JP2013515576A5 - - Google Patents
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- JP2013515576A5 JP2013515576A5 JP2012546244A JP2012546244A JP2013515576A5 JP 2013515576 A5 JP2013515576 A5 JP 2013515576A5 JP 2012546244 A JP2012546244 A JP 2012546244A JP 2012546244 A JP2012546244 A JP 2012546244A JP 2013515576 A5 JP2013515576 A5 JP 2013515576A5
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- JP
- Japan
- Prior art keywords
- item
- therapeutic agent
- tissue penetrating
- capsule
- penetrating member
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims description 96
- 229940124597 therapeutic agent Drugs 0.000 claims description 76
- 230000000149 penetrating effect Effects 0.000 claims description 68
- 239000002775 capsule Substances 0.000 claims description 40
- 238000002360 preparation method Methods 0.000 claims description 37
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 25
- 239000000463 material Substances 0.000 claims description 13
- -1 arubyglutide Chemical compound 0.000 claims description 10
- 239000000859 incretin Substances 0.000 claims description 10
- 230000033001 locomotion Effects 0.000 claims description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
- 239000008103 glucose Substances 0.000 claims description 9
- MGXWVYUBJRZYPE-YUGYIWNOSA-N incretin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=C(O)C=C1 MGXWVYUBJRZYPE-YUGYIWNOSA-N 0.000 claims description 9
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 7
- HTQBXNHDCUEHJF-XWLPCZSASA-N Exenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 claims description 6
- 108010011459 Exenatide Proteins 0.000 claims description 6
- 229960001519 exenatide Drugs 0.000 claims description 6
- 102000004877 Insulin Human genes 0.000 claims description 5
- 108090001061 Insulin Proteins 0.000 claims description 5
- 206010012601 diabetes mellitus Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 229940125396 insulin Drugs 0.000 claims description 5
- 108010004460 Gastric Inhibitory Polypeptide Proteins 0.000 claims description 4
- 102100039994 Gastric inhibitory polypeptide Human genes 0.000 claims description 4
- 230000015556 catabolic process Effects 0.000 claims description 4
- 238000002144 chemical decomposition reaction Methods 0.000 claims description 4
- 238000006731 degradation reaction Methods 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 4
- 230000000717 retained effect Effects 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 230000009747 swallowing Effects 0.000 claims description 4
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims description 2
- 108010019598 Liraglutide Proteins 0.000 claims description 2
- YSDQQAXHVYUZIW-QCIJIYAXSA-N Liraglutide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 YSDQQAXHVYUZIW-QCIJIYAXSA-N 0.000 claims description 2
- 229960002701 liraglutide Drugs 0.000 claims description 2
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims description 2
- 108010048573 taspoglutide Proteins 0.000 claims description 2
- WRGVLTAWMNZWGT-VQSPYGJZSA-N taspoglutide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 WRGVLTAWMNZWGT-VQSPYGJZSA-N 0.000 claims description 2
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- 229940123208 Biguanide Drugs 0.000 description 5
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 5
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 description 5
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- 101000886868 Homo sapiens Gastric inhibitory polypeptide Proteins 0.000 description 2
- 206010034133 Pathogen resistance Diseases 0.000 description 2
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- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 2
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- PJRSUKFWFKUDTH-JWDJOUOUSA-N (2s)-6-amino-2-[[2-[[(2s)-2-[[(2s,3s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[(2-aminoacetyl)amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl Chemical compound CSCC[C@H](NC(=O)CN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O PJRSUKFWFKUDTH-JWDJOUOUSA-N 0.000 description 1
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- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28476609P | 2009-12-24 | 2009-12-24 | |
| US61/284,766 | 2009-12-24 | ||
| US34033110P | 2010-03-15 | 2010-03-15 | |
| US61/340,331 | 2010-03-15 | ||
| US39530410P | 2010-05-10 | 2010-05-10 | |
| US61/395,304 | 2010-05-10 | ||
| PCT/US2010/062070 WO2011079302A2 (en) | 2009-12-24 | 2010-12-23 | Swallowable drug delivery device and methods of drug delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015115816A Division JP2015186590A (ja) | 2009-12-24 | 2015-06-08 | 嚥下可能薬物送達デバイスおよび薬物送達方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013515576A JP2013515576A (ja) | 2013-05-09 |
| JP2013515576A5 true JP2013515576A5 (cg-RX-API-DMAC10.html) | 2014-02-20 |
Family
ID=44196421
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546244A Withdrawn JP2013515576A (ja) | 2009-12-24 | 2010-12-23 | 嚥下可能薬物送達デバイスおよび薬物送達方法 |
| JP2015115816A Withdrawn JP2015186590A (ja) | 2009-12-24 | 2015-06-08 | 嚥下可能薬物送達デバイスおよび薬物送達方法 |
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Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8682440B2 (en) | 2009-08-03 | 2014-03-25 | Incube Labs, Llc | Swallowable capsule and method for stimulating incretin production within the intestinal tract |
| US8721620B2 (en) | 2009-12-24 | 2014-05-13 | Rani Therapeutics, Llc | Swallowable drug delivery device and methods of drug delivery |
| CN102905753B (zh) | 2009-12-24 | 2016-06-29 | 因卡伯实验室有限责任公司 | 可吞咽式药剂递送装置和药剂递送方法 |
| CN105168174B (zh) * | 2010-03-10 | 2019-01-08 | 拉尼医疗有限公司 | 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂 |
| US9402806B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8846040B2 (en) | 2010-12-23 | 2014-09-30 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9284367B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9149617B2 (en) | 2010-12-23 | 2015-10-06 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US9415004B2 (en) | 2010-12-23 | 2016-08-16 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8980822B2 (en) | 2010-12-23 | 2015-03-17 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9259386B2 (en) | 2010-12-23 | 2016-02-16 | Rani Therapeutics, Llc | Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9861683B2 (en) | 2010-12-23 | 2018-01-09 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8734429B2 (en) | 2010-12-23 | 2014-05-27 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US9283179B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US10639272B2 (en) | 2010-12-23 | 2020-05-05 | Rani Therapeutics, Llc | Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8764733B2 (en) | 2010-12-23 | 2014-07-01 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9629799B2 (en) | 2010-12-23 | 2017-04-25 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8969293B2 (en) | 2010-12-23 | 2015-03-03 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8809269B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8809271B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9402807B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| DK2665512T3 (en) | 2011-01-21 | 2016-10-10 | Obalon Therapeutics Inc | Intragastric device |
| ES2773115T3 (es) * | 2011-06-29 | 2020-07-09 | Rani Therapeutics Llc | Preparados de agentes terapéuticos para la administración hacia el interior de una luz del tubo intestinal utilizando un dispositivo tragable para la administración de fármacos |
| CN103987422B (zh) | 2011-06-29 | 2017-02-15 | 拉尼医疗有限公司 | 用于治疗化合物的口服递送的装置、系统和方法 |
| EP3964190A1 (en) * | 2013-03-15 | 2022-03-09 | Rani Therapeutics, LLC | Device for oral delivery of therapeutic compounds |
| US20150064241A1 (en) * | 2013-09-05 | 2015-03-05 | Google Inc. | Delivery of Functionalized Particles |
| CN103479401B (zh) * | 2013-09-29 | 2015-08-19 | 中山大学附属第一医院 | 一种肠道生物标志物采样器 |
| US10689460B2 (en) | 2014-05-15 | 2020-06-23 | Incube Labs, Llc | PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US11548940B2 (en) | 2014-05-15 | 2023-01-10 | Rani Therapeutics, Llc | Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| WO2015176031A2 (en) | 2014-05-15 | 2015-11-19 | Incube Labs, Llc | Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins |
| MX2016016406A (es) * | 2014-06-11 | 2017-10-12 | Massachusetts Inst Technology | Estructuras de permanencia, y métodos relacionados. |
| WO2016155671A1 (zh) * | 2015-04-02 | 2016-10-06 | 傅君志 | 可吞咽式装置 |
| EP3294273A4 (en) * | 2015-05-08 | 2018-12-05 | Incube Labs, LLC | Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| AU2016320867B2 (en) * | 2015-09-08 | 2023-03-30 | Rani Therapeutics, Llc | PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| WO2017156347A1 (en) * | 2016-03-09 | 2017-09-14 | Incube Labs, Llc | Methods and articles for delivering viable cells into solid tissue |
| EP4467182A3 (en) | 2016-09-09 | 2025-01-15 | Biora Therapeutics, Inc. | Electromechanical ingestible device for delivery of a dispensable substance |
| FR3059553B1 (fr) * | 2016-12-07 | 2021-04-23 | Univ Grenoble Alpes | Dispositif implantable |
| US11523772B2 (en) | 2016-12-14 | 2022-12-13 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immunosuppressant |
| CN107050578A (zh) * | 2017-05-04 | 2017-08-18 | 梁曦 | 一种药物自动注射装置 |
| US11207272B2 (en) * | 2017-05-17 | 2021-12-28 | Massachusetts Institute Of Technology | Tissue anchoring articles |
| IL270674B2 (en) * | 2017-05-19 | 2024-12-01 | Shalon Tidhar | Instruments and methods for collecting samples from the digestive system |
| CN110996754B (zh) * | 2017-06-12 | 2023-01-31 | 拉尼医疗有限公司 | 用于测定胃排空参数的可吞咽胶囊、系统和方法 |
| CN108324231A (zh) * | 2018-03-14 | 2018-07-27 | 潍坊学院 | 一种自清洁上药胶囊内镜 |
| AU2019250911B2 (en) * | 2018-04-10 | 2024-10-24 | Oneful Health, Inc. | Method and system for making personalized nutritional and pharmaceutical formulations using additive manufacturing |
| US10675248B2 (en) * | 2018-08-14 | 2020-06-09 | Alma Therapeutics Ltd. | Expandable pill |
| CA3118056A1 (en) * | 2018-08-15 | 2020-02-20 | Lyndra, Inc. | Systems for enteric delivery of therapeutic agents |
| WO2020041774A1 (en) * | 2018-08-23 | 2020-02-27 | Baywind Bioventures | Capsule device for delivery of active agent to gastrointestinal tract |
| US12128133B2 (en) * | 2018-09-25 | 2024-10-29 | Rani Therapeutics, Llc | Ingestible device with expandable enclosure |
| CN113348011B (zh) * | 2018-11-19 | 2023-04-18 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| US11771829B2 (en) | 2019-02-01 | 2023-10-03 | Massachusetts Institute Of Technology | Systems and methods for liquid injection |
| WO2020157324A1 (en) | 2019-02-01 | 2020-08-06 | Novo Nordisk A/S | Medical device with actuation mechanism |
| MX2021010450A (es) * | 2019-03-01 | 2021-12-10 | Rani Therapeutics Llc | Dispositivos, sistemas y métodos para administrar agentes terapéuticos en la pared de un estómago. |
| EP3980110A1 (en) * | 2019-06-07 | 2022-04-13 | Novo Nordisk A/S | Ingestible device with delivery member detachment |
| US11793980B2 (en) * | 2019-08-31 | 2023-10-24 | Celero Systems, Inc. | Intestinal attachment device |
| JP2022552829A (ja) * | 2019-10-08 | 2022-12-20 | インキューブ ラブズ， エルエルシー | 徐放性製剤送達デバイス |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| WO2021146296A1 (en) * | 2020-01-14 | 2021-07-22 | Rani Therapeutics, Llc | Swallowable devices for drug delivery in an intestinal tract |
| KR20220145851A (ko) * | 2020-02-18 | 2022-10-31 | 라니 테라퓨틱스, 엘엘씨 | 치료 제형의 위장관 벽 내로의 주사 |
| EP4125806B1 (en) * | 2020-03-31 | 2024-10-16 | Danmarks Tekniske Universitet | A flexible foil for the delivery of therapeutic cargos |
| WO2022000078A1 (en) * | 2020-06-29 | 2022-01-06 | The Governing Council Of The University Of Toronto | Magnetically actuated capsule |
| CN111772589B (zh) * | 2020-08-04 | 2022-07-12 | 重庆金山医疗技术研究院有限公司 | 一种判断胶囊内镜是否适用的检测系统及其探路胶囊 |
| AU2021343442B2 (en) * | 2020-09-16 | 2024-08-15 | Eli Lilly And Company | Oral drug delivery device with expanding arms |
| US20240358629A1 (en) * | 2021-07-19 | 2024-10-31 | Cochlear Limited | Self-propelled pharmaceutical delivery capsules |
| CN113598690B (zh) * | 2021-08-10 | 2023-07-28 | 安徽光阵光电科技有限公司 | 一种用于人体体内医疗的内窥镜药丸 |
| WO2023158837A1 (en) * | 2022-02-21 | 2023-08-24 | Rani Therapeutics, Llc | Devices, assemblies, and methods for delivering a fluid preparation into a gastrointestinal tract |
| CN119424884B (zh) * | 2024-09-29 | 2025-10-10 | 北京水木金昇医疗科技服务有限公司 | 一种递送注射药物的微针胶囊及其应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5474785A (en) * | 1990-01-24 | 1995-12-12 | Alza Corporation | Delivery system comprising means for controlling internal pressure |
| US5217449A (en) * | 1990-12-11 | 1993-06-08 | Miyarisan Kabushiki Kaisha | Medical capsule and apparatus for activating the same |
| DK42093D0 (da) | 1993-04-07 | 1993-04-07 | Bukh Meditec | Administrationsmetode |
| US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| JP2003508185A (ja) | 1999-08-03 | 2003-03-04 | スミス アンド ネフュー インコーポレーテッド | 埋め込み型制御放出装置 |
| US6478776B1 (en) | 2000-04-05 | 2002-11-12 | Biocardia, Inc. | Implant delivery catheter system and methods for its use |
| GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| JP4643089B2 (ja) * | 2001-09-27 | 2011-03-02 | オリンパス株式会社 | カプセル型医療装置 |
| JP2002186672A (ja) * | 2001-09-28 | 2002-07-02 | Olympus Optical Co Ltd | 医療用カプセル装置 |
| FR2835730B1 (fr) * | 2002-02-11 | 2004-12-10 | C T M Ct De Transfert Des Micr | Dispositif pour la delivrance de substances et le prelevement intracorporel |
| KR100993477B1 (ko) | 2002-06-25 | 2010-11-11 | 권성윤 | 약물 송달 및 다른 용도를 위한 신속 용해형마이크로-퍼포레이터 |
| US7118531B2 (en) * | 2002-09-24 | 2006-10-10 | The Johns Hopkins University | Ingestible medical payload carrying capsule with wireless communication |
| ATE547976T1 (de) * | 2002-12-26 | 2012-03-15 | Given Imaging Ltd | Immobilisierbare in-vivo messvorrichtung |
| US20050058701A1 (en) * | 2003-01-29 | 2005-03-17 | Yossi Gross | Active drug delivery in the gastrointestinal tract |
| CA2514392A1 (en) | 2003-01-29 | 2004-08-12 | E-Pill Pharma Ltd. | Active drug delivery in the gastrointestinal tract |
| JP2005021677A (ja) * | 2003-06-10 | 2005-01-27 | Medorekkusu:Kk | 経皮投薬用パッドベース、及び注射針 |
| US7857767B2 (en) * | 2004-04-19 | 2010-12-28 | Invention Science Fund I, Llc | Lumen-traveling device |
| DE102004026615A1 (de) | 2004-06-01 | 2005-12-29 | Siemens Ag | Vorrichtung und Verfahren zur Freisetzung eines in das Körperinnere eines Patienten geführten therapeutischen Mittels |
| US20060153894A1 (en) * | 2004-06-30 | 2006-07-13 | Ragae Ghabrial | Multi-compartment delivery system |
| US7430998B2 (en) * | 2004-09-13 | 2008-10-07 | Luk Lamellen Und Kupplungsbau Beteiligungs Kg | Method for positional determination of an EC motor |
| WO2006035446A2 (en) * | 2004-09-30 | 2006-04-06 | Duocure, Inc. | Device and method for treating weight disorders |
| CN101107038A (zh) * | 2005-01-18 | 2008-01-16 | 皇家飞利浦电子股份有限公司 | 电控胶囊 |
| CN101184523B (zh) * | 2005-05-27 | 2011-04-13 | 奥林巴斯株式会社 | 被检体内导入装置 |
| US20070078414A1 (en) | 2005-08-05 | 2007-04-05 | Mcallister Devin V | Methods and devices for delivering agents across biological barriers |
| JP4402648B2 (ja) * | 2005-12-16 | 2010-01-20 | オリンパス株式会社 | 被検体内導入装置 |
| AU2006334020B2 (en) | 2005-12-30 | 2012-07-05 | Mor Research Applications Ltd. | Device and method for treating the anal sphincter |
| GB0603252D0 (en) * | 2006-02-17 | 2006-03-29 | Axcess Ltd | Dissolution aids for oral peptide delivery |
| US7741273B2 (en) | 2006-04-13 | 2010-06-22 | Warsaw Orthopedic, Inc. | Drug depot implant designs |
| DE102006047537B4 (de) * | 2006-10-07 | 2024-05-16 | Sanofi-Aventis Deutschland Gmbh | Verfahren und Vorrichtung zur Bestimmung der Position eines Stopfens einer Ampulle für ein Arzneimittel in einem medizinischen Gerät sowie deren Verwendung, ein entsprechendes medizinisches Gerät sowie Herstellung eines medizinischen Geräts |
| US20080214919A1 (en) * | 2006-12-26 | 2008-09-04 | Lifescan, Inc. | System and method for implementation of glycemic control protocols |
| CN101808567B (zh) * | 2007-09-26 | 2012-09-05 | 奥林巴斯医疗株式会社 | 被检体内导入系统 |
| CN102905753B (zh) | 2009-12-24 | 2016-06-29 | 因卡伯实验室有限责任公司 | 可吞咽式药剂递送装置和药剂递送方法 |
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