JP2013517782A5 - - Google Patents

Info

Publication number

JP2013517782A5

JP2013517782A5 JP2012550441A JP2012550441A JP2013517782A5 JP 2013517782 A5 JP2013517782 A5 JP 2013517782A5 JP 2012550441 A JP2012550441 A JP 2012550441A JP 2012550441 A JP2012550441 A JP 2012550441A JP 2013517782 A5 JP2013517782 A5 JP 2013517782A5

Authority

JP

Japan

Prior art keywords

polypeptide

fvii

seq

acid sequence

amino acid

Prior art date

2011-01-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims 29
• 229920001184 polypeptide Polymers 0.000 claims 25
• 102000004196 processed proteins & peptides Human genes 0.000 claims 25
• 102100023804 Coagulation factor VII Human genes 0.000 claims 7
• 108010023321 Factor VII Proteins 0.000 claims 7
• 229940012413 factor vii Drugs 0.000 claims 7
• 108010054265 Factor VIIa Proteins 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 229940012414 factor viia Drugs 0.000 claims 5
• 102100022641 Coagulation factor IX Human genes 0.000 claims 3
• 208000032843 Hemorrhage Diseases 0.000 claims 3
• 230000003213 activating effect Effects 0.000 claims 3
• 230000000740 bleeding effect Effects 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 150000007523 nucleic acids Chemical group 0.000 claims 3
• 238000006467 substitution reaction Methods 0.000 claims 3
• 108010076282 Factor IX Proteins 0.000 claims 2
• 108010014173 Factor X Proteins 0.000 claims 2
• 208000015294 blood coagulation disease Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229960004222 factor ix Drugs 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102400000069 Activation peptide Human genes 0.000 claims 1
• 101800001401 Activation peptide Proteins 0.000 claims 1
• 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
• 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
• 208000009292 Hemophilia A Diseases 0.000 claims 1
• 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 206010073391 Platelet dysfunction Diseases 0.000 claims 1
• 208000027276 Von Willebrand disease Diseases 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 208000034158 bleeding Diseases 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 201000007386 factor VII deficiency Diseases 0.000 claims 1
• 201000007219 factor XI deficiency Diseases 0.000 claims 1
• 208000009429 hemophilia B Diseases 0.000 claims 1
• 238000001356 surgical procedure Methods 0.000 claims 1
• 206010043554 thrombocytopenia Diseases 0.000 claims 1
• 230000000451 tissue damage Effects 0.000 claims 1
• 231100000827 tissue damage Toxicity 0.000 claims 1
• 208000012137 von Willebrand disease (hereditary or acquired) Diseases 0.000 claims 1