JP2013516485A - 耳にモキシフロキサシンを適用するための方法および組成物 - Google Patents

耳にモキシフロキサシンを適用するための方法および組成物 Download PDF

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Publication number
JP2013516485A
JP2013516485A JP2012548156A JP2012548156A JP2013516485A JP 2013516485 A JP2013516485 A JP 2013516485A JP 2012548156 A JP2012548156 A JP 2012548156A JP 2012548156 A JP2012548156 A JP 2012548156A JP 2013516485 A JP2013516485 A JP 2013516485A
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Prior art keywords
moxifloxacin
formulation
viscosity
generating agent
middle ear
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Pending
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JP2012548156A
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English (en)
Japanese (ja)
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JP2013516485A5 (es
Inventor
ロナルド ジェイ． ソーチャック
ベリンダ ダブリュ．ワイ． チャン
ジー．マイケル ウォール
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University of Minnesota
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University of Minnesota
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Application filed by University of Minnesota filed Critical University of Minnesota
Publication of JP2013516485A publication Critical patent/JP2013516485A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
JP2012548156A 2010-01-07 2011-01-07 耳にモキシフロキサシンを適用するための方法および組成物 Pending JP2013516485A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29301910P 2010-01-07 2010-01-07
US61/293,019 2010-01-07
PCT/US2011/020531 WO2011085209A2 (en) 2010-01-07 2011-01-07 Methods and compositions for applying moxifloxacin to the ear

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016020395A Division JP6267246B2 (ja) 2010-01-07 2016-02-05 耳にモキシフロキサシンを適用するための方法および組成物

Publications (2)

Publication Number Publication Date
JP2013516485A true JP2013516485A (ja) 2013-05-13
JP2013516485A5 JP2013516485A5 (es) 2014-02-27

Family

ID=44306169

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2012548156A Pending JP2013516485A (ja) 2010-01-07 2011-01-07 耳にモキシフロキサシンを適用するための方法および組成物
JP2016020395A Expired - Fee Related JP6267246B2 (ja) 2010-01-07 2016-02-05 耳にモキシフロキサシンを適用するための方法および組成物
JP2017245040A Pending JP2018076352A (ja) 2010-01-07 2017-12-21 耳にモキシフロキサシンを適用するための方法および組成物

Family Applications After (2)

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JP2016020395A Expired - Fee Related JP6267246B2 (ja) 2010-01-07 2016-02-05 耳にモキシフロキサシンを適用するための方法および組成物
JP2017245040A Pending JP2018076352A (ja) 2010-01-07 2017-12-21 耳にモキシフロキサシンを適用するための方法および組成物

Country Status (23)

Country Link
US (1) US20120289541A1 (es)
EP (2) EP2521547B1 (es)
JP (3) JP2013516485A (es)
KR (2) KR101835895B1 (es)
CN (2) CN106309356A (es)
AU (1) AU2011204275B2 (es)
BR (1) BR112012016809A2 (es)
CA (1) CA2786525A1 (es)
CL (1) CL2012001835A1 (es)
CY (1) CY1119493T1 (es)
DK (1) DK2521547T3 (es)
ES (1) ES2644826T3 (es)
HR (1) HRP20171592T1 (es)
HU (1) HUE035586T2 (es)
LT (1) LT2521547T (es)
MX (1) MX337419B (es)
NO (1) NO2521547T3 (es)
PL (1) PL2521547T3 (es)
PT (1) PT2521547T (es)
RU (2) RU2016101214A (es)
SI (1) SI2521547T1 (es)
WO (1) WO2011085209A2 (es)
ZA (1) ZA201205965B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6255134B1 (ja) * 2016-11-02 2017-12-27 ヴェローチェ・バイオファーマ・エルエルシー 耳炎の治療のための組成物および方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220431B2 (en) * 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
DK2844309T3 (da) * 2012-06-28 2022-01-24 The Administrators Of The Tulane Educational Fund Selektivt polymeriserbare sammensætninger
CN103869033B (zh) * 2012-12-14 2016-10-05 南京长澳医药科技有限公司 一种液相色谱法分离测定盐酸莫西沙星及其杂质的方法
WO2019113425A1 (en) * 2017-12-08 2019-06-13 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
CN108593696B (zh) * 2018-04-26 2020-11-03 南京明捷生物医药检测有限公司 一种利用定量核磁测定多肽中三氟乙酸残留的方法
CN117045593B (zh) * 2023-09-19 2024-05-28 上海市第六人民医院 一种用于慢性中耳炎治疗的抗菌温敏水凝胶及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002525317A (ja) * 1998-09-30 2002-08-13 アルコン ラボラトリーズ，インコーポレイテッド 眼、耳および鼻治療用の抗生物質組成物
JP2006509791A (ja) * 2002-11-27 2006-03-23 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 耳に薬理的作用物質を適用するための方法及び組成物
JP2008523060A (ja) * 2004-12-10 2008-07-03 アルコン，インコーポレイティド 耳感染の処置のための組成物
WO2009142719A2 (en) * 2008-05-19 2009-11-26 Massachusetts Institute Of Technology Tympanic membrane permeating ear drops and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6740664B2 (en) * 1998-09-30 2004-05-25 Alcon, Inc. Methods for treating otic and ophthalmic infections
JP3450805B2 (ja) * 2000-08-08 2003-09-29 わかもと製薬株式会社 水性医薬組成物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002525317A (ja) * 1998-09-30 2002-08-13 アルコン ラボラトリーズ，インコーポレイテッド 眼、耳および鼻治療用の抗生物質組成物
JP2006509791A (ja) * 2002-11-27 2006-03-23 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 耳に薬理的作用物質を適用するための方法及び組成物
JP2008523060A (ja) * 2004-12-10 2008-07-03 アルコン，インコーポレイティド 耳感染の処置のための組成物
WO2009142719A2 (en) * 2008-05-19 2009-11-26 Massachusetts Institute Of Technology Tympanic membrane permeating ear drops and uses thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6255134B1 (ja) * 2016-11-02 2017-12-27 ヴェローチェ・バイオファーマ・エルエルシー 耳炎の治療のための組成物および方法
JP6271804B1 (ja) * 2016-11-02 2018-01-31 ヴェローチェ・バイオファーマ・エルエルシー 耳炎の治療のための組成物および方法
JP2018070655A (ja) * 2016-11-02 2018-05-10 ヴェローチェ・バイオファーマ・エルエルシー 耳炎の治療のための組成物および方法
JP2018070620A (ja) * 2016-11-02 2018-05-10 ヴェローチェ・バイオファーマ・エルエルシー 耳炎の治療のための組成物および方法
JP2018070583A (ja) * 2016-11-02 2018-05-10 ヴェローチェ・バイオファーマ・エルエルシー 耳炎の治療のための組成物および方法

Also Published As

Publication number Publication date
EP2521547A2 (en) 2012-11-14
CA2786525A1 (en) 2011-07-14
AU2011204275B2 (en) 2015-04-02
PL2521547T3 (pl) 2018-01-31
AU2011204275A1 (en) 2012-08-23
PT2521547T (pt) 2017-11-17
WO2011085209A2 (en) 2011-07-14
HUE035586T2 (en) 2018-05-28
RU2016101214A (ru) 2018-11-21
HRP20171592T1 (hr) 2018-02-09
SI2521547T1 (en) 2018-02-28
EP2521547B1 (en) 2017-08-16
CL2012001835A1 (es) 2013-03-22
US20120289541A1 (en) 2012-11-15
EP2521547A4 (en) 2014-03-26
CN106309356A (zh) 2017-01-11
ES2644826T3 (es) 2017-11-30
RU2012133568A (ru) 2014-02-20
KR20120114344A (ko) 2012-10-16
JP6267246B2 (ja) 2018-01-24
CY1119493T1 (el) 2018-03-07
KR101835895B1 (ko) 2018-03-07
KR20180027611A (ko) 2018-03-14
JP2016155808A (ja) 2016-09-01
JP2018076352A (ja) 2018-05-17
NO2521547T3 (es) 2018-01-13
CN102791270A (zh) 2012-11-21
ZA201205965B (en) 2014-01-29
MX2012007928A (es) 2012-11-22
EP3305280A1 (en) 2018-04-11
WO2011085209A3 (en) 2011-11-17
BR112012016809A2 (pt) 2017-09-26
RU2576029C2 (ru) 2016-02-27
MX337419B (es) 2016-03-03
LT2521547T (lt) 2017-12-11
DK2521547T3 (da) 2017-11-20

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