330 patent/US20200268909A1/en not_active Abandoned
-
2021
- 2021-02-18 FR FR21C1009C patent/FR21C1009I1/fr active Active
- 2021-02-19 HU HUS2100005C patent/HUS2100005I1/hu unknown
- 2021-03-18 CY CY20211100233T patent/CY1123967T1/el unknown
- 2021-03-26 HR HRP20210493TT patent/HRP20210493T1/hr unknown
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