JP5814247B2 - １−デソキシ−２−メチレン−１９−ノル−ビタミンｄ類似体及びそれらの使用 - Google Patents

１−デソキシ−２−メチレン−１９−ノル−ビタミンｄ類似体及びそれらの使用 Download PDF

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JP5814247B2
JP5814247B2 JP2012532328A JP2012532328A JP5814247B2 JP 5814247 B2 JP5814247 B2 JP 5814247B2 JP 2012532328 A JP2012532328 A JP 2012532328A JP 2012532328 A JP2012532328 A JP 2012532328A JP 5814247 B2 JP5814247 B2 JP 5814247B2
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Japan
Prior art keywords
vitamin
group
desoxy
compound
methylene
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English (en)
Japanese (ja)
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JP2013506688A (ja
JP2013506688A5 (enExample
Inventor
デルカ，ヘクター，エフ．
シビルスカ，イザベラ
バリッカ，カタルジーナ，エム．
シシンスキー，ラファル，アール．
プロンスカ−オシパ，カタルジーナ
バリッキ，ラファル
プラム，ロリ，エー．
クラゲット−デイム，マーガレット
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Wisconsin Alumni Research Foundation
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Wisconsin Alumni Research Foundation
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2012532328A 2009-10-02 2010-09-30 １−デソキシ−２−メチレン−１９−ノル−ビタミンｄ類似体及びそれらの使用 Expired - Fee Related JP5814247B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24812509P 2009-10-02 2009-10-02
US61/248,125 2009-10-02
PCT/US2010/050977 WO2011041590A2 (en) 2009-10-02 2010-09-30 1-desoxy-2-methylene-19-nor-vitamin d analogs and their uses

Publications (3)

Publication Number Publication Date
JP2013506688A JP2013506688A (ja) 2013-02-28
JP2013506688A5 JP2013506688A5 (enExample) 2014-01-09
JP5814247B2 true JP5814247B2 (ja) 2015-11-17

Family

ID=43823661

Family Applications (1)

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JP2012532328A Expired - Fee Related JP5814247B2 (ja) 2009-10-02 2010-09-30 １−デソキシ−２−メチレン−１９−ノル−ビタミンｄ類似体及びそれらの使用

Country Status (8)

Country Link
US (1) US8642579B2 (enExample)
EP (1) EP2483240B1 (enExample)
JP (1) JP5814247B2 (enExample)
AU (1) AU2010300539B9 (enExample)
CA (1) CA2776464C (enExample)
MX (1) MX2012003882A (enExample)
NZ (1) NZ599216A (enExample)
WO (1) WO2011041590A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012271759B2 (en) * 2011-06-14 2017-02-02 Wisconsin Alumni Research Foundation 3-desoxy-2-methylene-19-nor-vitamin D analogs and their uses
WO2013059021A1 (en) * 2011-10-21 2013-04-25 Wisconsin Alumni Research Foundation 2-methylene-vitamin d analogs and their uses

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3565924A (en) 1968-07-01 1971-02-23 Wisconsin Alumni Res Found 25-hydroxycholfcalciferol
DK162648C (da) 1979-02-15 1992-04-13 Teijin Ltd 3beta,25-dihydroxy-24-oxocholest-5-en-derivater og fremgangsmaade til fremstilling heraf
US4269777A (en) 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same
US4424161A (en) 1979-12-10 1984-01-03 Massachusetts General Hospital 1β3 H! 1α,25 Dihydroxyvitamin D3 and method for its preparation
US4248791A (en) 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4500460A (en) 1983-08-18 1985-02-19 Wisconsin Alumni Research Foundation 23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same
US4666634A (en) 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
US5086191A (en) 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds
EP0619306B1 (en) 1993-04-05 1996-09-11 Wisconsin Alumni Research Foundation 19-Nor-vitamin D3 compounds with substituent at 2-position
US5843928A (en) 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US5945410A (en) 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
JP3855017B2 (ja) * 2000-03-14 2006-12-06 財団法人理工学振興会 ビタミンｄ誘導体およびその製造方法
US6382071B1 (en) 2000-08-07 2002-05-07 Gilbert A. Bertani Bola capturing apparatus
KR100672886B1 (ko) 2000-09-08 2007-01-24 위스콘신 얼럼나이 리서어치 화운데이션 1α-히드록시-2-메틸렌-19-노르-호모프레그나칼시페롤 및그의 치료적 용도
US6627622B2 (en) 2002-02-18 2003-09-30 Wisconsin Alumni Research Foundation (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
US6566352B1 (en) 2002-02-18 2003-05-20 Wisconsin Alumni Research Foudation 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
US7259143B2 (en) * 2002-09-05 2007-08-21 Wisconsin Alumni Research Foundation Method of extending the dose range of vitamin D compounds
US20050101576A1 (en) * 2003-11-06 2005-05-12 Novacea, Inc. Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes
US20110052707A1 (en) * 2008-02-12 2011-03-03 Neil Robert Buck Combination of vitamin d and 25-hydroxyvitamin d 3
CN102341110B (zh) * 2009-01-27 2017-04-12 博格有限责任公司 用于减轻与化疗有关的副作用的维生素d3及其类似物
WO2013059021A1 (en) * 2011-10-21 2013-04-25 Wisconsin Alumni Research Foundation 2-methylene-vitamin d analogs and their uses

Also Published As

Publication number Publication date
CA2776464C (en) 2017-10-24
AU2010300539B9 (en) 2018-07-19
JP2013506688A (ja) 2013-02-28
WO2011041590A2 (en) 2011-04-07
MX2012003882A (es) 2012-06-25
AU2010300539A1 (en) 2012-05-03
US8642579B2 (en) 2014-02-04
EP2483240A2 (en) 2012-08-08
CA2776464A1 (en) 2011-04-07
WO2011041590A3 (en) 2011-06-30
AU2010300539B2 (en) 2016-03-03
NZ599216A (en) 2014-01-31
US20110082121A1 (en) 2011-04-07
EP2483240B1 (en) 2014-09-03

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