JP2013518615A5 - - Google Patents
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- Publication number
- JP2013518615A5 JP2013518615A5 JP2012551368A JP2012551368A JP2013518615A5 JP 2013518615 A5 JP2013518615 A5 JP 2013518615A5 JP 2012551368 A JP2012551368 A JP 2012551368A JP 2012551368 A JP2012551368 A JP 2012551368A JP 2013518615 A5 JP2013518615 A5 JP 2013518615A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen dioxide
- reservoir
- air
- container
- nitric oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 16
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 claims 15
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 15
- 239000007789 gas Substances 0.000 claims 12
- 239000003963 antioxidant agent Substances 0.000 claims 7
- 230000003078 antioxidant effect Effects 0.000 claims 7
- 235000006708 antioxidants Nutrition 0.000 claims 7
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229910001882 dioxygen Inorganic materials 0.000 claims 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 239000011149 active material Substances 0.000 claims 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 229940087168 alpha tocopherol Drugs 0.000 claims 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- WFPZPJSADLPSON-UHFFFAOYSA-N dinitrogen tetraoxide Chemical compound [O-][N+](=O)[N+]([O-])=O WFPZPJSADLPSON-UHFFFAOYSA-N 0.000 claims 2
- 235000010382 gamma-tocopherol Nutrition 0.000 claims 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000741 silica gel Substances 0.000 claims 2
- 229910002027 silica gel Inorganic materials 0.000 claims 2
- 229960000984 tocofersolan Drugs 0.000 claims 2
- 235000004835 α-tocopherol Nutrition 0.000 claims 2
- 239000002076 α-tocopherol Substances 0.000 claims 2
- 239000002478 γ-tocopherol Substances 0.000 claims 2
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30042510P | 2010-02-01 | 2010-02-01 | |
| US61/300,425 | 2010-02-01 | ||
| PCT/US2011/023172 WO2011094684A1 (en) | 2010-02-01 | 2011-01-31 | Nitric oxide delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518615A JP2013518615A (ja) | 2013-05-23 |
| JP2013518615A5 true JP2013518615A5 (enExample) | 2014-03-27 |
| JP5965845B2 JP5965845B2 (ja) | 2016-08-10 |
Family
ID=44319849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551368A Expired - Fee Related JP5965845B2 (ja) | 2010-02-01 | 2011-01-31 | 一酸化窒素送達システム |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110240019A1 (enExample) |
| EP (1) | EP2531249B1 (enExample) |
| JP (1) | JP5965845B2 (enExample) |
| AU (1) | AU2011210543B2 (enExample) |
| CA (1) | CA2788582C (enExample) |
| ES (1) | ES2873089T3 (enExample) |
| WO (1) | WO2011094684A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7618594B2 (en) * | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| WO2006023616A2 (en) | 2004-08-18 | 2006-03-02 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| AU2009209181B2 (en) | 2008-01-28 | 2014-01-16 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US8607785B2 (en) | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
| US8613958B2 (en) | 2009-06-22 | 2013-12-24 | Geno Llc | Nitric oxide therapies |
| EP2645860A4 (en) | 2010-12-03 | 2014-07-09 | Geno Llc | NITROGEN OXIDE TREATMENTS |
| CA2991860C (en) | 2011-01-06 | 2020-03-24 | Mallinckrodt Hospital Products IP Limited | Gas delivery device and system |
| AU2013257484B2 (en) * | 2011-01-06 | 2017-09-28 | Mallinckrodt Hospital Products IP Limited | Nitric oxide delivery device |
| CA2838829A1 (en) * | 2011-06-10 | 2012-12-13 | Geno Llc | Pressurized vessel of nitric oxide (no) |
| WO2013132497A1 (en) | 2012-03-07 | 2013-09-12 | Advanced Inhilation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| CN104411317A (zh) * | 2012-03-15 | 2015-03-11 | Ino治疗有限责任公司 | 用于施用高浓度一氧化碳的方法 |
| US9423051B2 (en) * | 2012-08-17 | 2016-08-23 | The Coca-Cola Company | Dispensing carbonated beverages from a closed package |
| US20140127330A1 (en) * | 2012-11-05 | 2014-05-08 | Geno Llc | Method of mixing gases including nitric oxide |
| WO2014136111A2 (en) | 2013-03-07 | 2014-09-12 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| MX375330B (es) * | 2013-03-13 | 2025-03-06 | Mallinckrodt Hospital Products Ip Ltd | Dispositivos y metodos para monitorizar la oxigenacion durante el tratamiento con el suminitro de oxido nitrico. |
| JP6072611B2 (ja) * | 2013-05-28 | 2017-02-01 | 住友精化株式会社 | 二酸化窒素の変換方法および二酸化窒素変換装置 |
| US10525226B2 (en) * | 2014-05-14 | 2020-01-07 | Mallinckrodt Hospital Products IP Limited | Systems and methods for indicating lifetime of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient |
| AU2016267090A1 (en) * | 2015-05-25 | 2017-12-07 | VERO Biotech LLC. | Nitric oxide treatment system and method |
| US10842812B2 (en) * | 2015-08-12 | 2020-11-24 | The General Hospital Corporation | Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders |
| BR112018006600B1 (pt) | 2015-10-01 | 2022-05-17 | Mallinckrodt Hospital Products IP Limited | Dispositivo e método para difusão de no de alta concentração com gás para terapia de inalação |
| US20170165294A1 (en) * | 2015-12-11 | 2017-06-15 | Geno Llc | Method and apparatus for administering gases including nitric oxide to address fibrosis |
| MX2019009931A (es) | 2017-02-27 | 2020-07-14 | Third Pole Inc | Sistemas y metodos para generacion ambulatoria de oxido nitrico. |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| JP6704094B2 (ja) | 2017-02-27 | 2020-06-03 | サード ポール, インコーポレイテッドThird Pole, Inc. | 酸化窒素を生成するためのシステムおよび方法 |
| US11577042B2 (en) * | 2017-06-08 | 2023-02-14 | Case Western Reserve University | Vaporization system for delivery in a controlled concentration |
| US11754538B1 (en) * | 2018-07-18 | 2023-09-12 | Vero Biotech Inc. | Method and apparatus for automatic calibration |
| US11672938B1 (en) * | 2018-07-18 | 2023-06-13 | Vero Biotech LLC | Start-up protocols for nitric oxide delivery device |
| WO2020146758A1 (en) | 2019-01-10 | 2020-07-16 | The General Hospital Corporation | Methods to treat mitochondrial-associated dysfunctions or diseases |
| WO2020232419A1 (en) | 2019-05-15 | 2020-11-19 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
| WO2020232414A1 (en) | 2019-05-15 | 2020-11-19 | Third Pole, Inc. | Architectures for production of nitric oxide |
| EP3969415A4 (en) | 2019-05-15 | 2023-08-16 | Third Pole, Inc. | ELECTRODES FOR GENERATING NITROUS OXIDE |
| EP4069069A4 (en) | 2020-01-11 | 2024-07-03 | Third Pole, Inc. | SYSTEMS AND METHODS FOR NITROGEN OXIDE PRODUCTION WITH HUMIDITY CONTROL |
| US12059531B2 (en) * | 2020-06-07 | 2024-08-13 | Alti Llc | Nitric oxide generation, delivery, and monitoring system |
| EP4167920A4 (en) | 2020-06-18 | 2024-06-12 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| WO2022082072A1 (en) | 2020-10-16 | 2022-04-21 | Third Pole, Inc. | Nitric oxide generation process controls |
| WO2023049873A1 (en) | 2021-09-23 | 2023-03-30 | Third Pole, Inc. | Systems and methods for delivering nitric oxide |
| US12569628B2 (en) | 2022-04-14 | 2026-03-10 | Third Pole, Inc. | Delivery of medicinal gas in a liquid medium |
| KR102831194B1 (ko) * | 2022-12-22 | 2025-07-09 | 성균관대학교산학협력단 | 관류 mri 획득 방법 및 시스템 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3521865A (en) * | 1968-05-20 | 1970-07-28 | Du Pont | Generation of accurately known vapor concentrations by permeation |
| US3856204A (en) * | 1973-03-12 | 1974-12-24 | Ecology Board Inc | Gas emitting device |
| US4399942A (en) * | 1981-11-09 | 1983-08-23 | Gc Industries | Gas emitting device |
| US5324478A (en) * | 1987-08-14 | 1994-06-28 | American Air Liquide | Gas generating apparatus |
| US5653885A (en) * | 1990-07-13 | 1997-08-05 | Isco, Inc. | Apparatus and method for supercritical fluid extraction |
| US5156334A (en) * | 1990-08-15 | 1992-10-20 | Kimbell Charles L | Gas permeation system |
| US5396882A (en) * | 1992-03-11 | 1995-03-14 | The General Hospital Corporation | Generation of nitric oxide from air for medical uses |
| DE59409834D1 (de) * | 1993-04-17 | 2001-09-27 | Messer Griesheim Austria Ges M | Gerät zur kontrollierten Zudosierung von NO zur Atemluft von Patienten |
| GB9320978D0 (en) * | 1993-10-12 | 1993-12-01 | Higenbottam Timohy W | Nitric oxide treatment |
| US5558083A (en) * | 1993-11-22 | 1996-09-24 | Ohmeda Inc. | Nitric oxide delivery system |
| JP3142716B2 (ja) * | 1994-04-28 | 2001-03-07 | 裕一 石部 | 呼吸器への一酸化窒素の供給装置 |
| DE19612289A1 (de) * | 1996-03-28 | 1997-10-02 | Messer Griesheim Gmbh | Verfahren und Vorrichtung zur Minderung von Risiken bei der inhalativen NO-Therapie |
| US5692495A (en) * | 1996-04-02 | 1997-12-02 | The Boc Group, Inc. | Method and apparatus for the production of nitric oxide gas mixture |
| US5743251A (en) * | 1996-05-15 | 1998-04-28 | Philip Morris Incorporated | Aerosol and a method and apparatus for generating an aerosol |
| US6564656B1 (en) * | 1998-05-19 | 2003-05-20 | Markes International Limited | Sampling device |
| US6089229A (en) * | 1998-05-26 | 2000-07-18 | Datex-Ohmeda, Inc. | High concentration no pulse delivery device |
| US7516742B2 (en) * | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
| MY136453A (en) * | 2000-04-27 | 2008-10-31 | Philip Morris Usa Inc | "improved method and apparatus for generating an aerosol" |
| WO2003012565A1 (en) * | 2001-07-31 | 2003-02-13 | Chrysalis Technologies Incorporated | Method and apparatus for generating a volatilized liquid |
| US6681769B2 (en) * | 2001-12-06 | 2004-01-27 | Crysalis Technologies Incorporated | Aerosol generator having a multiple path heater arrangement and method of use thereof |
| MXPA06013111A (es) * | 2004-05-11 | 2007-05-23 | Sensormedics Corp | Dosificacion intermitente de gas de oxido nitrico. |
| US7618594B2 (en) * | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| WO2006023616A2 (en) * | 2004-08-18 | 2006-03-02 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| US20070181126A1 (en) * | 2006-02-08 | 2007-08-09 | Tolmie Craig R | Method and apparatus for ventilating a patient with a breathing gas mixture formed from nitric oxide, air, and oxygen |
| AU2008232413B2 (en) * | 2007-03-23 | 2013-09-19 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| AU2009209181B2 (en) * | 2008-01-28 | 2014-01-16 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| WO2010011928A1 (en) * | 2008-07-24 | 2010-01-28 | Geno Llc | Methods for diagnosing and treating a heart condition in a patient |
| JP5995724B2 (ja) * | 2009-11-20 | 2016-09-21 | ゲノ エルエルシー | 一酸化窒素送達システム |
-
2011
- 2011-01-31 EP EP11737816.6A patent/EP2531249B1/en active Active
- 2011-01-31 ES ES11737816T patent/ES2873089T3/es active Active
- 2011-01-31 CA CA2788582A patent/CA2788582C/en active Active
- 2011-01-31 US US13/017,768 patent/US20110240019A1/en not_active Abandoned
- 2011-01-31 JP JP2012551368A patent/JP5965845B2/ja not_active Expired - Fee Related
- 2011-01-31 AU AU2011210543A patent/AU2011210543B2/en not_active Ceased
- 2011-01-31 WO PCT/US2011/023172 patent/WO2011094684A1/en not_active Ceased
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