CN107260740A - N‑2‑羟基‑乙基‑哌嗪‑n’‑2‑乙磺酸(hepes) 在疼痛控制和脱髓鞘损伤逆转中的作用 - Google Patents

N‑2‑羟基‑乙基‑哌嗪‑n’‑2‑乙磺酸(hepes) 在疼痛控制和脱髓鞘损伤逆转中的作用 Download PDF

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Publication number
CN107260740A
CN107260740A CN201710494640.6A CN201710494640A CN107260740A CN 107260740 A CN107260740 A CN 107260740A CN 201710494640 A CN201710494640 A CN 201710494640A CN 107260740 A CN107260740 A CN 107260740A
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Prior art keywords
hepes
disease
cancer
administration
pain
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Chinese (zh)
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I·E·丹霍夫
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Biss F C Bioscience Ltd
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Biss F C Bioscience Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201710494640.6A 2009-09-17 2010-09-17 N‑2‑羟基‑乙基‑哌嗪‑n’‑2‑乙磺酸(hepes) 在疼痛控制和脱髓鞘损伤逆转中的作用 Pending CN107260740A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24346409P 2009-09-17 2009-09-17
US61/243464 2009-09-17
CN2010800521032A CN102612366A (zh) 2009-09-17 2010-09-17 N-2-羟基-乙基-哌嗪-n’-2-乙磺酸(hepes)在疼痛控制和脱髓鞘损伤逆转中的作用

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2010800521032A Division CN102612366A (zh) 2009-09-17 2010-09-17 N-2-羟基-乙基-哌嗪-n’-2-乙磺酸(hepes)在疼痛控制和脱髓鞘损伤逆转中的作用

Publications (1)

Publication Number Publication Date
CN107260740A true CN107260740A (zh) 2017-10-20

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Application Number Title Priority Date Filing Date
CN201710494640.6A Pending CN107260740A (zh) 2009-09-17 2010-09-17 N‑2‑羟基‑乙基‑哌嗪‑n’‑2‑乙磺酸(hepes) 在疼痛控制和脱髓鞘损伤逆转中的作用
CN201811365002.5A Pending CN109224077A (zh) 2009-09-17 2010-09-17 N-2-羟基-乙基-哌嗪-n’-2-乙磺酸在疼痛控制和脱髓鞘损伤逆转中的作用
CN201410166019.3A Pending CN103977405A (zh) 2009-09-17 2010-09-17 N-2-羟基-乙基-哌嗪-n’-2-乙磺酸(hepes)在疼痛控制和脱髓鞘损伤逆转中的作用
CN2010800521032A Pending CN102612366A (zh) 2009-09-17 2010-09-17 N-2-羟基-乙基-哌嗪-n’-2-乙磺酸(hepes)在疼痛控制和脱髓鞘损伤逆转中的作用

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CN201811365002.5A Pending CN109224077A (zh) 2009-09-17 2010-09-17 N-2-羟基-乙基-哌嗪-n’-2-乙磺酸在疼痛控制和脱髓鞘损伤逆转中的作用
CN201410166019.3A Pending CN103977405A (zh) 2009-09-17 2010-09-17 N-2-羟基-乙基-哌嗪-n’-2-乙磺酸(hepes)在疼痛控制和脱髓鞘损伤逆转中的作用
CN2010800521032A Pending CN102612366A (zh) 2009-09-17 2010-09-17 N-2-羟基-乙基-哌嗪-n’-2-乙磺酸(hepes)在疼痛控制和脱髓鞘损伤逆转中的作用

Country Status (18)

Country Link
US (4) US8883855B2 (enExample)
EP (3) EP2477626A4 (enExample)
JP (4) JP2013505264A (enExample)
KR (1) KR101737775B1 (enExample)
CN (4) CN107260740A (enExample)
AR (1) AR078290A1 (enExample)
AU (1) AU2010295445B2 (enExample)
BR (1) BR112012006155A2 (enExample)
CA (3) CA3122553A1 (enExample)
HK (1) HK1199621A1 (enExample)
IL (2) IL264055B2 (enExample)
IN (1) IN2012DN02499A (enExample)
MX (2) MX360190B (enExample)
MY (2) MY174012A (enExample)
NZ (1) NZ598861A (enExample)
SG (3) SG179191A1 (enExample)
TW (2) TWI494106B (enExample)
WO (1) WO2011035212A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY174012A (en) * 2009-09-17 2020-03-03 Bespoke Bioscience Llc Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury
CA2956919C (en) 2014-07-21 2022-07-19 Glia, Llc Method for treating radiotherapy- and chemotherapy-associated cognitive or emotional impairment with cannabinoids
CA2984379C (en) * 2015-04-28 2024-06-11 Newsouth Innovations Pty Limited Targeting nad+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies, and inactivity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071919A (en) * 1996-02-13 2000-06-06 T. Ronald Theodore Zwitterionic compositions and methods as biological response modifiers

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US5643562A (en) * 1993-03-29 1997-07-01 Queen's University Of Kingston Method for treating amyloidosis
US5840294A (en) * 1993-03-29 1998-11-24 Queen's University At Kingston Method for treating amyloidosis
WO1997002270A1 (de) 1995-07-06 1997-01-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Thiolsilane, verfahren zu deren herstellung und deren verwendung
NZ550199A (en) * 1998-02-11 2008-07-31 Bellus Health Int Ltd Treatment of inflammation, abeta-induced cell toxicity, neuronal cell death or neuronal cell loss in subjects suffering from alzheimer's disease
US9044478B2 (en) 2004-11-10 2015-06-02 Institut National De La Sante Et De La Recherche Medicale Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases
JP2010532331A (ja) * 2007-07-05 2010-10-07 アンセルム(アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル) 抗痙攣医薬組成物
EP2011491A1 (en) 2007-07-05 2009-01-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anticonvulsive pharmaceutical compositions
EP2163246A1 (en) * 2008-09-12 2010-03-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Taurine or taurine-like substances for the prevention of the irreversible visual effects of vigabatrin
US8709299B2 (en) 2009-09-04 2014-04-29 Basf Se Dye sensitised solar cell
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MY174012A (en) 2009-09-17 2020-03-03 Bespoke Bioscience Llc Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

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US6071919A (en) * 1996-02-13 2000-06-06 T. Ronald Theodore Zwitterionic compositions and methods as biological response modifiers

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IN2012DN02499A (enExample) 2015-08-28
US9867820B2 (en) 2018-01-16
US20190142825A1 (en) 2019-05-16
MX360190B (es) 2018-10-24
JP6347807B2 (ja) 2018-06-27
CA3122553A1 (en) 2011-03-24
SG10201500510YA (en) 2015-03-30
HK1199621A1 (en) 2015-07-10
KR101737775B1 (ko) 2017-05-19
EP2835133B1 (en) 2019-04-24
CA2774375C (en) 2018-02-13
AU2010295445B2 (en) 2014-09-25
CA2977918A1 (en) 2011-03-24
EP2477626A2 (en) 2012-07-25
JP2013505264A (ja) 2013-02-14
EP3520794A3 (en) 2019-11-20
TWI494106B (zh) 2015-08-01
EP2477626A4 (en) 2013-05-22
IL264055B1 (en) 2024-05-01
JP2015052006A (ja) 2015-03-19
CA2774375A1 (en) 2011-03-24
MY159626A (en) 2017-01-13
SG179191A1 (en) 2012-04-27
SG10202100421XA (en) 2021-02-25
CN103977405A (zh) 2014-08-13
MX2012003212A (es) 2012-09-07
CA2977918C (en) 2021-08-10
JP2015129150A (ja) 2015-07-16
AR078290A1 (es) 2011-10-26
WO2011035212A2 (en) 2011-03-24
EP2835133A1 (en) 2015-02-11
NZ598861A (en) 2013-01-25
IL218677A0 (en) 2012-05-31
US8883855B2 (en) 2014-11-11
CN102612366A (zh) 2012-07-25
JP5974062B2 (ja) 2016-08-23
TWI562777B (en) 2016-12-21
US20140378467A1 (en) 2014-12-25
IL264055B2 (en) 2024-09-01
CN109224077A (zh) 2019-01-18
KR20120081151A (ko) 2012-07-18
US20180028530A1 (en) 2018-02-01
EP3520794A2 (en) 2019-08-07
JP2016216493A (ja) 2016-12-22
US20110071157A1 (en) 2011-03-24
TW201440769A (zh) 2014-11-01
BR112012006155A2 (pt) 2016-06-28
IL218677B (en) 2019-01-31
US10213425B2 (en) 2019-02-26
MY174012A (en) 2020-03-03
WO2011035212A3 (en) 2011-07-14
TW201117813A (en) 2011-06-01
IL264055A (en) 2019-01-31
AU2010295445A1 (en) 2012-04-12

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