JP2012533566A5 - - Google Patents
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- JP2012533566A5 JP2012533566A5 JP2012520814A JP2012520814A JP2012533566A5 JP 2012533566 A5 JP2012533566 A5 JP 2012533566A5 JP 2012520814 A JP2012520814 A JP 2012520814A JP 2012520814 A JP2012520814 A JP 2012520814A JP 2012533566 A5 JP2012533566 A5 JP 2012533566A5
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- JP
- Japan
- Prior art keywords
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- pharmaceutical composition
- atoms
- composition according
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 8
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims 8
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 6
- 229940122041 Cholinesterase inhibitor Drugs 0.000 claims 4
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 4
- 229960003530 donepezil Drugs 0.000 claims 4
- 229960003980 galantamine Drugs 0.000 claims 4
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims 4
- 229960004136 rivastigmine Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 235000010290 biphenyl Nutrition 0.000 claims 3
- 239000004305 biphenyl Substances 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 125000003944 tolyl group Chemical group 0.000 claims 3
- 208000006888 Agnosia Diseases 0.000 claims 2
- 241001047040 Agnosia Species 0.000 claims 2
- 208000000044 Amnesia Diseases 0.000 claims 2
- 208000031091 Amnestic disease Diseases 0.000 claims 2
- 206010003062 Apraxia Diseases 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 208000004547 Hallucinations Diseases 0.000 claims 2
- 230000006986 amnesia Effects 0.000 claims 2
- 201000007201 aphasia Diseases 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22642509P | 2009-07-17 | 2009-07-17 | |
| US61/226,425 | 2009-07-17 | ||
| PCT/US2010/042308 WO2011009061A1 (en) | 2009-07-17 | 2010-07-16 | Compositions comprising a cholinesterase inhibitor for treating cognitive disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012533566A JP2012533566A (ja) | 2012-12-27 |
| JP2012533566A5 true JP2012533566A5 (enExample) | 2013-09-05 |
Family
ID=42990151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520814A Pending JP2012533566A (ja) | 2009-07-17 | 2010-07-16 | 認識障害処置用のコリンエステラーゼ阻害剤を含む組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20110015179A1 (enExample) |
| EP (1) | EP2453890B1 (enExample) |
| JP (1) | JP2012533566A (enExample) |
| KR (1) | KR101757003B1 (enExample) |
| CN (1) | CN102497861A (enExample) |
| AU (1) | AU2010273977A1 (enExample) |
| BR (1) | BR112012001047A2 (enExample) |
| CA (1) | CA2768356A1 (enExample) |
| DK (1) | DK2453890T3 (enExample) |
| ES (1) | ES2809298T3 (enExample) |
| IN (1) | IN2012DN01209A (enExample) |
| PT (1) | PT2453890T (enExample) |
| RU (2) | RU2607946C2 (enExample) |
| WO (1) | WO2011009061A1 (enExample) |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| US4166452A (en) * | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) * | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US5409948A (en) * | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
| WO2005072713A2 (en) | 2004-01-27 | 2005-08-11 | The Feinstein Institute For Medical Research | Cholinesterase inhibitors for treating inflammation |
| US20070212253A1 (en) * | 2004-12-21 | 2007-09-13 | Elrod Scott A | Descenting systems and methods |
| US20090088433A1 (en) | 2005-01-26 | 2009-04-02 | Bertrand Leblond | Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| CA2616858A1 (en) * | 2005-07-27 | 2007-02-01 | Carlos Henrique Horta Lima | Pharmaceutical preparation containing an acetylcholinesterase ihibitor and an antidepressant with 5-ht and alpha-2-adrenoceptor blocking properties. |
| CA2620333A1 (en) * | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| US20100190792A1 (en) * | 2007-03-06 | 2010-07-29 | Allergan, Inc | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| DK2481407T3 (en) * | 2007-03-06 | 2019-01-07 | Allergan Inc | RELATIONSHIPS TO USE IN TREATMENT OF COGNITIVE DISORDERS |
| US8173683B2 (en) * | 2007-03-06 | 2012-05-08 | Allergan, Inc. | Methods for treating cognitive disorders |
| US20100105687A1 (en) * | 2007-03-06 | 2010-04-29 | Allergan, Inc. | Methods for treating cognitive disorders using 1-aryl-1-hydroxy-2,3-diamino-propyl amines, 1-heteroaryl-1-hydroxy-2,3-diamino-propyl amines and related compounds |
| AU2008276278A1 (en) * | 2007-07-17 | 2009-01-22 | Allergan, Inc. | Methods for treating anxiety |
-
2010
- 2010-07-16 RU RU2012103401A patent/RU2607946C2/ru not_active Application Discontinuation
- 2010-07-16 RU RU2016151986A patent/RU2016151986A/ru not_active Application Discontinuation
- 2010-07-16 KR KR1020127003979A patent/KR101757003B1/ko active Active
- 2010-07-16 WO PCT/US2010/042308 patent/WO2011009061A1/en not_active Ceased
- 2010-07-16 CN CN201080041187XA patent/CN102497861A/zh active Pending
- 2010-07-16 ES ES10735143T patent/ES2809298T3/es active Active
- 2010-07-16 IN IN1209DEN2012 patent/IN2012DN01209A/en unknown
- 2010-07-16 US US12/838,019 patent/US20110015179A1/en not_active Abandoned
- 2010-07-16 EP EP10735143.9A patent/EP2453890B1/en active Active
- 2010-07-16 JP JP2012520814A patent/JP2012533566A/ja active Pending
- 2010-07-16 AU AU2010273977A patent/AU2010273977A1/en not_active Abandoned
- 2010-07-16 PT PT107351439T patent/PT2453890T/pt unknown
- 2010-07-16 DK DK10735143.9T patent/DK2453890T3/da active
- 2010-07-16 CA CA2768356A patent/CA2768356A1/en not_active Abandoned
- 2010-07-16 BR BR112012001047A patent/BR112012001047A2/pt not_active IP Right Cessation
-
2012
- 2012-10-11 US US13/649,404 patent/US9492543B2/en active Active
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