CA2785266A1 - Orthogonal q-ribosomes - Google Patents
Orthogonal q-ribosomes Download PDFInfo
- Publication number
- CA2785266A1 CA2785266A1 CA2785266A CA2785266A CA2785266A1 CA 2785266 A1 CA2785266 A1 CA 2785266A1 CA 2785266 A CA2785266 A CA 2785266A CA 2785266 A CA2785266 A CA 2785266A CA 2785266 A1 CA2785266 A1 CA 2785266A1
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- CA
- Canada
- Prior art keywords
- orthogonal
- ribosome
- rrna
- mrna
- ribo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- FRGKKTITADJNOE-UHFFFAOYSA-N sulfanyloxyethane Chemical compound CCOS FRGKKTITADJNOE-UHFFFAOYSA-N 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229940098232 yersinia enterocolitica Drugs 0.000 description 1
- JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28842109P | 2009-12-21 | 2009-12-21 | |
| GB0922351.2 | 2009-12-21 | ||
| GBGB0922351.2A GB0922351D0 (en) | 2009-12-21 | 2009-12-21 | Orthogonal Q-Ribosomes |
| US61/288421 | 2009-12-21 | ||
| PCT/GB2010/002296 WO2011077075A1 (en) | 2009-12-21 | 2010-12-20 | Orthogonal q-ribosomes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2785266A1 true CA2785266A1 (en) | 2011-06-30 |
Family
ID=41717344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2785266A Abandoned CA2785266A1 (en) | 2009-12-21 | 2010-12-20 | Orthogonal q-ribosomes |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120264926A1 (enExample) |
| EP (1) | EP2516644A1 (enExample) |
| JP (1) | JP2013514799A (enExample) |
| CN (1) | CN102782132A (enExample) |
| AU (1) | AU2010334671A1 (enExample) |
| CA (1) | CA2785266A1 (enExample) |
| GB (1) | GB0922351D0 (enExample) |
| WO (1) | WO2011077075A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12139708B2 (en) | 2019-06-07 | 2024-11-12 | Massachusetts Institute Of Technology | Frameshift suppressor tRNA compositions and methods of use |
| GB202110137D0 (en) | 2021-07-14 | 2021-08-25 | Res & Innovation Uk | Methods for optimising protein production |
| CN116083378B (zh) * | 2022-10-08 | 2025-09-19 | 浙江大学杭州国际科创中心 | 古菌酪氨酰-tRNA合成酶突变体及其应用 |
| US20250163408A1 (en) * | 2023-06-14 | 2025-05-22 | POSTECH Research and Business Development Foundation | Genetic biocontainment system to prevent theft and misuse of biological resources and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0623974D0 (en) * | 2006-11-30 | 2007-01-10 | Medical Res Council | Evolved orthogonal ribosomes |
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2009
- 2009-12-21 GB GBGB0922351.2A patent/GB0922351D0/en not_active Ceased
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2010
- 2010-12-20 JP JP2012545428A patent/JP2013514799A/ja active Pending
- 2010-12-20 EP EP10810865A patent/EP2516644A1/en not_active Withdrawn
- 2010-12-20 CN CN201080064303XA patent/CN102782132A/zh active Pending
- 2010-12-20 WO PCT/GB2010/002296 patent/WO2011077075A1/en not_active Ceased
- 2010-12-20 AU AU2010334671A patent/AU2010334671A1/en not_active Abandoned
- 2010-12-20 US US13/517,372 patent/US20120264926A1/en not_active Abandoned
- 2010-12-20 CA CA2785266A patent/CA2785266A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120264926A1 (en) | 2012-10-18 |
| EP2516644A1 (en) | 2012-10-31 |
| CN102782132A (zh) | 2012-11-14 |
| WO2011077075A1 (en) | 2011-06-30 |
| JP2013514799A (ja) | 2013-05-02 |
| AU2010334671A1 (en) | 2012-07-12 |
| GB0922351D0 (en) | 2010-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20151222 |
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| FZDE | Discontinued |
Effective date: 20151222 |