JP2013199477A - シアニン骨格を有する疎水性色素含有粒子、及びそれを有する造影剤 - Google Patents

シアニン骨格を有する疎水性色素含有粒子、及びそれを有する造影剤 Download PDF

Info

Publication number
JP2013199477A
JP2013199477A JP2013033639A JP2013033639A JP2013199477A JP 2013199477 A JP2013199477 A JP 2013199477A JP 2013033639 A JP2013033639 A JP 2013033639A JP 2013033639 A JP2013033639 A JP 2013033639A JP 2013199477 A JP2013199477 A JP 2013199477A
Authority
JP
Japan
Prior art keywords
group
halogen atom
chemical formula
acetoxy
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013033639A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013199477A5 (https=
Inventor
Shige Fukui
樹 福井
Fumiko Tomatsu
史子 戸松
Kengo Kanezaki
健吾 金崎
Satoshi Yuasa
聡 湯浅
Mayuko Kishi
麻裕子 岸
Daisuke Sasakuri
大助 笹栗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Canon Inc
Original Assignee
Canon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canon Inc filed Critical Canon Inc
Priority to JP2013033639A priority Critical patent/JP2013199477A/ja
Publication of JP2013199477A publication Critical patent/JP2013199477A/ja
Publication of JP2013199477A5 publication Critical patent/JP2013199477A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2013033639A 2012-02-23 2013-02-22 シアニン骨格を有する疎水性色素含有粒子、及びそれを有する造影剤 Pending JP2013199477A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013033639A JP2013199477A (ja) 2012-02-23 2013-02-22 シアニン骨格を有する疎水性色素含有粒子、及びそれを有する造影剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012038035 2012-02-23
JP2012038035 2012-02-23
JP2013033639A JP2013199477A (ja) 2012-02-23 2013-02-22 シアニン骨格を有する疎水性色素含有粒子、及びそれを有する造影剤

Publications (2)

Publication Number Publication Date
JP2013199477A true JP2013199477A (ja) 2013-10-03
JP2013199477A5 JP2013199477A5 (https=) 2016-04-07

Family

ID=49003100

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013033639A Pending JP2013199477A (ja) 2012-02-23 2013-02-22 シアニン骨格を有する疎水性色素含有粒子、及びそれを有する造影剤

Country Status (2)

Country Link
US (1) US9138492B2 (https=)
JP (1) JP2013199477A (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017503004A (ja) * 2013-10-31 2017-01-26 ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド 近赤外蛍光造影バイオイメージング剤及びその使用方法
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
JP2021512748A (ja) * 2018-01-26 2021-05-20 ユニヴェルシテ・ドゥ・ストラスブールＵｎｉｖｅｒｓｉｔｅ Ｄｅ Ｓｔｒａｓｂｏｕｒｇ 医療機器用蛍光ポリマーコーティングフィルム
US12440585B2 (en) 2023-09-12 2025-10-14 Curadel Surgical Innovations, Inc. Zwitterionic metal chelators

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104470546B (zh) 2012-07-20 2018-02-27 佳能株式会社 化合物和含有所述化合物的光声成像造影剂
US9517278B2 (en) 2012-07-20 2016-12-13 Canon Kabushiki Kaisha Compound and photoacoustic imaging contrast medium containing the compound
US9675715B2 (en) 2012-07-20 2017-06-13 Canon Kabushiki Kaisha Contrast agent for photoacoustic imaging
US10245329B2 (en) 2014-09-08 2019-04-02 Canon Kabushiki Kaisha Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same
WO2016060277A1 (en) 2014-10-16 2016-04-21 Canon Kabushiki Kaisha Polymer, and contrast agent for photoacoustic imaging, including the polymer
US10398788B2 (en) 2014-10-24 2019-09-03 Canon Kabushiki Kaisha Polymer and contrast agent for photoacoustic imaging including the polymer
JP6552236B2 (ja) 2015-03-23 2019-07-31 キヤノン株式会社 近赤外色素結合トランスフェリン、前記近赤外色素結合トランスフェリンを有する光音響イメージング用造影剤
JP2017002000A (ja) * 2015-06-12 2017-01-05 キヤノン株式会社 化合物又はその薬学的に受容可能な塩、及び、前記化合物又はその薬学的に受容可能な塩を有する光音響イメージング用造影剤。
JP6789636B2 (ja) 2015-09-30 2020-11-25 キヤノン株式会社 重合体、前記重合体を有する光音響イメージング用造影剤
JP6752582B2 (ja) 2016-02-08 2020-09-09 キヤノン株式会社 光音響イメージング用造影剤
US20180200389A1 (en) * 2016-12-09 2018-07-19 The Johns Hopkins University Photoacoustic voltage-sensitive dyes for in vivo imaging
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
CN109529061A (zh) * 2018-11-29 2019-03-29 南方医科大学 脂肪乳剂作为光声成像造影剂的用途
WO2024041984A1 (en) * 2022-08-22 2024-02-29 Agfa-Gevaert Nv Near infrared and red light absorbing composite resin particles

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05501264A (ja) * 1989-10-20 1993-03-11 シキュース　ファーマシューティカルズ，インコーポレイテッド 充実性腫瘍治療法及び組成物
JP2003520868A (ja) * 2000-01-18 2003-07-08 マリンクロッド・インコーポレイテッド 造影用のデンドリマー前駆体染料
JP2011184329A (ja) * 2010-03-05 2011-09-22 Canon Inc 化合物及び前記化合物を有する粒子及び前記粒子を有する造影剤
JP2012012377A (ja) * 2009-10-05 2012-01-19 Canon Inc 光音響イメージング用造影剤及び前記光音響イメージング用造影剤を用いた光音響イメージング方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19539409C2 (de) 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
GB9710049D0 (en) 1997-05-19 1997-07-09 Nycomed Imaging As Method
GB9712525D0 (en) 1997-06-16 1997-08-20 Nycomed Imaging As Method
US6190641B1 (en) 2000-01-18 2001-02-20 Mallinckrodt Inc. Indocyanine dyes
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US20100034748A1 (en) 2008-08-07 2010-02-11 Guizhi Li Molecular imaging probes based on loaded reactive nano-scale latex
US20080181965A1 (en) 2006-04-10 2008-07-31 Leon Jeffrey W Loaded latex optical molecular imaging probes
US20120052017A1 (en) 2010-08-24 2012-03-01 Canon Kabushiki Kaisha Method for producing contrast agent for optical imaging
US20120052011A1 (en) 2010-08-24 2012-03-01 Canon Kabushiki Kaisha Composition and a method for producing contrast agent using the composition
US8753608B2 (en) 2010-08-24 2014-06-17 Canon Kabushiki Kaisha Complex and contrast agent for photoimaging using the same
WO2012032524A1 (en) * 2010-09-09 2012-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Near infrared fluorescent particles and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05501264A (ja) * 1989-10-20 1993-03-11 シキュース　ファーマシューティカルズ，インコーポレイテッド 充実性腫瘍治療法及び組成物
JP2003520868A (ja) * 2000-01-18 2003-07-08 マリンクロッド・インコーポレイテッド 造影用のデンドリマー前駆体染料
JP2012012377A (ja) * 2009-10-05 2012-01-19 Canon Inc 光音響イメージング用造影剤及び前記光音響イメージング用造影剤を用いた光音響イメージング方法
JP2011184329A (ja) * 2010-03-05 2011-09-22 Canon Inc 化合物及び前記化合物を有する粒子及び前記粒子を有する造影剤

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOELECTROCHEMISTRY, vol. Vol.87, JPN6016045431, 4 November 2011 (2011-11-04), pages 147 - 153 *
機能性ＤＤＳキャリアの製剤設計, JPN6016045433, 2008, pages p.75 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017503004A (ja) * 2013-10-31 2017-01-26 ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド 近赤外蛍光造影バイオイメージング剤及びその使用方法
JP2020138974A (ja) * 2013-10-31 2020-09-03 ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド 近赤外蛍光造影バイオイメージング剤及びその使用方法
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
US11077210B2 (en) 2013-10-31 2021-08-03 Beth Israel Deaconess Medical Center Near-infrared fluorescent contrast bioimaging agents and methods of use thereof
JP7023604B2 (ja) 2013-10-31 2022-02-22 ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド 近赤外蛍光造影バイオイメージング剤及びその使用方法
JP2021512748A (ja) * 2018-01-26 2021-05-20 ユニヴェルシテ・ドゥ・ストラスブールＵｎｉｖｅｒｓｉｔｅ Ｄｅ Ｓｔｒａｓｂｏｕｒｇ 医療機器用蛍光ポリマーコーティングフィルム
JP7423547B2 (ja) 2018-01-26 2024-01-29 ユニヴェルシテ・ドゥ・ストラスブール 医療機器用蛍光ポリマーコーティングフィルム
US12440585B2 (en) 2023-09-12 2025-10-14 Curadel Surgical Innovations, Inc. Zwitterionic metal chelators

Also Published As

Publication number Publication date
US9138492B2 (en) 2015-09-22
US20130224121A1 (en) 2013-08-29

Similar Documents

Publication Publication Date Title
JP2013199477A (ja) シアニン骨格を有する疎水性色素含有粒子、及びそれを有する造影剤
Wang et al. Photoacoustic/ultrasound dual-modality contrast agent and its application to thermotherapy
An et al. Aggregation-induced near-infrared absorption of squaraine dye in an albumin nanocomplex for photoacoustic tomography in vivo
Zhang et al. Mitochondria‐targeting IR‐780 dye and its derivatives: synthesis, mechanisms of action, and theranostic applications
Qin et al. Fluorescence quenching nanoprobes dedicated to in vivo photoacoustic imaging and high‐efficient tumor therapy in deep‐seated tissue
Nguyen et al. Gold nanorod enhanced photoacoustic microscopy and optical coherence tomography of choroidal neovascularization
JP5564427B2 (ja) ナノ粒子製剤に基づく光学イメージング用診断物質
CN109453398B (zh) 一种介孔聚多巴胺包载液态氟碳类超声造影剂及其制备方法
Liu et al. Biocompatible croconaine aggregates with strong 1.2–1.3 μm absorption for NIR-IIa photoacoustic imaging in vivo
Filippi et al. Indocyanine green labeling for optical and photoacoustic imaging of mesenchymal stem cells after in vivo transplantation
Ma et al. Oxygen and indocyanine green loaded microparticles for dual-mode imaging and sonodynamic treatment of cancer cells
Li et al. Conjugated polymer nanoparticles for tumor theranostics
Avigo et al. Enhanced photoacoustic signal of passion fruit-like nanoarchitectures in a biological environment
US20110081294A1 (en) Contrast agent for photoacoustic imaging and photoacoustic imaging method
Lu et al. Irradiation induced fluorescence enhancement in PEGylated cyanine-based NIR nano-and mesoscale GUMBOS
Ueya et al. Design of over-1000 nm near-infrared fluorescent polymeric micellar nanoparticles by matching the solubility parameter of the core polymer and dye
CN113735839B (zh) 二氢呫吨/苯并[cd]吲哚杂合物荧光探针及其制备方法与应用
US8974830B2 (en) Particles and contrast agent including the same for optical imaging
JP2015044790A (ja) フタロシアニン系色素含有光音響イメージング用造影剤
Yu et al. Multifunctional cancer phototherapy using fluorophore-functionalized nanodiamond supraparticles
Umezawa et al. Heat treatment effects for controlling dye molecular states in the hydrophobic core of over-1000 nm near-infrared (NIR-II) fluorescent micellar nanoparticles
JP2015028001A (ja) シリコンナフタロシアニン類縁体を含有する脂質粒子を有する光音響造影剤
Matsuura et al. NIR-II-Excitable Dye-Loaded Nanoemulsions for Two-Photon Microscopy Imaging of Capillary Blood Vessels in the Entire Hippocampal CA1 Region of Living Mice
JP2013224289A (ja) 粒子及び前記粒子を有する光音響イメージング用造影剤、センチネルリンパ節用造影剤
Xu et al. Multifunctional theragnostic ultrasmall gold nanodot-encapsuled perfluorocarbon nanodroplets for laser-focused ultrasound sequence irradiation (LFSI)-based enhanced tumor ablation

Legal Events

Date Code Title Description
RD05 Notification of revocation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7425

Effective date: 20130701

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160219

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160219

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161129

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170530