AU2010339410A1 - Methods for the prevention or treatment of vessel occlusion injury - Google Patents

Methods for the prevention or treatment of vessel occlusion injury Download PDF

Info

Publication number
AU2010339410A1
AU2010339410A1 AU2010339410A AU2010339410A AU2010339410A1 AU 2010339410 A1 AU2010339410 A1 AU 2010339410A1 AU 2010339410 A AU2010339410 A AU 2010339410A AU 2010339410 A AU2010339410 A AU 2010339410A AU 2010339410 A1 AU2010339410 A1 AU 2010339410A1
Authority
AU
Australia
Prior art keywords
peptide
subject
arg
lys
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2010339410A
Other languages
English (en)
Inventor
Kenneth Borow
D. Travis Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stealth Peptides International Inc
Original Assignee
Stealth Peptides International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stealth Peptides International Inc filed Critical Stealth Peptides International Inc
Publication of AU2010339410A1 publication Critical patent/AU2010339410A1/en
Priority to AU2015242952A priority Critical patent/AU2015242952A1/en
Priority to AU2017203662A priority patent/AU2017203662A1/en
Priority to AU2019200823A priority patent/AU2019200823A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2010339410A 2009-12-31 2010-12-30 Methods for the prevention or treatment of vessel occlusion injury Abandoned AU2010339410A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2015242952A AU2015242952A1 (en) 2009-12-31 2015-10-12 Methods for the prevention or treatment of vessel occlusion injury
AU2017203662A AU2017203662A1 (en) 2009-12-31 2017-05-31 Methods for the prevention or treatment of vessel occlusion injury
AU2019200823A AU2019200823A1 (en) 2009-12-31 2019-02-07 Methods for the prevention or treatment of vessel occlusion injury

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29169909P 2009-12-31 2009-12-31
US61/291,699 2009-12-31
US36313810P 2010-07-09 2010-07-09
US61/363,138 2010-07-09
PCT/US2010/062538 WO2011082324A1 (en) 2009-12-31 2010-12-30 Methods for the prevention or treatment of vessel occlusion injury

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2015242952A Division AU2015242952A1 (en) 2009-12-31 2015-10-12 Methods for the prevention or treatment of vessel occlusion injury

Publications (1)

Publication Number Publication Date
AU2010339410A1 true AU2010339410A1 (en) 2012-07-19

Family

ID=44226816

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2010339410A Abandoned AU2010339410A1 (en) 2009-12-31 2010-12-30 Methods for the prevention or treatment of vessel occlusion injury
AU2015242952A Abandoned AU2015242952A1 (en) 2009-12-31 2015-10-12 Methods for the prevention or treatment of vessel occlusion injury
AU2017203662A Abandoned AU2017203662A1 (en) 2009-12-31 2017-05-31 Methods for the prevention or treatment of vessel occlusion injury
AU2019200823A Abandoned AU2019200823A1 (en) 2009-12-31 2019-02-07 Methods for the prevention or treatment of vessel occlusion injury

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2015242952A Abandoned AU2015242952A1 (en) 2009-12-31 2015-10-12 Methods for the prevention or treatment of vessel occlusion injury
AU2017203662A Abandoned AU2017203662A1 (en) 2009-12-31 2017-05-31 Methods for the prevention or treatment of vessel occlusion injury
AU2019200823A Abandoned AU2019200823A1 (en) 2009-12-31 2019-02-07 Methods for the prevention or treatment of vessel occlusion injury

Country Status (7)

Country Link
US (7) US20130195837A1 (cg-RX-API-DMAC7.html)
EP (5) EP2910250A1 (cg-RX-API-DMAC7.html)
JP (4) JP2013516425A (cg-RX-API-DMAC7.html)
CN (2) CN102791280A (cg-RX-API-DMAC7.html)
AU (4) AU2010339410A1 (cg-RX-API-DMAC7.html)
CA (1) CA2786280A1 (cg-RX-API-DMAC7.html)
WO (1) WO2011082324A1 (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2808029A3 (en) * 2010-03-15 2015-04-01 Stealth Peptides International, Inc. Combination therapies using cyclosporine and aromatic cationic peptides
CN103249423A (zh) * 2010-07-09 2013-08-14 康肽德生物医药技术有限公司 预防或治疗缺血/再灌注损伤之后无复流的方法
CN107496899A (zh) * 2011-09-29 2017-12-22 梅约医学教育与研究基金会 芳族阳离子肽和使用它们的方法
CA2858550A1 (en) * 2011-12-09 2013-06-13 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
CA2869080C (en) * 2012-03-30 2020-09-01 Stealth Peptides International, Inc. Methods and compositions for the prevention and treatment neuropathy
EP4397314B1 (en) * 2012-10-22 2025-12-03 Stealth BioTherapeutics Inc. Treatment of left ventricular remodeling
US10793597B2 (en) 2013-03-01 2020-10-06 Stealth Biotherapeutics Corp Methods for the treatment of mitochondrial diseases associated with a mutation in SURF 1 or POLG gene resulting in a disruption of mitochondrial oxidative phosphorylation
EP3626252A1 (en) 2013-03-01 2020-03-25 Stealth Biotherapeutics Corp Methods and compositions for the prevention or treatment of barth syndrome
EP3586864A1 (en) * 2013-05-14 2020-01-01 Stealth Biotherapeutics Corp Methods for the prevention or treatment of left ventricle remodeling
US10047395B2 (en) 2013-06-26 2018-08-14 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
WO2015009414A1 (en) * 2013-06-26 2015-01-22 Stealth Peptides International, Inc. Methods and compositions for regulating srca2a expression levels in myocardial infarction
WO2016004441A1 (en) * 2014-07-03 2016-01-07 Stealth Peptides International, Inc. Methods for the prevention or treatment of acute myocardial infarction injury
US10744178B2 (en) 2014-08-21 2020-08-18 Stealth Biotherapeutics Corp Methods and compositions for the prevention and treatment of disease
CA3010321A1 (en) * 2015-12-31 2017-07-06 Scott Duncan Therapeutic compositions including peptides and uses thereof
WO2017156403A1 (en) * 2016-03-11 2017-09-14 Stealth Biotherapeutics Crystalline salt forms
US11034724B2 (en) 2017-04-05 2021-06-15 Stealth Biotherapeutics Corp. Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2
IL305687B2 (en) * 2017-12-15 2024-12-01 Stealth Biotherapeutics Inc Mitochondria-targeting peptides
US10676506B2 (en) 2018-01-26 2020-06-09 Stealth Biotherapeutics Corp. Crystalline bis- and tris-hydrochloride salt of elamipretide
CN117243895A (zh) * 2023-07-13 2023-12-19 河南大学 一种磷脂dspe-peg2000-ss31、负载药物的方法及其抗脑胶质瘤的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
SI2656854T1 (sl) * 2003-02-04 2015-09-30 Cornell Research Foundation, Inc. Uporabe aromatsko-kationskega peptida
CA3024434A1 (en) * 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
EP3725324A1 (en) * 2005-09-16 2020-10-21 Cornell Research Foundation, Inc. Aromatic-cationic peptide for use in a method for reducing cd36 expression
CN107802821A (zh) * 2008-02-26 2018-03-16 康奈尔大学 用于防止和治疗急性肾损伤的方法
EP2808029A3 (en) * 2010-03-15 2015-04-01 Stealth Peptides International, Inc. Combination therapies using cyclosporine and aromatic cationic peptides

Also Published As

Publication number Publication date
EP3269380A1 (en) 2018-01-17
JP2015147810A (ja) 2015-08-20
CA2786280A1 (en) 2011-07-07
US20180228864A1 (en) 2018-08-16
AU2019200823A1 (en) 2019-02-28
EP3446698A1 (en) 2019-02-27
WO2011082324A1 (en) 2011-07-07
JP2018087225A (ja) 2018-06-07
AU2015242952A1 (en) 2015-10-29
CN102791280A (zh) 2012-11-21
JP2017025093A (ja) 2017-02-02
US20170100451A1 (en) 2017-04-13
EP2519248A4 (en) 2013-06-26
EP3090754A1 (en) 2016-11-09
US20130195837A1 (en) 2013-08-01
US20210023160A1 (en) 2021-01-28
JP2013516425A (ja) 2013-05-13
AU2017203662A1 (en) 2017-06-15
EP2519248A1 (en) 2012-11-07
US20190336566A1 (en) 2019-11-07
CN103751763A (zh) 2014-04-30
EP2910250A1 (en) 2015-08-26
US20140341879A1 (en) 2014-11-20
US20160030501A1 (en) 2016-02-04

Similar Documents

Publication Publication Date Title
US20210023160A1 (en) Methods for the prevention or treatment of vessel occlusion injury
US20250262269A1 (en) Methods for performing a coronary artery bypass graft procedure
EP2590664B1 (en) Methods for the prevention or treatment of no-reflow following ischemia/reperfusion injury
CA2916497C (en) Methods for the regulation of matrix metalloproteinase expression
US9877997B2 (en) Methods and compositions for regulating SRCA2A expression levels in myocardial infarction
US20160151444A1 (en) Methods for the prevention or treatment of vessel occlusion injury
WO2016004441A1 (en) Methods for the prevention or treatment of acute myocardial infarction injury
HK1178086A (en) Methods for the prevention or treatment of vessel occlusion injury
AU2019203050A1 (en) Methods for performing a coronary artery bypass graft procedure

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted