JP2012529906A5 - - Google Patents
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- Publication number
- JP2012529906A5 JP2012529906A5 JP2012515627A JP2012515627A JP2012529906A5 JP 2012529906 A5 JP2012529906 A5 JP 2012529906A5 JP 2012515627 A JP2012515627 A JP 2012515627A JP 2012515627 A JP2012515627 A JP 2012515627A JP 2012529906 A5 JP2012529906 A5 JP 2012529906A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- chemokine
- seq
- polypeptide according
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 102000019034 Chemokines Human genes 0.000 claims 8
- 108010012236 Chemokines Proteins 0.000 claims 8
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 102000009410 Chemokine receptor Human genes 0.000 claims 2
- 108050000299 Chemokine receptor Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920003169 water-soluble polymer Polymers 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010053613 Type IV hypersensitivity reaction Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000006472 autoimmune response Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000012292 cell migration Effects 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000010410 reperfusion Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 230000005951 type IV hypersensitivity Effects 0.000 claims 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21349309P | 2009-06-15 | 2009-06-15 | |
| US61/213,493 | 2009-06-15 | ||
| PCT/IL2010/000473 WO2010146584A1 (en) | 2009-06-15 | 2010-06-15 | Novel chemokine binding polypeptides capable of inhibiting the course of autoimmunity, inflammation and cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012529906A JP2012529906A (ja) | 2012-11-29 |
| JP2012529906A5 true JP2012529906A5 (cg-RX-API-DMAC7.html) | 2013-08-01 |
| JP5784010B2 JP5784010B2 (ja) | 2015-09-24 |
Family
ID=42933139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515627A Expired - Fee Related JP5784010B2 (ja) | 2009-06-15 | 2010-06-15 | 自己免疫性、炎症およびガンの経過を阻害し得る新規なケモカイン結合ポリペプチド |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8685398B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2443137B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5784010B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20120046163A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102482324B (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI1009716A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2765188A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2443137T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE025294T2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011013457A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010146584A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7423007B2 (en) | 2002-08-27 | 2008-09-09 | Biokine Therapeutics Ltd. | Cxcr4 antagonist and use thereof |
| WO2008075370A2 (en) | 2006-12-21 | 2008-06-26 | Biokine Therapeutics Ltd. | T-140 peptide analogs having cxcr4 super-agonist activity for cancer therapy |
| US9427456B2 (en) | 2009-06-14 | 2016-08-30 | Biokine Therapeutics Ltd. | Peptide therapy for increasing platelet levels |
| DK2443137T3 (en) | 2009-06-15 | 2015-08-24 | Biokine Therapeutics Ltd | NOVEL chemokine-binding peptides capable of impeding the sequence for immunity, inflammation and cancer |
| US20130303460A1 (en) | 2011-01-10 | 2013-11-14 | Biokine Therapeutics Ltd. | Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma |
| WO2013160895A1 (en) | 2012-04-24 | 2013-10-31 | Biokine Therapeutics Ltd. | Peptides and use thereof in the treatment of large cell lung cancer |
| CN104327158B (zh) * | 2014-09-05 | 2017-02-01 | 山东省肿瘤防治研究院 | 大蒜中提取得到的抗肿瘤活性的多肽 |
| US20170226157A1 (en) * | 2014-12-09 | 2017-08-10 | Biokine Therapeutics Ltd. | Compositions and methods for the treatment of ocular diseases |
| CN107921087A (zh) | 2015-07-16 | 2018-04-17 | 百欧肯治疗有限公司 | 治疗癌症的组合物及方法 |
| EP3741432B1 (en) | 2015-12-17 | 2023-05-10 | AlonBio Ltd. | Quinolin-2,4-one derivatives for inhibiting chemokine activity |
| US10646465B2 (en) | 2015-12-17 | 2020-05-12 | Biokine Therapeutics Ltd. | Small molecules against cancer |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| EP3419645B1 (en) | 2016-02-23 | 2020-09-02 | BioLineRx Ltd. | Method of selecting a treatment regimen in acute myeloid leukemia (aml) |
| BR112021002333A2 (pt) * | 2018-08-10 | 2021-05-04 | Pantherna Therapeutics Gmbh | construto de ácido nucleico recombinante |
| KR20200044321A (ko) * | 2018-10-19 | 2020-04-29 | 아이진 주식회사 | 염증성 질환의 예방 또는 치료용 약학적 조성물 |
| CN114096524B (zh) | 2019-05-15 | 2025-03-04 | 阿龙拜欧有限公司 | 用于治疗癌症、抑制趋化因子活性和/或诱导细胞死亡的小分子 |
| KR102736939B1 (ko) * | 2021-09-30 | 2024-12-03 | (주)케어젠 | 항염증 활성을 갖는 펩타이드 및 이의 용도 |
| KR102609822B1 (ko) * | 2021-10-05 | 2023-12-06 | (주)케어젠 | 항염증 활성을 갖는 펩타이드와 이의 용도 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| WO1997034631A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20030221931A1 (en) | 2002-02-28 | 2003-12-04 | Steve Marsh | Sliding device |
| WO2007052173A2 (en) * | 2005-02-23 | 2007-05-10 | Endocube S.A.S. | Activity of thap-family chemokine-binding domains |
| EP1991578A2 (en) * | 2006-02-17 | 2008-11-19 | Rappaport Family Institute For Research in the Medical Sciences | Molecules and methods of using same for treating ccr5/ccr5 ligands associated diseases |
| DK2443137T3 (en) | 2009-06-15 | 2015-08-24 | Biokine Therapeutics Ltd | NOVEL chemokine-binding peptides capable of impeding the sequence for immunity, inflammation and cancer |
-
2010
- 2010-06-15 DK DK10735337.7T patent/DK2443137T3/en active
- 2010-06-15 CA CA2765188A patent/CA2765188A1/en not_active Abandoned
- 2010-06-15 WO PCT/IL2010/000473 patent/WO2010146584A1/en not_active Ceased
- 2010-06-15 HU HUE10735337A patent/HUE025294T2/en unknown
- 2010-06-15 US US13/378,063 patent/US8685398B2/en not_active Expired - Fee Related
- 2010-06-15 CN CN201080036127.9A patent/CN102482324B/zh not_active Expired - Fee Related
- 2010-06-15 KR KR1020127000920A patent/KR20120046163A/ko not_active Ceased
- 2010-06-15 BR BRPI1009716A patent/BRPI1009716A2/pt not_active IP Right Cessation
- 2010-06-15 EP EP10735337.7A patent/EP2443137B1/en not_active Not-in-force
- 2010-06-15 MX MX2011013457A patent/MX2011013457A/es active IP Right Grant
- 2010-06-15 JP JP2012515627A patent/JP5784010B2/ja not_active Expired - Fee Related
-
2014
- 2014-02-12 US US14/178,301 patent/US9493557B2/en not_active Expired - Fee Related
-
2016
- 2016-10-05 US US15/285,492 patent/US20170015708A1/en not_active Abandoned