JP2013503203A5 - - Google Patents
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- JP2013503203A5 JP2013503203A5 JP2012527086A JP2012527086A JP2013503203A5 JP 2013503203 A5 JP2013503203 A5 JP 2013503203A5 JP 2012527086 A JP2012527086 A JP 2012527086A JP 2012527086 A JP2012527086 A JP 2012527086A JP 2013503203 A5 JP2013503203 A5 JP 2013503203A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- item
- betamethasone
- composition according
- weight percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 64
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 16
- 239000000194 fatty acid Substances 0.000 claims description 16
- 229930195729 fatty acid Natural products 0.000 claims description 16
- 239000003961 penetration enhancing agent Substances 0.000 claims description 15
- -1 fatty acid esters Chemical class 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 229920000642 polymer Polymers 0.000 claims description 12
- 239000003995 emulsifying agent Substances 0.000 claims description 10
- 229960002537 betamethasone Drugs 0.000 claims description 9
- 150000004665 fatty acids Chemical class 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 201000004681 Psoriasis Diseases 0.000 claims description 5
- 229960001102 betamethasone dipropionate Drugs 0.000 claims description 5
- CIWBQSYVNNPZIQ-XYWKZLDCSA-N betamethasone dipropionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CIWBQSYVNNPZIQ-XYWKZLDCSA-N 0.000 claims description 5
- 229960004311 betamethasone valerate Drugs 0.000 claims description 5
- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 150000003431 steroids Chemical class 0.000 claims description 5
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 4
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 4
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
- 229940100242 glycol stearate Drugs 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- 235000019198 oils Nutrition 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000012049 topical pharmaceutical composition Substances 0.000 claims description 4
- 150000003626 triacylglycerols Chemical class 0.000 claims description 4
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 4
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical compound COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 239000002280 amphoteric surfactant Substances 0.000 claims description 3
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 claims description 3
- 229960002593 desoximetasone Drugs 0.000 claims description 3
- VWVSBHGCDBMOOT-IIEHVVJPSA-N desoximetasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@@H]2O VWVSBHGCDBMOOT-IIEHVVJPSA-N 0.000 claims description 3
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 3
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims description 3
- 239000002480 mineral oil Substances 0.000 claims description 3
- 229960002744 mometasone furoate Drugs 0.000 claims description 3
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims description 3
- 229960002117 triamcinolone acetonide Drugs 0.000 claims description 3
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims description 3
- BDSYKGHYMJNPAB-LICBFIPMSA-N ulobetasol propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]2(C)C[C@@H]1O BDSYKGHYMJNPAB-LICBFIPMSA-N 0.000 claims description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 2
- NZJXADCEESMBPW-UHFFFAOYSA-N 1-methylsulfinyldecane Chemical compound CCCCCCCCCCS(C)=O NZJXADCEESMBPW-UHFFFAOYSA-N 0.000 claims description 2
- RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 claims description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 2
- 241000416162 Astragalus gummifer Species 0.000 claims description 2
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 2
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 201000004624 Dermatitis Diseases 0.000 claims description 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims description 2
- 206010015150 Erythema Diseases 0.000 claims description 2
- 206010015278 Erythrodermic psoriasis Diseases 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 239000005639 Lauric acid Substances 0.000 claims description 2
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims description 2
- 240000007472 Leucaena leucocephala Species 0.000 claims description 2
- 229920000161 Locust bean gum Polymers 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 2
- 239000005642 Oleic acid Substances 0.000 claims description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 229920001615 Tragacanth Polymers 0.000 claims description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 239000003945 anionic surfactant Substances 0.000 claims description 2
- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 208000010668 atopic eczema Diseases 0.000 claims description 2
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims description 2
- 229950000210 beclometasone dipropionate Drugs 0.000 claims description 2
- 229960000870 betamethasone benzoate Drugs 0.000 claims description 2
- SOQJPQZCPBDOMF-YCUXZELOSA-N betamethasone benzoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@@H]1C)C(=O)CO)C(=O)C1=CC=CC=C1 SOQJPQZCPBDOMF-YCUXZELOSA-N 0.000 claims description 2
- 229960005354 betamethasone sodium phosphate Drugs 0.000 claims description 2
- PLCQGRYPOISRTQ-LWCNAHDDSA-L betamethasone sodium phosphate Chemical compound [Na+].[Na+].C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COP([O-])([O-])=O)(O)[C@@]1(C)C[C@@H]2O PLCQGRYPOISRTQ-LWCNAHDDSA-L 0.000 claims description 2
- 239000003093 cationic surfactant Substances 0.000 claims description 2
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 229960004703 clobetasol propionate Drugs 0.000 claims description 2
- 208000010247 contact dermatitis Diseases 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- FZCHYNWYXKICIO-FZNHGJLXSA-N cortisol 17-valerate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O FZCHYNWYXKICIO-FZNHGJLXSA-N 0.000 claims description 2
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 claims description 2
- 125000006159 dianhydride group Chemical group 0.000 claims description 2
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- 231100000321 erythema Toxicity 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims description 2
- 229940093471 ethyl oleate Drugs 0.000 claims description 2
- 229960001347 fluocinolone acetonide Drugs 0.000 claims description 2
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims description 2
- 229960000289 fluticasone propionate Drugs 0.000 claims description 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
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- 229960002453 hydrocortisone aceponate Drugs 0.000 claims description 2
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- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
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Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2637447T3 (es) | 2009-08-31 | 2017-10-13 | Dr. Reddy's Laboratories Ltd. | Formulaciones tópicas que contienen un esteroide |
| EP2704687B1 (en) | 2011-05-04 | 2015-07-08 | Chiesi Farmaceutici S.p.A. | A topical formulation comprising a corticosteroid as active ingredient |
| US9861645B2 (en) * | 2012-12-28 | 2018-01-09 | Rak Holdings Llc | Anti-itch scalp treatment compositions and combinations |
| US20140275265A1 (en) * | 2013-03-12 | 2014-09-18 | Core Products International, Inc. | Therapeutic cream for application to skin |
| UA119324C2 (uk) * | 2013-04-02 | 2019-06-10 | Теміс Медікер Лімітед | Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні |
| AU2014326221A1 (en) * | 2013-09-25 | 2016-04-28 | Sun Pharmaceutical Industries Limited | Propellant-free topical spray composition of halobetasol |
| JP6487949B2 (ja) * | 2014-03-11 | 2019-03-20 | プロミウス ファーマ, エルエルシーPromius Pharma, Llc | 局所用コルチコステロイド組成物 |
| US20160184431A1 (en) * | 2014-03-11 | 2016-06-30 | Promius Pharma Llc | Topical compositions comprising a corticosteroid |
| WO2016157112A1 (en) * | 2015-03-31 | 2016-10-06 | Dr. Reddy’S Laboratories Limited | Topical spray compositions of mometasone furoate |
| JP7145363B2 (ja) * | 2015-11-23 | 2022-10-03 | グレイス セラピューティクス インコーポレイテッド | 局所皮膜形成スプレー |
| WO2017091168A1 (en) * | 2015-11-28 | 2017-06-01 | Pharmacti̇ve İlaç San. Ve Ti̇c. A.Ş. | A topical spray comprising isoconazole nitrate and difluocortolone valerate |
| US20170340649A1 (en) * | 2016-05-30 | 2017-11-30 | Sun Pharmaceutical Industries Limited | Topical aqueous spray compositions of halobetasol |
| WO2018020385A1 (en) * | 2016-07-27 | 2018-02-01 | Sun Pharmaceutical Industries Limited | Touch-free topical spray of halobetasol |
| EP3528818B1 (en) * | 2016-10-21 | 2021-09-15 | Crescita Therapeutics Inc. | Pharmaceutical compositions |
| EP3542788A1 (en) | 2018-03-19 | 2019-09-25 | MC2 Therapeutics Limited | Topical composition comprising calcipotriol and betamethasone dipropionate |
| WO2019224035A1 (en) | 2018-05-24 | 2019-11-28 | Almirall, S.A. | Topical pharmaceutical compositions comprising a corticosteroid |
| CN113271979A (zh) | 2018-10-24 | 2021-08-17 | 费灵有限公司 | 皮质类固醇的粘膜粘附性药物组合物 |
| EP3937905A4 (en) | 2019-03-14 | 2022-12-28 | Crescita Therapeutics Inc. | RINSING COMPOSITIONS AND THEIR USES FOR THE ADMINISTRATION OF ACTIVE AGENTS |
| US20210069214A1 (en) * | 2019-09-06 | 2021-03-11 | Encore Dermatology, Inc. | Topical compositions comprising a corticosteroid for the treatment of psoriasis in pediatric patients |
| CN111329834B (zh) * | 2020-04-27 | 2023-01-31 | 重庆华邦制药有限公司 | 一种含有二丙酸阿氯米松的乳膏制剂及其制备方法 |
| MX2023007547A (es) * | 2020-12-24 | 2023-08-10 | Lutris Pharma Ltd | Composiciones topicas inhibidoras de braf para el tratamiento de reacciones inducidas por efectores posteriores de egfr. |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3892856A (en) | 1974-04-10 | 1975-07-01 | Squibb & Sons Inc | Topical steroid formulation |
| US3934013A (en) | 1975-02-21 | 1976-01-20 | Syntex (U.S.A.) Inc. | Pharmaceutical composition |
| US4053089A (en) | 1975-08-01 | 1977-10-11 | Lever Brothers Company | Pump for dispensing liquids |
| US4343798A (en) | 1981-06-23 | 1982-08-10 | The Procter & Gamble Company | Topical antimicrobial anti-inflammatory compositions |
| US4552872A (en) | 1983-06-21 | 1985-11-12 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing corticosteroids |
| WO1991008733A1 (en) | 1989-12-20 | 1991-06-27 | Schering Corporation | Stable cream and lotion bases for lipophilic drug compositions |
| FR2656900B1 (fr) | 1990-01-10 | 1994-01-28 | Oreal | Pompe manuelle a precompression pour la pulverisation d'un liquide, notamment d'un parfum. |
| US5068099A (en) | 1990-01-16 | 1991-11-26 | S. C. Johnson & Son, Inc. | Hair spray package with low volatile organic compound emission |
| IT1247529B (it) | 1991-04-24 | 1994-12-17 | Poli Ind Chimica Spa | Composizioni farmaceutiche in forma di schiuma per somministrazione intravaginale, cutanea e orale |
| WO1994013257A1 (en) | 1992-12-16 | 1994-06-23 | Creative Products Resource Associates, Ltd. | Occlusive/semi-occlusive lotion for treatment of a skin disease or disorder |
| FR2715585B1 (fr) | 1994-01-28 | 1996-03-08 | Oreal | Ensemble de distribution d'un liquide, de façon quasi-continue, comportant une pompe et utilisation d'un tel ensemble pour la pulvérisation d'une laque capillaire. |
| US5976555A (en) | 1994-09-07 | 1999-11-02 | Johnson & Johnson Consumer Products, Inc. | Topical oil-in-water emulsions containing retinoids |
| ATE223202T1 (de) | 1994-09-30 | 2002-09-15 | Mika Pharma Ges Fuer Die Entwi | Pharmazeutische zusammensetzung |
| DE69530616T2 (de) * | 1994-11-10 | 2004-04-01 | Pfizer Inc. | Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung |
| GB9504265D0 (en) | 1995-03-03 | 1995-04-19 | Medeva Plc | Corticosteroid-containing pharmaceutical composition |
| US6158617A (en) | 1996-10-30 | 2000-12-12 | The Procter & Gamble Company | Concentrated reduced dosage spray pump delivery system |
| CN1254256A (zh) | 1997-03-24 | 2000-05-24 | 维微亚美国交易股份有限公司 | 稳定的固体细菌组合物 |
| KR20010013377A (ko) | 1997-06-04 | 2001-02-26 | 데이비드 엠 모이어 | 마일드한 잔류성 항균 조성물 |
| US6075056A (en) * | 1997-10-03 | 2000-06-13 | Penederm, Inc. | Antifungal/steroid topical compositions |
| US5972920A (en) * | 1998-02-12 | 1999-10-26 | Dermalogix Partners, Inc. | Formulation containing a carrier, active ingredient, and surfactant for treating skin disorders |
| AUPP310798A0 (en) | 1998-04-22 | 1998-05-14 | Soltec Research Pty Ltd | Vehicle system for a composition comprising a piperidinopyrimidine derivative |
| FR2761600B1 (fr) | 1998-06-19 | 2000-03-31 | Oreal | Composition moussante pour le lavage et le traitement des cheveux et/ou du cuir chevelu a base d'un principe actif, d'un tensioactif anionique, d'un tensioactif amphotere et d'un agent propenetrant |
| US6284234B1 (en) | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
| US6670144B1 (en) | 1999-02-26 | 2003-12-30 | Cyclacel, Ltd. | Compositions and methods for monitoring the phosphorylation of natural binding partners |
| US7393548B2 (en) | 1999-03-22 | 2008-07-01 | J.P. M.E.D. Ltd. | Nano oil in glycerin emulsion |
| US6962691B1 (en) | 1999-05-20 | 2005-11-08 | U & I Pharmaceuticals Ltd. | Topical spray compositions |
| US6479058B1 (en) | 1999-09-02 | 2002-11-12 | Mccadden Michael E. | Composition for the topical treatment of poison ivy and other forms of contact dermatitis |
| US6656928B1 (en) * | 1999-09-02 | 2003-12-02 | Mccadden Michael E. | Composition for the topical treatment of rashes, dermatoses and lesions |
| US6432415B1 (en) | 1999-12-17 | 2002-08-13 | Axrix Laboratories, Inc. | Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces |
| US7029694B2 (en) | 2000-04-26 | 2006-04-18 | Watson Laboratories, Inc. | Compositions and methods for transdermal oxybutynin therapy |
| US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| US6579512B2 (en) | 2001-06-15 | 2003-06-17 | Crutchfield, Iii Charles E. | Topical steroid spray |
| FR2830187B1 (fr) | 2001-09-28 | 2004-10-15 | Oreal | Emulsion ultrafine contenant un derive haloalkynylique |
| DE10154237A1 (de) | 2001-11-07 | 2003-05-15 | Steag Microparts Gmbh | Zerstäuber für manuelle Betätigung |
| EP1448231A1 (en) | 2001-11-19 | 2004-08-25 | Control Delivery Systems, Inc. | Topical delivery of codrugs |
| US6765001B2 (en) | 2001-12-21 | 2004-07-20 | Medicis Pharmaceutical Corporation | Compositions and methods for enhancing corticosteroid delivery |
| GB0217866D0 (en) | 2002-08-01 | 2002-09-11 | Steag Microparts Gmbh | Low dose spray pump |
| US20060018937A1 (en) | 2002-10-25 | 2006-01-26 | Foamix Ltd. | Steroid kit and foamable composition and uses thereof |
| US20080206161A1 (en) | 2002-10-25 | 2008-08-28 | Dov Tamarkin | Quiescent foamable compositions, steroids, kits and uses thereof |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| KR100720213B1 (ko) | 2003-04-04 | 2007-05-21 | 화이자 프로덕츠 인코포레이티드 | 미세 유동화된 수중 유적형 유화액 및 백신 조성물 |
| NZ544851A (en) | 2003-06-23 | 2008-03-28 | Macrochem Corp | A vanishing cream base composition suitable for topical administration of an active agent to an animal or plant |
| FR2856301B1 (fr) | 2003-06-23 | 2007-08-03 | Galderma Res & Dev | Composition sous forme de spray comprenant un actif pharmaceutique, au moins un silicone volatile et une phase non polaire non volatile |
| CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| GB0403702D0 (en) | 2004-02-19 | 2004-03-24 | Boots Co Plc | Skincare compositions |
| US20060099173A1 (en) | 2003-10-24 | 2006-05-11 | Nancy Puglia | Topical skin care composition |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| EP1744760B1 (en) * | 2004-04-22 | 2015-01-07 | AcuCort AB | Pharmaceutical compositions for acute glucocorticoid therapy |
| US20070189977A1 (en) * | 2004-06-07 | 2007-08-16 | Jie Zhang | Spray-on formulations and methods for dermal delivery of drugs |
| FR2871700B1 (fr) | 2004-06-17 | 2006-11-17 | Galderma Sa | Composition sous forme de spray comprenant une association d'actifs pharmaceutiques, une phase alcoolique, et une phase huileuse |
| FR2871697B1 (fr) | 2004-06-17 | 2007-06-29 | Galderma Sa | Composition sous forme de spray comprenant une association d'actifs pharmaceutiques, une phase alcoolique, au moins un silicone volatile et une phase huileuse non volatile |
| DE102004033524A1 (de) | 2004-07-10 | 2006-02-16 | Continental Aktiengesellschaft | Verfahren zur beladungsabhängigen Luftmengenregelung in einem Luftfedersystem |
| KR101243526B1 (ko) | 2004-08-31 | 2013-03-20 | 스티펠 리서치 오스트레일리아 피티와이 리미티드 | 마이크로에멀젼 및 서브마이크론 에멀젼 방법 및 조성물 |
| US20080275014A1 (en) | 2004-12-08 | 2008-11-06 | Galderma S.A. | Clobetasol Propionate Shampoos for the Treatment of Seborrheic Dermatitis of the Scalp |
| US20060246098A1 (en) | 2005-03-16 | 2006-11-02 | Srinivasa Rao | Stable aqueous-based emulsion formulation comprising urea and salicylic acid and method of using same |
| WO2006102004A2 (en) * | 2005-03-16 | 2006-09-28 | Taro Pharmaceuticals U.S.A., Inc. | A stable aqueous-based emulsion formulation comprising urea and salicylic acid and method of using same |
| FR2884419B1 (fr) | 2005-04-19 | 2007-06-22 | Galderma Sa | Composition de type solution filmogene comprenant de la vitamine d ou un de ses derives et un corticosteroide, et son utilisation en dermatologie |
| JP2008539236A (ja) | 2005-04-25 | 2008-11-13 | ドウ ファーマシューティカル サイエンシーズ | 乾癬を治療するためのクロベタゾールスプレー製剤の使用 |
| FR2889662B1 (fr) | 2005-08-11 | 2011-01-14 | Galderma Res & Dev | Emulsion de type huile-dans-eau pour application topique en dermatologie |
| AU2006286497A1 (en) | 2005-08-31 | 2007-03-08 | Serentis Limited | Use of an aureolysin inhibitor for the treatment of inflammatory skin conditions characterised by colonisation with Staphylococcus aureus |
| CN100370981C (zh) * | 2005-11-07 | 2008-02-27 | 上海第二医科大学附属瑞金医院 | 毛萼乙素在制药中的应用 |
| FR2893845B1 (fr) | 2005-11-30 | 2010-10-29 | Galderma Sa | Composition sous forme de spray comprenant un corticoide et une phase huileuse |
| AU2006326870A1 (en) | 2005-12-22 | 2007-06-28 | Apollo Life Sciences | Transdermal delivery of pharmaceutical agents |
| WO2007079466A2 (en) | 2006-01-04 | 2007-07-12 | Nano Mist International, Llc | Air driven delivery system for sprayable media |
| WO2007094605A1 (en) | 2006-02-14 | 2007-08-23 | Amorepacific Corporation | Topical preparation composition containing a thiourea derivative for preventing or treating pruritic or irritant skin diseases |
| EP1998742A2 (en) * | 2006-03-08 | 2008-12-10 | Nuviance, INC. | Transdermal drug delivery compositions and topical compositions for application on the skin |
| FR2898499B1 (fr) | 2006-03-15 | 2008-11-28 | Galderma Sa | Nouvelles compositions topiques sous forme d'emulsion h/e comprenant un glycol pro-penetrant |
| FR2898498B1 (fr) * | 2006-03-15 | 2008-11-28 | Galderma Sa | Nouvelles compositions topiques sous forme d'emulsion h/e comprenant un glycol pro-penetrant |
| AU2007249811A1 (en) | 2006-05-11 | 2007-11-22 | Avicena Group, Inc. | Creatine-ligand compounds and methods of use thereof |
| JP2010502690A (ja) | 2006-09-08 | 2010-01-28 | フォーミックス エルティーディー． | 有色または着色可能発泡性組成物 |
| GB2443161B (en) * | 2006-10-28 | 2011-03-23 | Nupharm Lab Ltd | Clobetasol spray |
| GB2443162B (en) * | 2006-10-28 | 2011-02-09 | Nupharm Lab Ltd | Betamethasone spray |
| EP2073794A2 (en) | 2006-11-14 | 2009-07-01 | Foamix Ltd. | Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses |
| AU2007332800A1 (en) * | 2006-12-07 | 2008-06-19 | Avicena Group, Inc. | Creatine compositions for skin treatment |
| EP1958613A1 (en) * | 2007-02-15 | 2008-08-20 | Polichem S.A. | Dermal film-forming liquid formulations for drug release to skin |
| EP2173169B1 (en) | 2007-06-28 | 2014-05-21 | CyDex Pharmaceuticals, Inc. | Nasal delivery of aqueous corticosteroid solutions |
| WO2009015456A1 (en) | 2007-07-30 | 2009-02-05 | Generex Pharmaceuticals Inc. | Pharmaceutical formulation in mixed micellar form and dispenser for oral delivery of agents as a spray |
| CA2698752A1 (en) | 2007-08-06 | 2009-02-12 | Insys Therapeutics Inc. | Oral cannabinoid liquid formulations and methods of treatment |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| RU2470645C2 (ru) | 2007-09-10 | 2012-12-27 | Гленмарк Фармасьютикалс Лимитед | Фармацевтическая композиция для местного применения, содержащая комбинацию фузидовой кислоты и кортикостероида |
| AR068409A1 (es) | 2007-09-14 | 2009-11-18 | Drugtech Corp | Composiciones farmaceuticas, transdermicas sin alcohol |
| US20090093547A1 (en) | 2007-10-09 | 2009-04-09 | Sciele Pharma, Inc. | Compositions and Methods for Treating Premature Ejaculation |
| US20090130029A1 (en) | 2007-11-21 | 2009-05-21 | Foamix Ltd. | Glycerol ethers vehicle and pharmaceutical compositions thereof |
| US20090136430A1 (en) * | 2007-11-27 | 2009-05-28 | Dugger Harry A | Antihistamine/Corticosteroid preparations for the treatment of atopic dermatitis |
| US20100249060A1 (en) | 2009-02-23 | 2010-09-30 | Smith Jan G | Topical formulation of low level clobetasol propionate for treating disorders of the skin and mucous membranes |
| US20120238535A1 (en) | 2009-02-23 | 2012-09-20 | Smith Jan G | Topical formulation of low level clobetasol propionate for treating disorders of the skin and mucous membranes |
| CN102438590B (zh) | 2009-02-25 | 2013-07-10 | 施泰福研究澳大利亚有限公司 | 局部泡沫组合物 |
| ES2637447T3 (es) | 2009-08-31 | 2017-10-13 | Dr. Reddy's Laboratories Ltd. | Formulaciones tópicas que contienen un esteroide |
| US10029013B2 (en) | 2009-10-02 | 2018-07-24 | Foamix Pharmaceuticals Ltd. | Surfactant-free, water-free formable composition and breakable foams and their uses |
| JP5865360B2 (ja) | 2010-06-11 | 2016-02-17 | プレシジョン ダーマトロジー インコーポレイテッドＰｒｅｃｉｓｉｏｎ Ｄｅｒｍａｔｏｌｏｇｙ， Ｉｎｃ． | 油分高濃度配合軟化性エアロゾル発泡組成物 |
| MX2013004296A (es) | 2010-10-21 | 2013-09-26 | Cadila Healthcare Ltd | Composiciones farmaceuticas topicas que contienen gotas de tamaño nanometrico para el tratamiento de soriasis. |
| EP2704687B1 (en) * | 2011-05-04 | 2015-07-08 | Chiesi Farmaceutici S.p.A. | A topical formulation comprising a corticosteroid as active ingredient |
| CN102526070A (zh) | 2012-01-04 | 2012-07-04 | 西北农林科技大学 | 一种复方联苯苄唑纳米乳喷剂及其制备方法 |
| CA2905587A1 (en) | 2013-03-15 | 2014-09-18 | Medicis Pharmaceutical Corporation | Topical compositions of flunisolide and methods of treatment |
| US10111956B2 (en) | 2013-06-03 | 2018-10-30 | Tolmar, Inc. | Corticosteroid compositions |
| AR096459A1 (es) | 2013-06-03 | 2015-12-30 | Tolmar Inc | Composiciones de corticosteroides y método de fabricación |
| US20160184431A1 (en) | 2014-03-11 | 2016-06-30 | Promius Pharma Llc | Topical compositions comprising a corticosteroid |
| JP6487949B2 (ja) | 2014-03-11 | 2019-03-20 | プロミウス ファーマ, エルエルシーPromius Pharma, Llc | 局所用コルチコステロイド組成物 |
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2010
- 2010-08-31 ES ES10812737.4T patent/ES2637447T3/es active Active
- 2010-08-31 US US13/391,972 patent/US9364485B2/en active Active
- 2010-08-31 WO PCT/US2010/047240 patent/WO2011026076A2/en not_active Ceased
- 2010-08-31 JP JP2012527086A patent/JP5833007B2/ja not_active Expired - Fee Related
- 2010-08-31 DK DK10812737.4T patent/DK2473161T3/en active
- 2010-08-31 EP EP10812737.4A patent/EP2473161B1/en active Active
- 2010-08-31 EP EP16195862.4A patent/EP3141246A1/en not_active Withdrawn
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2016
- 2016-04-21 US US15/135,259 patent/US9433630B1/en active Active
- 2016-04-21 US US15/135,298 patent/US9439911B2/en active Active
- 2016-08-02 US US15/226,684 patent/US9655907B2/en active Active
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2017
- 2017-04-24 US US15/495,148 patent/US9775851B1/en active Active
- 2017-08-30 US US15/690,851 patent/US9877974B2/en active Active
- 2017-12-15 US US15/843,590 patent/US9956231B1/en active Active
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2018
- 2018-03-22 US US15/928,332 patent/US10064875B2/en active Active
- 2018-08-03 US US16/054,353 patent/US10179137B2/en active Active
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2019
- 2019-01-08 US US16/242,562 patent/US10588914B2/en active Active
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2020
- 2020-01-29 US US16/775,676 patent/US10905697B2/en not_active Expired - Fee Related
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2021
- 2021-01-07 US US17/143,648 patent/US20210386758A1/en not_active Abandoned
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