JP2013513657A5 - - Google Patents
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- Publication number
- JP2013513657A5 JP2013513657A5 JP2012544408A JP2012544408A JP2013513657A5 JP 2013513657 A5 JP2013513657 A5 JP 2013513657A5 JP 2012544408 A JP2012544408 A JP 2012544408A JP 2012544408 A JP2012544408 A JP 2012544408A JP 2013513657 A5 JP2013513657 A5 JP 2013513657A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- glu
- asp
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 206010003246 arthritis Diseases 0.000 claims description 4
- 206010007710 Cartilage injury Diseases 0.000 claims description 3
- 230000000069 prophylactic effect Effects 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 4
- 210000000845 cartilage Anatomy 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 2
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 229940099456 transforming growth factor beta 1 Drugs 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 208000012659 Joint disease Diseases 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 102000036444 extracellular matrix enzymes Human genes 0.000 claims 1
- 108091007167 extracellular matrix enzymes Proteins 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000005065 subchondral bone plate Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020100062467A KR101029705B1 (ko) | 2010-06-30 | 2010-06-30 | 신규 펩타이드 및 그 용도 |
| KR10-2010-0062467 | 2010-06-30 | ||
| PCT/KR2011/004541 WO2012002668A2 (en) | 2010-06-30 | 2011-06-22 | Novel peptide and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513657A JP2013513657A (ja) | 2013-04-22 |
| JP2013513657A5 true JP2013513657A5 (enExample) | 2014-02-27 |
| JP5607176B2 JP5607176B2 (ja) | 2014-10-15 |
Family
ID=44050220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012544408A Active JP5607176B2 (ja) | 2010-06-30 | 2011-06-22 | 新規ペプチドおよびその用途 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8772241B2 (enExample) |
| EP (1) | EP2588491B1 (enExample) |
| JP (1) | JP5607176B2 (enExample) |
| KR (1) | KR101029705B1 (enExample) |
| CN (1) | CN102892776B (enExample) |
| AU (1) | AU2011272137B2 (enExample) |
| BR (1) | BR112012031587B1 (enExample) |
| CA (1) | CA2801010C (enExample) |
| ES (1) | ES2606778T3 (enExample) |
| MX (1) | MX2012015000A (enExample) |
| PL (1) | PL2588491T3 (enExample) |
| RU (1) | RU2525913C1 (enExample) |
| SG (1) | SG186120A1 (enExample) |
| WO (1) | WO2012002668A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886564B (zh) * | 2015-05-12 | 2017-05-17 | 浙江海洋学院 | 一种路氏双髻鲨软骨血管生成抑制因子的用途 |
| KR101644982B1 (ko) | 2015-07-23 | 2016-08-02 | 주식회사 엔솔바이오사이언스 | 신규 펩타이드 및 그 용도 |
| WO2017155234A1 (ko) * | 2016-03-09 | 2017-09-14 | 주식회사 바이오펩 | 염증성 질환의 예방 또는 치료용 펩타이드 및 이의 용도 |
| WO2017155233A1 (ko) * | 2016-03-09 | 2017-09-14 | 주식회사 바이오펩 | 염증성 질환의 예방 또는 치료용 펩타이드 및 이의 용도 |
| US10913771B2 (en) | 2016-03-09 | 2021-02-09 | Kine Sciences Co., Ltd. | Peptide for preventing or treating inflammatory diseases and use thereof |
| KR101897122B1 (ko) | 2016-03-09 | 2018-09-10 | 주식회사 바이오펩 | 염증성 질환의 예방 또는 치료용 펩타이드 및 이의 용도 |
| US10913772B2 (en) | 2016-03-09 | 2021-02-09 | Kine Sciences Co., Ltd. | Peptide for preventing or treating inflammatory diseases and use thereof |
| KR101829631B1 (ko) * | 2016-07-20 | 2018-02-19 | 주식회사 엔솔바이오사이언스 | 신규 펩타이드 및 그 용도 |
| CN107670021B (zh) * | 2016-08-02 | 2020-09-18 | 富比积生物科技股份有限公司 | 五胜肽kttks在治疗退化性关节炎中的用途 |
| CN111093687B (zh) | 2017-09-15 | 2024-07-09 | 凯恩塞恩斯株式会社 | 作为自身免疫疾病及骨病治疗剂的肽的用途 |
| WO2019054809A2 (ko) * | 2017-09-15 | 2019-03-21 | 주식회사 바이오펩 | 자가면역질환 및 골질환 치료제로서의 펩타이드의 용도 |
| KR101995768B1 (ko) * | 2019-03-13 | 2019-07-03 | (주)엔솔바이오사이언스 | 신규 펩타이드 및 그 용도 |
| KR20230167231A (ko) | 2022-05-31 | 2023-12-08 | 주식회사 엔솔바이오사이언스 | 염형태 변형 펩타이드의 제조방법 및 그를 이용하여 제조된 펩타이드 |
| KR20230167253A (ko) | 2022-05-31 | 2023-12-08 | 주식회사 엔솔바이오사이언스 | 펩타이드 함유 액상제제 및 그 제조방법 |
| KR102877150B1 (ko) * | 2022-12-09 | 2025-10-28 | (주)케어젠 | 연골 재생용 펩타이드 및 이의 용도 |
| KR20240086941A (ko) * | 2022-12-09 | 2024-06-19 | (주)케어젠 | 연골 재생용 펩타이드 및 이의 용도 |
| KR102913342B1 (ko) * | 2022-12-09 | 2026-01-16 | (주)케어젠 | 연골 재생용 펩타이드 및 이의 용도 |
| WO2025089468A1 (ko) * | 2023-10-27 | 2025-05-01 | 주식회사 엔솔바이오사이언스 | 펩타이드 함유 액상제제 및 그 제조방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5955343A (en) * | 1992-12-28 | 1999-09-21 | Massachusetts Institute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US6638912B2 (en) * | 1995-05-01 | 2003-10-28 | The Regents Of The University Of California | Peptide compositions mimicking TGF-β activity |
| US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| US7687462B2 (en) * | 1999-10-05 | 2010-03-30 | The Regents Of The University Of California | Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition |
| US6716811B1 (en) * | 2000-07-20 | 2004-04-06 | Affymax, Inc. | Compounds having affinity for the granulocyte-colony stimulating factor receptor (G-CSFR) and associated uses |
| EP1367961B1 (en) | 2001-02-06 | 2008-12-31 | Massachusetts Institute Of Technology | Peptide scaffold encapsulation of tissue cells and uses thereof |
| ES2304069B1 (es) * | 2003-08-22 | 2009-08-12 | Proyecto De Biomedicina Cima, S.L. | Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1). |
| US8039258B2 (en) * | 2004-09-28 | 2011-10-18 | Ethicon, Inc. | Tissue-engineering scaffolds containing self-assembled-peptide hydrogels |
| KR20070121669A (ko) * | 2005-02-16 | 2007-12-27 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 뼈 상태 치료 또는 예방을 위한 약제학적 조성물 |
| AU2008209473B2 (en) * | 2007-01-22 | 2012-10-25 | Orthotrophix, Inc. | A peptide composition and a method of promoting cartilage formation |
| CA2618163A1 (en) * | 2008-02-07 | 2009-08-07 | K. W. Michael Siu | Head and neck cancer biomarkers |
-
2010
- 2010-06-30 KR KR1020100062467A patent/KR101029705B1/ko active Active
-
2011
- 2011-06-22 PL PL11801075T patent/PL2588491T3/pl unknown
- 2011-06-22 AU AU2011272137A patent/AU2011272137B2/en active Active
- 2011-06-22 EP EP11801075.0A patent/EP2588491B1/en active Active
- 2011-06-22 CN CN201180004884.2A patent/CN102892776B/zh active Active
- 2011-06-22 MX MX2012015000A patent/MX2012015000A/es active IP Right Grant
- 2011-06-22 ES ES11801075.0T patent/ES2606778T3/es active Active
- 2011-06-22 WO PCT/KR2011/004541 patent/WO2012002668A2/en not_active Ceased
- 2011-06-22 RU RU2013101051/04A patent/RU2525913C1/ru active
- 2011-06-22 SG SG2012088381A patent/SG186120A1/en unknown
- 2011-06-22 CA CA2801010A patent/CA2801010C/en active Active
- 2011-06-22 JP JP2012544408A patent/JP5607176B2/ja active Active
- 2011-06-22 US US13/701,465 patent/US8772241B2/en active Active
- 2011-06-22 BR BR112012031587-0A patent/BR112012031587B1/pt active IP Right Grant
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