JP2012532094A - アルツハイマ病の治療および診断方法における使用のためのN末端切断型アミロイドβプロトフィブリル/オリゴマ - Google Patents

アルツハイマ病の治療および診断方法における使用のためのN末端切断型アミロイドβプロトフィブリル/オリゴマ Download PDF

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JP2012532094A
JP2012532094A JP2012516964A JP2012516964A JP2012532094A JP 2012532094 A JP2012532094 A JP 2012532094A JP 2012516964 A JP2012516964 A JP 2012516964A JP 2012516964 A JP2012516964 A JP 2012516964A JP 2012532094 A JP2012532094 A JP 2012532094A
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antibody
alzheimer
terminal truncated
protofibril
oligomer
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ペール ゲラーフォース
ラース ランフェルト
リンダ セーデルベリ
カリン テーゲルステット
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バイオアークティック ニューロサイエンス アーベー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2012516964A 2009-06-29 2010-06-29 アルツハイマ病の治療および診断方法における使用のためのN末端切断型アミロイドβプロトフィブリル/オリゴマ Withdrawn JP2012532094A (ja)

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US22110509P 2009-06-29 2009-06-29
US61/221,105 2009-06-29
PCT/IB2010/052947 WO2011001366A1 (en) 2009-06-29 2010-06-29 N-terminal truncated amyloid beta protofibrils/ oligomers for use in therapeutic and diagnostic methods for alzheimer's disease

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JP2017083057A Division JP6884025B2 (ja) 2009-06-29 2017-04-19 アルツハイマ病の治療および診断方法における使用のためのN末端切断型アミロイドβプロトフィブリル/オリゴマ

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JP2012532094A5 JP2012532094A5 (enExample) 2013-08-08

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JP2012516964A Withdrawn JP2012532094A (ja) 2009-06-29 2010-06-29 アルツハイマ病の治療および診断方法における使用のためのN末端切断型アミロイドβプロトフィブリル/オリゴマ
JP2017083057A Active JP6884025B2 (ja) 2009-06-29 2017-04-19 アルツハイマ病の治療および診断方法における使用のためのN末端切断型アミロイドβプロトフィブリル/オリゴマ
JP2019142344A Pending JP2019218362A (ja) 2009-06-29 2019-08-01 アルツハイマ病の治療および診断方法における使用のためのN末端切断型アミロイドβプロトフィブリル/オリゴマ

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JP2019142344A Pending JP2019218362A (ja) 2009-06-29 2019-08-01 アルツハイマ病の治療および診断方法における使用のためのN末端切断型アミロイドβプロトフィブリル/オリゴマ

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US (2) US20120100129A1 (enExample)
EP (2) EP3892633A1 (enExample)
JP (3) JP2012532094A (enExample)
AU (1) AU2010267640B2 (enExample)
CA (1) CA2765602C (enExample)
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SE0401601D0 (sv) 2004-06-21 2004-06-21 Bioarctic Neuroscience Ab Protofibril specific antibodies and uses thereof
CN101421303B (zh) 2006-03-23 2013-06-12 生命北极神经科学公司 改进的初原纤维选择性抗体及其用途
HRP20180230T8 (hr) 2010-02-26 2021-04-30 Bioarctic Neuroscience Ab Protutijela koja se vežu na protofibrile i njihova upotreba u terapijskim i dijagnostičkim postupcima kod parkinsonove bolesti, demencije s lewyjevim tijelima i drugih alfa-sinukleinopatija
SG192805A1 (en) 2011-03-16 2013-09-30 Probiodrug Ag Diagnostic antibody assay
MY184890A (en) 2014-07-10 2021-04-29 Bioarctic Neuroscience Ab Improved a? protofibril binding antibodies
US11327080B2 (en) 2015-07-21 2022-05-10 BioArctic Neruoscience AB Method for treatment of traumatic brain injury targeting aggregated peptides
EP3484918A1 (en) 2016-07-14 2019-05-22 BioArctic Neuroscience AB Brain delivery protein
CA3070446A1 (en) 2017-07-25 2019-01-31 Immutics, Inc. Treating cancer by blocking the interaction of tim-3 and its ligand
JP7541505B2 (ja) 2018-07-24 2024-08-28 エーザイ・アール・アンド・ディー・マネジメント株式会社 アルツハイマー病の治療及び予防方法
CN120058944A (zh) 2019-01-30 2025-05-30 真和制药有限公司 抗gal3抗体及其用途
WO2021055670A1 (en) 2019-09-20 2021-03-25 Avx Corporation Somatic cell-based electrical biosensor
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
FI4172199T3 (fi) 2020-06-26 2025-08-12 Bioarctic Ab Alfa-synukleiinin protofibrilliin sitoutuvat vasta-aineet
EP4367516A1 (en) 2021-07-09 2024-05-15 Eisai R&D Management Co., Ltd. Biomarkers for alzheimer's disease treatment
EP4395821A1 (en) 2021-08-30 2024-07-10 Eisai R&D Management Co., Ltd. Subcutaneous formulations of anti-abeta protofibril antibody and methods of use thereof
US20250377367A1 (en) 2022-02-02 2025-12-11 Eisai R&D Management Co., Ltd. Methods of treatment using p-tau181 level
KR20250134612A (ko) 2022-12-22 2025-09-11 바이오악틱 에이비 Abetape3에 결합하는 항체
US20250388664A1 (en) 2024-06-20 2025-12-25 Bioarctic Ab Bispecific binding molecule

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US7122374B1 (en) * 2002-04-09 2006-10-17 Takaomi Saido Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
WO2007108756A1 (en) * 2006-03-23 2007-09-27 Bioarctic Neuroscience Ab Improved protofibril selective antibodies and the use thereof
WO2009065054A2 (en) * 2007-11-16 2009-05-22 The Rockefeller University Antibodies specific for the protofibril form of beta-amyloid protein

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EP2067789A1 (en) * 2004-04-13 2009-06-10 F. Hoffmann-La Roche Ag Anti-P selectin antibodies
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JPWO2021006212A1 (enExample) * 2019-07-08 2021-01-14
WO2021006212A1 (ja) * 2019-07-08 2021-01-14 テルモ株式会社 ハイブリドーマおよびその製造方法、並びにモノクローナル抗体およびその製造方法

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JP2019218362A (ja) 2019-12-26
CA2765602A1 (en) 2011-01-06
US20120100129A1 (en) 2012-04-26
EP2448968A1 (en) 2012-05-09
CA2765602C (en) 2021-05-25
SI2448968T1 (sl) 2021-07-30
EP3892633A1 (en) 2021-10-13
HRP20210611T1 (hr) 2021-05-28
PT2448968T (pt) 2021-04-30
AU2010267640B2 (en) 2015-03-05
JP6884025B2 (ja) 2021-06-09
ES2864049T3 (es) 2021-10-13
PL2448968T3 (pl) 2021-09-13
CY1124034T1 (el) 2022-05-27
HUE053949T2 (hu) 2021-08-30
SMT202100237T1 (it) 2021-05-07
EP2448968B1 (en) 2021-01-27
US20230295283A1 (en) 2023-09-21
JP2017197531A (ja) 2017-11-02
LT2448968T (lt) 2021-05-10
DK2448968T3 (da) 2021-04-12
AU2010267640A1 (en) 2012-01-19
WO2011001366A1 (en) 2011-01-06

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