JP2013503198A5 - - Google Patents

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Publication number
JP2013503198A5
JP2013503198A5 JP2012527053A JP2012527053A JP2013503198A5 JP 2013503198 A5 JP2013503198 A5 JP 2013503198A5 JP 2012527053 A JP2012527053 A JP 2012527053A JP 2012527053 A JP2012527053 A JP 2012527053A JP 2013503198 A5 JP2013503198 A5 JP 2013503198A5
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JP
Japan
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seq
rbd
oct4
sox2
sequence
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JP2012527053A
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English (en)
Japanese (ja)
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JP2013503198A (ja
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Priority claimed from PCT/US2010/047056 external-priority patent/WO2011031568A2/en
Publication of JP2013503198A publication Critical patent/JP2013503198A/ja
Publication of JP2013503198A5 publication Critical patent/JP2013503198A5/ja
Withdrawn legal-status Critical Current

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JP2012527053A 2009-08-27 2010-08-27 人工多能性幹（ｉＰＳ）細胞または組織特異的細胞を誘導するための新規タンパク質送達系 Withdrawn JP2013503198A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27529709P 2009-08-27 2009-08-27
US61/275,297 2009-08-27
PCT/US2010/047056 WO2011031568A2 (en) 2009-08-27 2010-08-27 A NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS

Publications (2)

Publication Number Publication Date
JP2013503198A JP2013503198A (ja) 2013-01-31
JP2013503198A5 true JP2013503198A5 (enExample) 2013-04-04

Family

ID=43625491

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012527053A Withdrawn JP2013503198A (ja) 2009-08-27 2010-08-27 人工多能性幹（ｉＰＳ）細胞または組織特異的細胞を誘導するための新規タンパク質送達系

Country Status (7)

Country Link
US (2) US8420352B2 (enExample)
EP (1) EP2470664A4 (enExample)
JP (1) JP2013503198A (enExample)
KR (1) KR20120061053A (enExample)
CN (1) CN102612562A (enExample)
CA (1) CA2772400A1 (enExample)
WO (1) WO2011031568A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011031568A2 (en) * 2009-08-27 2011-03-17 Synaptic Research, Llc A NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS
US9410128B2 (en) * 2011-02-22 2016-08-09 Sanford-Burnham Medical Research Institute Method and compounds for generation of iPSCs
TWI815599B (zh) 2011-04-22 2023-09-11 美商惠氏有限責任公司 與難養芽胞梭菌（Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅ）之突變毒素有關之組成物及彼之方法
ES2653249T3 (es) * 2011-09-29 2018-02-06 Cellsnap, Llc Composiciones y métodos para ensayos de toxigenicidad
WO2013084071A2 (en) 2011-12-08 2013-06-13 Novartis Ag Clostridium difficile toxin-based vaccine
AR089797A1 (es) * 2012-01-27 2014-09-17 Merck Sharp & Dohme Vacunas contra clostridum difficile que comprenden toxinas recombinantes
US8986704B2 (en) 2012-07-06 2015-03-24 Valneva Austria Gmbh Mutant fragments of OspA and methods and uses relating thereto
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
US9493518B2 (en) * 2013-03-14 2016-11-15 National Health Research Institutes Compositions and methods for treating clostridium difficile-associated diseases
AU2014301116B2 (en) 2013-06-28 2019-11-14 Merz Pharma Gmbh & Co. Kgaa Means and methods for the determination of the biological activity of Neurotoxin polypeptides in cells
KR20170020431A (ko) 2014-06-27 2017-02-22 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 변이형 헤마글루티닌 복합체 단백질, 및 그것을 사용한 다능성을 갖는 간세포의 배양 방법
US10633643B2 (en) 2015-05-15 2020-04-28 Board Of Regents Of The University Of Nebraska Engineered Clostridium botulinum toxin adapted to deliver molecules into selected cells
US12018054B2 (en) 2017-04-13 2024-06-25 Valneva Austria Gmbh Multivalent OspA polypeptides and methods and uses relating thereto
WO2020055915A1 (en) 2018-09-10 2020-03-19 Kavazanjian Edward Biocementation systems and methods
CA3174599A1 (en) * 2020-04-09 2021-10-14 Robert Schlegl Improvements in vaccine formulations for medical use
EP4132950A1 (en) 2020-04-09 2023-02-15 Valneva Austria GmbH Compositions comprising three ospa fusion proteins for medical use
WO2021255690A2 (en) 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
CN113563428B (zh) * 2021-06-22 2022-08-02 呈诺再生医学科技(珠海横琴新区)有限公司 特定空间结构多肽及其在制备iPSC中的应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6086900A (en) 1997-03-26 2000-07-11 Board Of Regents, The University Of Texas Systems Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes
US6054312A (en) 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors
EP1173192B1 (en) 1999-03-08 2018-08-15 Gerhart Graupner Methods and compositions for targeted drug delivery
WO2001011960A1 (en) 1999-08-18 2001-02-22 Agrivax, Inc. A mucosal specific gene delivery system based on modified bacterial exotoxin
US7906103B2 (en) 2000-03-08 2011-03-15 Gerhard Graupner Methods and compositions for targeted drug delivery
US20030166160A1 (en) 2001-09-06 2003-09-04 Hawley Stephen B. Compounds and molecular complexes comprising multiple binding regions directed to transcytotic ligands
IL155204A0 (en) 2000-10-02 2003-11-23 Arizeke Pharmaceuticals Inc Compositions and methods for the transport of biologically active agents across cellular barriers
CA2367636C (en) 2001-04-12 2010-05-04 Lisa Mckerracher Fusion proteins
EP1531859A4 (en) 2002-05-31 2005-12-07 Univ Jefferson COMPOSITIONS AND METHODS FOR TRANSEPITHELIAL MOLECULAR TRANSPORT
GB0216865D0 (en) 2002-07-19 2002-08-28 Microbiological Res Authority Targetted agents for nerve regeneration
WO2004069159A2 (en) 2003-01-27 2004-08-19 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
US20090203141A1 (en) 2003-05-15 2009-08-13 Shi-Lung Lin Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant RNA agents
US20050147593A1 (en) 2003-05-22 2005-07-07 Medimmune, Inc. EphA2, EphA4 and LMW-PTP and methods of treatment of hyperproliferative cell disorders
GB0321344D0 (en) 2003-09-11 2003-10-15 Health Prot Agency Re-targeted toxin conjugates
US20050153923A1 (en) 2003-12-04 2005-07-14 Kinch Michael S. Targeted drug delivery using EphA2 or EphA4 binding moieties
TW200640493A (en) 2005-02-16 2006-12-01 Insert Therapeutics Inc Cyclodextrin-based polymers for therapeutics delivery
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
CN105861443A (zh) 2007-04-07 2016-08-17 怀特黑德生物医学研究所 体细胞重编程
EP2164951A2 (en) * 2007-05-30 2010-03-24 The General Hospital Corporation Methods of generating pluripotent cells from somatic cells
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
WO2009009441A2 (en) 2007-07-06 2009-01-15 Cedars-Sinai Medical Center Self-assembling complex for targeting chemical agents to cells
WO2009032456A2 (en) 2007-08-01 2009-03-12 Primegen Biotech Llc Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
WO2009073523A2 (en) 2007-11-29 2009-06-11 Children's Hospital Of Orange County De-differentiation of human cells
EP2224940A1 (en) 2007-11-30 2010-09-08 Cytomatrix PTY LTD Methods of inducing pluripotency involving oct4 protein
US20110190729A1 (en) 2007-11-30 2011-08-04 Cytomatrix Pty Ltd Methods of inducing pluripotency involving sox2 protein
WO2009102983A2 (en) 2008-02-15 2009-08-20 President And Fellows Of Harvard College Efficient induction of pluripotent stem cells using small molecule compounds
CN101550406B (zh) 2008-04-03 2016-02-10 北京大学 制备多潜能干细胞的方法,试剂盒及用途
CA2695590C (en) 2008-06-27 2018-01-09 Kyoto University Method of efficiently establishing induced pluripotent stem cells
EP2307539B1 (en) 2008-07-30 2014-11-19 Kyoto University Method of efficiently establishing induced pluripotent stem cells
CN102272290B (zh) 2008-10-09 2018-08-14 米纳瓦生物技术公司 用于在细胞中诱导多能性的方法
JP2012507258A (ja) 2008-10-30 2012-03-29 国立大学法人京都大学 人工多能性幹細胞の作製方法
WO2011031568A2 (en) * 2009-08-27 2011-03-17 Synaptic Research, Llc A NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS

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