PT2448968T - ANTICORPOS SELETIVOS PARA PROTOFIBRILAS/OLIGÓMEROS DE ß- AMILOIDE TRUNCADA EM N-TERMINAL - Google Patents

ANTICORPOS SELETIVOS PARA PROTOFIBRILAS/OLIGÓMEROS DE ß- AMILOIDE TRUNCADA EM N-TERMINAL

Info

Publication number
PT2448968T
PT2448968T PT107397010T PT10739701T PT2448968T PT 2448968 T PT2448968 T PT 2448968T PT 107397010 T PT107397010 T PT 107397010T PT 10739701 T PT10739701 T PT 10739701T PT 2448968 T PT2448968 T PT 2448968T
Authority
PT
Portugal
Prior art keywords
alzheimer
oligomers
therapeutic
disease
diagnostic methods
Prior art date
Application number
PT107397010T
Other languages
English (en)
Original Assignee
Bioarctic Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioarctic Ab filed Critical Bioarctic Ab
Publication of PT2448968T publication Critical patent/PT2448968T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
PT107397010T 2009-06-29 2010-06-29 ANTICORPOS SELETIVOS PARA PROTOFIBRILAS/OLIGÓMEROS DE ß- AMILOIDE TRUNCADA EM N-TERMINAL PT2448968T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22110509P 2009-06-29 2009-06-29

Publications (1)

Publication Number Publication Date
PT2448968T true PT2448968T (pt) 2021-04-30

Family

ID=42832352

Family Applications (1)

Application Number Title Priority Date Filing Date
PT107397010T PT2448968T (pt) 2009-06-29 2010-06-29 ANTICORPOS SELETIVOS PARA PROTOFIBRILAS/OLIGÓMEROS DE ß- AMILOIDE TRUNCADA EM N-TERMINAL

Country Status (15)

Country Link
US (2) US20120100129A1 (pt)
EP (2) EP2448968B1 (pt)
JP (3) JP2012532094A (pt)
AU (1) AU2010267640B2 (pt)
CA (1) CA2765602C (pt)
CY (1) CY1124034T1 (pt)
DK (1) DK2448968T3 (pt)
ES (1) ES2864049T3 (pt)
HR (1) HRP20210611T1 (pt)
HU (1) HUE053949T2 (pt)
LT (1) LT2448968T (pt)
PL (1) PL2448968T3 (pt)
PT (1) PT2448968T (pt)
SI (1) SI2448968T1 (pt)
WO (1) WO2011001366A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0401601D0 (sv) 2004-06-21 2004-06-21 Bioarctic Neuroscience Ab Protofibril specific antibodies and uses thereof
KR101413615B1 (ko) 2006-03-23 2014-07-18 바이오악틱 뉴로사이언스 에이비 인간 프로토피브릴에 선택적인 개선된 항체 및 이의 용도
CN106397588B (zh) 2010-02-26 2020-09-08 生命北极神经科学公司 原细纤维结合抗体及其治疗和诊断帕金森氏症、路易体痴呆和其他α-共核蛋白病的应用
BR112013023211B1 (pt) * 2011-03-16 2022-11-08 Vivoryon Therapeutics N.V. Anticorpo monoclonal, seu uso, composição, linhagem celular, método diagnóstico in vitro e kit
EP3166970B1 (en) 2014-07-10 2021-03-10 BioArctic AB Improved a-beta protofibril binding antibodies
CN107849125A (zh) 2015-07-21 2018-03-27 生命北极神经科学公司 用于治疗靶向聚集的肽的创伤性脑损伤的方法
BR112019000098A2 (pt) 2016-07-14 2019-04-09 Bioarctic Ab proteína de fornecimento ao cérebro, método de tratamento e/ou profilaxia de distúrbios cerebrais em mamíferos que possuem ou encontram-se em risco de desenvolver o mencionado distúrbio e método de diagnóstico e/ou detecção de distúrbios cerebrais em mamíferos suspeitos de possuir ou que se encontram em risco de desenvolver o mencionado distúrbio
CN112805031A (zh) 2018-07-24 2021-05-14 卫材R&D管理有限公司 阿尔茨海默病的治疗及预防方法
US20220251518A1 (en) * 2019-07-08 2022-08-11 Terumo Kabushik Kaisha Hybridoma, method for making the same, monoclonal antibody, and method for making the same
EP4172199A1 (en) 2020-06-26 2023-05-03 BioArctic AB A-synuclein protofibril-binding antibodies
IL309468A (en) 2021-07-09 2024-02-01 Eisai R&D Man Co Ltd Biomarkers for the treatment of Alzheimer's disease
AU2022338055A1 (en) 2021-08-30 2024-02-29 Eisai R&D Management Co., Ltd. Subcutaneous formulations of anti-abeta protofibril antibody and methods of use thereof
WO2023149970A1 (en) 2022-02-02 2023-08-10 Eisai R&D Management Co., Ltd. Methods of treatment using p-tau181 level

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604102A (en) 1992-04-15 1997-02-18 Athena Neurosciences, Inc. Methods of screening for β-amyloid peptide production inhibitors
CA2381323C (en) * 1999-08-04 2009-10-06 University Of Southern California Amyloid .beta. protein (globular assembly and uses thereof)
EP1309341A2 (en) * 2000-07-07 2003-05-14 Lars Lannfelt Prevention and treatment of alzheimer's disease
US7122374B1 (en) * 2002-04-09 2006-10-17 Takaomi Saido Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
AU2003250102B2 (en) * 2002-07-24 2009-09-17 Innogenetics N.V. Fragments of beta-amyloid as targets for vaccination against alzheimer disease
CA2885854C (en) * 2004-04-13 2017-02-21 F. Hoffmann-La Roche Ag Anti-p-selectin antibodies
GB0413726D0 (en) * 2004-06-18 2004-07-21 Lauras As Compounds
SE0401601D0 (sv) * 2004-06-21 2004-06-21 Bioarctic Neuroscience Ab Protofibril specific antibodies and uses thereof
MX2007000998A (es) * 2004-07-30 2007-07-11 Rinat Neuroscience Corp Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos.
KR101413615B1 (ko) * 2006-03-23 2014-07-18 바이오악틱 뉴로사이언스 에이비 인간 프로토피브릴에 선택적인 개선된 항체 및 이의 용도
JP5616230B2 (ja) * 2007-11-16 2014-10-29 ザ ロックフェラー ユニバーシティー ベータ−アミロイドタンパク質のプロトフィブリルの形態に特異的な抗体
JP5747414B2 (ja) * 2008-04-29 2015-07-15 バイオアークティック ニューロサイエンス アーベー α−シヌクレイン関連疾患についての治療および診断方法における使用のための抗体およびワクチン

Also Published As

Publication number Publication date
EP2448968B1 (en) 2021-01-27
CY1124034T1 (el) 2022-05-27
US20230295283A1 (en) 2023-09-21
LT2448968T (lt) 2021-05-10
ES2864049T3 (es) 2021-10-13
DK2448968T3 (da) 2021-04-12
AU2010267640A1 (en) 2012-01-19
SI2448968T1 (sl) 2021-07-30
WO2011001366A1 (en) 2011-01-06
HRP20210611T1 (hr) 2021-05-28
PL2448968T3 (pl) 2021-09-13
US20120100129A1 (en) 2012-04-26
CA2765602A1 (en) 2011-01-06
EP2448968A1 (en) 2012-05-09
JP6884025B2 (ja) 2021-06-09
CA2765602C (en) 2021-05-25
AU2010267640B2 (en) 2015-03-05
JP2017197531A (ja) 2017-11-02
HUE053949T2 (hu) 2021-08-30
JP2019218362A (ja) 2019-12-26
EP3892633A1 (en) 2021-10-13
JP2012532094A (ja) 2012-12-13

Similar Documents

Publication Publication Date Title
PT2448968T (pt) ANTICORPOS SELETIVOS PARA PROTOFIBRILAS/OLIGÓMEROS DE ß- AMILOIDE TRUNCADA EM N-TERMINAL
HRP20190092T1 (hr) Antitijela i cjepiva za uporabu u terapijskim i dijagonstičkim postupcima za poremećaje vezane uz alfa-sinuklein
EP2566380A4 (en) METHOD AND SYSTEM FOR THE IMAGING OF AMYLOID BETA IN THE NETWORK OF THE EYE FOR THE TREATMENT OF MORBUS ALZHEIMER
ZA201107862B (en) Intrauterine system for use in medical treatment
PL2393399T3 (pl) Materac przeznaczony do użytku w domach opieki i szpitalach
LT2539366T (lt) Protofibriles surišantys antikūnai ir jų panaudojimas parkinsono ligos, demencijos su levi kūneliais ir kitų alfa-sinukleinopatijų terapiniuose ir diagnostiniuose būduose
LT2758433T (lt) Alzheimerio ligos tau-sąlygojamos patologijos terapija ir diagnostika baltymų pagrindu
HK1165793A1 (en) Indolizine derivative and use thereof for medical purposes
EP2519234A4 (en) ANAPLEROTIC THERAPY FOR ALZHEIMER'S DISEASE AND BRAIN AGING
EP2470116A4 (en) DEVICE FOR STIMULATING AND / OR MONITORING TISSUE ACTIVITIES
HK1162150A1 (en) Reduction of amyloid beta load in non brain tissue
EP2516001A4 (en) MRI AND ULTRASOUND GUIDED TREATMENT APPARATUS
PL2410922T3 (pl) Urządzenie do przeprowadzania procedur diagnostycznych i/lub terapeutycznych
GB201121597D0 (en) Polyurethane oligomers for use in restorative dentistry
EP2405928A4 (en) Methods of treatment and diagnosis for hypersensitivity disorders
GB0918392D0 (en) Diagnostic and therapeutic methods
EP2323680A4 (en) PROTEINS FOR USE IN THE DIAGNOSIS AND TREATMENT OF INFECTIONS AND DISEASES
HK1173181A1 (en) Medicament and agent for treating and diagnosing immune disorders and their use
EP2440233A4 (en) SORCS1-SIMILAR ACTIVE FOR USE IN THE TREATMENT OF INSULIN RESISTANCE AND RELATED DISEASES
PT2470066E (pt) Método não invasivo para avaliação da perfusão de tecidos num doente
EP2438167A4 (en) THERAPEUTIC AND DIAGNOSTIC MOLECULES
EP2660600A4 (en) DIAGNOSTIC MEDICINE AND DIAGNOSTIC METHOD FOR ALZHEIMER'S DISEASE
HRP20151393T8 (hr) UPORABA BENZIDAMINA U LIJEČENJU BOLESTI KOJE SU p40-OVISNE
GB0912665D0 (en) Force-transmitting element for use in medical catheters
GB0905970D0 (en) Depsipeptides and their therapeutic use