JP6355462B2 - 99mTc recovery device for medical diagnosis - Google Patents

Description

The present invention relates to a ^99m Tc recovery device for medical diagnosis.

Various types of ^99m Tc recovery devices for medical diagnosis are proposed from a high-concentration Mo ( ⁹⁹ Mo) solution.

The ^99m Tc recovery device for medical diagnosis described in Patent Document 1 has been proposed by the inventors of the present application, and a newly formed high-concentration Mo ( ⁹⁹ Mo) solution is applied to an adsorption column containing activated carbon. and liquid passing selectively adsorb ^99m Tc high concentration ^{Mo (99} Mo) solution to the ^activated carbon is recycled high density ^{Mo (99} Mo) after adsorbing the ^99m Tc, has been recycled to form a ^99m Tc high concentration ^{Mo (99} Mo) solution to form a radiation equilibrium for ^a high concentration ^{Mo (99} Mo) to form a solution containing the ^99m Tc, a high concentration Mo ⁽⁹⁹ containing the formed ^99m Tc Mo) solution, for medical diagnosis recovering ^99m Tc by and passed through the adsorption column that incorporates activated carbon selectively adsorbs ^99m Tc of the high concentration ^{Mo (99} Mo) solution to the activated carbon ⁹ the ^m Tc recovery system is the content.

Japanese Patent No. 5427483

As described above, the inventors of the present application have proposed a ^99m Tc recovery device for medical diagnosis. Such a ^99m Tc recovery device for medical diagnosis handles radioactive ^99m Tc solution, and therefore should not affect operators and environment engaged in ^99m Tc recovery. On the other hand, operational efficiency and operational simplicity must be considered.

In view of this point, the present invention proposes a ^99m Tc recovery device for medical diagnosis that has no effect on the operator and environment engaged in ^99m Tc recovery when handling radioactive ^99m Tc solution, and that takes into consideration operational efficiency and operational simplicity. The purpose is to do.

In the present invention, a newly formed high concentration Mo ( ⁹⁹ Mo) solution is passed through an adsorption column containing activated carbon, and ^{99 m} Tc in the high concentration Mo ( ⁹⁹ Mo) solution is selectively adsorbed on the activated carbon. is ^allowed, recirculated high concentration ^{Mo (99} Mo) after adsorbing the ^99m Tc, to form the ^99m Tc to form a radiation equilibrium for the high concentration ^{Mo (99} Mo) solution was ^{recirculated, 99m} A high-concentration Mo ( ⁹⁹ Mo) solution containing Tc is formed, and the formed high-concentration Mo ( ⁹⁹ Mo) solution containing ^99m Tc is passed through an adsorption column containing activated carbon, and the high-concentration Mo ( ⁹⁹ in ⁹⁹ Mo) ^99m Tc recovery device for medical diagnosis for recovering ^99m Tc by selectively adsorbing ^99m Tc in solution,
In the medical diagnostic ^99m Tc collecting in the device, built newly formed high concentration ^{Mo (99} Mo) solution incorporating a ^{Mo (99} Mo) solution built tank, recirculated high concentration ^{Mo (99} Mo) solution be one manufacturing cell ^99m Tc to produce the ^99m Tc is accommodated by,
Internal to form the outer shielding wall outer space which is cut off from the outside with a solution recovery port formed therein, the inner space portion cut off from the provided external shielding wall the outer space A shielding wall,
It said Hosora inter section the Mo (99 ^Mo) solution built tank within the housing, producing cells ^99m Tc with the activated carbon built adsorption column in the outer Hosora inter unit is housed,
The Mo ⁽⁹⁹ Mo) a solution built tank and producing cells of the ^99m Tc is connected, ^99m Tc adsorbed by the activated carbon built-adsorption column is taken out from the solution recovery port formed in the outer space A ^99m Tc recovery device for medical diagnosis is provided .

The present invention, in the above described medical diagnostic ^99m Tc recovery apparatus, the outer wherein the maintenance area for maintenance of the production cell of ^99m Tc is formed in the space portion Hosora medical diagnostic ^99m Tc A collection device is provided .

According to the present invention, it is accommodated ^{Mo (99} Mo) solution built tank inward space, producing cells of ^99m Tc with activated carbon built-adsorption column is housed in the outer space ^{portions, Mo (99} Mo ) and producing cell solution built tank and ^99m Tc is connected, it recovered ^{99m Tc} in the activated carbon built-adsorption column is to be taken outside. Since the Mo ( ⁹⁹ Mo) solution in the Mo ( ⁹⁹ Mo) solution built-in tank is newly formed, it has a relatively strong radioactivity. Therefore, the Mo ( ⁹⁹ Mo) solution is stored in the inner space and is sufficiently affected by the radioactivity. There is blocked, prepared ^{99m Tc} in the production of ^{99m Tc} cells, weak radioactive relatively, the influence of sufficiently radioactivity by accommodating outward space portion is cut off, to the outer space portions ^99m Tc recovery device for medical diagnosis that is convenient for taking out the recovered ^99m Tc solution to the outside and is considered to be operational efficiency and operational convenience It can be.

The figure which shows the form of the Example of this invention. ^The figure which shows the example of ^99m Tc extraction manufacturing apparatus 51. FIG. ^The figure which shows ^99m Tc extraction step.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings.

  FIG. 1 is a diagram showing an embodiment of the present invention.

The ^99m Tc recovery device 100 for medical diagnosis passes a newly formed high-concentration Mo ( ⁹⁹ Mo) solution through an adsorption column containing activated carbon, and ^{99 m} in the high-concentration Mo ( ⁹⁹ Mo) solution through the activated carbon. Tc selectively ^adsorb, recirculates high concentration ^{Mo (99} Mo) after adsorbing the ^99m Tc, recycled high concentration ^{Mo (99} Mo) solution to form a radiation equilibrium for ^99m Tc forming a ^high concentration ^{Mo (99} Mo) to form a solution, high concentration ^{Mo (99} Mo) solution containing the formed ^99m Tc, the activated carbon was passed through the adsorption column having a built-in active carbon containing ^99m Tc the high concentration ^Mo configured as a device for collecting the ^99m Tc in ⁽⁹⁹ Mo) the ^99m Tc in solution selectively be adsorbed.

In FIG. 1, a ^99m Tc recovery device 100 for medical diagnosis is configured in an integral box shape, and includes an outer shielding wall 1 arranged on the outer side and an inner shielding wall 2 arranged on the inner side. A maintenance area 3 is formed inside by the outer shielding wall 1. The maintenance area 3 is divided into upper and lower chambers by a separating body 6 for separating upper and lower chambers provided in the central portion thereof. Here, call outwardly maintenance Nan cell area of the upper formed by the shielding wall 1 and the inner shielding wall 2 and the upper outer of the outer space 4A, referred to as maintenance area below the lower outer of the outer space 4B . The chamber above the inner space portion 5 formed by the inner shielding wall 2 is referred to as a lower outer space 5A, and the lower chamber is referred to as a lower inner space 5B . A lower chamber 7 that is open to the outside is formed below the inner shielding wall 2, and a power supply control system 8 is disposed.

A ventilation system 9 is connected to the outer space portion 4A on the upper outer side and the outer space portion 4B on the lower outer side , and exhaust is performed.

Rails 10 are provided in the outer space portion 4A on the upper outer side and the outer space portion 4B on the lower outer side . In this example, there are two sets of rail arrangements.

Door 11 to the outer shield wall 1 above the upper outer of the outer space 4A, the upper and lower compartment door 12 outwardly in separator 6 for separation, the door 13 is provided inside the lower outer of the outer space Pb glass is disposed on the outer shielding wall 1 on the side of 4B, and a manipulator 15 is laid on the outside thereof. A pair of ^99m Tc solution recovery ports 16 are formed in the outer shielding wall 1 below the lower outer space 4B.

An adjustment tank 21 that is a Mo ( ⁹⁹ Mo) solution built-in tank and two Mo ( ⁹⁹ Mo) solution tanks 22 and 23 are installed in the inner space 5B inside the lower part. Manufacturing cells 24 and 25 of ^99m Tc are installed in the outer space 4B outside the lower part. Both are connected. Producing cells 24 and 25 of the ^99m Tc has a charcoal internal adsorption column.

The manufacturing cell 24, 25 of the ^99m Tc, the pair of discharge path 26 is provided for discharging the ^99m Tc solution prepared ^{respectively,} are connected to the ^99m Tc solution recovery port 16.

^99m Tc manufacturing cell 24 and 25, the upper rail 10 respectively is drawn to the upper outer side of the external space portion 4A maintenance through periodic surface maintenance 27 is made.

As described above, the external shielding wall 1 formed so as to form the maintenance area therein, and the internal shielding wall formed in the maintenance area 3 so as to form the inner space portion in the maintenance area 3. provided with 2, and a maintenance area within 3, the outer space of the upper outer of the outer space 4A and lower outer of the outer space 4B between the outer shielding wall 1 and the inner shielding wall 2 Part 4 is formed.

Further, housed adjustment tank ^{21, Mo (99 Mo)} solution tank 22 to form a ^{Mo (99} Mo) solution built tank inwardly space portion 5, an activated carbon built-adsorption column in the external space portion 4 ^99m Tc manufacturing cell 24, 25 with is housed.

^{Further, Mo (99} Mo) and generating cell 24, 25 of a solution built tanks 22, 23 and ^99m Tc is connected, recovered ^99m Tc in the activated carbon built-adsorption column is taken out from the ^99m Tc solution recovery port 16 .

FIG. 2 shows an adjustment tank 21 forming a Mo ( ⁹⁹ Mo) solution built-in tank in the inner space 5 , Mo ( ⁹⁹ Mo) solution tanks 22 and 23, and an activated carbon built-in adsorption column in the outer space 4 . The functions of the ^99m Tc manufacturing cells 24 and 25 are shown. In the comparison between FIG. 1 and FIG. 2, the adjustment tank 21 corresponds to the control tank 54, and the Mo ( ⁹⁹ Mo) solution tanks 22 and 23 correspond to the Mo containers 52 and 53. Producing cells 24 and 25 of the ^99m Tc encompass Tc concentration and purification recovery system 66. Hereinafter, the configuration of FIG. 2 will be described.

FIG. 2 is a diagram showing an example of a ^99m Tc extraction and production apparatus 51 that constitutes the ^99m Tc extraction apparatus 26. FIG. 3 is a diagram showing the manufacturing steps by extraction of a high-purity ^99m Tc solution in steps S1 to S7.

2 and 3, the ^99m Tc extraction and production apparatus 51 is installed in a hot cell that shields radiation emitted from ⁹⁹ Mo and ^99m Tc. ^{The 99m} Tc extraction and production apparatus 51 includes a Mo container (1) 52, a Mo container (2) 53, and a control tank. A plurality of Mo containers may be provided. The Mo container (1) 52 and the Mo container (2) 55 are supplied with a Na ₂ ⁹⁹ MoO ₄ solution generated by neutron irradiation to generate ⁹⁹ Mo and dissolve the contained MoO ₃ with an alkali (NaOH) solution. The That is, the Mo solution containing the radionuclide ⁹⁹ Mo as a radiopharmaceutical raw material is supplied to the Mo container (1) 52 and the Mo container (2) 53. ^{When 99} MoO ₃ is dissolved in an alkaline solution, a pH neutral Na ₂ ⁹⁹ MoO ₄ solution is formed as shown in the figure.

At the time of production, the Mo solution containing radioactive ⁹⁹ Mo is, for example, a high concentration Mo solution containing 500 g of Mo in 2 L. Hereinafter, this solution is referred to as a high concentration Mo solution. Here, the high concentration is, for example, a concentration at which a high concentration Mo solution containing 500 g of Mo in 2 L described above is required to obtain a necessary amount of ^99m Tc of about 500 Ci at a time.

  Pipings 57 and 58 having three-way valves 55 and 56 are respectively provided at the bottoms of the Mo container (1) 52 and the Mo container (2) 53, and the Mo container (1) 52 and the Mo container (2) 53 are Three-way valves 55 and 56 and pipes 57 and 58 are connected to the bottom of the control tank 54 via other pipes 59 and 60. A three-way valve 63 is provided at the end of the pipes 57 and 58. The control tank 54 has a function as a liquid level adjustment mechanism. The bottom of the control tank 54 is further connected to one end (upper surface in the figure) of the Tc concentration purification / recovery system 66 via a pipe 64 and a three-way valve 65 provided in the pipe 64. As will be described later, the Tc concentration purification / recovery system 66 includes an adsorption column containing activated carbon.

The other end (lower end in the figure) of the Tc concentration purification system 66 is provided with a pipe 67 and a three-way valve 68 provided on the pipe 67 and connected to a three-way valve 63 provided at the end of the pipe 57 and the pipe 58. The In the Mo container (1) 52 and the Mo container (2) 53, ^99m Tc which is a daughter nuclide of ⁹⁹ Mo is generated in the high concentration Mo solution, and a high concentration Mo solution containing the radionuclides ⁹⁹ Mo and ^99m Tc is formed. Is done. A new high-concentration Mo solution containing ⁹⁹ Mo is alternately supplied to, for example, every Mo container (1) 52 and Mo container (2) 53 every two weeks.

Technetium 99 ( ^99m Tc), which emits weak energy gamma rays (radiation), is used for medical diagnosis such as SPECT, but its half-life is 6 hours, so its radioactivity is reduced to 1/16 of a day. Will decrease. It holds a ⁹⁹ Mo, which is the parent nuclide of ^99m Tc in order to compensate for this, to separate and use the ^99m Tc born causing the beta-minus decay. A method for obtaining a daughter nuclide using the radiation equilibrium relationship between the parent nuclide and the daughter nuclide is called milking.

Here, the method for obtaining the daughter nuclide by using the radiation equilibrium relationship between the parent nuclide and the daughter nuclide is called milking. Moreover, performing this milking is called a milking process, and the solution containing a daughter nuclide is called a milking solution. Thus, where a high concentration Mo solution containing ^{99 Mo,} as described above, is that a solution containing ^{99 Mo} for obtaining ^{99m Tc} required amount by utilizing radiation equilibrium.

The high-concentration ⁹⁹ Mo solution is introduced into the Tc concentration purification / recovery system 66 containing the activated carbon column from the lower part of the Tc concentration purification / recovery system 66 through the pipe 57, the pipe 58, the three-way valve 63, and the pipe 67. The Tc concentration purification / recovery system 66 includes an adsorption column, and activated carbon is incorporated in the adsorption column, so ^99m Tc is selected by passing a high concentration ⁹⁹ Mo solution containing a necessary amount of ^99m Tc through the activated carbon. Can be adsorbed. In this step, ^99m Tc is purified and concentrated. Here, the relationship between the ⁹⁹ Mo amount and the ^99m Tc amount with respect to the Mo amount (here, 500 g) in the high-concentration Mo solution is as follows.

⁹⁹ Mo half-life: 65.94 h, ^99m Tc half-life: 6.01 h
500 Ci ⁹⁹ Mo amount = 1.04 mg (1 / 500,000 for 500 g Mo)
500 Ci ^99m Tc amount = 0.095 mg (1/5 million for 500 g Mo)
^{In the case of 99} Mo 5 × 10 ⁴ Bq or less, 6 × 10 ⁻¹⁵ or less with respect to 500 g Mo
^{In the case of 99m} Tc 6 × 10 ⁴ Bq or less, 6 × 10 ⁻¹⁶ or less with respect to 500 g Mo. Thus, even when ^99m Tc is present in a very high concentration Mo solution, it can be adsorbed by activated carbon.

A large amount of Mo containing ⁹⁹ Mo that is not adsorbed by the Tc concentration purification / recovery system 66 passes through the three-way valve 65 and the pipe 64 to the control tank 54, and further to either the Mo container (1) 52 or the Mo container (2) 53. It will be returned. A ^99m Tc adsorption step is performed every day, and the Mo solution from which ^99m Tc has been recovered is returned to the original Mo container (either 52 or 53). After this step, ^99m Tc adsorbed and recovered by the Tc concentration purification recovery system 66 is transferred to a desorption step.

In this way, a high concentration Mo solution containing the radionuclide ⁹⁹ Mo is dissolved in the neutron-irradiated Mo compound (MoO ₃ ) directly in an alkaline solution to form a high concentration Mo solution containing ⁹⁹ Mo. A high concentration ⁹⁹ Mo solution stored in a plurality of Mo containers is alternately passed through an adsorption column containing the activated carbon, and Tc is adsorbed and concentrated. Do.

An external supply system 22 is connected to the three-way valve 68 via a pipe 70 and a three-way valve 71. From this supply system 72, a cleaning solution for desorbing ⁹⁹ Mo remaining in the Tc concentration purification / recovery system 66 (activated carbon column). And Tc eluate and the like are supplied, and these solutions are introduced into the Tc concentration purification collection system 66.

First, in the desorption process, ⁹⁹ Mo desorbent is introduced from the supply system 72, ⁹⁹ Mo is desorbed, and this solution is introduced into the cleaning waste liquid 82. Next, the ⁹⁹ Mo desorption process is stopped, a Tc desorption agent is introduced from the supply system 72, and the process proceeds to a Tc desorption process in which Tc adsorbed on the activated carbon is desorbed.

The Tc concentration purification / recovery system 66 is connected to a liquidity adjustment system 75 via a three-way valve 65 and a pipe 73 and a three-way valve 74 provided thereon. The desorbed Tc is introduced into the liquid property adjusting system 75 together with the desorbing agent. In this liquid adjustment system, a liquid adjustment reagent 84 is added to adjust the liquidity. Further, the liquid adjustment reagent 84 is further connected to the secondary purification system 77 via the pipe 76 and further connected to the Tc recovery device 79 via the pipe 78. ^99m Tc Collected as eluate.

As shown in FIG. 2, this system is provided with ⁹⁹ Mo waste liquid systems 80 and 81 and a cleaning waste liquid system 82, and each system is appropriately controlled by a control system 83.

As described above, a high-concentration Mo solution containing radionuclide ⁹⁹ Mo as a radiopharmaceutical raw material is formed, ^99m Tc which is a daughter nuclide of ⁹⁹ Mo is generated, and high concentration ⁹⁹ containing radionuclide ⁹⁹ Mo and ^99m Tc is formed. Forming a Mo solution;
Formed was the high concentration ⁹ Mo solution was passed through the adsorption column that incorporates activated carbon is selectively adsorb ^{99m Tc} of the high density ^{99 Mo} solution to the activated carbon and selectively adsorbing the ^{99m Tc} is derived recirculation system at a high concentration ⁹⁹ Mo after the ⁹⁹ Mo remaining in the activated carbon subjected to desorption removed by Mo desorbent, the desorption process of the ^99m Tc by desorbing agent ^99m Tc traces remaining on the activated carbon activated carbon Go and collect ^99m Tc,
Perform secondary purification to remove ⁹⁹ Mo slightly remaining in the recovered ^99m Tc by the alumina column method,
^99m Tc is adsorbed, extracted into the recirculation system, and recovered from the highly concentrated ⁹⁹ Mo solution.
^99m Tc is generated again to a radiation equilibrium state, a high concentration ⁹⁹ Mo solution containing radionuclides ⁹⁹ Mo and ^99m Tc is formed again, and the formed high concentration ⁹⁹ Mo solution is recirculated to adsorb activated carbon. high concentration and elution purification and recovery method of ^{99m Tc} as a radiopharmaceutical material was passed through the column, characterized in that selectively adsorbs ^{99m Tc} of the high density ^{99 Mo} solution to the activated carbon is formed.

According to this embodiment, is accommodated ^{Mo (99} Mo) solution built tank inward space, producing cells of ^99m Tc with activated carbon built-adsorption column is housed in the outer space portions, Mo ⁽⁹⁹ Mo) and producing cell solution built tank and ^99m Tc is connected, it recovered ^{99m Tc} in the activated carbon built-adsorption column is to be taken outside. Since the Mo ( ⁹⁹ Mo) solution in the Mo ( ⁹⁹ Mo) solution built-in tank is newly formed, it has a relatively strong radioactivity. Therefore, the Mo ( ⁹⁹ Mo) solution is stored in the inner space and is sufficiently affected by the radioactivity. There is blocked, prepared ^{99m Tc} in the manufacturing cell of ^99m Tc is weak radioactive relatively, the influence of sufficiently radioactivity by accommodating outward space portion is blocked, yet in the outer space portions Since it is connected to an adsorption column with built-in activated carbon, it is convenient for taking out ^99m Tc to the outside, and it can be a ^99m Tc recovery device for medical diagnosis in consideration of operational efficiency and operational convenience. .

1 ... outer shielding wall, 2 ... inner shielding wall, 3 ... maintenance area, 4 ... outer space, the external space of 4A ... upper outer, 4B ... outer space of the lower outer, 5 ... inner side space , the internal space of 5A ... upper inner, 5B ... inner space of the lower inner, 6 ... upper and lower chambers separator for separation, 21 ... adjustment tank, 22,23 ... ^{Mo (99 Mo)} solution tank, 24, 25 ... production cell of ^99m Tc, 100 ... medical diagnostic ^99m Tc recovery system.

Claims (2)

The newly formed high concentration ^{Mo (99} Mo) solution was passed through the adsorption column that incorporates activated carbon is selectively adsorb ^99m Tc high concentration ^{Mo (99} Mo) solution to the activated ^carbon, 99m Tc The high-concentration Mo ( ⁹⁹ Mo) after adsorbing is recycled, and a radiative equilibrium state is formed for the recirculated high-concentration Mo ( ⁹⁹ Mo) solution to form ^99m Tc, and the high concentration containing ^99m Tc A high-concentration Mo ( ⁹⁹ Mo) solution is formed, and the high-concentration Mo ( ⁹⁹ Mo) solution containing ^99m Tc formed is passed through an adsorption column containing activated carbon, and the high-concentration Mo ( ⁹⁹ Mo) solution is passed through the activated carbon. in ^99m Tc recovery apparatus for medical diagnosis for recovering ^99m Tc by selectively adsorbing ^99m Tc in,
In the medical diagnostic ^99m Tc collecting in the device, built newly formed high concentration ^{Mo (99} Mo) solution incorporating a ^{Mo (99} Mo) solution built tank, recirculated high concentration ^{Mo (99} Mo) solution be one manufacturing cell ^99m Tc to produce the ^99m Tc is accommodated by,
Internal to form the outer shielding wall outer space which is cut off from the outside with a solution recovery port formed therein, the inner space portion cut off from the provided external shielding wall the outer space A shielding wall,
It said Hosora inter section the Mo (99 ^Mo) solution built tank within the housing, producing cells ^99m Tc with the activated carbon built adsorption column in the outer Hosora inter unit is housed,
The Mo ⁽⁹⁹ Mo) a solution built tank and producing cells of the ^99m Tc is connected, is adsorbed by the activated carbon built-adsorption column ^99m Tc is extracted out from the solution recovery port formed in the outer space ^99m Tc recovery device for medical diagnosis, characterized in that it is configured as described above. In medical diagnostic ^{99m Tc} recovery device according to claim 1, wherein the outer characterized in that the maintenance area for maintenance of the production cell of ^99m Tc is formed in the space portion Hosora medical diagnostic ^99m Tc Recovery device.

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