JP2013514799A - 直交性ｑ−リボソーム - Google Patents

直交性ｑ−リボソーム Download PDF

Info

Publication number
JP2013514799A
JP2013514799A JP2012545428A JP2012545428A JP2013514799A JP 2013514799 A JP2013514799 A JP 2013514799A JP 2012545428 A JP2012545428 A JP 2012545428A JP 2012545428 A JP2012545428 A JP 2012545428A JP 2013514799 A JP2013514799 A JP 2013514799A
Authority
JP
Japan
Prior art keywords
orthogonal
trna
ribosome
rrna
mrna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012545428A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013514799A5 (enExample
Inventor
ジェイソン チン
カイハン ワン
ハインツ ニューマン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council filed Critical Medical Research Council
Publication of JP2013514799A publication Critical patent/JP2013514799A/ja
Publication of JP2013514799A5 publication Critical patent/JP2013514799A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012545428A 2009-12-21 2010-12-20 直交性ｑ−リボソーム Pending JP2013514799A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28842109P 2009-12-21 2009-12-21
GBGB0922351.2A GB0922351D0 (en) 2009-12-21 2009-12-21 Orthogonal Q-Ribosomes
GB0922351.2 2009-12-21
US61/288421 2009-12-21
PCT/GB2010/002296 WO2011077075A1 (en) 2009-12-21 2010-12-20 Orthogonal q-ribosomes

Publications (2)

Publication Number Publication Date
JP2013514799A true JP2013514799A (ja) 2013-05-02
JP2013514799A5 JP2013514799A5 (enExample) 2014-01-16

Family

ID=41717344

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012545428A Pending JP2013514799A (ja) 2009-12-21 2010-12-20 直交性ｑ−リボソーム

Country Status (8)

Country Link
US (1) US20120264926A1 (enExample)
EP (1) EP2516644A1 (enExample)
JP (1) JP2013514799A (enExample)
CN (1) CN102782132A (enExample)
AU (1) AU2010334671A1 (enExample)
CA (1) CA2785266A1 (enExample)
GB (1) GB0922351D0 (enExample)
WO (1) WO2011077075A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020247803A2 (en) 2019-06-07 2020-12-10 Massachusetts Institute Of Technology Frameshift suppressor trna compositions and methods of use
GB202110137D0 (en) 2021-07-14 2021-08-25 Res & Innovation Uk Methods for optimising protein production
CN116083378B (zh) * 2022-10-08 2025-09-19 浙江大学杭州国际科创中心 古菌酪氨酰-tRNA合成酶突变体及其应用
EP4477736A1 (en) * 2023-06-14 2024-12-18 POSTECH Research and Business Development Foundation Genetic biocontainment system to prevent theft and misuse of biological resources and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008065398A2 (en) * 2006-11-30 2008-06-05 Medical Research Council Evolved orthogonal ribosomes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008065398A2 (en) * 2006-11-30 2008-06-05 Medical Research Council Evolved orthogonal ribosomes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6015005093; Ｂｉｏｃｈｅｍｉｓｔｒｙ，２０００，３９（１４），ｐ．４０６８-７４ *

Also Published As

Publication number Publication date
AU2010334671A1 (en) 2012-07-12
GB0922351D0 (en) 2010-02-03
WO2011077075A1 (en) 2011-06-30
CA2785266A1 (en) 2011-06-30
EP2516644A1 (en) 2012-10-31
US20120264926A1 (en) 2012-10-18
CN102782132A (zh) 2012-11-14

Similar Documents

Publication Publication Date Title
Xie et al. An expanding genetic code
Mukai et al. Highly reproductive Escherichia coli cells with no specific assignment to the UAG codon
Link et al. Reassignment of sense codons in vivo
Wang et al. Expanding the genetic code
JP6294368B2 (ja) 直交ｔＲＮＡ−アミノアシルｔＲＮＡシンテターゼ対を生産するための方法及び組成物
Jin et al. Incorporation of non-standard amino acids into proteins: challenges, recent achievements, and emerging applications
EP1412504B1 (en) Methods of rna and protein synthesis
Wang et al. Expanding the structural diversity of protein building blocks with noncanonical amino acids biosynthesized from aromatic thiols
EP2584037B1 (en) Method for constructing recombinant bacterium for producing non-native protein, and utilization of same
Karbalaei-Heidari et al. Combating antimicrobial resistance with new-to-nature lanthipeptides created by genetic code expansion
Wang et al. Protein engineering with non-natural amino acids
JP2013514799A (ja) 直交性ｑ−リボソーム
Nickling et al. Antimicrobial peptides produced by selective pressure incorporation of non-canonical amino acids
Koch et al. Engineered bacterial host for genetic encoding of physiologically stable protein nitration
JP5307020B2 (ja) 進化した直交性リボソーム
US20240384267A1 (en) Compositions and methods for multiplex decoding of quadruplet codons
EP3872185A1 (en) Compound library and method for producing compound library
WO2015115661A1 (ja) アゾール誘導体骨格を有するペプチドの製造方法
US20250206782A1 (en) Biological polymers
Gan et al. Engineering a ribozyme with aminoacyl-tRNA synthetase activity
Magliery In Vitro Tools and in Vivo Engineering
WO2025235287A1 (en) Engineered trnas and cognate synthetases for quadruplet decoding and incorporation of non-canonical amino acids
Biddle Expanding and Evaluating Sense Codon Reassignment for Genetic Code Expansion
Abdeljabbar The Incorporation of Azide-bearing Unnatural Amino Acids into Proteins for Bio-orthogonal Reactions
Longstaff Requirements and rationale for amber translation as pyrrolysine

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131119

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20131119

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150209

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150630