JP2013511958A - Imp−3オリゴペプチドおよびそれを含むワクチン - Google Patents

Imp−3オリゴペプチドおよびそれを含むワクチン Download PDF

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Publication number
JP2013511958A
JP2013511958A JP2012524961A JP2012524961A JP2013511958A JP 2013511958 A JP2013511958 A JP 2013511958A JP 2012524961 A JP2012524961 A JP 2012524961A JP 2012524961 A JP2012524961 A JP 2012524961A JP 2013511958 A JP2013511958 A JP 2013511958A
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hla
antigen
oligopeptide
imp
ctl
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JP2012524961A
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JP2013511958A5 (enExample
Inventor
泰治 西村
美智子 原尾
雄介 冨田
祐輔 中村
卓也 角田
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Oncotherapy Science Inc
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Oncotherapy Science Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/55—Lung
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012524961A 2009-12-01 2010-11-30 Imp−3オリゴペプチドおよびそれを含むワクチン Pending JP2013511958A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26565709P 2009-12-01 2009-12-01
US61/265,657 2009-12-01
US37143410P 2010-08-06 2010-08-06
US61/371,434 2010-08-06
PCT/JP2010/006966 WO2011067920A1 (en) 2009-12-01 2010-11-30 Imp-3 oligopeptides and vaccines including the same

Publications (2)

Publication Number Publication Date
JP2013511958A true JP2013511958A (ja) 2013-04-11
JP2013511958A5 JP2013511958A5 (enExample) 2014-01-23

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JP2012524961A Pending JP2013511958A (ja) 2009-12-01 2010-11-30 Imp−3オリゴペプチドおよびそれを含むワクチン

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US (1) US20120308590A1 (enExample)
EP (1) EP2507256A4 (enExample)
JP (1) JP2013511958A (enExample)
KR (1) KR20120099106A (enExample)
CN (1) CN102741271B (enExample)
AU (1) AU2010327878B2 (enExample)
BR (1) BR112012013139A2 (enExample)
CA (1) CA2782271A1 (enExample)
IL (1) IL219976A0 (enExample)
MX (1) MX2012006126A (enExample)
RU (1) RU2550695C2 (enExample)
SG (2) SG10201407944TA (enExample)
TW (1) TW201124530A (enExample)
WO (1) WO2011067920A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016021506A1 (ja) * 2014-08-04 2016-02-11 オンコセラピー・サイエンス株式会社 Koc1由来ペプチドおよびそれを含むワクチン
JP2016525498A (ja) * 2013-05-24 2016-08-25 オンコセラピー・サイエンス株式会社 Th1細胞のIMP−3エピトープペプチドおよびこれを含有するワクチン
JP2019512242A (ja) * 2016-03-16 2019-05-16 イマティクス バイオテクノロジーズ ゲーエムベーハー がんに対する免疫療法で使用するための形質移入t細胞およびt細胞受容体
JP2019515653A (ja) * 2016-03-16 2019-06-13 イマティクス バイオテクノロジーズ ゲーエムベーハー がんに対する免疫療法で使用されるペプチドおよびペプチドの組み合わせ
US11730796B2 (en) 2016-03-16 2023-08-22 Immatics Biotechnologies Gmbh Transfected t-cells and t-cell receptors for use in immunotherapy against cancers

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140138900A (ko) 2012-03-09 2014-12-04 온코세라피 사이언스 가부시키가이샤 펩티드를 포함한 의약 조성물
PE20181583A1 (es) * 2016-03-01 2018-10-04 Immatics Biotechnologies Gmbh Peptido recombinante derivado de la proteina duoxa2
GB201603568D0 (en) * 2016-03-01 2016-04-13 Immatics Biotechnologies Gmbh Efficient treatment options including peptides and combination of peptide and cell based medicaments for use in immunotherapy against urinary bladder cancer
CN110191703B (zh) 2017-01-25 2022-04-08 奥塞免疫疗法公司 用于肽递送的稳定乳液的制造方法
CA3084674A1 (en) * 2017-12-23 2019-06-27 Rubius Therapeutics, Inc. Artificial antigen presenting cells and methods of use
CN114853847B (zh) 2022-06-29 2022-09-27 中国农业大学 辣椒籽分离的寡肽ftle及其在预防或治疗癌症中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020036A1 (de) * 2000-09-06 2002-03-14 Mueller Friederike Arzneimittel mit einer für das rna-bindende koc-protein kodierenden dna-sequenz, einem koc-protein oder einer dna-sequenz des koc-promotors
JP2008510464A (ja) * 2004-08-19 2008-04-10 コリクサ コーポレイション 肺癌の治療および診断のための組成物および方法
JP2008530975A (ja) * 2005-02-25 2008-08-14 オンコセラピー・サイエンス株式会社 Ttk、urlc10、またはkoc1ポリペプチドを発現する肺癌に対するペプチドワクチン

Family Cites Families (2)

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WO2009039854A2 (en) * 2007-09-27 2009-04-02 Dako Denmark A/S Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics
ES2536465T3 (es) * 2008-10-01 2015-05-25 Immatics Biotechnologies Gmbh Composición de péptidos tumor-asociados y relacionados con la vacuna contra el cáncer para el tratamiento de glioblastoma (GBM) y otros cánceres

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020036A1 (de) * 2000-09-06 2002-03-14 Mueller Friederike Arzneimittel mit einer für das rna-bindende koc-protein kodierenden dna-sequenz, einem koc-protein oder einer dna-sequenz des koc-promotors
JP2008510464A (ja) * 2004-08-19 2008-04-10 コリクサ コーポレイション 肺癌の治療および診断のための組成物および方法
JP2008530975A (ja) * 2005-02-25 2008-08-14 オンコセラピー・サイエンス株式会社 Ttk、urlc10、またはkoc1ポリペプチドを発現する肺癌に対するペプチドワクチン

Non-Patent Citations (2)

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Title
JPN6015007974; Cancer Sci. 98 (11), 2007, p.1803-1808 *
JPN7015000540; J. Immunol. 152, 1994, p.163-175 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016525498A (ja) * 2013-05-24 2016-08-25 オンコセラピー・サイエンス株式会社 Th1細胞のIMP−3エピトープペプチドおよびこれを含有するワクチン
JP7070945B2 (ja) 2014-08-04 2022-05-18 オンコセラピー・サイエンス株式会社 Koc1由来ペプチドおよびそれを含むワクチン
JPWO2016021506A1 (ja) * 2014-08-04 2017-05-18 オンコセラピー・サイエンス株式会社 Koc1由来ペプチドおよびそれを含むワクチン
AU2015300256B2 (en) * 2014-08-04 2020-01-30 Oncotherapy Science, Inc. KOC1-Derived peptide and vaccine including same
US10576102B2 (en) 2014-08-04 2020-03-03 Oncotherapy Science, Inc. KOC1-derived peptide and vaccine including same
JP2020182487A (ja) * 2014-08-04 2020-11-12 オンコセラピー・サイエンス株式会社 Koc1由来ペプチドおよびそれを含むワクチン
IL280417A (en) * 2014-08-04 2021-03-01 Oncotherapy Science Inc A peptide derived from KOC1 and a vaccine containing it
WO2016021506A1 (ja) * 2014-08-04 2016-02-11 オンコセラピー・サイエンス株式会社 Koc1由来ペプチドおよびそれを含むワクチン
US11547723B2 (en) 2014-08-04 2023-01-10 Oncotherapy Science, Inc. KOC1-derived peptide and vaccine including same
JP2019512242A (ja) * 2016-03-16 2019-05-16 イマティクス バイオテクノロジーズ ゲーエムベーハー がんに対する免疫療法で使用するための形質移入t細胞およびt細胞受容体
JP2019515653A (ja) * 2016-03-16 2019-06-13 イマティクス バイオテクノロジーズ ゲーエムベーハー がんに対する免疫療法で使用されるペプチドおよびペプチドの組み合わせ
JP2022130472A (ja) * 2016-03-16 2022-09-06 イマティクス バイオテクノロジーズ ゲーエムベーハー がんに対する免疫療法で使用されるペプチドおよびペプチドの組み合わせ
US11730796B2 (en) 2016-03-16 2023-08-22 Immatics Biotechnologies Gmbh Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
US12466878B2 (en) 2016-03-16 2025-11-11 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against cancers

Also Published As

Publication number Publication date
KR20120099106A (ko) 2012-09-06
RU2550695C2 (ru) 2015-05-10
MX2012006126A (es) 2012-06-19
SG10201407944TA (en) 2015-01-29
US20120308590A1 (en) 2012-12-06
TW201124530A (en) 2011-07-16
AU2010327878B2 (en) 2014-11-20
BR112012013139A2 (pt) 2016-10-11
EP2507256A4 (en) 2013-10-16
CA2782271A1 (en) 2011-06-09
IL219976A0 (en) 2012-07-31
SG181107A1 (en) 2012-07-30
AU2010327878A1 (en) 2012-06-21
CN102741271A (zh) 2012-10-17
RU2012127358A (ru) 2014-01-10
WO2011067920A1 (en) 2011-06-09
CN102741271B (zh) 2014-11-05
EP2507256A1 (en) 2012-10-10

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