JP2013505938A - 抗抗体応答を軽減する方法、組成物およびキット - Google Patents

抗抗体応答を軽減する方法、組成物およびキット Download PDF

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Publication number
JP2013505938A
JP2013505938A JP2012531015A JP2012531015A JP2013505938A JP 2013505938 A JP2013505938 A JP 2013505938A JP 2012531015 A JP2012531015 A JP 2012531015A JP 2012531015 A JP2012531015 A JP 2012531015A JP 2013505938 A JP2013505938 A JP 2013505938A
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Japan
Prior art keywords
allotype
monoclonal antibody
subject
phenotype
antibody
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JP2012531015A
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Japanese (ja)
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JP2013505938A5 (https=
Inventor
シマール，ジョン
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Xbiotech Inc
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Xbiotech Inc
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Publication of JP2013505938A publication Critical patent/JP2013505938A/ja
Publication of JP2013505938A5 publication Critical patent/JP2013505938A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012531015A 2009-09-24 2010-09-23 抗抗体応答を軽減する方法、組成物およびキット Pending JP2013505938A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24530509P 2009-09-24 2009-09-24
US61/245,305 2009-09-24
PCT/US2010/049924 WO2011038069A1 (en) 2009-09-24 2010-09-23 Methods, compositions, and kits for reducing anti-antibody responses

Publications (2)

Publication Number Publication Date
JP2013505938A true JP2013505938A (ja) 2013-02-21
JP2013505938A5 JP2013505938A5 (https=) 2013-10-31

Family

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JP2012531015A Pending JP2013505938A (ja) 2009-09-24 2010-09-23 抗抗体応答を軽減する方法、組成物およびキット

Country Status (8)

Country Link
US (6) US20110071054A1 (https=)
EP (1) EP2480252A4 (https=)
JP (1) JP2013505938A (https=)
KR (1) KR20120093229A (https=)
CN (1) CN102573895A (https=)
AU (1) AU2010298264B2 (https=)
CA (1) CA2775291A1 (https=)
WO (1) WO2011038069A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160279239A1 (en) * 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
JP2013505938A (ja) * 2009-09-24 2013-02-21 エックスバイオテク，インコーポレイテッド 抗抗体応答を軽減する方法、組成物およびキット
AU2012250924B2 (en) 2011-05-02 2017-05-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
JP2014523884A (ja) * 2011-06-24 2014-09-18 セントローズ， エルエルシー 細胞外標的化薬物複合体
US20130089496A1 (en) * 2011-10-07 2013-04-11 Musc Foundation For Research Development Tumor targeted antibodies and method for using the same
US10282875B2 (en) 2015-12-11 2019-05-07 International Business Machines Corporation Graph-based analysis for bio-signal event sensing
WO2018187074A1 (en) 2017-04-03 2018-10-11 Immunomedics, Inc. Subcutaneous administration of antibody-drug conjugates for cancer therapy
US10975146B2 (en) 2018-06-29 2021-04-13 Cedars-Sinai Medical Center Interleukin-1 inhibition for combination treatment of pancreatic cancer
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06510659A (ja) * 1991-03-12 1994-12-01 リンクスベイル　リミティド 変更されたアロタイプ抗原決定基をもつヒト化抗体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9122820D0 (en) * 1991-10-28 1991-12-11 Wellcome Found Stabilised antibodies
AU5152293A (en) * 1992-10-08 1994-05-09 Kennedy Institute Of Rheumatology, The Treatment of autoimmune and inflammatory disorders
GB9316989D0 (en) * 1993-08-16 1993-09-29 Lynxvale Ltd Binding molecules
US5856095A (en) * 1995-08-14 1999-01-05 St. Jude Children's Research Hospital Identification of two novel mutant alleles of human thiopurine S-methyltransferase, and diagnostic uses thereof
DK0929578T3 (da) * 1996-02-09 2003-08-25 Abbott Lab Bermuda Ltd Humane antistoffer, der binder human TNFalfa
GB9925490D0 (en) * 1999-10-28 1999-12-29 Univ Cambridge Tech Binding molecules and treatment and screening methods
US20020127625A1 (en) * 2000-03-31 2002-09-12 Forskarpatent Is Syd Ab Methods of diagnosing immune related diseases
EP2288733A4 (en) * 2008-03-18 2012-03-21 Merck Sharp & Dohme PROTEIN CHANGE TEST WITH HIGH THROUGHPUT
JP2013505938A (ja) * 2009-09-24 2013-02-21 エックスバイオテク，インコーポレイテッド 抗抗体応答を軽減する方法、組成物およびキット

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06510659A (ja) * 1991-03-12 1994-12-01 リンクスベイル　リミティド 変更されたアロタイプ抗原決定基をもつヒト化抗体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6014045097; Ｓ．Ｄ．Ｇｏｒｍａｎ　ｅｔ　ａｌ: 'Ｈｕｍａｎｉｓａｔｉｏｎ　ｏｆ　Ｍｏｎｏｃｌｏｎａｌ　Ａｎｔｉｂｏｄｉｅｓ　ｆｏｒ　Ｔｈｅｒａｐｙ' Ｓｅｍｉｎａｒｓ　ｉｎ　Ｉｍｍｕｎｏｌｏｇｙ ｖｏｌ．２，　ｎｏ．６, 1990, ４５７-４６６　（１-２５頁） *

Also Published As

Publication number Publication date
KR20120093229A (ko) 2012-08-22
US20120094395A1 (en) 2012-04-19
EP2480252A4 (en) 2014-04-30
AU2010298264B2 (en) 2014-10-23
US20120094301A1 (en) 2012-04-19
CA2775291A1 (en) 2011-03-31
US20110071054A1 (en) 2011-03-24
WO2011038069A1 (en) 2011-03-31
US20110070230A1 (en) 2011-03-24
EP2480252A1 (en) 2012-08-01
US20110071276A1 (en) 2011-03-24
AU2010298264A1 (en) 2012-04-19
CN102573895A (zh) 2012-07-11
US20110070229A1 (en) 2011-03-24

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