JP2013515698A5 - - Google Patents
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- Publication number
- JP2013515698A5 JP2013515698A5 JP2012545331A JP2012545331A JP2013515698A5 JP 2013515698 A5 JP2013515698 A5 JP 2013515698A5 JP 2012545331 A JP2012545331 A JP 2012545331A JP 2012545331 A JP2012545331 A JP 2012545331A JP 2013515698 A5 JP2013515698 A5 JP 2013515698A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- group
- methyl
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382302.9 | 2009-12-23 | ||
| EP09382302 | 2009-12-23 | ||
| US30757910P | 2010-02-24 | 2010-02-24 | |
| US61/307,579 | 2010-02-24 | ||
| PCT/EP2010/070562 WO2011076878A1 (en) | 2009-12-23 | 2010-12-22 | Aminoalkylpyrimidine derivatives as histamine h4 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515698A JP2013515698A (ja) | 2013-05-09 |
| JP2013515698A5 true JP2013515698A5 (https=) | 2014-02-20 |
| JP5781537B2 JP5781537B2 (ja) | 2015-09-24 |
Family
ID=41667549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012545331A Expired - Fee Related JP5781537B2 (ja) | 2009-12-23 | 2010-12-22 | ヒスタミンｈ４受容体アンタゴニストとしてのアミノアルキルピリミジン誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8901146B2 (https=) |
| EP (1) | EP2516420B8 (https=) |
| JP (1) | JP5781537B2 (https=) |
| KR (1) | KR101740085B1 (https=) |
| CN (1) | CN102803248B (https=) |
| AR (1) | AR079725A1 (https=) |
| AU (1) | AU2010334804B2 (https=) |
| BR (1) | BR112012017126A2 (https=) |
| CA (1) | CA2785353C (https=) |
| IL (1) | IL220554A (https=) |
| MX (1) | MX345142B (https=) |
| NZ (1) | NZ601021A (https=) |
| PE (1) | PE20121505A1 (https=) |
| RU (1) | RU2573828C2 (https=) |
| TW (1) | TWI487697B (https=) |
| UA (1) | UA107818C2 (https=) |
| WO (1) | WO2011076878A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA109775C2 (xx) | 2009-10-29 | 2015-10-12 | N-вмісні гетероарильні похідні як інгібітори jak3-кінази | |
| KR102507287B1 (ko) * | 2011-09-02 | 2023-03-07 | 인사이트 홀딩스 코포레이션 | Ｐｉ３ｋ 억제제로서 헤테로시클릴아민 |
| TWI797176B (zh) | 2017-10-17 | 2023-04-01 | 西班牙商帕羅製藥有限公司 | ４-胺基嘧啶化合物之合成 |
| GB201817047D0 (en) | 2018-10-19 | 2018-12-05 | Heptares Therapeutics Ltd | H4 antagonist compounds |
| JP2022165429A (ja) * | 2019-10-02 | 2022-11-01 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | ヒスタミンｈ４受容体調節作用を有する新規トリアジン誘導体 |
| CN117018194B (zh) * | 2023-07-26 | 2026-04-17 | 同济大学 | 毒蕈碱型受体5型受体拮抗剂的用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999023076A1 (en) * | 1997-11-04 | 1999-05-14 | Pfizer Products Inc. | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
| ES2273047T3 (es) | 2002-10-28 | 2007-05-01 | Bayer Healthcare Ag | Fenilaminopirimidinas sustituidas con heteroariloxi como inhibidores de rho-cinasa. |
| JP4544999B2 (ja) * | 2002-11-25 | 2010-09-15 | 持田製薬株式会社 | ４−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤 |
| EP1505064A1 (en) * | 2003-08-05 | 2005-02-09 | Bayer HealthCare AG | 2-Aminopyrimidine derivatives |
| WO2005054239A1 (en) | 2003-12-05 | 2005-06-16 | Bayer Healthcare Ag | 2-aminopyrimidine derivatives |
| KR20080004585A (ko) * | 2005-04-08 | 2008-01-09 | 바이엘 파마슈티칼스 코포레이션 | 피리미딘 유도체 및 암의 치료에서의 이의 용도 |
| US20090306038A1 (en) | 2005-09-13 | 2009-12-10 | Carceller Gonzalez Elena | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity |
| CN103626742B (zh) * | 2005-11-01 | 2017-04-26 | 塔格根公司 | 激酶的联-芳基间-嘧啶抑制剂 |
| NL2000323C2 (nl) | 2005-12-20 | 2007-11-20 | Pfizer Ltd | Pyrimidine-derivaten. |
| WO2008031556A2 (en) | 2006-09-12 | 2008-03-20 | Ucb Pharma, S.A. | 2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions |
| US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| CL2008000467A1 (es) | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma |
| WO2009068512A1 (en) * | 2007-11-30 | 2009-06-04 | Palau Pharma, S. A. | 2 -amino-pyrimidine derivatives as histamine h4 antagonists |
| WO2009077608A1 (en) | 2007-12-19 | 2009-06-25 | Palau Pharma, S. A. | 2 -aminopyrimidine derivatives as histamine h4 antagonists |
| SI2235012T1 (sl) * | 2007-12-21 | 2013-11-29 | Palau Pharma, S.A. | 4-aminopirimidinski derivati kot antagonisti histaminskega receptorja H4 |
-
2010
- 2010-12-22 TW TW099145246A patent/TWI487697B/zh active
- 2010-12-22 US US13/518,729 patent/US8901146B2/en active Active
- 2010-12-22 WO PCT/EP2010/070562 patent/WO2011076878A1/en not_active Ceased
- 2010-12-22 UA UAA201207986A patent/UA107818C2/uk unknown
- 2010-12-22 BR BR112012017126A patent/BR112012017126A2/pt not_active Application Discontinuation
- 2010-12-22 AU AU2010334804A patent/AU2010334804B2/en active Active
- 2010-12-22 MX MX2012007385A patent/MX345142B/es active IP Right Grant
- 2010-12-22 KR KR1020127019521A patent/KR101740085B1/ko active Active
- 2010-12-22 EP EP10799037.6A patent/EP2516420B8/en active Active
- 2010-12-22 CN CN201080064585.3A patent/CN102803248B/zh active Active
- 2010-12-22 PE PE2012000880A patent/PE20121505A1/es not_active Application Discontinuation
- 2010-12-22 AR ARP100104921A patent/AR079725A1/es not_active Application Discontinuation
- 2010-12-22 NZ NZ601021A patent/NZ601021A/en unknown
- 2010-12-22 RU RU2012131223/04A patent/RU2573828C2/ru active
- 2010-12-22 JP JP2012545331A patent/JP5781537B2/ja not_active Expired - Fee Related
- 2010-12-22 CA CA2785353A patent/CA2785353C/en active Active
-
2012
- 2012-06-21 IL IL220554A patent/IL220554A/en active IP Right Grant
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