JP2013134062A - Recovery system for 99mtc - Google Patents

Abstract

PROBLEM TO BE SOLVED: To recoverTc with high concentration by dealing with needs for the efficient recovery ofTc fromMo generated by a neutron method.SOLUTION: In a recovery system forTc, an AC column unit, a waste liquid tank and an AL column unit are incorporated while being shielded with a shielding material. The AC column unit includes a cassette type activated carbon (AC) column which incorporates an activated carbon, in which a high-concentration Mo solution is dipped andMo is adsorbed to the activated carbon, and which adsorbsTc and is removed each timeTc is eluted. The waste liquid tank is connected to the AC column unit via connection piping and stores aMo waste liquid therein in the case where the adsorbedMo is desorbed by a desorption liquid. The AL column unit purifies and prepares the recoveredTc solution. The waste liquid tank and the AL column unit are connected to a pressure reduction line having a pressure reduction source, theMo solution stored in a Mo tank is transferred to the AC column unit through a pressure reduction operation of the pressure reduction source, and the desorbed liquid ofMo from the AC column unit is transferred to the waste liquid tank.

Description

The present invention relates to a ^99m Tc recovery apparatus, that is, an apparatus for recovering ^99m Tc produced by the decay of ⁹⁹ Mo.

Technetium 99m ( ^99m Tc) is used as a radioactive tracer for detection in medical devices. ^99m Tc emits easily detectable gamma rays and has a half-life of 6 hours. ^99m Tc is used for imaging the brain, myocardium, thyroid gland, liver, gallbladder, kidney, skeleton, blood, and tumor.

^{The 99m} Tc generator is an apparatus used in extracting ^99m Tc from decaying molybdenum 99 ( ⁹⁹ Mo).

Patent Document 1 describes that ^99m Tc removal from a generator is usually performed every 6 hours or twice a day, ⁹⁹ Mo is adsorbed on alumina, and physiological saline is applied to a fixed column of ⁹⁹ Mo. It is described that ^99m Tc is eluted by circulation.

Patent Document 2 describes that the formed high-concentration Mo ( ⁹⁹ Mo) solution is passed through an adsorption column containing activated carbon to selectively adsorb ^99m Tc to the activated carbon.

Patent Document 3 describes that ^99m Tc is separated from ⁹⁹ Mo using a reusable and replaceable cassette.

JP 2008-139272 A JP 2011-2370 A US Pat. No. 7,586.102

^99m Tc recovery method described in Patent Document 1, instead of using the ⁹⁹ Mo produced by the neutron method, uses a ⁹⁹ Mo produced by the fission process, ⁹⁹ Mo produced by the neutron method To meet the need for efficient recovery of ^99m Tc.

As described in Patent Document 2, a high-concentration Mo solution produced by dissolving a radionuclide ⁹⁹ Mo of a parent nuclide produced by irradiating neutrons by a neutron method, the daughter nuclide produced it has become necessary that the ^99m Tc from a high concentration Mo solution containing recovering ^99m Tc.

Patent Document 2 describes the use of a cassette that is reusable and replaceable, but cannot meet the needs of generating ⁹⁹ Mo by neutron method and recovering ^99m Tc.

Patent Document 3 describes that ⁹⁹ Mo is generated by neutron method and ^99m Tc is recovered, but the generator device is transferred to a medical institution and is suitable for highly concentrated recovery of ^99m Tc in a hospital. No mention is made of suitable for ^99m Tc recovery and making the transfer safe and easy.

The present invention is, in view of the above corresponds to the needs of recovering efficiently ^99m Tc from ⁹⁹ Mo produced by the neutron method, and then transferring the generator device as ^99m Tc recovery device for medical ^99m Tc It is suitable for highly concentrated collection and aims to make transportation safe and easy.

The present invention comprises a movable box,
A Mo tank for storing a high-concentration Mo solution produced by dissolving the parent nuclide radionuclide ⁹⁹ Mo produced by neutron irradiation in the box and containing the daughter nuclide radionuclide ^99m Tc; It is possible to detach from the connection part connected to the tank, is connected to the Mo tank, contains activated carbon, and adsorbs ^99m Tc by bringing the high-concentration Mo solution into contact with activated carbon in the activated carbon column, and activated charcoal column unit with activated charcoal column of a cassette type which is replaced every ^{99m Tc} elution, it is connected via a connecting pipe to the activated carbon column unit, ⁹⁹ Mo when the ^{99 Mo} remaining in the activated carbon column was leached in the washing solution a waste liquid tank for storing waste liquid, are connected via the other connecting pipe to the activated carbon column unit, when eluted adsorbed ^{99m Tc} in the eluate The ^{99m Tc} solution was collected, and the alumina column unit for purifying adjust recovered recovered ^{99m Tc} solution is shielded by the shielding material is embedded is sectioning,
The waste liquid tank and the alumina column unit are connected to a vacuum line having a vacuum source, and the high-concentration solution stored in the Mo tank is transferred to the activated carbon column unit by a vacuum operation, and the activated carbon column unit A ^99m Tc recovery device is provided, wherein ⁹⁹ Mo cleaning liquid is transferred to the waste liquid tank, and ^99m Tc solution recovered from the activated carbon column unit is transferred to the AL cassette unit.

The present invention also includes an opening / closing door on the one side of the box, and the alumina column unit described above is in the front upper chamber which is the opening / closing door, the AC column unit is in the front lower chamber, A ^99m Tc recovery device is provided, characterized in that a waste liquid tank is disposed in a back side upper chamber, and the Mo tank is disposed in a back side lower chamber.

The present invention is also the alumina column unit described above, a control tank for liquid adjusted eluting adjusted solution, and an alumina column to purify the recovered ^{99m Tc} solution, ^{99m Tc} recovery tank for collecting the purified ^{99m Tc} solution The purification tank and the purification column are connected to a vacuum line having a vacuum source, and the recovered ^99m Tc solution adjusted in the adjustment tank is transferred to the purification column by a vacuum operation of the vacuum source, Provided is a ^99m Tc recovery device, wherein the purified ^99m Tc solution is recovered in the ^99m Tc recovery container.

The present invention also includes a moving part formed of the movable box described above and a stationary part integrated therewith, and the decompression source, the AC cassette unit and the AL cassette are installed in the stationary part. A ^99m Tc recovery device is provided that includes a reagent supply unit that supplies the unit.

The present invention also provides a ^99m Tc recovery device, wherein the activated carbon column unit described above includes a column operation desorption device that desorbs a constituent AC column from a connection portion connected to the Mo tank. To do.

Since the present invention is configured as described above, the ^99m Tc recovery device as a generator device can be used as a generator device in a medical institution capable of meeting the need to efficiently recover ^99m Tc from ⁹⁹ Mo generated by the neutron method. ^99m Tc can be safely concentrated and recovered, and the apparatus can be transported safely and easily.

The side view which shows the structure of the Example of this invention. The top view of the Example of this invention. Side surface sectional drawing of the Example of this invention. Sectional drawing which shows each cross section of FIG. Sectional drawing which shows the method of operation of a column operation desorption apparatus. Sectional drawing from the upper surface of FIG. The figure which shows the structure of a column operation desorption apparatus. The figure which shows the operation state of a column operation desorption apparatus. The figure which shows arrangement | positioning and connection of piping of the Example of this invention.

  Embodiments of the present invention will be described below with reference to the drawings.

1 and 2 are views showing the appearance of a ^99m Tc recovery device (generator device) according to an embodiment of the present invention. FIG. 1 shows a side view, FIG. 2 shows a top view, and FIG. 1B shows the main body 200 of the ^99m Tc recovery device 100, FIG. 1B shows the transfer section main body 300, FIG. 1C shows the stationary main body 400, and FIG. 2A shows the main body 200 of FIG. 2B shows the top surface of FIG. 1B, and FIG. 2C shows the top surface of FIG. 1C.

As shown in FIGS. 1 and 2, the ^99m Tc recovery device 100 includes a movable main body 200. The main body 200 includes a transfer unit main body 300 and a stationary unit main body 400, and the transfer unit main body 300 and the stationary unit main body 400 can be coupled and detached. When combined, they are integrated and divided into two parts by desorption. The transfer unit main body 300 can be transferred, and can be easily carried into and out of a hospital as a medical institution. The stationary part main body 400 is usually fixedly installed in a hospital. The transfer part main body 300 and the stationary part main body 400 are combined to form a ^99m Tc recovery device 100.

3 is a side cross-sectional view showing a state in which various devices are arranged inside the ^99m Tc recovery apparatus 100, and FIG. 3 (a) is a side cross-sectional view showing a state in which various devices are arranged inside the main body 200. 3 and FIG. 3B are side sectional views showing a state in which various devices are arranged inside the transfer unit 300, and FIG. 3C is a state in which various devices are arranged inside and outside the stationary unit 400. FIG. 4A and 4B show cross sections in the planes A, B, and C of FIG. 3A, FIG. 4A is a cross-sectional view of the A plane, and FIG. 4C is a cross-sectional view of the stationary B surface, and FIG. 4D is a cross-sectional view of the C surface. In these drawings, the transfer unit main body 300 is a unit for storing and operating radioactive substances, in which the ^99m Tc solution is recovered from the Mo solution, and the recovered solution is adjusted and purified. The parent nuclide radionuclide ⁹⁹ Mo is produced by neutron irradiation by the neutron irradiation method, and ⁹⁹ Mo is dissolved to produce a high concentration Mo solution. This high-concentration Mo solution contains the daughter nuclide ^99m Tc produced by the decay of ⁹⁹ Mo, and its concentration is extremely low.

The transfer unit main body 300 stores therein a Mo tank unit 11, a generator including an AC (activated carbon) column unit 12, an AL (alumina) column unit 13, and a waste liquid tank 14. The ^99m Tc solution, which is a product, is temporarily stored in the AL column unit 13 and is taken out from this during use.

  The moving unit 300 includes a box 1, a wheel 2 is attached to the box 1, is movable, is divided into upper and lower chambers to store these devices, and is on the front side (left side in the figure) of the upper chamber. Further, the AL column unit 13 is disposed, the waste liquid tank 14 is disposed on the back side of the upper chamber, the AC column unit 12 is disposed on the front side of the lower chamber, and the Mo tank unit 11 is disposed on the back side of the lower chamber.

  A holding tool 3 that can be lifted on the same plane as the wheel 2 is attached to the box 1, and an operating tool 4 is attached to the upper end on the near side that is the operating side. By operating the operating tool 4, the box 1, that is, the moving unit 300 can be moved and transported.

  The Mo tank unit 11, the AC column unit 12, and the waste liquid tank 14 are shielded from lead. The Mo tank unit 11 has a thick lead shielding.

  The AL column unit 13 is shielded from lead glass. The lead glass shield covers the outer periphery of the lead shield covering the waste liquid tank 14.

  The stationary part 400 includes a box 5 having substantially the same height and width as the box 1, and the box 5 includes two fixed ends 6 and 6 ′ at the lower end and an operation panel 7 at the upper end surface.

  The box 5 includes a space chamber 8 and a back chamber 9 on the front side (left side in the figure). The back chamber 9 is divided into upper and lower chambers, a sequencer control system 21 as a control unit is disposed in the upper chamber, and a reagent supply unit 22 is disposed in the lower chamber. As will be described later, the reagent supply unit 22 includes a liquid feed pump 23 and a series of reagent bottles 24 constituting the reagent supply unit 22. Lead shielding is applied to the front side of the reagent supply unit 22, and safety when the stationary unit 400 is integrated with the moving unit 300 is ensured.

  The right half on the back side of the moving unit 300 can enter the space chamber 8, and the moving unit 300 and the stationary unit 400 are integrated by entering.

  This is described in FIG. 4C as “Mo tank unit and waste liquid part of the transfer part enter the dotted line part”.

  The stationary unit 400 is fixedly installed in a hospital, is transported by a transport vehicle, and is moved by a manual push operation. The moving unit 300 is attached to the stationary unit 400, and various pipes are connected as described later. Are integrated and operate as one device. Therefore, the radioactive material is not held in the stationary part 400.

  FIG. 5 shows a state in which the column operation detaching device 30 for operating the AL column of the AL column unit 13 is arranged in the front upper chamber. Although not shown, the column operation desorption device 30 having the same configuration is also arranged in the lower chamber on the near side where the AC column unit 12 is arranged.

  FIG. 6 is a plan view of FIG. 5 viewed from above.

  As shown in FIGS. 5 and 6, the box 1 includes double-opening open / close doors 31 and 31 ′ that can be opened and closed on the front side.

  The column operation detaching apparatus 30 is operated by opening the open / close doors 31 and 31 '.

  The AL column unit 13 is in the front upper chamber which is the open / close door 31, 31 ', the AC column unit 12 is in the front lower chamber, the waste liquid tank 14 is in the rear upper chamber, and the Mo tank 11 is in the rear side. Arranged in the lower chamber.

When the AL column unit 13 is disposed in the front upper chamber, when the open / close doors 31 and 31 ′ are opened, the AL columns 52 and 53 are mounted and detached at an appropriate height and ^{99 m} from the TC collection container 54. The recovery of the Tc solution can be performed very easily from the outside.

  Since the AC column unit 12 is disposed in the lower chamber on the near side, when the open / close doors 31 and 31 ′ are opened, the attachment and detachment of the AC column 55 can be easily performed to the outside.

Since the Mo tank 11 is disposed in the lower lower chamber, lead shielding can be sufficiently ensured and stabilized. The Mo tank 11 stores a high-concentration Mo solution containing dissolved ⁹⁹ Mo and collapsed ^99m Tc, and this back side lower chamber is suitable as the first place to be set.

The waste liquid tank 14 is taken out only when it returns to the manufacturer's manufacturing factory, and is preferably set in the back-side upper chamber.
Moreover, as shown in FIG. 9, the above arrangement is most desirable from the strength of the radioactive level.

7 and 8 show details of the configuration of the column operation desorption device 30. FIG.
In these drawings, the column operation desorption device 30 is provided on a fixing base 32, a column fixing jig 33 provided on the fixing base 32, and on the column fixing jig 33, and relative to the column fixing jig 33. It consists of a column connection holder 34 that can be moved, a lever 35, and two springs 36 and 36 ′ attached to the lever 35.

  In this example, the column 41 is an AL column, but may be an AC column.

  The AL column 41 ′ is a column that can be desorbed by a cassette method. In this example, the AL column 41 ′ indicates a mounting column, and the AL column 40 indicates a mounted column.

  The column fixing jig 33 includes a fixing jig lower part 33A and a fixing jig upper part 33B.

  The column connection part holding body 34 includes a column connection upper part 37 at the upper end, and the column connection lower part 38 is fixed to the fixed base 32.

  The column fixing jig 33 is slidable in the horizontal direction on the fixing table 32, and this sliding is performed by pushing a protrusion 39 provided on the fixing table 32 in the horizontal direction by operating the lever 35. The fixed base 32 is pulled to the near side (left side in the figure) by a spring 36 '.

  The lever 35 can be bent at two fulcrums, and a spring 36 that engages with a fixed end above the upper fulcrum always operates. The lever 35 has a groove-like engagement portion 45, and this engagement portion 45 engages with another engagement portion 46 provided on the column connection portion holding body 34.

  In FIG. 7, a new column 41 'is mounted and fixed on the fixing jig 33A of the column fixing jig 33 (set as the column 41 as shown in the figure).

When the lever 35 is lowered by one step, the column 41 and the column fixing jig 33 slide and stop at the same position as the column connection lower part 38. The engaging part 45 and the engaging part 46 are engaged.
When the lever 35 is lowered one more stage, the column 41 is connected to the column connection lower portion 38.

  When the lever 35 is lowered to the lowest position, the column connection upper part 37 comes down as shown in FIG.

  After the entire operation, perform the column exchange operation. The column replacement operation may be performed as described in the reverse direction, and the column replacement operation is performed in the state shown in FIG.

  As described above, the column replacement work is performed by opening the open / close doors 31 and 31 ′ and operating from the outside of the box 1.

  In the above description, an example of performing column replacement work by input has been described. However, column replacement work is automatically performed by using an electric motor, reducing the rotational speed, and using a gear mechanism to convert rotational motion into linear motion. Can be done automatically.

  Even in this case, the above-described operation is performed using the rotational force of the electric motor.

FIG. 9 shows various piping systems used in this embodiment.
As shown in FIG. ^{In the 99m} Tc recovery apparatus 100, the main body 200 is configured by the moving unit 300 and the stationary unit 400. The moving unit 300 can recover the Tc elution as described above, and the stationary unit 300 has reagent supply, liquid feeding, and control functions. The AL column unit 13 shown in FIGS. 3 to 6 includes a series of adjustment tanks (indicated as Tc-99m eluent adjustment tank) 51, AL columns 52 and 53, and a Tc recovery container 54.

  The AC column unit 12 includes an AC column 55, a column heater 56, and a line heater 56 ′.

The Mo tank unit 11 includes a pair of Mo tanks 57. The waste liquid tank 14 stores waste liquid from the ⁹⁹ Mo tank 57 and other devices.

^{The 99} Mo stock solution tank 58 is not disposed outside the ^99m Tc recovery device 100, that is, in the box 1, and the ⁹⁹ Mo stock solution is preliminarily supplied to the Mo tank 57 (Mo-99 via the pipe 60 at the ⁹⁹ Mo manufacturing factory. (Displayed as a tank). Thus, since ^{99 Mo} stock solution tank 58 in FIG. 9 to be removed at the time of the transfer, in this example it will be appreciated that is set forth for reference.

As described above, the moving unit 300 and the stationary unit 400 constitute the main body 200 shown in FIGS. ^{The 99m} Tc recovery device 100, that is, the generator device includes the main body 200.

  Each device arranged in the moving unit 300 and each device arranged in the stationary unit 400 are connected by a decompression line 61 and a liquid feeding line 62. Connection portions 70 and 64 are provided at the connection locations, respectively. A hydraulic pump 69 and a connector 70 are provided in the hydraulic pressure line 61.

The liquid feeding pump 69 can depressurize the decompression line 61, and supplies each reagent in the reagent bottle 24 of the reagent supply unit 24 to each device arranged in the moving unit 300 via the liquid feeding line 62. can do. Each reagent is appropriately selected and fed. That is, H ₂ O is used for washing and leaching the Mo solution remaining on the AC column, a strong alkaline solution is used for conditioning activated carbon, and ^{99 m} Tc on which H ₂ O is adsorbed.

The pair of Mo tank 57, waste liquid tank 14, adjustment tank 5, and Tc collection container 54 are connected to the decompression line 61 via the pipes 71 to 75. By the depressurization operation, the ⁹⁹ Mo stock solution in the Mo tank 57 is transferred to the AC column 55, and the ^99m Tc eluent is transferred to the AL columns 52 and 53.

  The pair of Mo tank 57 and the adjustment tank 51 are connected to the liquid feed line 62 via pipes 76 and 77, respectively.

  A controllable three-way valve 78 is provided in the pipe 76, and the pipe 76 from the Mo tank 57 is connected to a column connection upper part 79 of the AC column 55. The column connection lower portion 80 of the AC column 55 is connected to the adjustment tank 51 via a pipe 81 and is connected to the upper portion of the waste liquid tank 14 via a pipe 82.

  The Mo tank 57 is connected to the waste liquid tank 14 via a pipe 83, and the pipe 82 and the pipe 83 are connected by a controllable three-way valve 84.

  The pipe 81 and the pipe 82 are connected by a controllable three-way valve 85.

  The adjustment tank 51 and the AL columns 52 and 53 are connected by a pipe 86, and the AL column 53 and the Tc recovery container 54 are connected by a pipe 87.

  3 to 6 do not describe the state of arrangement of these pipes and the state of arrangement of various control valves to the pipes, the arrangement state of FIG. 9 is arranged in FIGS. 3 to 6. Should be understood.

The AC column 55 is detachable from a connection portion 79 connected to the Mo tank 57, and is connected to the Mo tank 57. The activated carbon, preferably a spherical activated carbon is built in, and a high-concentration Mo solution is contained in the AC column. ^99m Tc is adsorbed by contacting with activated carbon. The ⁹⁹ Mo remaining in the activated carbon column 55 is leached with the cleaning liquid (H ₂ O) fed from the reagent supply unit 22 and stored in the waste liquid tank 14.

Thus, in the movable box 1, the high-concentration Mo solution produced by dissolving the parent nuclide radionuclide ⁹⁹ Mo and produced by the neutron irradiation method and containing the daughter nuclide radionuclide ^99m Tc. Can be removed from the Mo tank 57 for storing the water, and the column connection upper part 79 connected to the Mo tank 57, and connected to the Mo tank 57. The AC column unit 12 having a cassette type AC (activated carbon) column 55 that adsorbs ^99m Tc by contacting the Mo solution with activated carbon in the activated carbon column and is desorbed every ^99m Tc elution, and the AC column unit AC. A waste liquid tank 14 that is connected to the column 55 via a connection pipe and stores ⁹⁹ Mo waste liquid when the attached ⁹⁹ Mo is leached with a cleaning liquid; The AL column unit 13 is connected to the AC column 55 of the ram unit via another connecting pipe, recovers ^99m Tc when the adsorbed ^99m Tc is eluted with the eluent, and adjusts the recovered ^99m Tc solution. Built in with shielding material.

  The AL column unit 13 is in the front upper chamber which is the open / close door 31, 31 ', the AC column unit 12 is in the front lower chamber, the waste liquid tank 14 is in the rear upper chamber, and the Mo tank 11 is in the rear side. Arranged in the lower chamber.

The waste liquid tank 58 and the AL column unit 13 are connected to a decompression line having a decompression source composed of a liquid feed pump (may be a multiple tube pump). The stored ⁹⁹ Mo solution is transferred to the AC column unit 12, and the ⁹⁹ Mo cleaning liquid from the AC column unit 12 is transferred to the waste liquid tank 14.

  A moving part 300 formed of a movable box 1 and a stationary part 400 integrated with the moving part 300, a decompression source to the stationary part 400, and a reagent supply unit that supplies the AC cassette unit 12 and the AL cassette unit 13 22 are provided.

  The AC column unit 12 includes a column operation detaching device 30 that detaches the constituent AC column from a connection portion connected to the Mo tank 57.

  The AL column unit includes a column operation desorbing device that desorbs the AL columns 52 and 53 as the constituent elements from the connection part connected to the AC column 30 as the constituent column of the AC column unit.

^{The 99m} Tc recovery device (generator device) 100 is configured to be detachable into two parts, a moving unit 300 and a stationary unit 400. The moving unit 300 has a box shape and can be transported by itself, and can be easily taken out of the hospital. On the other hand, the stationary unit 400 is fixedly arranged in the hospital and integrated with the moved moving unit 300 to form the ^99m Tc recovery device 100.

The moving unit 300 is a device that uses a radioactive substance. In this unit, a ^99m Tc solution from ⁹⁹ Mo is collected and purified by a decompression operation.

As described above, the Mo tank unit 11, the waste liquid tank 14, the AC column unit 12, and the AL column unit 13 are stored inside the moving unit 300, and a ^99m Tc solution that is a product is also collected from here. Each unit is equipped with the necessary lead shield.

Only the moving unit 300 is carried into the ⁹⁹ Mo solution manufacturer (manufacturing factory), and the Mo solution is supplied, recovered, maintained, and transferred to the hospital.

  In the stationary part 400, a reagent supply unit 23 of a control system unit (sequencer or the like) is installed. Even when integrated with the moving unit 300, lead shielding is possible, and external exposure during use is avoided.

  Since the stationary part 400 is configured not to store radioactive substances, there is no risk of external exposure when the moving part 300 is not integrated, so that maintenance is easily performed without worrying about external exposure. be able to.

  Hereinafter, processes performed in each device will be described.

^99m Tc adsorption collection operation process The ⁹⁹ Mo solution is stored in the Mo tank 57, and each of the maximum 35 ml can be stored.

In one Mo tank, ^99m Tc in a radiation equilibrium state coexists. At this time, the other Mo tank is empty. Thus, one of the tanks is always empty.

The ⁹⁹ Mo solution in the Mo tank 57 passes through the activated carbon column 55 and is transferred and stored in the Mo tank 57. At this time, the ⁹⁹ Mo solution does not stay in the activated carbon but passes through the activated carbon as it is and is transferred to the Mo tank 57.
Only ^99m Tc is adsorbed on the activated carbon and ⁹⁹ Mo passes without adsorbing and is transferred to the other tank.

Since activated carbon is used, a small amount of Mo remains in the holes. The Mo is washed with a small amount of H ₂ O and collected in one Mo tank 57.
Most of the ⁹⁹ Mo solution passes through activated carbon and is collected in a separate tank.
The next day (after 24 hours), starting from one Mo tank, ^99m Tc is collected.
If it shows with a flow, it will become one Mo tank 57-> activated carbon column 55-> other Mo tank 57.

In this way, ^99m Tc recovery operation is performed using alternating Mo tanks up to the allowable range of ⁹⁹ Mo amount.

^99m Tc elution pre-treatment step. ⁹⁹ Mo cleaning operation is performed, and after Mo cleaning and recovery with a small amount of H ₂ O, the remaining Mo cleaning operation is performed.
At room temperature, ⁹⁹ Mo remaining in the column is washed with H ₂ O and discarded into the waste liquid tank 14.
In this operation, although it was a heating (85 degreeC) condition, it changed to room temperature and the kind and liquid volume of the reagent were improved.
-Activated carbon conditioning operation (alkali occlusion)
In order to facilitate Tc leaching, the activated carbon is conditioned by passing an alkali (1.3 M NaOH) through the activated carbon adsorbed on Tc.
The passing liquid is discarded in the waste liquid tank 14.
In this operation, the alkaline solution used is the same. The column temperature condition was improved from the warming condition to room temperature.

^99m Tc elution step Under the best conditions, the alkali-conditioned activated carbon column 55 can elute ^99m Tc with only H ₂ O.
By passing H ₂ O at a specified flow rate, the adsorbed ^99m Tc is eluted by an alkali concentration gradient.
The eluate (including Tc) is collected in the adjustment tank 51.
A major characteristic of the spherical activated carbon is that ^99m Tc can be eluted at 80 ° C. (low temperature heating) and in a small amount. Reagents could also be eluted with H ₂ O alone, and sufficient recovery was possible without using a low-concentration alkaline solution. The liquid volume was also improved to a small amount.

^99m Tc liquidity adjustment process A small amount of several percent NaCl solution is added to the eluate collected in the adjustment tank 51 to adjust the salt concentration.
The Tc eluate collected in the adjustment tank 33 is alkaline. However, since the volume of the activated carbon and the amount of the alkaline solution used under the previous conditions were small, the alkali concentration (absolute amount) was much smaller than the eluate using the coconut shell activated carbon before the improvement.
If the amount of the solution and the amount of alkali were sufficient, the solution was sufficiently buffered with the set alumina (acidic), and a neutral solution was possible.
The passing-through liquid had a pH of 5-6, and was well adapted to the pH 4.5-7 range of the Pharmaceutical Affairs Law.
Since the amount of liquid and the amount of alkali are large, the pH adjustment operation is performed with an acid solution (1.0 M HCl), and the operation according to this example is improved compared to the operation where pH adjustment and salt concentration adjustment are performed. In addition, the pH sensor, reagent line, reagent supply device, etc. were eliminated and the system was greatly improved.

^99m Tc purification step / eluate pH adjustment and purification step The eluate adjusted in the adjustment tank 51 passes through the 34 and 35 alumina columns 34 and 35 by depressurizing the recovery vessel 54, and enters the Tc recovery vessel 54. Collected.
By this operation, the pH of the Tc eluate is adjusted and collected. However, ^99m Tc solution remains in alumina.

-Alumina column washing & Tc recovery Since there is ^{much 99m} Tc remaining in the alumina columns 52 and 53, it collects.
A 0.9% NaCl solution is placed in the adjustment tank 33. It passes through the alumina columns 52 and 53 again, and the remaining Tc is recovered in the Tc recovery container 54.

DESCRIPTION OF SYMBOLS 1 ... Box, 11 ... Mo tank unit, 12 ... AC (activated carbon) column unit, 13 ... AL (alumina) column unit, 14 ... Waste liquid unit, 100 ... ^99m Tc collection ^| recovery apparatus (generator apparatus), 200 ... Main body, 300 ... moving part, 400 ... stationary part.

Claims (5)

It has a movable box,
A Mo tank for storing a high-concentration Mo solution produced by dissolving the parent nuclide radionuclide ⁹⁹ Mo produced by neutron irradiation in the box and containing the daughter nuclide radionuclide ^99m Tc; It is possible to detach from the connection part connected to the tank, is connected to the Mo tank, contains activated carbon, and adsorbs ^99m Tc by bringing the high-concentration Mo solution into contact with activated carbon in the activated carbon column, and activated charcoal column unit with activated charcoal column of a cassette type which is replaced every ^{99m Tc} elution, it is connected via a connecting pipe to the activated carbon column unit, ⁹⁹ Mo when the ^{99 Mo} remaining in the activated carbon column was leached in the washing solution a waste liquid tank for storing waste liquid, are connected via the other connecting pipe to the activated carbon column unit, when eluted adsorbed ^{99m Tc} in the eluate The ^{99m Tc} solution was collected, and the alumina column unit for purifying adjust recovered recovered ^{99m Tc} solution is shielded by the shielding material is embedded is sectioning,
The waste liquid tank and the alumina column unit are connected to a vacuum line having a vacuum source, and the high-concentration solution stored in the Mo tank is transferred to the activated carbon column unit by a vacuum operation, and the activated carbon column unit ^99m Tc recovery device, wherein ⁹⁹ Mo Tc cleaning solution is transferred to the waste liquid tank, and ^99m Tc solution recovered from the activated carbon column unit is transferred to the AL cassette unit. 2. The box according to claim 1, wherein the box has an open / close door on one side, the alumina column unit is in the front upper chamber which is the open / close door, the AC column unit is in the front lower chamber, and the waste liquid tank. However, the ^99m Tc recovery device is characterized in that the Mo tank is disposed in the back side upper chamber and the Mo tank is disposed in the back side lower chamber. According to claim 2, wherein the alumina column unit, composed of an adjustment tank for liquid adjusted eluting adjusted solution, and an alumina column to purify the recovered ^{99m Tc} solution, and ^{99m Tc} recovery tank for collecting the purified ^{99m Tc} solution The regulated tank and the purification column were connected to a decompression line having a decompression source, and the recovered ^99m Tc solution adjusted in the regulation tank was transferred to the purification column by the decompression operation of the decompression source and purified. A ^99m Tc recovery device that recovers a ^99m Tc solution in the ^99m Tc recovery container. 2. The moving part formed by the movable box and a stationary part integrated with the movable part, and the decompression source, the AC cassette unit, and the AL cassette unit are supplied to the stationary part. ^99m Tc recovery apparatus, comprising a reagent supply unit for The ^99m Tc recovery device according to claim 1, wherein the activated carbon column unit includes a column operation desorption device for desorbing a constituent AC column from a connection portion connected to the Mo tank.

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