JP2013047220A - Blood cholesterol reducer, and food for reducing blood cholesterol - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a blood cholesterol reducer having a more remarkable effect than a conventional technology, with the background that many drugs or foods for reducing blood cholesterol have been developed hitherto because an excessive amount of blood cholesterol causes hyperlipidemia though cholesterol is a kind of lipids and is a physiologically indispensable material for animals.SOLUTION: This blood cholesterol reducer includes a chrysalis and/or a larva of an insect. The insect may be Musca domestica.

Description

The present invention relates to a blood cholesterol-reducing agent containing insect wings and / or larvae, and a food for reducing blood cholesterol containing insect wings and / or larvae.

Cholesterol is a kind of lipid and is an essential substance in animal physiology. However, when the amount of cholesterol in the blood becomes excessive, it causes hyperlipidemia, and many drugs and foods that reduce blood cholesterol have been developed (see Patent Documents 1 to 5).

Moreover, it is known that polysaccharide chitin * chitosan has a blood cholesterol lowering effect, and the composition for eating and drinking using the effect | action is developed (refer patent document 6).

JP 2010-183924 A JP 2009-280517 A JP 2008-271983 A JP 2003-238423 A JP 2002-068979 A JP 2007-236222 A

An object of this invention is to provide the blood cholesterol reducing agent which has a remarkable effect rather than a prior art.

The present invention provides a blood cholesterol-reducing agent containing insect wings and / or larvae.

Furthermore, the present invention provides a food for reducing blood cholesterol, which contains insect wings and / or larvae.

The insect is preferably a housefly. Furthermore, another invention is characterized in that the house fly is produced from livestock manure and / or food waste.

The blood cholesterol-reducing agent and the blood cholesterol-reducing food of the present invention exhibit a blood cholesterol-reducing action that is more marked than that of the prior art.

It is a figure which shows the blood cholesterol reduction effect of a house fly. It is a figure which shows the blood cholesterol reduction effect | action of a housefly larva.

Hereinafter, preferred embodiments of the feed of the present invention will be described.

The present invention contains insect larvae and / or moths, and uses insect larvae and / or moths as active ingredients. The insect used in the present invention is preferably a fly. A fly is an insect belonging to the order of the fly order (Diptera), and grows by changing the form of eggs, larvae, moths and adults. There are families such as houseflies, fliesflies, dungflies, fly flies, drosophilids, blackflies, drosophilids, and species such as houseflies, dromedaries, drosophila, yellow flies, sentinella, Drosophila. These insects can be used in the present invention.

In the present invention, it is preferable to use a housefly (scientific name: Musca domestica) belonging to the family Flies. Houseflies are distributed throughout the world. Houseflies are suitable for mass production because they grow fast and can be produced with simple equipment. Moreover, since livestock manure, food waste, etc. can be used as a raw material for growth, production is possible at low cost.

The insect larvae and / or moths used in the present invention are preferably heat-treated. The heat treatment means a treatment at a high temperature such as a boiling treatment, a dry heat treatment, a wet heat treatment, or a friction heat treatment, and includes a high-temperature and high-pressure treatment. Conditions such as the temperature and time of the heat treatment are not limited. For example, the temperature of the heat treatment is about 40 ° C. to about 300 ° C., preferably about 80 ° C. to about 200 ° C., and more preferably about 100 ° C. to about 300 ° C. 120 ° C. Further, for example, the heat treatment time is about 5 seconds to about 1 hour.

The high temperature and high pressure treatment means that the treatment is performed under conditions of high temperature and high pressure, and includes treatment by an autoclave or an extruder. The temperature, time, and pressure conditions of the high-temperature and high-pressure treatment are not limited. For example, the temperature of the high-temperature and high-pressure treatment is about 40 ° C. to about 300 ° C., preferably about 80 ° C. to about 200 ° C., more preferably. Is about 100 ° C to about 120 ° C. Further, for example, the time of the high-temperature and high-pressure treatment is about 5 seconds to about 1 hour. Moreover, for example, the pressure of the high-temperature and high-pressure treatment is 0.1 MPa to 50 MPa.

For the processing by the extruder, an extruder having a single-axis type or multi-axis screw can be used. The raw material is kneaded by a screw in the extruder, subjected to a high-temperature and high-pressure treatment, and extruded from a die. The number of rotations of the extruder screw is not limited, but is, for example, 20 rpm to 200 rpm.

In addition to the above treatment, the insect larvae and / or moths used in the present invention may be subjected to treatments such as pulverization, powdering, and drying.

Furthermore, although this invention is demonstrated concretely using an Example, this invention is not limited to these Examples.

1. Production of house fly and / or housefly larvae Housefly and / or housefly larvae used in this example were produced as follows. First, livestock manure housefly eggs were inoculated. The environment during production was maintained at a temperature of 25 ° C. to 40 ° C. and a humidity of 20% to 90%. House flies hatched and became larvae 1 to 2 days after inoculation with eggs. Housefly larvae have the property of craving from the medium 3-5 days after hatching. A collection container was installed in a place where the housefly larvae crawl out, and the housefly larvae moved into the collection container themselves, so that a housefly larva was obtained. The housefly larvae that had moved to the collection container hatched 1 to 2 days after the transfer to obtain housefly pupae.

2. Verification of blood cholesterol-reducing action by housefly moth The blood cholesterol-reducing action of housefly moth was verified using rats. Rat feeds of Examples 1 to 4 and Comparative Examples 1 and 2 containing fly meal were prepared. In Examples 1 and 2, casein was replaced with fly meal, and in Examples 3 and 4, corn starch was replaced with fly meal. Comparative Example 2 contains 5% of crab shell-derived chitin (manufactured by Nacalai Tesque). The fly cake used was subjected to high-temperature and high-pressure treatment at 120 ° C. for 20 minutes by an autoclave. Table 1 shows the composition (dry weight) in 1000 g.

81 6-week-old male SD rats were housed at a room temperature of 23 ± 1 ° C. and a cycle of 12L · 12D and habituated to AIN93 basic diet for 5 days. After acclimatization, 9 animals were divided into 9 groups and bred for 28 days with the above feed. Feed and drinking water were ad libitum. After the breeding, blood was collected and the total cholesterol level in the blood was measured.

The measurement result of blood cholesterol is shown in FIG. In Examples 1 to 4, a significant reduction in total cholesterol was observed. However, in Comparative Example 2 containing chitin derived from crab shell, no reduction in cholesterol was observed. In addition, there was no significant change in feed intake or weight gain between the examples and the comparative examples.

3. Verification of blood cholesterol-reducing action by fly larva Subsequently, blood cholesterol-reducing action by the above-mentioned housefly larvae was verified using rats. Example 5 and Example 6 containing fly larvae and the rat feed of Comparative Example 3 were prepared. In Examples 5 and 6, casein was replaced with fly larvae. The fly larvae used in Example 5 were boiled at 100 ° C. for 20 minutes, and the fly larvae used in Example 6 were those subjected to high temperature and high pressure treatment at 120 ° C. for 20 minutes by an autoclave. Table 2 shows the composition (dry weight) in 1000 g.

Twenty-seven 6-week-old male SD rats were housed at a room temperature of 23 ± 1 ° C. and a cycle of 12 L · 12D and habituated to AIN93 basic diet for 5 days. After acclimatization, 9 animals were divided into 9 groups and bred for 28 days with the above feed. Feed and drinking water were ad libitum. After the breeding, blood was collected and the total cholesterol level in the blood was measured.

The measurement result of blood cholesterol is shown in FIG. In Examples 5 and 6, a significant reduction in total cholesterol was observed. There was no significant change in feed intake or weight gain between the examples and the comparative examples.

Claims (6)

Blood cholesterol-reducing agent containing insect wings and / or larvae The blood cholesterol-reducing agent according to claim 1, wherein the insect is a housefly. The blood cholesterol-reducing agent according to claim 2, wherein the house fly is produced from livestock manure and / or food waste. Food for reducing blood cholesterol containing insect wings and / or larvae The food for reducing blood cholesterol according to claim 4, wherein the insect is a housefly. The food for reducing blood cholesterol according to claim 5, wherein the house fly is produced from livestock manure and / or food waste.