JP2013049637A - Gel-like skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a gel-like skin care preparation not having a sticky feeling upon application, having excellent skin familiarity and supple film feeling, excellent in persistence of a moisturization feeling, and also having excellent storage stability.SOLUTION: This gel-like skin care preparation contains following components (A) to (D): (A) phospholipid, (B) macadamia nut oil, (C) one or two or more kinds of cholesterol derivatives and/or phytosterol derivatives selected from macadamia nut fatty acid cholesteryl, lanolin fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, and lanolin fatty acid phytosteryl, and (D) shea butter.

Description

  The present invention relates to a gel-like external preparation for skin having excellent moisturizing feeling and skin conformability, and having a good feeling with reduced stickiness.

Gel (also referred to as jelly or gel) dosage forms are used for various skin external preparations such as various pharmaceuticals and cosmetics because of their fresh and refreshing feeling. In such a gel-like external preparation for skin, a water-soluble polymer such as carboxyvinyl polymer is often used as a thickener. And in order to raise a moisturizing feeling, the gel-form skin external preparation which used the high concentration polyhydric alcohol together is proposed (refer patent document 1).
However, a gel-like external preparation for skin that does not contain an oil agent using a water-soluble polymer such as carboxyvinyl polymer cannot suppress moisture transpiration from the skin, and thus it is difficult to maintain a moisturizing feeling for a long time. Moreover, the sticky feeling originating in water-soluble polymer may be felt strongly.

  In recent years, gel cosmetics using phospholipids that have good affinity for skin, little irritation, and excellent moisture retention have been proposed (see Patent Documents 2 and 3).

JP 2010-64986 A JP 2005-320285 A JP 2008-7430 A

However, the gel-type skin external preparation containing a nonionic surfactant having a phospholipid and a glycerin skeleton and water described in Patent Document 2 gives a sense of irritation and sliminess due to the surfactant, and moisturizes for a long time. It was difficult to give a feeling.
Moreover, in the gel-form skin external preparation containing the phospholipid, the higher alcohol, and water described in Patent Document 3, a certain moisturizing feeling is obtained, but the effect is not satisfactory. In addition, skin familiarity was poor and the feeling of use was not satisfactory.

  Therefore, the problem of the present invention is that gel-like skin external use has no sticky feeling at the time of application, has good skin familiarity, has a supple film feeling, has excellent moisturizing feeling, and has good storage stability. It is to provide an agent.

  Therefore, the present inventor has been variously examining the oil content in the gel-like external preparation for skin using phospholipids. By including macadamia nut oil, specific cholesterol derivative and / or phytosterol derivative, and shea fat in combination. Thus, the present inventors have found that a gel-like skin external preparation having no stickiness when applied, good skin familiarity, soft film feeling and excellent moisturizing feeling can be obtained, and the present invention has been completed.

That is, this invention relates to the gel-form skin external preparation characterized by containing the following (A)-(D).
(A) Phospholipid (B) Macadamia nut oil (C) Macadamia nut fatty acid cholesteryl, lanolin fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl and lanolin fatty acid phytosteryl selected from one or more cholesterol derivatives and / or phytosterol derivatives (D) Shea fat

  The external preparation for gel-like skin of the present invention has no stickiness when applied, has good skin familiarity, has a supple film feeling, has excellent moisturizing feeling, and has good storage stability. ADVANTAGE OF THE INVENTION According to this invention, the gel-form skin external preparation useful as a pharmaceutical and cosmetics can be provided.

Hereinafter, embodiments of the present invention will be described in detail.
In the present invention, the gel-like external preparation for skin refers to a composition in which viscosity is imparted to an arbitrary liquid medium containing water. The viscosity is preferably 15000 mPa · s or more, more preferably 15000 to 50000 mPa · s, using a B-type viscometer (rotor No. 4, rotation speed 12 rpm, measurement time 30 seconds) at 25 ° C. and 1 atm. More preferably, it is 20000-45000 mPa * s, More preferably, it is 25000-40000 mPa * s. Since such gel-like external preparation for skin has an appropriate viscosity, it is easy to scrub with a finger and is easy to apply to the skin.

  The phospholipid (A) in the present invention is preferably a phospholipid having a phosphatidylcholine content of 60% by mass or more in the phospholipid. Preferably, the phospholipid has a phosphatidylcholine content of 65% by mass or more, more preferably 70% by mass or more. Examples of phospholipid components other than phosphatidylcholine include phosphatidic acid, phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidylglycerol.

  The phospholipid used in the present invention may be a natural product extracted and purified from animals and plants, or may be chemically synthesized, and may be subjected to processing such as hydrogenation or hydroxylation. As a natural product, lecithin, which is an extract / purified product from soybean or egg yolk, is preferable because it is easy to obtain a commercial product. More preferred phospholipids are hydrogenated and hydroxylated phospholipids from the viewpoint of improving the stability of the emulsion, and preferably include hydrogenated soybean lecithin and hydrogenated egg yolk lecithin.

  The content of phosphatidylcholine in the phospholipid can be analyzed by a method using thin layer chromatography (TLC), high performance liquid chromatography (HPLC), Iatroscan (manufactured by Yatron) or the like. For example, an organic solvent containing phospholipid described in JP-A-2001-186898 is spotted on TLC, developed with chloroform: methanol: acetic acid = 65: 25: 10, sprayed with 50 wt% ethanol sulfate, and after heating A method of analyzing phospholipids with a densitometer is mentioned. In addition to the above method, any method may be used as long as it can measure and calculate the content and content of phosphatidylcholine contained in the phospholipid.

  Examples of phospholipids containing 60% by mass or more of phosphatidylcholine include coatsome NC-21 (hydrogenated soybean lecithin; manufactured by NOF Corporation), resinol S-10E, and resinol S-10EX (hydrogenated soybean lecithin; Nikko Chemicals). Manufactured).

  A phospholipid may be used independently and may be used in mixture of 2 or more types. The content of the component (A) is preferably 0.001 to 5% by mass, more preferably 0.01 to 2% by mass, and still more preferably from the viewpoint of stability and sensory characteristics with respect to the total amount of the external preparation for skin. 0.1 to 1% by mass.

  The (B) macadamia nut oil used in the present invention is a liquid vegetable oil obtained from the fruit (nut) of a subtropical fruit tree (MACADEMIA TERNIFOLIAF. MUELL) belonging to the family Porcupine belonging to Australia. Macadamia nut oil is readily available on the market and does not require any special quality, but preferably refined macadamia nut oil is more colorless, odorless, and the same palmito oleic acid as human sebum It is more suitable for use since it has a high content and excellent oxidation stability.

  Although content of (B) component of this invention is not specifically limited, 0.01-8 mass with respect to the composition whole quantity of a skin external preparation from the point of suppression of moisture retention, skin familiarity, and stickiness. % Is preferable, more preferably 0.1 to 5% by mass, and still more preferably 0.1 to 2% by mass.

  (C) Cholesterol derivatives and / or phytosterol derivatives used in the present invention are esterified products of fatty acids and sterols obtained from animal fats and oils (lanolin) and / or vegetable fats and oils (macadamia nut oil), and hydrolyze these natural fats and oils. It is an esterified product of a mixture of fatty acids and cholesterol or phytosterol. Specific examples include macadamia nut fatty acid cholesteryl, lanolin fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, lanolin fatty acid phytosteryl, preferably macadamia nut oil fatty acid phytosteryl and lanolin fatty acid phytosteryl, and more preferably macadamia nut oil fatty acid phytosteryl.

  These components are generally commercially available, and examples include YOFCO CLE series (lanolin fatty acid cholesteryl), YOFCO MAC (macadamia nut fatty acid cholesteryl), YOFCO YOFCO MAS (macadamia nut fatty acid phytosteryl) and the like (all manufactured by Nippon Seika Co., Ltd.). .

  The content of the component (C) of the present invention is not particularly limited, but is preferably 0.01 to 7% by mass with respect to the total amount of the composition for external preparation of skin, from the viewpoint of moisture retention. More preferably, it is 0.1-5 mass%, More preferably, it is 0.1-3 mass%.

  The (D) shea fat used in the present invention is a vegetable oil collected from the fruit seeds of butyrospermum parkii that inhabit the savanna region. The shea butter can be used in either a liquid or solid form, but it is preferable to use a paste to a solid shea butter because the moisturizing feeling is maintained for a long time.

  The content of the component (D) of the present invention is not particularly limited, but is preferably 0.01 to 10% by mass with respect to the total amount of the composition for external preparation for skin, from the viewpoint of moisture retention. More preferably, it is 0.1-5 mass%, More preferably, it is 0.1-3 mass%.

  The mass ratio [(C) / (D)] of the component (C) and the component (D) is preferably 0.05 to 10, more preferably 0.1 to 10, still more preferably. It is 0.2-6, More preferably, it is 0.5-2. When used in this range, the sticky feeling is further reduced and the durability of the moisturizing feeling is excellent.

  In the present invention, it is further preferable to use (E) cholesterol and / or phytosterol in combination. These components are generally commercially available, and examples thereof include cholesterol (manufactured by Nippon Seika Co., Ltd.) and phytosterol (manufactured by Eisai Food Chemical Co., Ltd.). The content mass ratio [(A) / (E)] of the component (A) and the component (E) is preferably 1 to 10 and more preferably 1.5 to 8 from the viewpoint of storage stability. More preferably, it is 2-5.

  In the present invention, it is preferable to use (F) a saturated monohydric alcohol having 1 to 3 carbon atoms from the viewpoint of imparting freshness at the time of application, improving the refreshing feeling, and reducing stickiness after application. Examples of the saturated monohydric alcohol having 1 to 3 carbon atoms include methyl alcohol, ethyl alcohol, propyl alcohol, isopropyl alcohol, and the like, preferably ethyl alcohol.

  Although content of (F) component of this invention is not specifically limited, 1-15 mass% is preferable with respect to the composition whole quantity of a skin external preparation from the point of storage stability, More preferably It is 2-10 mass%, More preferably, it is 2-8 mass%.

  In addition to the above-mentioned components, the gel-like skin external preparation of the present invention includes water; water-soluble dyes; preservatives such as paraben and phenoxyethanol; anionic surfactants such as sodium cetyl sulfate and N-stearoyl-L-glutamate ; Nonionic surfactants such as polyhydric alcohol fatty acid esters, polyglycerin fatty acid esters, modified silicones, sucrose fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid esters; cationic surface activity such as tetraalkylammonium salts Agents: amphoteric surfactants such as betaine type, sulfobetaine type, sulfoamino acid type; natural surfactants such as lecithin, ceramide, cerebroside; antioxidants such as dibutylhydroxytoluene; sodium chloride, magnesium chloride, sodium sulfate, Potassium nitrate Inorganic salts such as potassium acid and sodium phosphate; citric acid, sodium citrate, potassium acetate, sodium oxalate, sodium aspartate, sodium lactate, carnitine salt, gamma aminobutyric acid, lipoic acid and other organic acid salts; ethanolamine hydrochloride , Salts such as ammonium nitrate and arginine hydrochloride, chelating agents such as edetic acid; neutralizing agents such as potassium hydroxide, diisopropanolamine and triethanolamine; biopolymers such as collagen; placental extract; hydroxymethoxybenzophenone sulfonate UV-absorbing agents such as ascorbyl palmitate, ascorbyl stearate, ascorbyl tetraisostearate, etc .; polysaccharides extracted from xanthan gum, beta glucan, oats, white jellyfish, and carragee Emissions and alginate, those extracted from seaweeds such as agar, water-soluble polymers such as pectin; plant may contain an extract or the like seaweed or bacteria.

  Examples of extracts of plants, seaweed or fungus used include artichoke, eye, arnica, aloe, altea, ashitaba, acerola, apricot, almond, amacha, akebi, anise, avocado, ginseng, nettle, strawberry, fennel, turmeric Prickly pear, prickly pear, oolong tea, euglena, geese, pear, oat, enmeado, edelweiss, dutch mustard, duckweed, ogon, auren, giant clam, hypericum, orange, okra, olive leaf, cassis, valerian, bonito Cam Come, Carrot, Kawaramugi, Oats, Licorice, Cucumber, Kyonin, Kiwi, Kina, Kiraya, Kizuta, Gabba Tea, Kiso, Clara, Kumazasa, Mulberry, Walnut, Grapefruit, Gen Ginger, Gentiana, Getto, Kohiratambutsu, Burdock, Comfrey, Wheat germ, Sakura, Savonso, Salvia, Hawthorn, Saishin, Saitai, Sanshishi, Shimotsuke, Jujuyaku, Shichigenge, Shobu, Ginger, Shikon, Shiso, Birch, Peonies, Peonies Seacurser, Simon, Horsetail, Star Fruit, Zeni Oyster, Senkyu, Hawthorn, Kizota, Pear, White Willow, Sage, Assembly, Soybean, Daidai, Thyme, Tachibana, Tatymado, Tamarind, Tea, Clove, Chinpi, Salmon, Dokudami, Toki, Tounin, Spruce, Tomato, Tokisenka, Fujicha, Tormentilla, Corn, Neem, Nigahakka, Elderberry, Garlic, Carrot, Novara, Papuames, Ha Biscus, parsley, banana, rose, pearl barley, hazelnut, pecan nut, cypress, hyssop, himalayan raspberry, himefuuro, sandalwood, bilberry, loquat, prunes, grapes, chrysanthemum daffodil, chrysanthemum larvae, yellow peach, peppermint, safflower , White genepi, cypress, linden tree, button-bow-fu, button, hop, jojoba, quince, maika, maroni, pine, mandarin, mugwort, melissa, pine primrose, peach, maple, cornflower, saxifrage, eucalyptus, lily, moth, yokuinin, Artemisia, Orchid, Lime, Lavender Lettuce, Apple, Ryukyu Artemisia, Rooibos, Astragalus, Lemon, Lemon Balm, Rosehip, Rosemary, Green Algae, Red Algae, Brown Algae, Bucurraceae, Shii Bamboo, Kurita, Sarnoshokutake, Snow Jellyfish, Reishi, Cordyceps, Yeast, Lactobacillus, Rhizobium, Leaf, Stem, Root, Fruit, Seed, Flower, Fruiting Body, Fungus to Water, or Glycerol, Propylene Glycol, Ethanol, Examples thereof include an extract extracted with an organic solvent such as butylene glycol or a mixture thereof. Chlorophyll is also a plant extract. In addition, lactic acid bacteria and yeast culture solutions using raw milk, fruit juice, synthetic medium, and semi-synthetic medium can be used regardless of whether or not the cells are removed.

  There is no restriction | limiting in particular as a use of the gel-form skin external preparation of this invention, It can use suitably for cosmetics, a pharmaceutical, a quasi-drug, etc. Specifically, for external use such as facial cleansers, cleansing cosmetics, lotions, emulsions, beauty creams, base cosmetics, sunscreen cosmetics, packs, massage cosmetics and other skin cosmetics, ointments containing various drugs, creams, etc. It can be suitably used as a medicine. In particular, since the external preparation for skin of the present invention is excellent in the moisturizing feeling, it is preferably used as a type of external preparation for skin that is not washed away and is retained on the skin.

  EXAMPLES Next, although an Example demonstrates this invention still in detail, this invention is not limited to these.

Examples 1-6, Comparative Examples 1-4
According to the formulation shown in Table 1, a gel-like external preparation for skin was prepared. Using these, the following (1) sensory test and (2) storage stability test were carried out and evaluated. The results are also shown in Table 1.

(1) Sensory test For female panelists (10 persons), the gel-type skin external preparations shown in the examples and comparative examples were used, and “stickiness when applied”, “skin familiarity”, “film feeling”, “moisturizing” A questionnaire was conducted on the four items of “sustained feeling”, and the evaluation was performed based on the following evaluation criteria. The results are also shown in Table 1.

(Evaluation criteria)
Stickiness 5: None 4: Slightly absent 3: Neither can be said 2: Slightly present 1: Present

Skin familiarity 5: Good 4: Slightly good 3: Not good 2: Slightly bad 1: Bad

Feeling of film 5: Flexible 4: Slightly flexible 3: Neither can be said 2: Slightly hard 1: Hard

Persistence of moisturizing feeling 5: Persistence 4: Slightly persistent 3: Neither can be said 2: Slightly non-persistent 1: Not persistent (Criteria)
◎: Average point is 4.0 or more ○: Average point is 3.0 or more and less than 4.0 △: Average point is 2.0 or more and less than 3.0 ×: Average point is less than 2.0

(2) Storage stability test The gel skin external preparation shown in Table 1 was put in a glass bottle and stored in a thermostatic bath at 60 ° C for 1 month. Based on the state immediately after preparation, the change in appearance after one month was determined from the following criteria.
(Evaluation criteria)
◎: No change ○: Some change in viscosity is seen △: Clear change in viscosity is seen ×: Separated

(Production method)
A. Ingredients 1-11 are uniformly mixed and dissolved at 80 ° C.
B. Ingredients 16 to 18 are uniformly mixed and dissolved at 80 ° C.
C. B was added to A and stirred, then components 12 to 15 were added and stirred, and a gel was obtained after cooling.

  It is clear that the gel-like external preparation for skin shown in the examples is superior in the feeling of stickiness, the goodness of skin familiarity, the softness of the film feeling, and the moisturizing property as compared with the comparative example. The viscosity after manufacture of the gel-form skin external preparation shown in Examples 1-6 is 25000-40000 mPa.s. It is in the range of s.

  The formulation example of the gel skin external preparation of this invention is given to the following. All of them are expected to be gel-type skin external preparations that are excellent in feeling of use (no stickiness, softness to skin, and softness of film feeling), and have good moisture retention and storage stability.

(Formulation example 1: Gel cream for moisturizing)
Component Content (mass%)
1. Hydrogenated soybean phospholipid (Note 1) 0.5
2. Macadamia nut oil 1.0
3. Macadamia nut oil fatty acid phytosteryl 2.0
4). Shea fat 1.0
5. Cholesterol 0.2
6). Squalane 3.0
7). Dipropylene glycol 7.0
8). Acrylic acid / alkyl methacrylate copolymer 0.2
9. Carboxyvinyl polymer 0.3
10. Ethanol 5.0
11. Dipotassium glycyrrhizinate 0.01
12 Edetate disodium 0.01
13. Potassium hydroxide 0.2
14 Sodium hyaluronate (Note 2) 0.01
15. Rose water 0.01
16. Carrot extract 0.01
17. Water-soluble collagen (Note 3) 0.01
18. Star fruit leaf extract 0.01
19. Licorice leaf extract 0.01
20. Senkyu Extract 0.01
21. Fermented soymilk extract 0.01
22. Yokuinin extract 0.01
23. Nicotinamide 0.01
24. Acetylglucosamine 0.01
25. Coenzyme Q10 0.01
26. Thioctic acid 0.01
27. Phenoxyethanol appropriate amount 28. Purified water remaining amount Note 1: Coatsome NC-21 (manufactured by NOF)
Note 2: Hyaluronic acid FCH-SU (manufactured by Kikkoman Biochemifa)
Note 3: Solu-Mar Native (Arch Personal Care Products LP)

(Formulation example 2: Moisturizing gel cream)
Component Content (mass%)
1. Hydrogenated soybean phospholipid (Note 1) 0.5
2. Macadamia nut oil 1.0
3. Lanolin Fatty Acid Cholesteryl 2.0
4). Shea fat 1.0
5. Cholesterol 0.2
6). Squalane 3.0
7). Isostearic acid 0.1
8). Nicotinic acid dl-α-tocopherol 0.01
9. Glycerin 3.0
10. Sorbitol 2.0
11.1,3-butylene glycol 10.0
12 Polyethylene glycol 4000 1.0
13. Acrylic acid / alkyl methacrylate copolymer 0.2
14 Carboxyvinyl polymer 0.3
15. Ethanol 5.0
16. Dipotassium glycyrrhizinate 0.01
17. Edetate trisodium 0.03
18. Potassium hydroxide 0.2
19. Xanthan gum 0.1
20. Arbutin 1.0
21. Fragrance 0.1
22. Methylparaben appropriate amount 23. Purified water remaining amount Note 1: Coatsome NC-21 (manufactured by NOF)

  As a fragrance | flavor used by the said formulation example, the fragrance | flavor prescription A of following Table 2 can be illustrated.

Claims (5)

A gel-like external preparation for skin containing the following components (A) to (D).
(A) Phospholipid (B) Macadamia nut oil (C) Macadamia nut fatty acid cholesteryl, lanolin fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl and lanolin fatty acid phytosteryl selected from one or more cholesterol derivatives and / or phytosterol derivatives (D) Shea fat   The gel external preparation according to claim 1, wherein the content of the component (B) relative to the total composition is 0.01 to 8% by mass.   The gel-form skin external preparation of Claim 1 or 2 whose containing mass ratio [(C) / (D)] of (C) component and (D) component is 0.05-10.   Furthermore, the gel-form skin external preparation of any one of Claims 1-3 containing a component (E) cholesterol and / or a phytosterol.   Viscosity is 15000-50000 mPa * s, The gel-form skin external preparation of any one of Claims 1-4.