JP2013514778A5 - - Google Patents
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- Publication number
- JP2013514778A5 JP2013514778A5 JP2012544863A JP2012544863A JP2013514778A5 JP 2013514778 A5 JP2013514778 A5 JP 2013514778A5 JP 2012544863 A JP2012544863 A JP 2012544863A JP 2012544863 A JP2012544863 A JP 2012544863A JP 2013514778 A5 JP2013514778 A5 JP 2013514778A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- chain gene
- gamma
- mouse
- alpha chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28856209P | 2009-12-21 | 2009-12-21 | |
| US61/288,562 | 2009-12-21 | ||
| PCT/US2010/060925 WO2011084664A1 (en) | 2009-12-21 | 2010-12-17 | HUMANIZED FCγ R MICE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014087973A Division JP5891259B2 (ja) | 2009-12-21 | 2014-04-22 | ヒト化ＦｃγＲマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013514778A JP2013514778A (ja) | 2013-05-02 |
| JP2013514778A5 true JP2013514778A5 (enExample) | 2014-02-13 |
| JP5595517B2 JP5595517B2 (ja) | 2014-09-24 |
Family
ID=43601078
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012544863A Active JP5595517B2 (ja) | 2009-12-21 | 2010-12-17 | ヒト化ＦｃγＲマウス |
| JP2014087973A Active JP5891259B2 (ja) | 2009-12-21 | 2014-04-22 | ヒト化ＦｃγＲマウス |
| JP2014165102A Active JP6073840B2 (ja) | 2009-12-21 | 2014-08-14 | ヒト化ＦｃγＲマウス |
| JP2016030271A Pending JP2016093201A (ja) | 2009-12-21 | 2016-02-19 | ヒト化ＦｃγＲマウス |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014087973A Active JP5891259B2 (ja) | 2009-12-21 | 2014-04-22 | ヒト化ＦｃγＲマウス |
| JP2014165102A Active JP6073840B2 (ja) | 2009-12-21 | 2014-08-14 | ヒト化ＦｃγＲマウス |
| JP2016030271A Pending JP2016093201A (ja) | 2009-12-21 | 2016-02-19 | ヒト化ＦｃγＲマウス |
Country Status (26)
| Country | Link |
|---|---|
| US (9) | US8658154B2 (enExample) |
| EP (3) | EP3498730B1 (enExample) |
| JP (4) | JP5595517B2 (enExample) |
| KR (4) | KR101862277B1 (enExample) |
| CN (2) | CN102762590B (enExample) |
| AU (3) | AU2010339863B2 (enExample) |
| CA (2) | CA3000246C (enExample) |
| CY (1) | CY1120316T1 (enExample) |
| DK (1) | DK2516457T3 (enExample) |
| ES (1) | ES2671188T3 (enExample) |
| HK (1) | HK1257001A1 (enExample) |
| HR (1) | HRP20180911T1 (enExample) |
| HU (1) | HUE038684T2 (enExample) |
| IL (4) | IL220365A (enExample) |
| LT (1) | LT2516457T (enExample) |
| MY (1) | MY156743A (enExample) |
| NO (1) | NO2516457T3 (enExample) |
| PL (1) | PL2516457T3 (enExample) |
| PT (1) | PT2516457T (enExample) |
| RS (1) | RS57280B1 (enExample) |
| RU (1) | RU2549695C2 (enExample) |
| SG (3) | SG10201408415PA (enExample) |
| SI (1) | SI2516457T1 (enExample) |
| SM (1) | SMT201800296T1 (enExample) |
| TR (1) | TR201808011T4 (enExample) |
| WO (1) | WO2011084664A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2516457T3 (enExample) | 2009-12-21 | 2018-08-11 | ||
| RU2634417C2 (ru) | 2011-10-28 | 2017-10-26 | Регенерон Фармасьютикалс, Инк. | Гуманизированные il-6 и рецептор il-6 |
| US20160058891A1 (en) * | 2011-11-01 | 2016-03-03 | Roche Glycart Ag | In vivo adcc model |
| EP3939423B1 (en) * | 2012-11-05 | 2024-03-06 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals and methods of use thereof |
| EP3842528A1 (en) | 2013-09-18 | 2021-06-30 | Kymab Limited | Methods, cells and organisms |
| RU2674910C2 (ru) * | 2013-10-15 | 2018-12-13 | Регенерон Фармасьютикалс, Инк. | Животные с гуманизированным геном il-15 |
| MX388127B (es) | 2013-12-11 | 2025-03-19 | Regeneron Pharma | Metodos y composiciones para la modificacion dirigida de un genoma. |
| KR102846903B1 (ko) * | 2014-03-21 | 2025-08-20 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
| HUE051088T2 (hu) | 2014-04-08 | 2021-03-01 | Regeneron Pharma | Humanizált FC-gamma receptorokkal rendelkezõ nem humán élõlények |
| CN111118047B (zh) | 2014-05-30 | 2023-09-22 | 再生元制药公司 | 人源化二肽基肽酶iv(dpp4)动物 |
| LT3230320T (lt) * | 2014-12-09 | 2021-01-11 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, išskyrus žmogų, turintys humanizuotą diferenciacijos klasterio 274 geną |
| FI3282835T3 (fi) * | 2015-04-13 | 2023-07-20 | Regeneron Pharma | Humanisoituja sirpa-il15-poistogeenisiä hiiriä ja niiden käyttömenetelmiä |
| CN107529739B (zh) * | 2015-04-30 | 2021-01-08 | 株式会社特殊免疫研究所 | 表达人特定分子和人Fcγ受体家族的转基因非人动物 |
| CN113831407B (zh) | 2016-05-20 | 2024-06-11 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
| US11879014B2 (en) * | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
| KR20250121150A (ko) | 2018-03-26 | 2025-08-11 | 리제너론 파마슈티칼스 인코포레이티드 | 치료제를 시험하기 위한 인간화된 설치류 |
| JP6935383B2 (ja) | 2018-09-27 | 2021-09-15 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
| EP3861854B1 (en) * | 2018-09-27 | 2025-01-22 | Central Institute for Experimental Medicine and Life Science | Immunodeficient mouse |
| SG11202107589PA (en) | 2019-02-22 | 2021-08-30 | Regeneron Pharma | Rodents having genetically modified sodium channels and methods of use thereof |
| CN113614238B (zh) * | 2019-03-28 | 2024-10-22 | 公益财团法人实中研 | 免疫缺陷小鼠 |
| KR20230147048A (ko) | 2020-12-16 | 2023-10-20 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 Fc 알파 수용체를 발현하는 마우스 |
| CN114410643B (zh) * | 2021-02-02 | 2024-08-02 | 百奥赛图(北京)医药科技股份有限公司 | FcRn基因人源化的非人动物及其构建方法和应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68929256T2 (de) | 1988-05-27 | 2001-05-17 | Applied Research Systems Ars Holding N.V., Curacao | Humaner Rezeptor Fc(gamma)RIII |
| JP2938569B2 (ja) * | 1990-08-29 | 1999-08-23 | ジェンファーム インターナショナル，インコーポレイティド | 異種免疫グロブリンを作る方法及びトランスジェニックマウス |
| US5258359A (en) * | 1991-08-02 | 1993-11-02 | Monsanto Company | Glyphosant-containing herbicidal compositions comprising acetylenic diol rainfastness enhancing agents |
| WO1994006908A1 (en) | 1992-09-11 | 1994-03-31 | The Regents Of The University Of California | Transgenic non-human animals having targeted lymphocyte transduction genes |
| US5877396A (en) | 1993-04-23 | 1999-03-02 | Sloan Kettering Institute For Cancer Research | Mice mutant for functional Fc receptors and method of treating autoimmune diseases |
| US6111166A (en) * | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
| CA2273194C (en) | 1996-12-03 | 2011-02-01 | Abgenix, Inc. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
| US5899312A (en) * | 1997-07-22 | 1999-05-04 | Lucent Technologies Inc | Anti-fraud string grabbing device |
| US6676927B1 (en) | 1999-01-20 | 2004-01-13 | The Rockefeller University | Animal model and methods for its use in the selection of cytotoxic antibodies |
| FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| JP2003531149A (ja) | 2000-04-13 | 2003-10-21 | ザ・ロツクフエラー・ユニバーシテイ | 抗体由来の免疫応答の増強 |
| CN101498731A (zh) * | 2000-05-18 | 2009-08-05 | 日本烟草产业株式会社 | 抗协同刺激信号转导分子ailim的人单克隆抗体及其药物用途 |
| US7413031B2 (en) | 2000-07-18 | 2008-08-19 | The Charles Machine Works, Inc. | Apparatus and method for maintaining control of a drilling machine |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| FR2822161B1 (fr) | 2001-03-15 | 2003-09-19 | Genoway | Cellule et animal transgenique modelisant les reponses humaines allergiques mediees par les ige, et leurs utilisations |
| JP4653915B2 (ja) | 2001-10-29 | 2011-03-16 | 独立行政法人科学技術振興機構 | 全身性エリテマトーデスモデル非ヒト動物 |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| WO2003104459A1 (en) | 2002-06-07 | 2003-12-18 | Arthron Limited | Fcyriia transgenic animal model for autoimmune disease |
| JP2004147535A (ja) | 2002-10-29 | 2004-05-27 | Japan Science & Technology Agency | ギラン・バレー症候群及び／又はフィッシャー症候群発症モデル非ヒト動物 |
| WO2004060053A2 (en) * | 2002-12-16 | 2004-07-22 | Genentech, Inc. | Transgenic mice expressing human cd20 |
| FR2858235B1 (fr) | 2003-07-31 | 2006-02-17 | Lab Francais Du Fractionnement | Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs |
| BRPI0506771A (pt) * | 2004-01-12 | 2007-05-22 | Applied Molecular Evolution | anticorpo, e, composição farmacêutica |
| DK1802193T3 (da) | 2004-10-19 | 2014-06-10 | Regeneron Pharma | Fremgangsmåde til frembringelse af en homozygot mus til genetisk modifikation |
| WO2007041635A2 (en) * | 2005-10-03 | 2007-04-12 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
| SG170110A1 (en) | 2006-03-10 | 2011-04-29 | Macrogenics Inc | Identification and engineering of antibodies with variant heavy chains and methods of using same |
| US20080003225A1 (en) | 2006-06-29 | 2008-01-03 | Henri Vie | Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors |
| EP2066349B1 (en) * | 2006-09-08 | 2012-03-28 | MedImmune, LLC | Humanized anti-cd19 antibodies and their use in treatment of tumors, transplantation and autoimmune diseases |
| HU0700534D0 (en) * | 2006-11-24 | 2007-10-29 | Mezoegazdasagi Biotechnologiai | Transgenic animal with enhanced immune response and method for the preparation thereof |
| KR101561020B1 (ko) | 2007-07-31 | 2015-10-26 | 리제너론 파아마슈티컬스, 인크. | 사람 ｃｄ20에 대한 사람 항체 및 이의 사용 방법 |
| EP2245155A4 (en) * | 2007-12-10 | 2011-05-25 | Aliva Biopharmaceuticals Inc | METHODS FOR SEQUENTIALLY REPLACING A TARGETED AREA BY HOMOLOGOUS RECOMBINATION |
| US20090271884A1 (en) | 2008-03-07 | 2009-10-29 | Regeneron Pharmaceuticals, Inc. | ES Cell-Derived Mice From Diploid Host Embryo Injection |
| EP2318439A2 (en) * | 2008-07-23 | 2011-05-11 | Rappaport Family Institute for Research in the Medical Sciences | Methods of altering peripheral b cell populations and uses thereof |
| NO2516457T3 (enExample) * | 2009-12-21 | 2018-08-11 | ||
| US8883496B2 (en) * | 2009-12-21 | 2014-11-11 | Regeneron Phamaceuticals, Inc. | Humanized FcgR mice |
-
2010
- 2010-12-17 NO NO10791039A patent/NO2516457T3/no unknown
- 2010-12-17 WO PCT/US2010/060925 patent/WO2011084664A1/en not_active Ceased
- 2010-12-17 HU HUE10791039A patent/HUE038684T2/hu unknown
- 2010-12-17 DK DK10791039.0T patent/DK2516457T3/en active
- 2010-12-17 KR KR1020127019435A patent/KR101862277B1/ko active Active
- 2010-12-17 EP EP19154880.9A patent/EP3498730B1/en active Active
- 2010-12-17 PT PT107910390T patent/PT2516457T/pt unknown
- 2010-12-17 JP JP2012544863A patent/JP5595517B2/ja active Active
- 2010-12-17 ES ES10791039.0T patent/ES2671188T3/es active Active
- 2010-12-17 EP EP10791039.0A patent/EP2516457B9/en active Active
- 2010-12-17 SI SI201031700T patent/SI2516457T1/en unknown
- 2010-12-17 AU AU2010339863A patent/AU2010339863B2/en active Active
- 2010-12-17 SM SM20180296T patent/SMT201800296T1/it unknown
- 2010-12-17 SG SG10201408415PA patent/SG10201408415PA/en unknown
- 2010-12-17 HR HRP20180911TT patent/HRP20180911T1/hr unknown
- 2010-12-17 CN CN201080064262.4A patent/CN102762590B/zh active Active
- 2010-12-17 SG SG10202011814TA patent/SG10202011814TA/en unknown
- 2010-12-17 SG SG2012043683A patent/SG181690A1/en unknown
- 2010-12-17 MY MYPI2012002669A patent/MY156743A/en unknown
- 2010-12-17 RU RU2012131296/10A patent/RU2549695C2/ru active
- 2010-12-17 CN CN201410471291.2A patent/CN104232589B/zh active Active
- 2010-12-17 CA CA3000246A patent/CA3000246C/en active Active
- 2010-12-17 KR KR1020207007903A patent/KR102178064B1/ko active Active
- 2010-12-17 TR TR2018/08011T patent/TR201808011T4/tr unknown
- 2010-12-17 KR KR1020197011653A patent/KR102092744B1/ko active Active
- 2010-12-17 PL PL10791039T patent/PL2516457T3/pl unknown
- 2010-12-17 KR KR1020187014568A patent/KR101973524B1/ko active Active
- 2010-12-17 CA CA2784953A patent/CA2784953C/en active Active
- 2010-12-17 RS RS20180653A patent/RS57280B1/sr unknown
- 2010-12-17 EP EP18154933.8A patent/EP3336102A3/en not_active Withdrawn
- 2010-12-17 US US12/971,080 patent/US8658154B2/en active Active
- 2010-12-17 LT LTEP10791039.0T patent/LT2516457T/lt unknown
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2012
- 2012-05-08 US US13/466,225 patent/US8658853B2/en active Active
- 2012-06-13 IL IL220365A patent/IL220365A/en active IP Right Grant
-
2014
- 2014-01-10 US US14/152,090 patent/US9056130B2/en active Active
- 2014-01-10 US US14/152,106 patent/US9089599B2/en active Active
- 2014-04-22 JP JP2014087973A patent/JP5891259B2/ja active Active
- 2014-08-08 AU AU2014210646A patent/AU2014210646B2/en active Active
- 2014-08-08 AU AU2014210645A patent/AU2014210645B2/en active Active
- 2014-08-14 JP JP2014165102A patent/JP6073840B2/ja active Active
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2015
- 2015-07-15 US US14/800,253 patent/US9687566B2/en active Active
- 2015-11-23 IL IL242719A patent/IL242719A/en active IP Right Grant
-
2016
- 2016-02-19 JP JP2016030271A patent/JP2016093201A/ja active Pending
-
2017
- 2017-05-22 US US15/601,363 patent/US10426848B2/en active Active
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2018
- 2018-06-12 CY CY20181100608T patent/CY1120316T1/el unknown
- 2018-08-20 IL IL261257A patent/IL261257B/en active IP Right Grant
- 2018-12-14 HK HK18116115.6A patent/HK1257001A1/en unknown
-
2019
- 2019-08-02 US US16/530,336 patent/US11020495B2/en active Active
- 2019-12-01 IL IL271083A patent/IL271083A/en unknown
-
2021
- 2021-04-27 US US17/241,763 patent/US12036288B2/en active Active
-
2024
- 2024-06-05 US US18/734,482 patent/US20240424145A1/en active Pending
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