JP2013510882A5 - - Google Patents
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- Publication number
- JP2013510882A5 JP2013510882A5 JP2012539057A JP2012539057A JP2013510882A5 JP 2013510882 A5 JP2013510882 A5 JP 2013510882A5 JP 2012539057 A JP2012539057 A JP 2012539057A JP 2012539057 A JP2012539057 A JP 2012539057A JP 2013510882 A5 JP2013510882 A5 JP 2013510882A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pgp
- immunogenic composition
- protecting
- glycerol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- 230000002163 immunogen Effects 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 15
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000000178 monomer Substances 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 230000001419 dependent effect Effects 0.000 claims 7
- 125000005647 linker group Chemical group 0.000 claims 7
- 241000894006 Bacteria Species 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 6
- XYZZKVRWGOWVGO-UHFFFAOYSA-N Glycerol-phosphate Chemical compound OP(O)(O)=O.OCC(O)CO XYZZKVRWGOWVGO-UHFFFAOYSA-N 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- -1 succinimidyl Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 4
- 241000191967 Staphylococcus aureus Species 0.000 claims 3
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 3
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 claims 3
- 125000005597 hydrazone group Chemical group 0.000 claims 3
- 229940058352 levulinate Drugs 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 2
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 2
- 241000295644 Staphylococcaceae Species 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 238000010511 deprotection reaction Methods 0.000 claims 2
- 229960003983 diphtheria toxoid Drugs 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 125000005252 haloacyl group Chemical group 0.000 claims 2
- 150000008300 phosphoramidites Chemical class 0.000 claims 2
- 125000002743 phosphorus functional group Chemical group 0.000 claims 2
- 229960000814 tetanus toxoid Drugs 0.000 claims 2
- FLCQLSRLQIPNLM-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 2-acetylsulfanylacetate Chemical compound CC(=O)SCC(=O)ON1C(=O)CCC1=O FLCQLSRLQIPNLM-UHFFFAOYSA-N 0.000 claims 1
- MHBCAXJUTKVVOW-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 2-hydrazinylpyridine-3-carboxylate Chemical compound NNC1=NC=CC=C1C(=O)ON1C(=O)CCC1=O MHBCAXJUTKVVOW-UHFFFAOYSA-N 0.000 claims 1
- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 claims 1
- BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical group OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 claims 1
- VTDOEFXTVHCAAM-UHFFFAOYSA-N 4-methylpent-3-ene-1,2,3-triol Chemical compound CC(C)=C(O)C(O)CO VTDOEFXTVHCAAM-UHFFFAOYSA-N 0.000 claims 1
- NFSMUNQYUHPFAB-UHFFFAOYSA-N C(CCCCC)(=O)O.N1=C(C=CC=C1)SSCCC(=O)N Chemical compound C(CCCCC)(=O)O.N1=C(C=CC=C1)SSCCC(=O)N NFSMUNQYUHPFAB-UHFFFAOYSA-N 0.000 claims 1
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 108050001049 Extracellular proteins Proteins 0.000 claims 1
- 101000597577 Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) Outer membrane protein Proteins 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 101710116435 Outer membrane protein Proteins 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 125000005598 acylhydrazone group Chemical group 0.000 claims 1
- IBVAQQYNSHJXBV-UHFFFAOYSA-N adipic acid dihydrazide Chemical compound NNC(=O)CCCCC(=O)NN IBVAQQYNSHJXBV-UHFFFAOYSA-N 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 claims 1
- 239000012038 nucleophile Substances 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 238000002515 oligonucleotide synthesis Methods 0.000 claims 1
- JIQXKYSNGXUDJU-UHFFFAOYSA-N propan-2-ylidenehydrazine Chemical compound CC(C)=NN JIQXKYSNGXUDJU-UHFFFAOYSA-N 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26157209P | 2009-11-16 | 2009-11-16 | |
| US61/261,572 | 2009-11-16 | ||
| PCT/US2010/056742 WO2011060379A2 (en) | 2009-11-16 | 2010-11-15 | (poly)-glycerolphosphate-based anti-gram positive bacterial vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013510882A JP2013510882A (ja) | 2013-03-28 |
| JP2013510882A5 true JP2013510882A5 (enExample) | 2013-12-05 |
| JP6091214B2 JP6091214B2 (ja) | 2017-03-08 |
Family
ID=43992459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012539057A Expired - Fee Related JP6091214B2 (ja) | 2009-11-16 | 2010-11-15 | ポリ−グリセロールリン酸をベースにした抗グラム陽性細菌ワクチン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130052204A1 (enExample) |
| EP (1) | EP2501403A4 (enExample) |
| JP (1) | JP6091214B2 (enExample) |
| AU (2) | AU2010320031B2 (enExample) |
| CA (1) | CA2781049A1 (enExample) |
| WO (1) | WO2011060379A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3120140B1 (en) * | 2014-03-21 | 2018-10-31 | Biotage AB | Method and apparatus for the equilibration of a packed chromatography column |
| US10781175B2 (en) | 2016-07-15 | 2020-09-22 | Am Chemicals Llc | Solid supports and phosphoramidite building blocks for oligonucleotide conjugates |
| WO2025166099A1 (en) * | 2024-02-02 | 2025-08-07 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Fire-retardant wood and wood composites, and compositions useful for making same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9202219D0 (en) * | 1992-02-03 | 1992-03-18 | Connaught Lab | A synthetic heamophilus influenzae conjugate vaccine |
| GB9808932D0 (en) * | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| GB9811347D0 (en) * | 1998-05-28 | 1998-07-22 | Oxoid Ltd | Improvements in or relating diagnosis and treatment of bacterial infections |
| US6800728B2 (en) * | 2000-03-22 | 2004-10-05 | Solulink Biosciences, Inc. | Hydrazine-based and carbonyl-based bifunctional crosslinking reagents |
| AU2004299501B2 (en) * | 2003-12-17 | 2010-12-23 | Wyeth Llc | Immunogenic peptide carrier conjugates and methods of producing same |
| WO2005072778A2 (en) * | 2004-01-29 | 2005-08-11 | Biosynexus, Inc. | Use of amino-oxy functional groups in the preparation of vaccines conjugates |
| ES2730275T3 (es) * | 2004-09-22 | 2019-11-11 | Glaxosmithkline Biologicals Sa | Composición inmunógena para uso en vacunación contra estafilococos |
| US7754225B2 (en) * | 2006-07-20 | 2010-07-13 | Glaxosmithkline Biologicals S.A. | Method of protecting against staphylococcal infection |
-
2010
- 2010-11-15 CA CA2781049A patent/CA2781049A1/en not_active Abandoned
- 2010-11-15 AU AU2010320031A patent/AU2010320031B2/en not_active Ceased
- 2010-11-15 EP EP10830870.1A patent/EP2501403A4/en not_active Withdrawn
- 2010-11-15 JP JP2012539057A patent/JP6091214B2/ja not_active Expired - Fee Related
- 2010-11-15 US US13/508,860 patent/US20130052204A1/en not_active Abandoned
- 2010-11-15 WO PCT/US2010/056742 patent/WO2011060379A2/en not_active Ceased
-
2015
- 2015-10-12 AU AU2015238927A patent/AU2015238927A1/en not_active Abandoned
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