JP2012533582A5 - - Google Patents

Info

Publication number

JP2012533582A5

JP2012533582A5 JP2012520933A JP2012520933A JP2012533582A5 JP 2012533582 A5 JP2012533582 A5 JP 2012533582A5 JP 2012520933 A JP2012520933 A JP 2012520933A JP 2012520933 A JP2012520933 A JP 2012520933A JP 2012533582 A5 JP2012533582 A5 JP 2012533582A5

Authority

JP

Japan

Prior art keywords

line device

adsorbent

patient

matrix

line

Prior art date

2010-07-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000003463 adsorbent Substances 0.000 claims 10
• 210000001124 body fluid Anatomy 0.000 claims 6
• 239000011159 matrix material Substances 0.000 claims 5
• XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims 4
• 239000008280 blood Substances 0.000 claims 4
• 210000004369 blood Anatomy 0.000 claims 4
• 239000012530 fluid Substances 0.000 claims 4
• 239000010839 body fluid Substances 0.000 claims 3
• 102000018511 hepcidin Human genes 0.000 claims 3
• 229940066919 hepcidin Drugs 0.000 claims 3
• 108060003558 hepcidin Proteins 0.000 claims 3
• 239000003446 ligand Substances 0.000 claims 3
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
• 208000007502 anemia Diseases 0.000 claims 2
• 239000011148 porous material Substances 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 102100033312 Alpha-2-macroglobulin Human genes 0.000 claims 1
• 101800003310 Hepcidin-25 Proteins 0.000 claims 1
• 102400001151 Hepcidin-25 Human genes 0.000 claims 1
• 108010015078 Pregnancy-Associated alpha 2-Macroglobulins Proteins 0.000 claims 1
• 208000020832 chronic kidney disease Diseases 0.000 claims 1
• 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
• 230000000779 depleting effect Effects 0.000 claims 1
• 238000010494 dissociation reaction Methods 0.000 claims 1
• 230000005593 dissociations Effects 0.000 claims 1
• 238000001631 haemodialysis Methods 0.000 claims 1
• 230000000322 hemodialysis Effects 0.000 claims 1
• 229910052742 iron Inorganic materials 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 229920000620 organic polymer Polymers 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1