JP2013521233A - Aβを標的とする免疫療法のPETモニタリング - Google Patents

Aβを標的とする免疫療法のPETモニタリング Download PDF

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JP2013521233A
JP2013521233A JP2012555201A JP2012555201A JP2013521233A JP 2013521233 A JP2013521233 A JP 2013521233A JP 2012555201 A JP2012555201 A JP 2012555201A JP 2012555201 A JP2012555201 A JP 2012555201A JP 2013521233 A JP2013521233 A JP 2013521233A
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pet
patient
brain
amyloid
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JP2013521233A5 (enExample
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ロナルド ブラック,
マイケル グランドマン,
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ヤンセン アルツハイマー イミュノセラピー
ワイス・エルエルシー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/0429Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K51/0431Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2012555201A 2010-02-25 2011-02-25 Aβを標的とする免疫療法のPETモニタリング Pending JP2013521233A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30825310P 2010-02-25 2010-02-25
US61/308,253 2010-02-25
PCT/US2011/026365 WO2011106732A1 (en) 2010-02-25 2011-02-25 Pet monitoring of ab-directed immunotherapy

Related Child Applications (1)

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JP2016093421A Division JP2016185964A (ja) 2010-02-25 2016-05-06 Aβを標的とする免疫療法のPETモニタリング

Publications (2)

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JP2013521233A true JP2013521233A (ja) 2013-06-10
JP2013521233A5 JP2013521233A5 (enExample) 2014-09-25

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JP2012555201A Pending JP2013521233A (ja) 2010-02-25 2011-02-25 Aβを標的とする免疫療法のPETモニタリング
JP2016093421A Pending JP2016185964A (ja) 2010-02-25 2016-05-06 Aβを標的とする免疫療法のPETモニタリング

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JP2016093421A Pending JP2016185964A (ja) 2010-02-25 2016-05-06 Aβを標的とする免疫療法のPETモニタリング

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US (1) US20130084245A1 (enExample)
EP (1) EP2538982A4 (enExample)
JP (2) JP2013521233A (enExample)
WO (1) WO2011106732A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021515005A (ja) * 2018-03-01 2021-06-17 トライジェミナ, インコーポレイテッド 標識オキシトシンならびに製造および使用の方法
JP2021535378A (ja) * 2018-08-21 2021-12-16 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. アミロイドスクリーニング方法及び装置
JP2023506450A (ja) * 2019-12-11 2023-02-16 アンベテックス ピーティーワイ エルティーディー 拡張機能障害の防止及び治療のためのアミロイドベータ抗体又はワクチンを含む療法組成物

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TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
PE20061329A1 (es) 2004-12-15 2006-12-08 Neuralab Ltd Anticuerpos ab humanizados para mejorar la cognicion
WO2009017467A1 (en) 2007-07-27 2009-02-05 Elan Pharma International Limited Treatment of amyloidogenic diseases
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
PL2579042T3 (pl) * 2011-10-04 2014-12-31 Affiris Ag Sposób wykrywania przeciwciał swoistych wobec Aß w próbce biologicznej
IN2014CN03661A (enExample) 2011-11-16 2015-10-16 Koninkl Philips Nv
JP2015526409A (ja) * 2012-07-03 2015-09-10 ヤンセン・サイエンシズ・アイルランド・ユーシー C−末端及び中心エピトープa−ベータ抗体
CN106831799B (zh) * 2016-12-20 2018-12-21 四川大学 羟基苯乙烯吡啶曼尼希碱类化合物、其制备方法和用途
KR102031652B1 (ko) * 2018-01-19 2019-10-14 서울대학교산학협력단 전이체 단백질 과발현 관련 질환의 양성자방출단층촬영 방사성추적자, 형광영상 진단 및 광역학 치료를 위한 전이체 단백질 표적 리간드 및 이의 제조방법
IL280315B2 (en) * 2018-07-24 2024-06-01 Eisai R&D Man Co Ltd Methods for treating and preventing Alzheimer's disease

Citations (6)

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US20050214222A1 (en) * 2004-02-13 2005-09-29 Mckinnon Stuart J In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes
JP2008505115A (ja) * 2004-07-02 2008-02-21 ユニバーシティー オブ ピッツバーグ 抗アミロイド治療の有効性に対する代用マーカーとしてのアミロイドイメージング
WO2008114801A1 (en) * 2007-03-12 2008-09-25 National Institute Of Radiological Sciences Pet visualization of amyloid-associated neuroinflammation in the brain
WO2008131298A2 (en) * 2007-04-18 2008-10-30 Elan Pharma International Limited Prevention and treatment of cerebral amyloid angiopathy
WO2009017467A1 (en) * 2007-07-27 2009-02-05 Elan Pharma International Limited Treatment of amyloidogenic diseases
WO2009052439A2 (en) * 2007-10-17 2009-04-23 Elan Pharma International Limited Immunotherapy regimes dependent on apoe status

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ATE344803T1 (de) 1999-12-08 2006-11-15 Intellect Neurosciences Inc Schimärische amyloid-beta peptide
EP1296705B1 (en) 2000-06-28 2012-06-13 Prana Biotechnology Limited Amyloid Beta oligomers for use in treatment, alleviation or prevention of Alzheimer's Disease
JP5362164B2 (ja) 2000-07-07 2013-12-11 バイオアークティック ニューロサイエンス アーベー アルツハイマー病の予防及び治療
US6395837B1 (en) 2000-08-03 2002-05-28 King Industries, Inc. Alkylated aryl disulfonic acid catalysts for crosslinking polyethylene
PT1524994E (pt) 2002-07-19 2011-08-01 Cytos Biotechnology Ag Composições de vacina contendo fileiras de antigénio amilóide beta 1-6
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
US20040242845A1 (en) 2003-02-21 2004-12-02 Nicolau Yves Claude Methods and compositions comprising supramolecular antigenic constructs and antibodies elicited against them
WO2005012330A2 (en) 2003-07-30 2005-02-10 Brigham And Women's Hospital, Inc. AMYLOID β-PEPTIDE AND METHODS OF USE
AT413946B (de) 2004-07-13 2006-07-15 Mattner Frank Dr Impfstoff gegen die alzheimer-krankheit
BRPI0610093A2 (pt) 2005-05-05 2008-12-09 Merck & Co Inc composiÇço farmacÊutica, e, mÉtodo para prevenir ou tratar uma doenÇa associada com os depàsitos de amilàides de alfa-beta no cÉrebro de um paciente

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050214222A1 (en) * 2004-02-13 2005-09-29 Mckinnon Stuart J In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes
JP2008505115A (ja) * 2004-07-02 2008-02-21 ユニバーシティー オブ ピッツバーグ 抗アミロイド治療の有効性に対する代用マーカーとしてのアミロイドイメージング
WO2008114801A1 (en) * 2007-03-12 2008-09-25 National Institute Of Radiological Sciences Pet visualization of amyloid-associated neuroinflammation in the brain
WO2008131298A2 (en) * 2007-04-18 2008-10-30 Elan Pharma International Limited Prevention and treatment of cerebral amyloid angiopathy
WO2009017467A1 (en) * 2007-07-27 2009-02-05 Elan Pharma International Limited Treatment of amyloidogenic diseases
WO2009052439A2 (en) * 2007-10-17 2009-04-23 Elan Pharma International Limited Immunotherapy regimes dependent on apoe status

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021515005A (ja) * 2018-03-01 2021-06-17 トライジェミナ, インコーポレイテッド 標識オキシトシンならびに製造および使用の方法
JP2021535378A (ja) * 2018-08-21 2021-12-16 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. アミロイドスクリーニング方法及び装置
JP7442505B2 (ja) 2018-08-21 2024-03-04 コーニンクレッカ フィリップス エヌ ヴェ アミロイドスクリーニング方法及び装置
JP2023506450A (ja) * 2019-12-11 2023-02-16 アンベテックス ピーティーワイ エルティーディー 拡張機能障害の防止及び治療のためのアミロイドベータ抗体又はワクチンを含む療法組成物

Also Published As

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EP2538982A4 (en) 2016-02-17
EP2538982A1 (en) 2013-01-02
JP2016185964A (ja) 2016-10-27
US20130084245A1 (en) 2013-04-04
WO2011106732A1 (en) 2011-09-01

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