JP2013032293A - ヒトｄＵＴＰａｓｅ阻害活性を有する５−フルオロウラシル化合物又はその塩 - Google Patents
ヒトｄＵＴＰａｓｅ阻害活性を有する５−フルオロウラシル化合物又はその塩 Download PDFInfo
- Publication number
- JP2013032293A JP2013032293A JP2009272187A JP2009272187A JP2013032293A JP 2013032293 A JP2013032293 A JP 2013032293A JP 2009272187 A JP2009272187 A JP 2009272187A JP 2009272187 A JP2009272187 A JP 2009272187A JP 2013032293 A JP2013032293 A JP 2013032293A
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- JP
- Japan
- Prior art keywords
- group
- substituent
- carbon atoms
- added
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UWMYHQMDRSIVDG-DCRNPWPISA-N C/C=C\C(\C(c1ccccc1)(c1ccccc1)OCCOCN(C=CC(N1)=O)C1=O)=C/C Chemical compound C/C=C\C(\C(c1ccccc1)(c1ccccc1)OCCOCN(C=CC(N1)=O)C1=O)=C/C UWMYHQMDRSIVDG-DCRNPWPISA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009272187A JP2013032293A (ja) | 2009-11-30 | 2009-11-30 | ヒトｄＵＴＰａｓｅ阻害活性を有する５−フルオロウラシル化合物又はその塩 |
| PCT/JP2010/071289 WO2011065545A1 (fr) | 2009-11-30 | 2010-11-29 | 5-FLUOROURACILE PRÉSENTANT UNE ACTIVITÉ INHIBITRICE DE LA dUTPase OU L'UN DE SES SELS |
| TW099141285A TW201121944A (en) | 2009-11-30 | 2010-11-29 | 5-fluorouracil compound having dutpase-inhibiting activity or salt thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009272187A JP2013032293A (ja) | 2009-11-30 | 2009-11-30 | ヒトｄＵＴＰａｓｅ阻害活性を有する５−フルオロウラシル化合物又はその塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2013032293A true JP2013032293A (ja) | 2013-02-14 |
Family
ID=44066649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009272187A Pending JP2013032293A (ja) | 2009-11-30 | 2009-11-30 | ヒトｄＵＴＰａｓｅ阻害活性を有する５−フルオロウラシル化合物又はその塩 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2013032293A (fr) |
| TW (1) | TW201121944A (fr) |
| WO (1) | WO2011065545A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2016178416A1 (ja) * | 2015-05-01 | 2017-10-26 | 大鵬薬品工業株式会社 | ウラシル化合物の新規結晶 |
| CN115872923A (zh) * | 2022-12-29 | 2023-03-31 | 成都泰和伟业生物科技有限公司 | 一种化合物及其制备方法 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2548913C2 (ru) * | 2009-11-30 | 2015-04-20 | Тайхо Фармасьютикал Ко., Лтд. | Усилитель действия противоопухолевого средства |
| WO2014107622A1 (fr) | 2013-01-07 | 2014-07-10 | University Of Southern California | Inhibiteurs de la désoxyuridine triphosphatase |
| CA2935717C (fr) | 2014-01-03 | 2022-06-21 | University Of Southern California | Isostere d'uracile et compositions pharmaceutiques connexes utiles commeinhibiteurs de triphosphatase de deoxyuridine |
| US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| US10570100B2 (en) | 2015-07-08 | 2020-02-25 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| US10570098B2 (en) | 2015-07-08 | 2020-02-25 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US10858344B2 (en) | 2016-11-23 | 2020-12-08 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| WO2018098204A1 (fr) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Isostères d'uracile à 6 chaînons |
| WO2018098208A1 (fr) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Inhibiteurs de désoxyuridine triphosphatase liés à un cycle azote |
| WO2018098209A1 (fr) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Composés aminosulfonyle |
| US11014924B2 (en) | 2016-11-23 | 2021-05-25 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| WO2018128720A1 (fr) | 2017-01-05 | 2018-07-12 | Cv6 Therapeutics (Ni) Limited | Composés contenant de l'uracile |
| CN114907274A (zh) * | 2022-05-11 | 2022-08-16 | 宁夏医科大学 | 5-氟尿嘧啶-1-烷基酸衍生物及制备方法及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5839672A (ja) * | 1981-09-03 | 1983-03-08 | Chugai Pharmaceut Co Ltd | ウラシル誘導体 |
| JPH09286786A (ja) * | 1996-04-18 | 1997-11-04 | Nippon Paper Ind Co Ltd | ピリミジン誘導体及びその抗腫瘍剤としての用途 |
| GB0400290D0 (en) * | 2004-01-08 | 2004-02-11 | Medivir Ab | dUTPase inhibitors |
| EP1939186A1 (fr) * | 2006-12-22 | 2008-07-02 | Sulfidris S.r.l. | Derives de 5-Fluorouracil come agent anticancéreux |
-
2009
- 2009-11-30 JP JP2009272187A patent/JP2013032293A/ja active Pending
-
2010
- 2010-11-29 TW TW099141285A patent/TW201121944A/zh unknown
- 2010-11-29 WO PCT/JP2010/071289 patent/WO2011065545A1/fr active Application Filing
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2016178416A1 (ja) * | 2015-05-01 | 2017-10-26 | 大鵬薬品工業株式会社 | ウラシル化合物の新規結晶 |
| CN115872923A (zh) * | 2022-12-29 | 2023-03-31 | 成都泰和伟业生物科技有限公司 | 一种化合物及其制备方法 |
| CN115872923B (zh) * | 2022-12-29 | 2023-04-28 | 成都泰和伟业生物科技有限公司 | 一种化合物及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201121944A (en) | 2011-07-01 |
| WO2011065545A1 (fr) | 2011-06-03 |
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