JP2013516425A - 血管閉塞傷害の予防または治療方法 - Google Patents
血管閉塞傷害の予防または治療方法 Download PDFInfo
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| PCT/US2010/062538 WO2011082324A1 (en) | 2009-12-31 | 2010-12-30 | Methods for the prevention or treatment of vessel occlusion injury |
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| JP2021506823A (ja) * | 2017-12-15 | 2021-02-22 | ステルス バイオセラピューティクス コーポレーション | ミトコンドリア標的化ペプチド |
Families Citing this family (18)
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| EP2808029A3 (en) * | 2010-03-15 | 2015-04-01 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| CN103249423A (zh) * | 2010-07-09 | 2013-08-14 | 康肽德生物医药技术有限公司 | 预防或治疗缺血/再灌注损伤之后无复流的方法 |
| CN107496899A (zh) * | 2011-09-29 | 2017-12-22 | 梅约医学教育与研究基金会 | 芳族阳离子肽和使用它们的方法 |
| CA2858550A1 (en) * | 2011-12-09 | 2013-06-13 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| CA2869080C (en) * | 2012-03-30 | 2020-09-01 | Stealth Peptides International, Inc. | Methods and compositions for the prevention and treatment neuropathy |
| EP4397314B1 (en) * | 2012-10-22 | 2025-12-03 | Stealth BioTherapeutics Inc. | Treatment of left ventricular remodeling |
| US10793597B2 (en) | 2013-03-01 | 2020-10-06 | Stealth Biotherapeutics Corp | Methods for the treatment of mitochondrial diseases associated with a mutation in SURF 1 or POLG gene resulting in a disruption of mitochondrial oxidative phosphorylation |
| EP3626252A1 (en) | 2013-03-01 | 2020-03-25 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention or treatment of barth syndrome |
| EP3586864A1 (en) * | 2013-05-14 | 2020-01-01 | Stealth Biotherapeutics Corp | Methods for the prevention or treatment of left ventricle remodeling |
| US10047395B2 (en) | 2013-06-26 | 2018-08-14 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| WO2015009414A1 (en) * | 2013-06-26 | 2015-01-22 | Stealth Peptides International, Inc. | Methods and compositions for regulating srca2a expression levels in myocardial infarction |
| WO2016004441A1 (en) * | 2014-07-03 | 2016-01-07 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of acute myocardial infarction injury |
| US10744178B2 (en) | 2014-08-21 | 2020-08-18 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention and treatment of disease |
| CA3010321A1 (en) * | 2015-12-31 | 2017-07-06 | Scott Duncan | Therapeutic compositions including peptides and uses thereof |
| WO2017156403A1 (en) * | 2016-03-11 | 2017-09-14 | Stealth Biotherapeutics | Crystalline salt forms |
| US11034724B2 (en) | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| CN117243895A (zh) * | 2023-07-13 | 2023-12-19 | 河南大学 | 一种磷脂dspe-peg2000-ss31、负载药物的方法及其抗脑胶质瘤的应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006516652A (ja) * | 2003-02-04 | 2006-07-06 | コーネル リサーチ ファウンデイション インコーポレイテッド | ミトコンドリア透過性転移の阻止方法 |
| JP2007518818A (ja) * | 2004-01-23 | 2007-07-12 | コーネル リサーチ ファウンデイション インコーポレイテッド | 酸化的損傷を低減する方法 |
| JP2009509941A (ja) * | 2005-09-16 | 2009-03-12 | コーネル リサーチ ファウンデイション インコーポレイテッド | Cd36の発現を減少させる方法 |
| WO2009108695A2 (en) * | 2008-02-26 | 2009-09-03 | Cornell University | Methods for prevention and treatment of acute renal injury |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| EP2808029A3 (en) * | 2010-03-15 | 2015-04-01 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
-
2010
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- 2010-12-30 WO PCT/US2010/062538 patent/WO2011082324A1/en not_active Ceased
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- 2010-12-30 EP EP17169757.6A patent/EP3269380A1/en not_active Withdrawn
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2014
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2015
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2016
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2017
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2018
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2019
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2020
- 2020-02-28 US US16/804,900 patent/US20210023160A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006516652A (ja) * | 2003-02-04 | 2006-07-06 | コーネル リサーチ ファウンデイション インコーポレイテッド | ミトコンドリア透過性転移の阻止方法 |
| JP2007518818A (ja) * | 2004-01-23 | 2007-07-12 | コーネル リサーチ ファウンデイション インコーポレイテッド | 酸化的損傷を低減する方法 |
| JP2009509941A (ja) * | 2005-09-16 | 2009-03-12 | コーネル リサーチ ファウンデイション インコーポレイテッド | Cd36の発現を減少させる方法 |
| WO2009108695A2 (en) * | 2008-02-26 | 2009-09-03 | Cornell University | Methods for prevention and treatment of acute renal injury |
Non-Patent Citations (5)
| Title |
|---|
| CHO, J ET AL, CORON ARTERY DIS, 2007, VOL.18, NO.3, P.215-20, JPN7014003327, ISSN: 0002948755 * |
| CHO, J ET AL, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, VOL.49, NO.9, SUPPL.A, P.184A, JPN7014003328, ISSN: 0002948756 * |
| CHO, S ET AL, J BIOL CHEM, 2007, VOL.282, NO.7, P.4634-42, JPN6014049508, ISSN: 0002948754 * |
| YOUSIF, LF ET AL, CHEMBIOCHEM, 2009 AUG, VOL.10, NO.12, P.1939-50, JPN6014049510, ISSN: 0002948757 * |
| ZHAO, K T AL, J BIOL CHEM, 2004, VOL.279, NO.33, P.34682-90, JPN6014049511, ISSN: 0002948758 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021506823A (ja) * | 2017-12-15 | 2021-02-22 | ステルス バイオセラピューティクス コーポレーション | ミトコンドリア標的化ペプチド |
| JP7335880B2 (ja) | 2017-12-15 | 2023-08-30 | ステルス バイオセラピューティクス インコーポレイテッド | ミトコンドリア標的化ペプチド |
| JP2023162279A (ja) * | 2017-12-15 | 2023-11-08 | ステルス バイオセラピューティクス インコーポレイテッド | ミトコンドリア標的化ペプチド |
| JP7576670B2 (ja) | 2017-12-15 | 2024-10-31 | ステルス バイオセラピューティクス インコーポレイテッド | ミトコンドリア標的化ペプチド |
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| EP3269380A1 (en) | 2018-01-17 |
| JP2015147810A (ja) | 2015-08-20 |
| CA2786280A1 (en) | 2011-07-07 |
| US20180228864A1 (en) | 2018-08-16 |
| AU2019200823A1 (en) | 2019-02-28 |
| EP3446698A1 (en) | 2019-02-27 |
| WO2011082324A1 (en) | 2011-07-07 |
| JP2018087225A (ja) | 2018-06-07 |
| AU2015242952A1 (en) | 2015-10-29 |
| CN102791280A (zh) | 2012-11-21 |
| JP2017025093A (ja) | 2017-02-02 |
| US20170100451A1 (en) | 2017-04-13 |
| EP2519248A4 (en) | 2013-06-26 |
| EP3090754A1 (en) | 2016-11-09 |
| US20130195837A1 (en) | 2013-08-01 |
| US20210023160A1 (en) | 2021-01-28 |
| AU2017203662A1 (en) | 2017-06-15 |
| EP2519248A1 (en) | 2012-11-07 |
| AU2010339410A1 (en) | 2012-07-19 |
| US20190336566A1 (en) | 2019-11-07 |
| CN103751763A (zh) | 2014-04-30 |
| EP2910250A1 (en) | 2015-08-26 |
| US20140341879A1 (en) | 2014-11-20 |
| US20160030501A1 (en) | 2016-02-04 |
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