JP2013512898A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013512898A5 JP2013512898A5 JP2012541988A JP2012541988A JP2013512898A5 JP 2013512898 A5 JP2013512898 A5 JP 2013512898A5 JP 2012541988 A JP2012541988 A JP 2012541988A JP 2012541988 A JP2012541988 A JP 2012541988A JP 2013512898 A5 JP2013512898 A5 JP 2013512898A5
- Authority
- JP
- Japan
- Prior art keywords
- hdaci
- composition
- transdermal patch
- transdermal
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 42
- 239000003795 chemical substances by application Substances 0.000 claims description 33
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims description 19
- 229960002436 cladribine Drugs 0.000 claims description 19
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims description 14
- 229950005837 Entinostat Drugs 0.000 claims description 13
- INVTYAOGFAGBOE-UHFFFAOYSA-N pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate Chemical compound NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC(=O)OCC1=CC=CN=C1 INVTYAOGFAGBOE-UHFFFAOYSA-N 0.000 claims description 13
- 239000012528 membrane Substances 0.000 claims description 12
- 238000009093 first-line therapy Methods 0.000 claims description 8
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims description 7
- FWZRWHZDXBDTFK-ZHACJKMWSA-N Panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims description 5
- WAEXFXRVDQXREF-UHFFFAOYSA-N Vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims description 5
- 229960000237 Vorinostat Drugs 0.000 claims description 5
- 229960005184 panobinostat Drugs 0.000 claims description 5
- NIJJYAXOARWZEE-UHFFFAOYSA-N Depacane Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims description 4
- 229960003094 belinostat Drugs 0.000 claims description 4
- NCNRHFGMJRPRSK-MDZDMXLPSA-N belinostat Chemical compound ONC(=O)\C=C\C1=CC=CC(S(=O)(=O)NC=2C=CC=CC=2)=C1 NCNRHFGMJRPRSK-MDZDMXLPSA-N 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 238000002625 monoclonal antibody therapy Methods 0.000 claims description 4
- 229960003452 romidepsin Drugs 0.000 claims description 4
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 claims description 4
- 108010091666 romidepsin Proteins 0.000 claims description 4
- 229960000604 valproic acid Drugs 0.000 claims description 4
- 229940121372 histone deacetylase inhibitors Drugs 0.000 claims description 3
- 229960000070 antineoplastic Monoclonal antibodies Drugs 0.000 claims description 2
- 229960000060 monoclonal antibodies Drugs 0.000 claims description 2
- 102000005614 monoclonal antibodies Human genes 0.000 claims description 2
- 108010045030 monoclonal antibodies Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000011510 cancer Diseases 0.000 description 3
- 206010039491 Sarcoma Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000003000 nontoxic Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000003068 static Effects 0.000 description 1
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28330509P | 2009-12-02 | 2009-12-02 | |
US61/283,305 | 2009-12-02 | ||
US30195610P | 2010-02-05 | 2010-02-05 | |
US61/301,956 | 2010-02-05 | ||
US32008310P | 2010-04-01 | 2010-04-01 | |
US61/320,083 | 2010-04-01 | ||
US12/769,913 US8491927B2 (en) | 2009-12-02 | 2010-04-29 | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
US12/769,913 | 2010-04-29 | ||
PCT/US2010/001287 WO2011068522A1 (en) | 2009-12-02 | 2010-04-30 | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013512898A JP2013512898A (ja) | 2013-04-18 |
JP2013512898A5 true JP2013512898A5 (US07981874-20110719-C00313.png) | 2013-06-20 |
JP6002040B2 JP6002040B2 (ja) | 2016-10-05 |
Family
ID=44069079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012541988A Expired - Fee Related JP6002040B2 (ja) | 2009-12-02 | 2010-04-30 | 低メチル化剤及びヒストン脱アセチル化酵素阻害剤を含む薬学的組成物 |
Country Status (9)
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
US20150087687A1 (en) | 2012-03-23 | 2015-03-26 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
WO2013162054A1 (ja) * | 2012-04-24 | 2013-10-31 | 公立大学法人首都大学東京 | クロマチン構造を制御する組成物 |
JP6243102B2 (ja) * | 2012-05-01 | 2017-12-06 | 株式会社ジェムインターナショナル | 貼付剤 |
FR2993461B1 (fr) | 2012-07-19 | 2014-08-08 | Genethon | Utilisation de composes modifiant l'epigenome pour le traitement des maladies genetiques musculaires liees a une anomalie de conformation proteique |
WO2014022524A1 (en) * | 2012-07-31 | 2014-02-06 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
US20140142522A1 (en) * | 2012-11-16 | 2014-05-22 | NU Technology, LLC | Moist dressing with honeycomb pattern and drain channels |
CN107072984B (zh) * | 2014-07-15 | 2021-10-01 | 约翰·霍普金斯大学 | 源自骨髓的抑制细胞的抑制和免疫检查点阻断 |
US9962340B2 (en) | 2015-06-09 | 2018-05-08 | Life Tech Global, Llc | Device and method for the transdermal delivery of cannabidiol |
US10272125B2 (en) * | 2015-09-14 | 2019-04-30 | Life Tech Global, Llc | Transdermal delivery of cannabidiol with other active moieties including cannabinoids |
WO2018226939A1 (en) * | 2017-06-07 | 2018-12-13 | Ranedis Pharmaceuticals, Llc | Compositions and methods of treating and/or preventing cancer |
CN114206447A (zh) | 2019-05-31 | 2022-03-18 | 维拉克塔附属公司 | 用组蛋白脱乙酰基酶抑制剂治疗病毒相关的癌症的方法 |
JP2022552642A (ja) * | 2019-10-07 | 2022-12-19 | ヴィラクタ サブシディアリー,インク. | 副作用が軽減されたhdac治療の調剤 |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
EP0143949B1 (en) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
JPS62126123A (ja) * | 1985-11-28 | 1987-06-08 | Shigeki Suzuki | バルプロ酸の経皮吸収方法 |
JPH06510290A (ja) * | 1991-08-27 | 1994-11-17 | シグナス,インコーポレイテッド | プラゾシンを投与するための経皮処方物 |
EP0819016A1 (de) * | 1995-04-07 | 1998-01-21 | Novartis AG | Iontophoretisches transdermales system zum verabreichen von mindestens zwei substanzen |
US5736154A (en) | 1996-03-11 | 1998-04-07 | Fuisz Technologies Ltd. | Transdermal delivery system |
FR2749514B1 (fr) * | 1996-06-11 | 1998-08-07 | Hoechst Marion Roussel | Systemes transdermiques renfermant 2 principes actifs dans des compartiments separes, leur procede de preparation et leur application comme medicament |
US6479074B2 (en) * | 1996-10-24 | 2002-11-12 | Pharmaceutical Applications Associates Llc | Methods and transdermal compositions for pain relief |
AU5495798A (en) | 1997-01-16 | 1998-08-07 | Sekisui Chemical Co., Ltd. | External preparations for percutaneous absorption |
AU4841599A (en) | 1998-06-29 | 2000-01-17 | Pharmaceuticals Applications Asociates, Llc | Methods and transdermal compositions for pain relief |
AU780454B2 (en) | 1999-06-03 | 2005-03-24 | Jessie L.S. Au | Methods and compositions for modulating cell proliferation and cell death |
IL138686A0 (en) | 1999-10-01 | 2001-10-31 | Pfizer Prod Inc | α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS |
JP2004504585A (ja) * | 2000-07-14 | 2004-02-12 | トランスフォーム ファーマシューティカルズ,インコーポレーティッド. | 化合物の組織バリア輸送を最適にするためのシステムおよび方法 |
US6682757B1 (en) * | 2000-11-16 | 2004-01-27 | Euro-Celtique, S.A. | Titratable dosage transdermal delivery system |
US6905669B2 (en) | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
EP1293205A1 (en) | 2001-09-18 | 2003-03-19 | G2M Cancer Drugs AG | Valproic acid and derivatives thereof for the combination therapy of human cancers, for the treatment of tumour metastasis and minimal residual disease |
DE60238276D1 (de) | 2001-12-13 | 2010-12-23 | Vital Health Sciences Pty Ltd | Transdermaler transport von verbindungen |
US6841565B1 (en) | 2002-03-29 | 2005-01-11 | The Ohio State University | Treatment of patients with chronic lymphocytic leukemia |
CN1795193B (zh) | 2003-05-20 | 2010-08-18 | 诺瓦提斯公司 | 用作过氧化物酶体增殖物激活受体的配体的n-酰基含氮杂环化合物 |
JP2009513523A (ja) | 2003-07-08 | 2009-04-02 | ノバルティス アクチエンゲゼルシャフト | ベンゼンスルホニルアミノ化合物およびそれらを含む医薬組成物 |
US20050059682A1 (en) | 2003-09-12 | 2005-03-17 | Supergen, Inc., A Delaware Corporation | Compositions and methods for treatment of cancer |
US8012944B2 (en) * | 2003-10-30 | 2011-09-06 | Pharmascience Inc. | Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent |
US7582782B2 (en) | 2003-11-26 | 2009-09-01 | Novartis Ag | Organic compounds |
WO2005065668A2 (en) | 2003-12-29 | 2005-07-21 | Qlt Usa, Inc. | Topical compositions comprising halo-deoxyadenosines for treatment of skin disorders |
US20050255150A1 (en) | 2004-04-26 | 2005-11-17 | Cassel Douglas R | Wound treatment patch for alleviating pain |
KR100602434B1 (ko) | 2004-09-10 | 2006-07-19 | 최상식 | 복수 개의 단위 구획을 포함하는 약물의 경피 투여용 패치 |
AU2006283677A1 (en) | 2005-08-19 | 2007-03-01 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Topical formulations of histone deacetylase inhibitors and methods of using the same |
US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
WO2007041584A2 (en) * | 2005-10-03 | 2007-04-12 | Combinatorx, Incorporated | Implantable sensors, implantable pumps, and anti-scarring drug combinations |
AU2005339587B2 (en) | 2005-11-16 | 2011-11-03 | Universidad Nacional Autonoma De Mexico | Use of transcriptome-modifying agents and chemotherapy or radiotherapy against cancer |
EP3000480A1 (en) | 2005-12-01 | 2016-03-30 | ProNAi Therapeutics, Inc. | Cancer therapies and pharmaceutical compositions used therein |
WO2007067695A2 (en) | 2005-12-07 | 2007-06-14 | University Of Utah Research Foundation | Dna methylation as a target for diagnosis and treatment of chronic lymphocytic leukemia (cll) |
EP2522352B1 (en) | 2006-03-02 | 2017-01-11 | Agency for Science, Technology and Research | Methods for stem cells modulation |
US8585753B2 (en) * | 2006-03-04 | 2013-11-19 | John James Scanlon | Fibrillated biodegradable prosthesis |
WO2007109178A2 (en) | 2006-03-16 | 2007-09-27 | Pharmacyclics, Inc. | Indole derivatives as inhibitors of histone deacetylase |
WO2007114697A1 (en) | 2006-03-31 | 2007-10-11 | Erasmus University Medical Center Rotterdam | Novel composition for tumor growth control |
EP2018161B1 (en) * | 2006-05-05 | 2011-07-13 | Coloplast A/S | A pressure sensitive adhesive composition comprising cross-linked polyalkylene oxide and water absorbent hydrophilic agents |
WO2008082646A2 (en) | 2006-12-28 | 2008-07-10 | The Johns Hopkins University | Histone deacetylase inhibitors, combination therapies and methods of use |
KR20090110913A (ko) | 2007-02-15 | 2009-10-23 | 노파르티스 아게 | Lbh589와 암을 치료하기 위한 다른 치료제와의 조합물 |
WO2008116163A1 (en) | 2007-03-22 | 2008-09-25 | Oregon Health & Science University | Therapeutic drug combinations for treatment of b-cell malignancies |
WO2008127735A1 (en) | 2007-04-13 | 2008-10-23 | Stemline Therapeutics, Inc. | Il3ralpha antibody conjugates and uses thereof |
US20090025274A1 (en) | 2007-07-23 | 2009-01-29 | Tim Lail | Animal trap |
WO2009055343A2 (en) | 2007-10-22 | 2009-04-30 | Schering Corporation | Fully human anti-vegf antibodies and methods of using |
WO2009067543A2 (en) | 2007-11-19 | 2009-05-28 | The Regents Of The University Of Colorado | Treatment of histone deacetylase mediated disorders |
US20090131367A1 (en) * | 2007-11-19 | 2009-05-21 | The Regents Of The University Of Colorado | Combinations of HDAC Inhibitors and Proteasome Inhibitors |
EP3692983B1 (en) | 2008-05-15 | 2021-08-11 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
WO2009155477A1 (en) | 2008-06-19 | 2009-12-23 | The Trustees Of The University Of Pennsylvania | Inducible regulatory t-cell generation for hematopoietic transplants |
WO2010020787A1 (en) | 2008-08-22 | 2010-02-25 | Oncomethylome Sciences Sa | Diagnosis and treatment of tumours |
ES2628219T3 (es) * | 2009-05-19 | 2017-08-02 | Vivia Biotech S.L. | Métodos para proporcionar ensayos de medicina personalizada ex vivo para neoplasias hematológicas |
US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
JP5548470B2 (ja) * | 2010-02-16 | 2014-07-16 | 日本碍子株式会社 | ハニカム触媒体 |
WO2011113013A2 (en) * | 2010-03-11 | 2011-09-15 | Hemaquest Pharmaceuticals, Inc. | Methods and compositions for treating viral or virally-induced conditions |
EP2382993A1 (en) * | 2010-04-19 | 2011-11-02 | KTB Tumorforschungsgesellschaft mbH | Combination of drugs with protein-binding prodrugs |
US20130244963A1 (en) * | 2010-09-30 | 2013-09-19 | Portola Pharmaceuticals, Inc. | Combination therapy with 4-(3-(2h-1,2,3-triazol-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino)pyrimidine-5-carboxamide |
TR201903859T4 (tr) * | 2010-11-12 | 2019-04-22 | Pharma Mar Sa | Bir antitümör antibiyotik ile kombinasyon terapisi. |
US20130004481A1 (en) * | 2011-01-12 | 2013-01-03 | Boehringer Ingelheim International Gmbh | Anticancer therapy |
CN103596951A (zh) * | 2011-04-08 | 2014-02-19 | 阿弗拉克西斯控股股份有限公司 | 用于治疗神经系统障碍和癌症的8-乙基-6-(芳基)吡啶并[2,3-d]嘧啶-7(8h)-酮 |
WO2012142480A1 (en) * | 2011-04-14 | 2012-10-18 | Beth Israel Deaconess Medical Center, Inc. | Chimeric rna oligonucleotides and uses thereof |
US20140170148A1 (en) * | 2011-04-20 | 2014-06-19 | Genmab A/S | Bispecific antibodies against her2 |
JP2014519813A (ja) * | 2011-04-25 | 2014-08-21 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 癌薬剤発見、診断、および治療におけるemt遺伝子シグネチャーの使用 |
AU2012275275A1 (en) * | 2011-06-28 | 2014-01-23 | Pharmacyclics Llc | Methods and compositions for inhibition of bone resorption |
BR112014010417A2 (pt) * | 2011-11-01 | 2014-11-18 | Celgene Corp | Métodos para o tratamento de cânceres com o uso de formulações orais de análogos de citidina |
US20130158043A1 (en) * | 2011-12-09 | 2013-06-20 | Afraxis, Inc. | Pak inhibitors for the treatment of cancer |
US8921367B2 (en) * | 2012-05-31 | 2014-12-30 | Amgen Inc. | Use of AMG 900 for the treatment of cancer |
SG11201408067YA (en) * | 2012-06-04 | 2015-01-29 | Pharmacyclics Inc | Crystalline forms of a bruton's tyrosine kinase inhibitor |
WO2014009318A1 (en) * | 2012-07-11 | 2014-01-16 | Boehringer Ingelheim International Gmbh | 3-{3-[1 -(4-dimethylaminomethyl-phenylamino)-1 -phenyl-meth-(z)-ylidene]-2-oxo-2,3-dihydro-1 h-indol-6-yll-propynoic acid ethylamide and its use in the treatment of cancer |
WO2014009319A1 (en) * | 2012-07-11 | 2014-01-16 | Boehringer Ingelheim International Gmbh | Indolinone derivatives anticancer compounds |
JP6347782B2 (ja) * | 2012-08-09 | 2018-06-27 | セルジーン コーポレイション | 3−(4−((4−(モルホリノメチル)ベンジル)オキシ)−1−オキソイソインドリン−2−イル)ピペリジン−2,6−ジオンを使用する癌の治療方法 |
NZ628030A (en) * | 2012-08-09 | 2016-12-23 | Celgene Corp | Salts and solid forms of (s)-3-(4-((4-morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and compositions comprising and methods of using the same |
US9682143B2 (en) * | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
AU2013302696B9 (en) * | 2012-08-14 | 2018-08-09 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
US20140120083A1 (en) * | 2012-11-01 | 2014-05-01 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
KR20230078823A (ko) * | 2012-12-13 | 2023-06-02 | 이뮤노메딕스, 인코오포레이티드 | 개선된 효능 및 감소된 독성을 위한 항체 및 sn-38의 면역컨쥬게이트의 투약 |
-
2010
- 2010-04-29 US US12/769,913 patent/US8491927B2/en not_active Expired - Fee Related
- 2010-04-30 WO PCT/US2010/001287 patent/WO2011068522A1/en active Application Filing
- 2010-04-30 MX MX2012006128A patent/MX2012006128A/es active IP Right Grant
- 2010-04-30 CA CA2782205A patent/CA2782205A1/en not_active Abandoned
- 2010-04-30 AU AU2010326699A patent/AU2010326699B2/en not_active Ceased
- 2010-04-30 EP EP10834854.1A patent/EP2506814A4/en not_active Withdrawn
- 2010-04-30 KR KR1020127017074A patent/KR20120127580A/ko not_active Application Discontinuation
- 2010-04-30 JP JP2012541988A patent/JP6002040B2/ja not_active Expired - Fee Related
- 2010-04-30 US US13/513,327 patent/US10434090B2/en not_active Expired - Fee Related
- 2010-04-30 CN CN2010800617444A patent/CN102711686A/zh active Pending
-
2019
- 2019-08-23 US US16/549,442 patent/US20200222379A1/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2013512898A5 (US07981874-20110719-C00313.png) | ||
JP6002040B2 (ja) | 低メチル化剤及びヒストン脱アセチル化酵素阻害剤を含む薬学的組成物 | |
Dragu et al. | Therapies targeting cancer stem cells: Current trends and future challenges | |
JP2022180461A5 (US07981874-20110719-C00313.png) | ||
JP2016517434A5 (US07981874-20110719-C00313.png) | ||
JP2012525393A5 (US07981874-20110719-C00313.png) | ||
BRPI0416260A (pt) | método para tratar, prevenir ou controlar uma doença ou distúrbio relacionada com amianto, e, composição farmacêutica | |
BRPI0518622A2 (pt) | usos de antagonistas de receptor do tipo 1 de interleucina-1(il-1r1) para a fabricaÇço de um medicamento para o tratamento de uma doenÇa respiratària; composiÇço farmacÊutica que compreende um antagonista do il-1r1 e um veÍculo fisiologicamente aceitÁvel e dispositivo de liberaÇço de medicamento | |
WO2018005695A1 (en) | Use of neurokinin-1 antagonists to treat a variety of pruritic conditions | |
Zorzi et al. | A phase I study of histone deacetylase inhibitor, pracinostat (SB939), in pediatric patients with refractory solid tumors: IND203 a trial of the NCIC IND program/C17 pediatric phase I consortium | |
CN115087665A (zh) | 用于靶向递送治疗剂的工程化血小板 | |
JP2019531356A5 (US07981874-20110719-C00313.png) | ||
UY31417A1 (es) | Una composicion farmacéutica y un proceso para dicha composicion farmacéutica | |
NI202100031A (es) | Formulación basada en ciclodextrina de un inhibidor de bcl-2 | |
JP2005500298A5 (US07981874-20110719-C00313.png) | ||
JP2018516936A5 (US07981874-20110719-C00313.png) | ||
JP2014534229A5 (US07981874-20110719-C00313.png) | ||
Cao et al. | Chidamide: Targeting epigenetic regulation in the treatment of hematological malignancy | |
CA2912830A1 (en) | Specific cancer treatment regimens with ganetespib | |
JP2007524616A (ja) | Hivを処置するための組成物および方法 | |
JP2012524772A5 (US07981874-20110719-C00313.png) | ||
JP2015510945A5 (US07981874-20110719-C00313.png) | ||
BRPI0416266A (pt) | método para tratar, prevenir e/ou controlar uma doença ou distúrbio relacionada com amianto em um paciente | |
EP3917507A1 (en) | Tumescent infiltration drug delivery of cannabinoids | |
BRPI0416247A (pt) | método para tratar, prevenir ou controlar uma doença ou distúrbio relacionada com amianto, e, composição farmacêutica |