JP2013505264A - 疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割 - Google Patents

疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割 Download PDF

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JP2013505264A
JP2013505264A JP2012529955A JP2012529955A JP2013505264A JP 2013505264 A JP2013505264 A JP 2013505264A JP 2012529955 A JP2012529955 A JP 2012529955A JP 2012529955 A JP2012529955 A JP 2012529955A JP 2013505264 A JP2013505264 A JP 2013505264A
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disease
hepes
cancer
composition
treatment
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JP2013505264A5 (enExample
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アイヴァン イー. ダンホフ
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North Texas Medical Associates
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North Texas Medical Associates
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012529955A 2009-09-17 2010-09-17 疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割 Pending JP2013505264A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24346409P 2009-09-17 2009-09-17
US61/243,464 2009-09-17
PCT/US2010/049405 WO2011035212A2 (en) 2009-09-17 2010-09-17 Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

Related Child Applications (1)

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JP2014231168A Division JP5974062B2 (ja) 2009-09-17 2014-11-14 疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割

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JP2013505264A true JP2013505264A (ja) 2013-02-14
JP2013505264A5 JP2013505264A5 (enExample) 2013-09-26

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JP2012529955A Pending JP2013505264A (ja) 2009-09-17 2010-09-17 疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割
JP2014231168A Active JP5974062B2 (ja) 2009-09-17 2014-11-14 疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割
JP2015024177A Pending JP2015129150A (ja) 2009-09-17 2015-02-10 疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割
JP2016140167A Active JP6347807B2 (ja) 2009-09-17 2016-07-15 疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割

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JP2014231168A Active JP5974062B2 (ja) 2009-09-17 2014-11-14 疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割
JP2015024177A Pending JP2015129150A (ja) 2009-09-17 2015-02-10 疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割
JP2016140167A Active JP6347807B2 (ja) 2009-09-17 2016-07-15 疼痛制御及び脱髄損傷の回復におけるn−2−ヒドロキシ−エチル−ピペラジン−n’−2−エタンスルホン酸(hepes)の役割

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Country Link
US (4) US8883855B2 (enExample)
EP (3) EP2477626A4 (enExample)
JP (4) JP2013505264A (enExample)
KR (1) KR101737775B1 (enExample)
CN (4) CN107260740A (enExample)
AR (1) AR078290A1 (enExample)
AU (1) AU2010295445B2 (enExample)
BR (1) BR112012006155A2 (enExample)
CA (3) CA3122553A1 (enExample)
HK (1) HK1199621A1 (enExample)
IL (2) IL264055B2 (enExample)
IN (1) IN2012DN02499A (enExample)
MX (2) MX360190B (enExample)
MY (2) MY174012A (enExample)
NZ (1) NZ598861A (enExample)
SG (3) SG179191A1 (enExample)
TW (2) TWI494106B (enExample)
WO (1) WO2011035212A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9867820B2 (en) 2009-09-17 2018-01-16 Bespoke Bioscience, Llc Role of N-2-hydroxy-ethyl-piperazine-N′-2-ethane sulfonic acid (HEPES) in pain control and reversal of demyelinization injury

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2956919C (en) 2014-07-21 2022-07-19 Glia, Llc Method for treating radiotherapy- and chemotherapy-associated cognitive or emotional impairment with cannabinoids
CA2984379C (en) * 2015-04-28 2024-06-11 Newsouth Innovations Pty Limited Targeting nad+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies, and inactivity

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JPH11504050A (ja) * 1996-02-13 1999-04-06 シオドー,ティー.ロナルド 生物学的応答修飾因子としての双性イオンの組成物及び方法
WO2009004082A2 (en) * 2007-07-05 2009-01-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Anticonvulsive pharmaceutical compositions

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US5643562A (en) * 1993-03-29 1997-07-01 Queen's University Of Kingston Method for treating amyloidosis
US5840294A (en) * 1993-03-29 1998-11-24 Queen's University At Kingston Method for treating amyloidosis
WO1997002270A1 (de) 1995-07-06 1997-01-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Thiolsilane, verfahren zu deren herstellung und deren verwendung
NZ550199A (en) * 1998-02-11 2008-07-31 Bellus Health Int Ltd Treatment of inflammation, abeta-induced cell toxicity, neuronal cell death or neuronal cell loss in subjects suffering from alzheimer's disease
US9044478B2 (en) 2004-11-10 2015-06-02 Institut National De La Sante Et De La Recherche Medicale Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases
EP2011491A1 (en) 2007-07-05 2009-01-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anticonvulsive pharmaceutical compositions
EP2163246A1 (en) * 2008-09-12 2010-03-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Taurine or taurine-like substances for the prevention of the irreversible visual effects of vigabatrin
US8709299B2 (en) 2009-09-04 2014-04-29 Basf Se Dye sensitised solar cell
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MY174012A (en) 2009-09-17 2020-03-03 Bespoke Bioscience Llc Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

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JPH11504050A (ja) * 1996-02-13 1999-04-06 シオドー,ティー.ロナルド 生物学的応答修飾因子としての双性イオンの組成物及び方法
WO2009004082A2 (en) * 2007-07-05 2009-01-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Anticonvulsive pharmaceutical compositions

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9867820B2 (en) 2009-09-17 2018-01-16 Bespoke Bioscience, Llc Role of N-2-hydroxy-ethyl-piperazine-N′-2-ethane sulfonic acid (HEPES) in pain control and reversal of demyelinization injury
US10213425B2 (en) 2009-09-17 2019-02-26 Bespoke Bioscience, Llc Role of N-2-hydroxy-ethyl-piperazine-N′-2-ethane sulfonic acid (HEPES) in pain control and reversal of demyelinization injury

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Publication number Publication date
IN2012DN02499A (enExample) 2015-08-28
US9867820B2 (en) 2018-01-16
US20190142825A1 (en) 2019-05-16
MX360190B (es) 2018-10-24
JP6347807B2 (ja) 2018-06-27
CA3122553A1 (en) 2011-03-24
SG10201500510YA (en) 2015-03-30
HK1199621A1 (en) 2015-07-10
KR101737775B1 (ko) 2017-05-19
EP2835133B1 (en) 2019-04-24
CA2774375C (en) 2018-02-13
AU2010295445B2 (en) 2014-09-25
CA2977918A1 (en) 2011-03-24
EP2477626A2 (en) 2012-07-25
EP3520794A3 (en) 2019-11-20
TWI494106B (zh) 2015-08-01
EP2477626A4 (en) 2013-05-22
IL264055B1 (en) 2024-05-01
JP2015052006A (ja) 2015-03-19
CA2774375A1 (en) 2011-03-24
MY159626A (en) 2017-01-13
SG179191A1 (en) 2012-04-27
SG10202100421XA (en) 2021-02-25
CN103977405A (zh) 2014-08-13
MX2012003212A (es) 2012-09-07
CN107260740A (zh) 2017-10-20
CA2977918C (en) 2021-08-10
JP2015129150A (ja) 2015-07-16
AR078290A1 (es) 2011-10-26
WO2011035212A2 (en) 2011-03-24
EP2835133A1 (en) 2015-02-11
NZ598861A (en) 2013-01-25
IL218677A0 (en) 2012-05-31
US8883855B2 (en) 2014-11-11
CN102612366A (zh) 2012-07-25
JP5974062B2 (ja) 2016-08-23
TWI562777B (en) 2016-12-21
US20140378467A1 (en) 2014-12-25
IL264055B2 (en) 2024-09-01
CN109224077A (zh) 2019-01-18
KR20120081151A (ko) 2012-07-18
US20180028530A1 (en) 2018-02-01
EP3520794A2 (en) 2019-08-07
JP2016216493A (ja) 2016-12-22
US20110071157A1 (en) 2011-03-24
TW201440769A (zh) 2014-11-01
BR112012006155A2 (pt) 2016-06-28
IL218677B (en) 2019-01-31
US10213425B2 (en) 2019-02-26
MY174012A (en) 2020-03-03
WO2011035212A3 (en) 2011-07-14
TW201117813A (en) 2011-06-01
IL264055A (en) 2019-01-31
AU2010295445A1 (en) 2012-04-12

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