JP2013514994A5 - - Google Patents
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- JP2013514994A5 JP2013514994A5 JP2012544899A JP2012544899A JP2013514994A5 JP 2013514994 A5 JP2013514994 A5 JP 2013514994A5 JP 2012544899 A JP2012544899 A JP 2012544899A JP 2012544899 A JP2012544899 A JP 2012544899A JP 2013514994 A5 JP2013514994 A5 JP 2013514994A5
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- Japan
- Prior art keywords
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- oil
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- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 83
- 239000003795 chemical substances by application Substances 0.000 claims description 78
- 238000000034 method Methods 0.000 claims description 56
- 239000000739 antihistaminic agent Substances 0.000 claims description 46
- 239000003814 drug Substances 0.000 claims description 45
- 229940124597 therapeutic agent Drugs 0.000 claims description 43
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 34
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 32
- 230000001387 anti-histamine Effects 0.000 claims description 32
- -1 isconazole Chemical compound 0.000 claims description 29
- 150000003839 salts Chemical class 0.000 claims description 29
- 108090000862 Ion Channels Proteins 0.000 claims description 28
- 102000004310 Ion Channels Human genes 0.000 claims description 28
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 28
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical group C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 claims description 26
- 229960005426 doxepin Drugs 0.000 claims description 26
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 24
- 206010061218 Inflammation Diseases 0.000 claims description 23
- 230000004054 inflammatory process Effects 0.000 claims description 23
- 239000003921 oil Substances 0.000 claims description 22
- 235000019198 oils Nutrition 0.000 claims description 22
- 229940123445 Tricyclic antidepressant Drugs 0.000 claims description 19
- 239000003029 tricyclic antidepressant agent Substances 0.000 claims description 19
- 239000003443 antiviral agent Substances 0.000 claims description 18
- 150000003973 alkyl amines Chemical class 0.000 claims description 17
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 claims description 14
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 14
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 14
- 229950000688 phenothiazine Drugs 0.000 claims description 14
- 229940125715 antihistaminic agent Drugs 0.000 claims description 12
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims description 12
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 11
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 claims description 10
- 229960004150 aciclovir Drugs 0.000 claims description 10
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 10
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- 239000000284 extract Substances 0.000 claims description 9
- 239000000341 volatile oil Substances 0.000 claims description 9
- 244000062730 Melissa officinalis Species 0.000 claims description 8
- 235000010654 Melissa officinalis Nutrition 0.000 claims description 8
- 244000228451 Stevia rebaudiana Species 0.000 claims description 8
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 8
- 229960000520 diphenhydramine Drugs 0.000 claims description 8
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 8
- 239000003195 sodium channel blocking agent Substances 0.000 claims description 8
- CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 claims description 8
- 229960001128 triprolidine Drugs 0.000 claims description 8
- 244000269722 Thea sinensis Species 0.000 claims description 7
- 239000003242 anti bacterial agent Substances 0.000 claims description 7
- 229940121375 antifungal agent Drugs 0.000 claims description 7
- 239000003429 antifungal agent Substances 0.000 claims description 7
- 240000001432 Calendula officinalis Species 0.000 claims description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 6
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 6
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 claims description 6
- 229960000836 amitriptyline Drugs 0.000 claims description 6
- 239000003963 antioxidant agent Substances 0.000 claims description 6
- 230000003078 antioxidant effect Effects 0.000 claims description 6
- 229960005274 benzocaine Drugs 0.000 claims description 6
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 6
- 229960000991 ketoprofen Drugs 0.000 claims description 6
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- 229960002372 tetracaine Drugs 0.000 claims description 6
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- 239000001993 wax Substances 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 5
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical group CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 5
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 claims description 4
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims description 4
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims description 4
- 240000006914 Aspalathus linearis Species 0.000 claims description 4
- 235000005881 Calendula officinalis Nutrition 0.000 claims description 4
- VWFCHDSQECPREK-LURJTMIESA-N Cidofovir Chemical compound NC=1C=CN(C[C@@H](CO)OCP(O)(O)=O)C(=O)N=1 VWFCHDSQECPREK-LURJTMIESA-N 0.000 claims description 4
- 235000005979 Citrus limon Nutrition 0.000 claims description 4
- 244000131522 Citrus pyriformis Species 0.000 claims description 4
- 235000005976 Citrus sinensis Nutrition 0.000 claims description 4
- 240000002319 Citrus sinensis Species 0.000 claims description 4
- 239000005698 Dodecyl acetate Substances 0.000 claims description 4
- VTUSIVBDOCDNHS-UHFFFAOYSA-N Etidocaine Chemical compound CCCN(CC)C(CC)C(=O)NC1=C(C)C=CC=C1C VTUSIVBDOCDNHS-UHFFFAOYSA-N 0.000 claims description 4
- 241000208152 Geranium Species 0.000 claims description 4
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims description 4
- 239000004166 Lanolin Substances 0.000 claims description 4
- 235000019501 Lemon oil Nutrition 0.000 claims description 4
- 241000366182 Melaleuca alternifolia Species 0.000 claims description 4
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 4
- 241001479543 Mentha x piperita Species 0.000 claims description 4
- 235000010676 Ocimum basilicum Nutrition 0.000 claims description 4
- 240000007926 Ocimum gratissimum Species 0.000 claims description 4
- 244000270673 Pelargonium graveolens Species 0.000 claims description 4
- 235000017927 Pelargonium graveolens Nutrition 0.000 claims description 4
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 claims description 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 4
- 235000004443 Ricinus communis Nutrition 0.000 claims description 4
- 244000178231 Rosmarinus officinalis Species 0.000 claims description 4
- 235000006092 Stevia rebaudiana Nutrition 0.000 claims description 4
- 235000006468 Thea sinensis Nutrition 0.000 claims description 4
- 235000009499 Vanilla fragrans Nutrition 0.000 claims description 4
- 244000263375 Vanilla tahitensis Species 0.000 claims description 4
- 235000012036 Vanilla tahitensis Nutrition 0.000 claims description 4
- OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 claims description 4
- 244000273928 Zingiber officinale Species 0.000 claims description 4
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 4
- VZWGRQBCURJOMT-UHFFFAOYSA-N acetic acid n-dodecyl ester Natural products CCCCCCCCCCCCOC(C)=O VZWGRQBCURJOMT-UHFFFAOYSA-N 0.000 claims description 4
- 239000010619 basil oil Substances 0.000 claims description 4
- 229940018006 basil oil Drugs 0.000 claims description 4
- 235000013871 bee wax Nutrition 0.000 claims description 4
- 239000012166 beeswax Substances 0.000 claims description 4
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- 229960003150 bupivacaine Drugs 0.000 claims description 4
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 claims description 4
- 235000013869 carnauba wax Nutrition 0.000 claims description 4
- 239000004203 carnauba wax Substances 0.000 claims description 4
- 239000004359 castor oil Substances 0.000 claims description 4
- 235000019438 castor oil Nutrition 0.000 claims description 4
- 229960000724 cidofovir Drugs 0.000 claims description 4
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 4
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- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 claims description 4
- 229960001447 fomivirsen Drugs 0.000 claims description 4
- XCWFZHPEARLXJI-UHFFFAOYSA-N fomivirsen Chemical compound C1C(N2C3=C(C(NC(N)=N3)=O)N=C2)OC(CO)C1OP(O)(=S)OCC1OC(N(C)C(=O)\N=C(\N)C=C)CC1OP(O)(=S)OCC1OC(N2C3=C(C(NC(N)=N3)=O)N=C2)CC1OP(O)(=S)OCC1OC(N2C(NC(=O)C(C)=C2)=O)CC1OP(O)(=S)OCC1OC(N2C(NC(=O)C(C)=C2)=O)CC1OP(O)(=S)OCC1OC(N2C(NC(=O)C(C)=C2)=O)CC1OP(O)(=S)OCC1OC(N2C3=C(C(NC(N)=N3)=O)N=C2)CC1OP(O)(=S)OCC1OC(N2C(N=C(N)C=C2)=O)CC1OP(O)(=S)OCC(C(C1)OP(S)(=O)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)O)OC1N1C=C(C)C(=O)NC1=O XCWFZHPEARLXJI-UHFFFAOYSA-N 0.000 claims description 4
- 229960002963 ganciclovir Drugs 0.000 claims description 4
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims description 4
- 235000008397 ginger Nutrition 0.000 claims description 4
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- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims description 4
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- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 4
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- QJBZDBLBQWFTPZ-UHFFFAOYSA-N pyrrolnitrin Chemical compound [O-][N+](=O)C1=C(Cl)C=CC=C1C1=CNC=C1Cl QJBZDBLBQWFTPZ-UHFFFAOYSA-N 0.000 claims description 4
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims description 4
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- GUXHBMASAHGULD-SEYHBJAFSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O GUXHBMASAHGULD-SEYHBJAFSA-N 0.000 claims description 2
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| PCT/US2010/061051 WO2011075654A1 (en) | 2009-12-18 | 2010-12-17 | Methods and compositions for treating inflammation of skin |
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| JP2013514994A JP2013514994A (ja) | 2013-05-02 |
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| WO2011075691A1 (en) | 2009-12-18 | 2011-06-23 | Exodos Life Sciences Limited Partnership | Methods and compositions for stable liquid drug formulations |
| WO2014028780A2 (en) * | 2012-08-15 | 2014-02-20 | Nexmed Holdings, Inc. | Antifungal compounds and methods of use |
| US10302630B2 (en) | 2012-10-09 | 2019-05-28 | The Procter & Gamble Company | Method of identifying or evaluating beneficial actives and compositions containing the same |
| JP6189962B2 (ja) | 2012-10-09 | 2017-08-30 | ザ プロクター アンド ギャンブル カンパニー | 相乗作用する美容成分の組み合わせを特定する方法 |
| US10471064B2 (en) * | 2013-01-29 | 2019-11-12 | Lily Hsiao | Medicament for treating peripheral neuropathies |
| US9144538B2 (en) | 2013-02-08 | 2015-09-29 | The Procter & Gamble Company | Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin |
| US9138393B2 (en) | 2013-02-08 | 2015-09-22 | The Procter & Gamble Company | Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin |
| US8883747B1 (en) | 2013-10-09 | 2014-11-11 | Craig W. Carver | Topical antifungal compositions and methods of use thereof |
| WO2015120412A1 (en) * | 2014-02-07 | 2015-08-13 | The Johns Hopkins University | Compositions and methods for controlling fungal growth |
| US20170182040A1 (en) * | 2014-05-02 | 2017-06-29 | The Board Of Trustees Of The Leland Stanford Junior University | Epithelial ion channel (enac) blockers to treat psoriasis |
| US20170252390A1 (en) * | 2014-10-10 | 2017-09-07 | Regina Monibi | Topical skin care formulation |
| WO2016089893A1 (en) | 2014-12-01 | 2016-06-09 | Achelios Therapeutics Inc. | Methods and compositions for treating migraine and conditions associated with pain |
| EP3319598A4 (en) * | 2015-07-08 | 2019-02-27 | Elliptical Therapeutics, LLC | IMPROVED TOPICAL KETOPROFEN FORMULATIONS |
| US10286095B2 (en) | 2015-09-11 | 2019-05-14 | Olson Ip Technologies, Inc. | Travel kit |
| WO2017130638A1 (ja) * | 2016-01-28 | 2017-08-03 | 花王株式会社 | アストロサイトのグルコース代謝活性化剤 |
| JP6735224B2 (ja) | 2016-01-28 | 2020-08-05 | 花王株式会社 | アストロサイトのグルコース代謝活性化剤 |
| KR101873218B1 (ko) * | 2016-07-29 | 2018-07-03 | 코스맥스 주식회사 | 홀리바질, 박하, 님나무 추출 혼합물을 유효성분으로 함유하는 미세먼지에 의한 피부자극 및 피부염증 완화용 조성물 |
| DE102017215154A1 (de) * | 2017-08-30 | 2019-02-28 | Markus Bläss | Zusammensetzung zur topischen Behandlung von nicht-Mikroorganismus-verursachten entzündlichen Haut- und Schleimhauterkrankungen |
| WO2019135125A1 (en) * | 2018-01-02 | 2019-07-11 | Nal Pharmaceutical Group Limited | Semi-solid dosage form for topical application |
| CN113750126A (zh) * | 2021-09-30 | 2021-12-07 | 梵申兰科技(上海)有限公司 | 一种治疗皮肤疱疹的青蒿精油、白茶精油及它们的组合物 |
| TR2021016066A1 (tr) * | 2021-10-14 | 2023-04-24 | Univ Istanbul Medipol | Yara-yanik tedavi̇si̇ i̇çi̇n geli̇şti̇ri̇len mi̇kroemülsi̇yon formülasyonlari |
| KR102935253B1 (ko) * | 2022-01-26 | 2026-03-09 | (주)유스케어팜 | 타이바질, 물엉겅퀴 및 눈개승마의 복합추출물을 유효성분으로 포함하는 염증질환 예방 또는 치료용 조성물 |
| US12465645B2 (en) * | 2022-04-01 | 2025-11-11 | Alexia Reif | Anti-viral composition and method for preparing the same |
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| US4185100A (en) * | 1976-05-13 | 1980-01-22 | Johnson & Johnson | Topical anti-inflammatory drug therapy |
| US4256763A (en) * | 1978-09-19 | 1981-03-17 | Mchugh John E | Treatment of herpes simplex infections and acne |
| US4499084A (en) * | 1983-02-03 | 1985-02-12 | Dixon Glen J | Ara-A Antiviral composition and method of administering the same |
| US4914131A (en) * | 1984-03-08 | 1990-04-03 | Dana P. Brigham | Antiviral pharmaceutical preparations and methods for their use |
| US4748022A (en) * | 1985-03-25 | 1988-05-31 | Busciglio John A | Topical composition |
| GB8521342D0 (en) * | 1985-08-27 | 1985-10-02 | Univ Glasgow | Medicament |
| NL9500216A (nl) * | 1995-02-06 | 1996-09-02 | Bio Pharma Sciences Bv | Farmaceutische samenstelling voor de behandeling van herpes. |
| ZA989251B (en) * | 1997-10-17 | 2000-04-10 | Lilly Co Eli | Potentiation of pharmaceuticals. |
| US6967023B1 (en) * | 2000-01-10 | 2005-11-22 | Foamix, Ltd. | Pharmaceutical and cosmetic carrier or composition for topical application |
| US8124141B2 (en) * | 2003-03-12 | 2012-02-28 | Mitsui Norin Co., Ltd. | Rapidly absorbing lipophilic skin compositions and uses therefor |
| US20050118261A1 (en) * | 2003-06-12 | 2005-06-02 | Oien Hal J. | Compositions and methods of administering doxepin to mucosal tissue |
| JP5011739B2 (ja) * | 2005-02-03 | 2012-08-29 | アステラス製薬株式会社 | テトラヒドロ−２ｈ−チオピラン−４−カルボキサミド誘導体を含有する医薬組成物 |
| US20060229364A1 (en) * | 2005-03-10 | 2006-10-12 | 3M Innovative Properties Company | Antiviral compositions and methods of use |
| TW200711649A (en) * | 2005-06-17 | 2007-04-01 | Combinatorx Inc | Combination therapy for the treatment of immunoinflammatory disorders |
| ITRM20060163A1 (it) * | 2006-03-24 | 2007-09-25 | Ist Farmacoterapico It Spa | Composizione spray ad uso topico per il tratamento e la prevenzione delle infezioni labiali da herpes simplex |
| US8450330B2 (en) * | 2007-08-29 | 2013-05-28 | Yung Shin Pharmaceutical Industrial Co., Ltd. | Pharmaceutical acceptable composition containing non-steroidal anti-inflammatory drug and local anesthetics |
| CA2724607A1 (en) * | 2008-05-30 | 2009-12-31 | Fairfield Clinical Trials, Llc | Method and composition for skin inflammation and discoloration |
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- 2010-12-17 AU AU2010330812A patent/AU2010330812B2/en not_active Ceased
- 2010-12-17 WO PCT/US2010/061051 patent/WO2011075654A1/en not_active Ceased
- 2010-12-17 US US13/517,008 patent/US20130059019A1/en not_active Abandoned
- 2010-12-17 EP EP10838296.1A patent/EP2513343A4/en not_active Withdrawn
- 2010-12-17 CA CA2784785A patent/CA2784785A1/en not_active Abandoned
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