JP2013511560A5 - - Google Patents
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- JP2013511560A5 JP2013511560A5 JP2012540229A JP2012540229A JP2013511560A5 JP 2013511560 A5 JP2013511560 A5 JP 2013511560A5 JP 2012540229 A JP2012540229 A JP 2012540229A JP 2012540229 A JP2012540229 A JP 2012540229A JP 2013511560 A5 JP2013511560 A5 JP 2013511560A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- mirna
- mir
- cells
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000001301 EGF receptor Human genes 0.000 claims 11
- 108060006698 EGF receptor Proteins 0.000 claims 11
- 108091070501 miRNA Proteins 0.000 claims 11
- 239000002679 microRNA Substances 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 108091023818 miR-7 stem-loop Proteins 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 8
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 8
- 239000002243 precursor Substances 0.000 claims 7
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 230000019491 signal transduction Effects 0.000 claims 4
- 230000004936 stimulating effect Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 108091067625 Homo sapiens miR-7-1 stem-loop Proteins 0.000 claims 2
- 108091067630 Homo sapiens miR-7-2 stem-loop Proteins 0.000 claims 2
- 108091067633 Homo sapiens miR-7-3 stem-loop Proteins 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 2
- 229960001433 erlotinib Drugs 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 230000036456 mitotic arrest Effects 0.000 claims 1
- 230000000394 mitotic effect Effects 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2009905758A AU2009905758A0 (en) | 2009-11-24 | Method of Modulating Epidermal Growth Factor (EGF) Ligands | |
| AU2009905758 | 2009-11-24 | ||
| PCT/AU2010/001578 WO2011063456A1 (en) | 2009-11-24 | 2010-11-24 | Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013511560A JP2013511560A (ja) | 2013-04-04 |
| JP2013511560A5 true JP2013511560A5 (https=) | 2014-01-16 |
Family
ID=44065735
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540228A Pending JP2013511559A (ja) | 2009-11-24 | 2010-11-24 | 上皮成長因子受容体リガンドのモジュレーション |
| JP2012540229A Pending JP2013511560A (ja) | 2009-11-24 | 2010-11-24 | チロシンキナーゼインヒビターに対する感受性を増加する方法と組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540228A Pending JP2013511559A (ja) | 2009-11-24 | 2010-11-24 | 上皮成長因子受容体リガンドのモジュレーション |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9051551B2 (https=) |
| EP (2) | EP2521555B1 (https=) |
| JP (2) | JP2013511559A (https=) |
| CN (2) | CN102762214A (https=) |
| AU (2) | AU2010324530B2 (https=) |
| CA (2) | CA2781572A1 (https=) |
| DK (1) | DK2521555T3 (https=) |
| ES (1) | ES2608923T3 (https=) |
| WO (2) | WO2011063455A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2302055B1 (en) | 2004-11-12 | 2014-08-27 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| EP2591106A1 (en) * | 2010-07-06 | 2013-05-15 | InteRNA Technologies B.V. | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
| CA2856594A1 (en) * | 2011-11-25 | 2013-05-30 | Integragen | A method for predicting responsiveness to a treatment with an egfr inhibitor |
| FR2984168B1 (fr) * | 2011-12-19 | 2019-07-05 | Chanel Parfums Beaute | Micro-rna pour leur utilisation dans la pigmentation |
| US20150126621A1 (en) * | 2012-05-15 | 2015-05-07 | New York University | METHOD FOR PREDICTING RECURRENCE OF MELANOMA USING miRNA ALTERATIONS |
| CN104994861B (zh) * | 2012-10-18 | 2019-10-11 | 西澳大学 | 使用miRNA的癌症疗法 |
| US20140308274A1 (en) * | 2013-03-15 | 2014-10-16 | Mirna Therapeutics, Inc. | Combination cancer treatments utilizing synthetic oligonucleotides and egfr-tki inhibitors |
| KR20150131312A (ko) * | 2013-03-15 | 2015-11-24 | 미르나 테라퓨틱스 인코포레이티드 | 마이크로rna 및 egfr-tki 억제제를 이용한 조합 암 치료 |
| AU2014296288B2 (en) | 2013-07-31 | 2020-02-13 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating thermogenesis using PTH-related and EGF-related molecules |
| CN108537001B (zh) * | 2018-04-12 | 2021-06-01 | 华中科技大学鄂州工业技术研究院 | 一种预测用于治疗肝癌的特异性治疗药物的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2338994B1 (en) * | 2004-09-02 | 2014-03-19 | Yale University | Regulation of oncogenes by microRNAs |
| EP2302055B1 (en) * | 2004-11-12 | 2014-08-27 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| US8673872B2 (en) * | 2006-08-28 | 2014-03-18 | The University Of Western Australia | Method of modulation of expression of epidermal growth factor receptor(EGFR) involving miRNA |
| AU2007333109A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro RNAs |
| JP2010516692A (ja) | 2007-01-19 | 2010-05-20 | バイエル・ヘルスケア・エルエルシー | 化学療法剤に対し抵抗性を有する癌の処置 |
-
2010
- 2010-11-24 JP JP2012540228A patent/JP2013511559A/ja active Pending
- 2010-11-24 AU AU2010324530A patent/AU2010324530B2/en not_active Ceased
- 2010-11-24 CA CA2781572A patent/CA2781572A1/en not_active Abandoned
- 2010-11-24 AU AU2010324529A patent/AU2010324529A1/en not_active Abandoned
- 2010-11-24 EP EP10832418.7A patent/EP2521555B1/en active Active
- 2010-11-24 CA CA2781571A patent/CA2781571A1/en not_active Abandoned
- 2010-11-24 DK DK10832418.7T patent/DK2521555T3/en active
- 2010-11-24 EP EP10832417.9A patent/EP2504014A4/en not_active Withdrawn
- 2010-11-24 US US13/511,181 patent/US9051551B2/en active Active
- 2010-11-24 ES ES10832418.7T patent/ES2608923T3/es active Active
- 2010-11-24 CN CN2010800604035A patent/CN102762214A/zh active Pending
- 2010-11-24 CN CN2010800604001A patent/CN102762213A/zh active Pending
- 2010-11-24 US US13/511,183 patent/US20130090366A1/en not_active Abandoned
- 2010-11-24 JP JP2012540229A patent/JP2013511560A/ja active Pending
- 2010-11-24 WO PCT/AU2010/001577 patent/WO2011063455A1/en not_active Ceased
- 2010-11-24 WO PCT/AU2010/001578 patent/WO2011063456A1/en not_active Ceased
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