CA2781572A1 - Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors - Google Patents
Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors Download PDFInfo
- Publication number
- CA2781572A1 CA2781572A1 CA2781572A CA2781572A CA2781572A1 CA 2781572 A1 CA2781572 A1 CA 2781572A1 CA 2781572 A CA2781572 A CA 2781572A CA 2781572 A CA2781572 A CA 2781572A CA 2781572 A1 CA2781572 A1 CA 2781572A1
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- egfr
- mirna
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- cancer
- tyrosine kinase
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Applications Claiming Priority (3)
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| AU2009905758A AU2009905758A0 (en) | 2009-11-24 | Method of Modulating Epidermal Growth Factor (EGF) Ligands | |
| AU2009905758 | 2009-11-24 | ||
| PCT/AU2010/001578 WO2011063456A1 (en) | 2009-11-24 | 2010-11-24 | Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors |
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| CA2781572A1 true CA2781572A1 (en) | 2011-06-03 |
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| CA2781572A Abandoned CA2781572A1 (en) | 2009-11-24 | 2010-11-24 | Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors |
| CA2781571A Abandoned CA2781571A1 (en) | 2009-11-24 | 2010-11-24 | Modulation of epidermal growth factor receptor ligands |
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| CA2781571A Abandoned CA2781571A1 (en) | 2009-11-24 | 2010-11-24 | Modulation of epidermal growth factor receptor ligands |
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| US (2) | US9051551B2 (https=) |
| EP (2) | EP2521555B1 (https=) |
| JP (2) | JP2013511559A (https=) |
| CN (2) | CN102762214A (https=) |
| AU (2) | AU2010324530B2 (https=) |
| CA (2) | CA2781572A1 (https=) |
| DK (1) | DK2521555T3 (https=) |
| ES (1) | ES2608923T3 (https=) |
| WO (2) | WO2011063455A1 (https=) |
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| EP2302055B1 (en) | 2004-11-12 | 2014-08-27 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| EP2591106A1 (en) * | 2010-07-06 | 2013-05-15 | InteRNA Technologies B.V. | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
| CA2856594A1 (en) * | 2011-11-25 | 2013-05-30 | Integragen | A method for predicting responsiveness to a treatment with an egfr inhibitor |
| FR2984168B1 (fr) * | 2011-12-19 | 2019-07-05 | Chanel Parfums Beaute | Micro-rna pour leur utilisation dans la pigmentation |
| US20150126621A1 (en) * | 2012-05-15 | 2015-05-07 | New York University | METHOD FOR PREDICTING RECURRENCE OF MELANOMA USING miRNA ALTERATIONS |
| CN104994861B (zh) * | 2012-10-18 | 2019-10-11 | 西澳大学 | 使用miRNA的癌症疗法 |
| US20140308274A1 (en) * | 2013-03-15 | 2014-10-16 | Mirna Therapeutics, Inc. | Combination cancer treatments utilizing synthetic oligonucleotides and egfr-tki inhibitors |
| KR20150131312A (ko) * | 2013-03-15 | 2015-11-24 | 미르나 테라퓨틱스 인코포레이티드 | 마이크로rna 및 egfr-tki 억제제를 이용한 조합 암 치료 |
| AU2014296288B2 (en) | 2013-07-31 | 2020-02-13 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating thermogenesis using PTH-related and EGF-related molecules |
| CN108537001B (zh) * | 2018-04-12 | 2021-06-01 | 华中科技大学鄂州工业技术研究院 | 一种预测用于治疗肝癌的特异性治疗药物的方法 |
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| EP2338994B1 (en) * | 2004-09-02 | 2014-03-19 | Yale University | Regulation of oncogenes by microRNAs |
| EP2302055B1 (en) * | 2004-11-12 | 2014-08-27 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| US8673872B2 (en) * | 2006-08-28 | 2014-03-18 | The University Of Western Australia | Method of modulation of expression of epidermal growth factor receptor(EGFR) involving miRNA |
| AU2007333109A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro RNAs |
| JP2010516692A (ja) | 2007-01-19 | 2010-05-20 | バイエル・ヘルスケア・エルエルシー | 化学療法剤に対し抵抗性を有する癌の処置 |
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| CA2781571A1 (en) | 2011-06-03 |
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| AU2010324529A1 (en) | 2012-07-19 |
| AU2010324530A1 (en) | 2012-07-19 |
| JP2013511559A (ja) | 2013-04-04 |
| CN102762214A (zh) | 2012-10-31 |
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