JP2013506688A5 - - Google Patents
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- Publication number
- JP2013506688A5 JP2013506688A5 JP2012532328A JP2012532328A JP2013506688A5 JP 2013506688 A5 JP2013506688 A5 JP 2013506688A5 JP 2012532328 A JP2012532328 A JP 2012532328A JP 2012532328 A JP2012532328 A JP 2012532328A JP 2013506688 A5 JP2013506688 A5 JP 2013506688A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydroxy
- hydrogen
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 239000001257 hydrogen Substances 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 150000002431 hydrogen Chemical group 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 4
- 229930003316 Vitamin D Natural products 0.000 claims 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 4
- 229910052805 deuterium Inorganic materials 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 235000019166 vitamin D Nutrition 0.000 claims 4
- 239000011710 vitamin D Substances 0.000 claims 4
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 4
- 229940046008 vitamin d Drugs 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 125000001118 alkylidene group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 125000005345 deuteroalkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 0 *CC=CCN=C Chemical compound *CC=CCN=C 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24812509P | 2009-10-02 | 2009-10-02 | |
| US61/248,125 | 2009-10-02 | ||
| PCT/US2010/050977 WO2011041590A2 (en) | 2009-10-02 | 2010-09-30 | 1-desoxy-2-methylene-19-nor-vitamin d analogs and their uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506688A JP2013506688A (ja) | 2013-02-28 |
| JP2013506688A5 true JP2013506688A5 (enExample) | 2014-01-09 |
| JP5814247B2 JP5814247B2 (ja) | 2015-11-17 |
Family
ID=43823661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532328A Expired - Fee Related JP5814247B2 (ja) | 2009-10-02 | 2010-09-30 | １−デソキシ−２−メチレン−１９−ノル−ビタミンｄ類似体及びそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8642579B2 (enExample) |
| EP (1) | EP2483240B1 (enExample) |
| JP (1) | JP5814247B2 (enExample) |
| AU (1) | AU2010300539B9 (enExample) |
| CA (1) | CA2776464C (enExample) |
| MX (1) | MX2012003882A (enExample) |
| NZ (1) | NZ599216A (enExample) |
| WO (1) | WO2011041590A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012174095A1 (en) * | 2011-06-14 | 2012-12-20 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylene-19-nor-vitamin d analogs and their uses |
| AU2012326538B2 (en) * | 2011-10-21 | 2016-12-08 | Wisconsin Alumni Research Foundation | 2-methylene-vitamin D analogs and their uses |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3565924A (en) | 1968-07-01 | 1971-02-23 | Wisconsin Alumni Res Found | 25-hydroxycholfcalciferol |
| CA1138859A (en) | 1979-02-15 | 1983-01-04 | Teijin Limited | 25-hydroxy-24-oxocholestane derivatives and preparation thereof |
| US4269777A (en) | 1979-05-21 | 1981-05-26 | Wisconsin Alumni Research Foundation | Isotopically labeled vitamin D derivatives and processes for preparing same |
| US4424161A (en) | 1979-12-10 | 1984-01-03 | Massachusetts General Hospital | 1β3 H! 1α,25 Dihydroxyvitamin D3 and method for its preparation |
| US4248791A (en) | 1980-02-04 | 1981-02-03 | Wisconsin Alumni Research Foundation | 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol |
| US4500460A (en) | 1983-08-18 | 1985-02-19 | Wisconsin Alumni Research Foundation | 23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same |
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| DE69400495T2 (de) | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| US5843928A (en) | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| JP3855017B2 (ja) * | 2000-03-14 | 2006-12-06 | 財団法人理工学振興会 | ビタミンｄ誘導体およびその製造方法 |
| US6382071B1 (en) | 2000-08-07 | 2002-05-07 | Gilbert A. Bertani | Bola capturing apparatus |
| ATE273709T1 (de) | 2000-09-08 | 2004-09-15 | Wisconsin Alumni Res Found | 1alpha-hydroxy-2-methylene-19-nor- homopregnacalciferol und seine therapeutische verwendungen |
| US6627622B2 (en) | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| US7259143B2 (en) * | 2002-09-05 | 2007-08-21 | Wisconsin Alumni Research Foundation | Method of extending the dose range of vitamin D compounds |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| US20110052707A1 (en) * | 2008-02-12 | 2011-03-03 | Neil Robert Buck | Combination of vitamin d and 25-hydroxyvitamin d 3 |
| CA2750659C (en) * | 2009-01-27 | 2017-11-21 | Berg Biosystems, Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| AU2012326538B2 (en) * | 2011-10-21 | 2016-12-08 | Wisconsin Alumni Research Foundation | 2-methylene-vitamin D analogs and their uses |
-
2010
- 2010-09-30 EP EP10763286.1A patent/EP2483240B1/en not_active Not-in-force
- 2010-09-30 MX MX2012003882A patent/MX2012003882A/es active IP Right Grant
- 2010-09-30 NZ NZ599216A patent/NZ599216A/en not_active IP Right Cessation
- 2010-09-30 CA CA2776464A patent/CA2776464C/en not_active Expired - Fee Related
- 2010-09-30 WO PCT/US2010/050977 patent/WO2011041590A2/en not_active Ceased
- 2010-09-30 JP JP2012532328A patent/JP5814247B2/ja not_active Expired - Fee Related
- 2010-09-30 US US12/895,478 patent/US8642579B2/en active Active
- 2010-09-30 AU AU2010300539A patent/AU2010300539B9/en not_active Ceased
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