JP2013507369A - Ｇタンパク質共役受容体８８の調節因子 - Google Patents
Ｇタンパク質共役受容体８８の調節因子 Download PDFInfo
- Publication number
- JP2013507369A JP2013507369A JP2012533264A JP2012533264A JP2013507369A JP 2013507369 A JP2013507369 A JP 2013507369A JP 2012533264 A JP2012533264 A JP 2012533264A JP 2012533264 A JP2012533264 A JP 2012533264A JP 2013507369 A JP2013507369 A JP 2013507369A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- mmol
- phenyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(*)CC1=CC(C)(*)C=C(C(F)(F)F)C=C1 Chemical compound CC(*)CC1=CC(C)(*)C=C(C(F)(F)F)C=C1 0.000 description 1
- WTNZAPZOSSPUHI-ACRUOGEOSA-N CCC(CC)COc1ccc([C@H](CO)NC([C@@H](C2)[C@H]2c2ccc[s]2)=O)c(C)c1 Chemical compound CCC(CC)COc1ccc([C@H](CO)NC([C@@H](C2)[C@H]2c2ccc[s]2)=O)c(C)c1 WTNZAPZOSSPUHI-ACRUOGEOSA-N 0.000 description 1
- FDGXWFLFJLMESD-FBOXXWIASA-N CCCC(C)COc1ccc([C@H](CO)NC([C@@H](C2)[C@H]2c2ccc[s]2)=O)cc1 Chemical compound CCCC(C)COc1ccc([C@H](CO)NC([C@@H](C2)[C@H]2c2ccc[s]2)=O)cc1 FDGXWFLFJLMESD-FBOXXWIASA-N 0.000 description 1
- XXQRMVONZZWLKF-DSITVLBTSA-N CC[C@@H](c(cc1)ccc1-c(cc1)ccc1OC)NC([C@@H](C1)[C@H]1c1ccccc1)=O Chemical compound CC[C@@H](c(cc1)ccc1-c(cc1)ccc1OC)NC([C@@H](C1)[C@H]1c1ccccc1)=O XXQRMVONZZWLKF-DSITVLBTSA-N 0.000 description 1
- BODVPNMHLGISLM-DSYPUSFNSA-N CC[C@H](C)COc1ccc([C@H](CN)NC([C@@H](C2)[C@H]2c2ccc[s]2)=O)c(C)c1 Chemical compound CC[C@H](C)COc1ccc([C@H](CN)NC([C@@H](C2)[C@H]2c2ccc[s]2)=O)c(C)c1 BODVPNMHLGISLM-DSYPUSFNSA-N 0.000 description 1
- OHWJVFXCFOFCAJ-ZFCZOSEKSA-N CC[C@H](C)COc1ccc([C@H](CO)NC([C@@H](C2)[C@H]2C2=CC=CSC2)=O)cc1 Chemical compound CC[C@H](C)COc1ccc([C@H](CO)NC([C@@H](C2)[C@H]2C2=CC=CSC2)=O)cc1 OHWJVFXCFOFCAJ-ZFCZOSEKSA-N 0.000 description 1
- DCGJSXHMNZQIQN-FKBYEOEOSA-N CCc(cc1)ccc1-c1cc(OC)c([C@H](CO)NC([C@@H](C2)[C@H]2c2ccc[s]2)=O)cc1 Chemical compound CCc(cc1)ccc1-c1cc(OC)c([C@H](CO)NC([C@@H](C2)[C@H]2c2ccc[s]2)=O)cc1 DCGJSXHMNZQIQN-FKBYEOEOSA-N 0.000 description 1
- BAWUIVSQZHKYDH-FKBYEOEOSA-N CCc(cc1)ccc1-c1ccc([C@H](CO)NC([C@@H](C2)[C@H]2c2ccc[s]2)=O)cc1 Chemical compound CCc(cc1)ccc1-c1ccc([C@H](CO)NC([C@@H](C2)[C@H]2c2ccc[s]2)=O)cc1 BAWUIVSQZHKYDH-FKBYEOEOSA-N 0.000 description 1
- FTJGKCRCBGQPIG-NJYVYQBISA-N Cc(cc1)ccc1-c1ccc([C@H](CO)NC([C@H](C2)[C@@H]2c2ccc[s]2)=O)cc1 Chemical compound Cc(cc1)ccc1-c1ccc([C@H](CO)NC([C@H](C2)[C@@H]2c2ccc[s]2)=O)cc1 FTJGKCRCBGQPIG-NJYVYQBISA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24946509P | 2009-10-07 | 2009-10-07 | |
| US61/249,465 | 2009-10-07 | ||
| PCT/US2010/051572 WO2011044195A1 (en) | 2009-10-07 | 2010-10-06 | Modulators of g protein-coupled receptor 88 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013507369A true JP2013507369A (ja) | 2013-03-04 |
| JP2013507369A5 JP2013507369A5 (enExample) | 2013-11-21 |
Family
ID=43480829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533264A Withdrawn JP2013507369A (ja) | 2009-10-07 | 2010-10-06 | Ｇタンパク質共役受容体８８の調節因子 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8497271B2 (enExample) |
| EP (1) | EP2486030B1 (enExample) |
| JP (1) | JP2013507369A (enExample) |
| CN (1) | CN102686575A (enExample) |
| ES (1) | ES2428492T3 (enExample) |
| IN (1) | IN2012DN02876A (enExample) |
| WO (1) | WO2011044195A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014520785A (ja) * | 2011-07-08 | 2014-08-25 | ハー・ルンドベック・アクチエゼルスカベット | ニコチン性アセチルコリン受容体の陽性アロステリックモジュレーター |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8304577B2 (en) | 2009-10-09 | 2012-11-06 | Bristol-Myers Squibb Company | Modulators of G protein-coupled receptor 88 |
| US8426414B2 (en) | 2009-10-09 | 2013-04-23 | Bristol-Myers Squibb Company | Modulators of G protein-coupled receptor 88 |
| HRP20180913T1 (hr) | 2011-07-08 | 2018-07-27 | H. Lundbeck A/S | Pozitivni alosterni modulatori receptora nikotinskog acetilkolina |
| US8703953B2 (en) | 2012-03-09 | 2014-04-22 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| WO2014006120A1 (en) * | 2012-07-06 | 2014-01-09 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
| US20150315130A1 (en) * | 2012-12-10 | 2015-11-05 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
| WO2015006100A1 (en) | 2013-07-08 | 2015-01-15 | Bristol-Myers Squibb Company | Aryl amide kinase inhibitors |
| ES2678877T3 (es) | 2013-10-11 | 2018-08-20 | Bristol-Myers Squibb Company | Inhibidores de pirrolotriazina quinasa |
| CN113005089A (zh) * | 2019-12-20 | 2021-06-22 | 泰州医药城国科化物生物医药科技有限公司 | 一种无标记细胞膜受体gpr88的细胞筛选模型及应用 |
| CN111592531B (zh) * | 2020-06-23 | 2023-08-15 | 上海鲲博玖瑞医药科技发展有限公司 | 福瑞塞替的制备方法 |
| GB202209195D0 (en) | 2022-06-22 | 2022-08-10 | Pandeia Therapeutics Ltd | Modulators of g protein-coupled receptor 88 |
| GB202209193D0 (en) | 2022-06-22 | 2022-08-10 | Pandeia Therapeutics Ltd | Modulators of g protein-coupled receptor 88 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0672031B1 (en) | 1992-12-02 | 2003-03-12 | Pfizer Inc. | Catechol diethers as selective pde iv inhibitors |
| US5709861A (en) | 1993-04-22 | 1998-01-20 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| JP2002527414A (ja) * | 1998-10-14 | 2002-08-27 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | １，２−ジ置換シクロプロパン |
| EP1495009B1 (en) | 2002-04-05 | 2008-03-12 | Boehringer Ingelheim Pharmaceuticals Inc. | Cyanamides useful as reversible inhibitors of cysteine proteases |
| WO2003103666A2 (en) | 2002-06-07 | 2003-12-18 | Altana Pharma Ag | Novel 4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-ones |
| US7144881B2 (en) | 2002-11-22 | 2006-12-05 | Bristol-Myers Squibb Company | Arylcyclopropylcarboxylic amides as potassium channel openers |
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| WO2004072018A1 (ja) | 2003-02-12 | 2004-08-26 | Takeda Pharmaceutical Company Limited | アミン誘導体 |
| WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
| US7834013B2 (en) * | 2003-11-19 | 2010-11-16 | Glaxosmithkline Llc | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to GPR40 |
| WO2006012227A2 (en) | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| JP2008512417A (ja) | 2004-09-10 | 2008-04-24 | ユセベ ファルマ ソシエテ アノニム | シグマ受容体リガンド |
| BRPI0608436A2 (pt) * | 2005-03-17 | 2009-12-29 | Pfizer | derivados de n-(n-sulfonilaminometil) ciclopropanocarboxamida utilizáveis para o tratamento de dor |
| CN100494167C (zh) | 2005-08-02 | 2009-06-03 | 天津大学 | 抗乙肝病毒的叔胺氧化物及制备方法和制备药物的应用 |
| JP2007217408A (ja) | 2006-01-19 | 2007-08-30 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| ES2882684T3 (es) | 2006-04-07 | 2021-12-02 | Vertex Pharma | Preparación de moduladores de transportadores del casete de unión a ATP |
| WO2007129188A1 (en) | 2006-05-10 | 2007-11-15 | Pfizer Japan Inc. | Cyclopropanecarboxamide compound |
| US20080039535A1 (en) | 2006-08-14 | 2008-02-14 | Wyeth | Methods of identifying agents for treating neurological disorders |
| US8304577B2 (en) | 2009-10-09 | 2012-11-06 | Bristol-Myers Squibb Company | Modulators of G protein-coupled receptor 88 |
| US8426414B2 (en) | 2009-10-09 | 2013-04-23 | Bristol-Myers Squibb Company | Modulators of G protein-coupled receptor 88 |
-
2010
- 2010-10-01 US US12/895,916 patent/US8497271B2/en active Active
- 2010-10-06 JP JP2012533264A patent/JP2013507369A/ja not_active Withdrawn
- 2010-10-06 ES ES10765715T patent/ES2428492T3/es active Active
- 2010-10-06 IN IN2876DEN2012 patent/IN2012DN02876A/en unknown
- 2010-10-06 CN CN2010800552740A patent/CN102686575A/zh active Pending
- 2010-10-06 EP EP10765715.7A patent/EP2486030B1/en not_active Not-in-force
- 2010-10-06 WO PCT/US2010/051572 patent/WO2011044195A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014520785A (ja) * | 2011-07-08 | 2014-08-25 | ハー・ルンドベック・アクチエゼルスカベット | ニコチン性アセチルコリン受容体の陽性アロステリックモジュレーター |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2486030B1 (en) | 2013-07-24 |
| EP2486030A1 (en) | 2012-08-15 |
| IN2012DN02876A (enExample) | 2015-07-24 |
| ES2428492T3 (es) | 2013-11-08 |
| WO2011044195A1 (en) | 2011-04-14 |
| CN102686575A (zh) | 2012-09-19 |
| US8497271B2 (en) | 2013-07-30 |
| US20110245264A1 (en) | 2011-10-06 |
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Legal Events
| Date | Code | Title | Description |
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| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131001 |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20131001 |
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| A977 | Report on retrieval |
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| A761 | Written withdrawal of application |
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