JP2012529437A - Jakの阻害剤としてのジヒドロピロロナフチリジノン化合物 - Google Patents
Jakの阻害剤としてのジヒドロピロロナフチリジノン化合物 Download PDFInfo
- Publication number
- JP2012529437A JP2012529437A JP2012514236A JP2012514236A JP2012529437A JP 2012529437 A JP2012529437 A JP 2012529437A JP 2012514236 A JP2012514236 A JP 2012514236A JP 2012514236 A JP2012514236 A JP 2012514236A JP 2012529437 A JP2012529437 A JP 2012529437A
- Authority
- JP
- Japan
- Prior art keywords
- naphthyridin
- oxopyrrolo
- mmol
- methyl
- dihydropyrrolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 335
- 239000003112 inhibitor Substances 0.000 title description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 80
- 238000000034 method Methods 0.000 claims abstract description 48
- 201000010099 disease Diseases 0.000 claims abstract description 42
- 208000035475 disorder Diseases 0.000 claims abstract description 38
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 14
- 206010039073 rheumatoid arthritis Diseases 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- -1 3-Methyl-1-oxo-1- (pyrrolidin-1-yl) butan-2-yl Chemical group 0.000 claims description 81
- 125000000217 alkyl group Chemical group 0.000 claims description 56
- 150000003839 salts Chemical class 0.000 claims description 54
- 229910052757 nitrogen Inorganic materials 0.000 claims description 32
- 229910052739 hydrogen Inorganic materials 0.000 claims description 30
- 239000001257 hydrogen Substances 0.000 claims description 30
- 150000001408 amides Chemical class 0.000 claims description 22
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 20
- OVQGARHQNSNISN-LLVKDONJSA-N (r)-2-(6-fluoro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3-methylbutanoic acid Chemical compound O=C1N([C@H](C(C)C)C(O)=O)CC2=C(F)C=NC3=C2C1=CN3 OVQGARHQNSNISN-LLVKDONJSA-N 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 19
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 17
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 125000001072 heteroaryl group Chemical group 0.000 claims description 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 11
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims description 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 10
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
- IJUJKFCNSPUXQQ-UHFFFAOYSA-N 4-(4-ethylpiperidin-4-yl)-3,4-dihydropyrrolo[4,3,2-de][2,6]naphthyridin-5(1h)-one Chemical compound C1C(C=23)=CNC3=NC=CC=2C(=O)N1C1(CC)CCNCC1 IJUJKFCNSPUXQQ-UHFFFAOYSA-N 0.000 claims description 5
- 208000006673 asthma Diseases 0.000 claims description 5
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims description 5
- PXOASSQTDFEUJS-UHFFFAOYSA-N 2,4-dihydro-1h-2,6-naphthyridin-3-one Chemical compound N1=CC=C2CNC(=O)CC2=C1 PXOASSQTDFEUJS-UHFFFAOYSA-N 0.000 claims description 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 4
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 4
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 4
- 208000007536 Thrombosis Diseases 0.000 claims description 4
- 201000010105 allergic rhinitis Diseases 0.000 claims description 4
- 201000008937 atopic dermatitis Diseases 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 229960000485 methotrexate Drugs 0.000 claims description 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 4
- ZAPRCMVJDYLHBJ-SJKOYZFVSA-N (2R,3R)-N-cyclopentyl-3-methyl-2-(5-oxo-2,6,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-yl)pentanamide Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC=C(C2=3)C1)=O)[C@H](C)CC)NC1CCCC1 ZAPRCMVJDYLHBJ-SJKOYZFVSA-N 0.000 claims description 3
- ZRIMCWPZXHIINQ-OAHLLOKOSA-N (r)-1-(2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3-methylbutanoyl)azetidine-3-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(Cl)=C(C2=3)C1)=O)C(C)C)N1CC(C#N)C1 ZRIMCWPZXHIINQ-OAHLLOKOSA-N 0.000 claims description 3
- SNVFEJDYYUVZLQ-CYBMUJFWSA-N (r)-4-(1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-4,5-dihydropyrrolo[4,3,2-de][2,6]naphthyridin-3(1h)-one Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC=C(C2=3)C1)=O)CC)N1CCCC1 SNVFEJDYYUVZLQ-CYBMUJFWSA-N 0.000 claims description 3
- SNVFEJDYYUVZLQ-ZDUSSCGKSA-N (s)-4-(1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-4,5-dihydropyrrolo[4,3,2-de][2,6]naphthyridin-3(1h)-one Chemical compound O=C([C@@H](N1C(C2=CNC=3N=CC=C(C2=3)C1)=O)CC)N1CCCC1 SNVFEJDYYUVZLQ-ZDUSSCGKSA-N 0.000 claims description 3
- SORCZGDNTKFULV-UHFFFAOYSA-N 4-(4-methylpiperidin-4-yl)-3,4-dihydropyrrolo[4,3,2-de][2,6]naphthyridin-5(1h)-one Chemical compound C1C(C=23)=CNC3=NC=CC=2C(=O)N1C1(C)CCNCC1 SORCZGDNTKFULV-UHFFFAOYSA-N 0.000 claims description 3
- GMUQVZBDGDACDW-UHFFFAOYSA-N 4-(piperidin-4-yl)-3,4-dihydropyrrolo[4,3,2-de][2,6]naphthyridin-5(1h)-one Chemical compound C1C(C=23)=CNC3=NC=CC=2C(=O)N1C1CCNCC1 GMUQVZBDGDACDW-UHFFFAOYSA-N 0.000 claims description 3
- 208000028622 Immune thrombocytopenia Diseases 0.000 claims description 3
- 201000004681 Psoriasis Diseases 0.000 claims description 3
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 3
- 201000009961 allergic asthma Diseases 0.000 claims description 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
- 201000006417 multiple sclerosis Diseases 0.000 claims description 3
- HKJXQYNTMHHOIO-UHFFFAOYSA-N tert-butyl 3-(5-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)piperidine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC1N(C1)C(=O)C2=C3C1=CNC3=NC=C2 HKJXQYNTMHHOIO-UHFFFAOYSA-N 0.000 claims description 3
- WOGCQMJLCFGBAV-UHFFFAOYSA-N tert-butyl 4-ethyl-4-(5-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)piperidine-1-carboxylate Chemical compound C1C(C=23)=CNC3=NC=CC=2C(=O)N1C1(CC)CCN(C(=O)OC(C)(C)C)CC1 WOGCQMJLCFGBAV-UHFFFAOYSA-N 0.000 claims description 3
- OIECMEFBRSIQPY-OAHLLOKOSA-N (2R)-2-(5-oxo-2,6,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-yl)-N-phenylbutanamide Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC=C(C2=3)C1)=O)CC)NC1=CC=CC=C1 OIECMEFBRSIQPY-OAHLLOKOSA-N 0.000 claims description 2
- ADRZPWYCMXFQKI-IWSPRGBSSA-N (2r)-n-(1-cyanoethyl)-2-(6-fluoro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3-methylbutanamide Chemical compound O=C1N([C@H](C(C)C)C(=O)NC(C)C#N)CC2=C(F)C=NC3=C2C1=CN3 ADRZPWYCMXFQKI-IWSPRGBSSA-N 0.000 claims description 2
- CCVWSVLPHADWTM-GENIYJEYSA-N (2r)-n-(3,3-difluorocyclopentyl)-2-(6-fluoro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3-methylbutanamide Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(F)=C(C2=3)C1)=O)C(C)C)NC1CCC(F)(F)C1 CCVWSVLPHADWTM-GENIYJEYSA-N 0.000 claims description 2
- ASHPTAVPJHAKLI-BDJLRTHQSA-N (r)-1-((r)-2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3-methylbutanoyl)pyrrolidine-2-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(Cl)=C(C2=3)C1)=O)C(C)C)N1CCC[C@@H]1C#N ASHPTAVPJHAKLI-BDJLRTHQSA-N 0.000 claims description 2
- XFNCZWQGXYKLQX-HNNXBMFYSA-N (r)-1-(2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3,3-dimethylbutanoyl)azetidine-3-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(Cl)=C(C2=3)C1)=O)C(C)(C)C)N1CC(C#N)C1 XFNCZWQGXYKLQX-HNNXBMFYSA-N 0.000 claims description 2
- SWRCBOUSPFPUCR-QGZVFWFLSA-N (r)-1-(2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3-methylbutanoyl)piperidine-4-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(Cl)=C(C2=3)C1)=O)C(C)C)N1CCC(C#N)CC1 SWRCBOUSPFPUCR-QGZVFWFLSA-N 0.000 claims description 2
- KMZHAOSGFRQUCS-OAHLLOKOSA-N (r)-1-(2-(6-fluoro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3-methylbutanoyl)-3-methylazetidine-3-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(F)=C(C2=3)C1)=O)C(C)C)N1CC(C)(C#N)C1 KMZHAOSGFRQUCS-OAHLLOKOSA-N 0.000 claims description 2
- RTTLNMZYPQKNLQ-HNNXBMFYSA-N (r)-1-(3,3-dimethyl-2-(3-oxopyrrolo [4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)butanoyl)azetidine-3-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC=C(C2=3)C1)=O)C(C)(C)C)N1CC(C#N)C1 RTTLNMZYPQKNLQ-HNNXBMFYSA-N 0.000 claims description 2
- KXJSLDINKXGRLO-INIZCTEOSA-N (r)-1-(3,3-dimethyl-2-(6-methyl-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)butanoyl)azetidine-3-carbonitrile Chemical compound O=C([C@H](N1C(=O)C2=CNC3=NC=C(C(C1)=C32)C)C(C)(C)C)N1CC(C#N)C1 KXJSLDINKXGRLO-INIZCTEOSA-N 0.000 claims description 2
- PZVVSAFYCWLGMY-OAHLLOKOSA-N (r)-1-(3-methyl-2-(3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)butanoyl)azetidine-3-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC=C(C2=3)C1)=O)C(C)C)N1CC(C#N)C1 PZVVSAFYCWLGMY-OAHLLOKOSA-N 0.000 claims description 2
- CJHMBITZXMADSW-MRXNPFEDSA-N (r)-1-(3-methyl-2-(6-methyl-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)butanoyl)azetidine-3-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(C)=C(C2=3)C1)=O)C(C)C)N1CC(C#N)C1 CJHMBITZXMADSW-MRXNPFEDSA-N 0.000 claims description 2
- UTXGIGMNFXKZFZ-BDJLRTHQSA-N (r)-2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-n-((r)-1-cyanobutan-2-yl)-3-methylbutanamide Chemical compound O=C1N([C@H](C(C)C)C(=O)N[C@@H](CC#N)CC)CC2=C(Cl)C=NC3=C2C1=CN3 UTXGIGMNFXKZFZ-BDJLRTHQSA-N 0.000 claims description 2
- UTXGIGMNFXKZFZ-MEDUHNTESA-N (r)-2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-n-((s)-1-cyanobutan-2-yl)-3-methylbutanamide Chemical compound O=C1N([C@H](C(C)C)C(=O)N[C@H](CC#N)CC)CC2=C(Cl)C=NC3=C2C1=CN3 UTXGIGMNFXKZFZ-MEDUHNTESA-N 0.000 claims description 2
- LPIOATNQRXLPJR-AWEZNQCLSA-N (r)-2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-n-(2-cyanoethyl)-3,3-dimethylbutanamide Chemical compound O=C1N([C@H](C(C)(C)C)C(=O)NCCC#N)CC2=C(Cl)C=NC3=C2C1=CN3 LPIOATNQRXLPJR-AWEZNQCLSA-N 0.000 claims description 2
- JKTZZYIREZIDKI-GOSISDBHSA-N (r)-2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-n-(3-cyanophenyl)-3-methylbutanamide Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(Cl)=C(C2=3)C1)=O)C(C)C)NC1=CC=CC(C#N)=C1 JKTZZYIREZIDKI-GOSISDBHSA-N 0.000 claims description 2
- CCSLFLVFXIXXAU-GOSISDBHSA-N (r)-2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-n-(4-cyanophenyl)-3-methylbutanamide Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(Cl)=C(C2=3)C1)=O)C(C)C)NC1=CC=C(C#N)C=C1 CCSLFLVFXIXXAU-GOSISDBHSA-N 0.000 claims description 2
- ZWJJRTRFBRRGAN-CYBMUJFWSA-N (r)-2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-n-(cyanomethyl)-3-methylbutanamide Chemical compound O=C1N([C@H](C(C)C)C(=O)NCC#N)CC2=C(Cl)C=NC3=C2C1=CN3 ZWJJRTRFBRRGAN-CYBMUJFWSA-N 0.000 claims description 2
- TYFHWYXPEQPPJB-CQSZACIVSA-N (r)-2-(6-fluoro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3-methyl-n-(2-(methylsulfonyl)ethyl)butanamide Chemical compound O=C1N([C@H](C(C)C)C(=O)NCCS(C)(=O)=O)CC2=C(F)C=NC3=C2C1=CN3 TYFHWYXPEQPPJB-CQSZACIVSA-N 0.000 claims description 2
- GMDAVQBRYVGGLW-OAHLLOKOSA-N (r)-2-(6-fluoro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-n,3-dimethyl-n-(2-(methylsulfonyl)ethyl)butanamide Chemical compound O=C1N([C@H](C(C)C)C(=O)N(C)CCS(C)(=O)=O)CC2=C(F)C=NC3=C2C1=CN3 GMDAVQBRYVGGLW-OAHLLOKOSA-N 0.000 claims description 2
- MXAVVBQRVCRWMJ-OAHLLOKOSA-N (r)-3-(fluoromethyl)-1-(3-methyl-2-(3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)butanoyl)azetidine-3-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC=C(C2=3)C1)=O)C(C)C)N1CC(CF)(C#N)C1 MXAVVBQRVCRWMJ-OAHLLOKOSA-N 0.000 claims description 2
- AFBHJRPZYFHHNQ-OAHLLOKOSA-N (r)-3-methyl-1-(3-methyl-2-(3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)butanoyl)azetidine-3-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC=C(C2=3)C1)=O)C(C)C)N1CC(C)(C#N)C1 AFBHJRPZYFHHNQ-OAHLLOKOSA-N 0.000 claims description 2
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- ASHPTAVPJHAKLI-MEDUHNTESA-N (s)-1-((r)-2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3-methylbutanoyl)pyrrolidine-2-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(Cl)=C(C2=3)C1)=O)C(C)C)N1CCC[C@H]1C#N ASHPTAVPJHAKLI-MEDUHNTESA-N 0.000 claims description 2
- OBFQHKLXSMZAOZ-WVQRXBFSSA-N 1-((r)-2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)-3-methylbutanoyl)pyrrolidine-3-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(Cl)=C(C2=3)C1)=O)C(C)C)N1CCC(C#N)C1 OBFQHKLXSMZAOZ-WVQRXBFSSA-N 0.000 claims description 2
- RBPPJMUPCNVFPS-OAHLLOKOSA-N 1-[(2R)-2-(9-fluoro-5-oxo-2,6,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),3,8(12),9-tetraen-6-yl)-3-methylbutanoyl]azetidine-3-carbonitrile Chemical compound O=C([C@H](N1C(C2=CNC=3N=CC(F)=C(C2=3)C1)=O)C(C)C)N1CC(C#N)C1 RBPPJMUPCNVFPS-OAHLLOKOSA-N 0.000 claims description 2
- JAYOULHIBFQPKM-UHFFFAOYSA-N 3-(4-ethyl-4-(5-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)piperidin-1-yl)-3-oxopropanenitrile Chemical compound C1C(C=23)=CNC3=NC=CC=2C(=O)N1C1(CC)CCN(C(=O)CC#N)CC1 JAYOULHIBFQPKM-UHFFFAOYSA-N 0.000 claims description 2
- AWDLJJQJAVBHSC-UHFFFAOYSA-N 3-(4-methyl-4-(5-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1h,3h,5h)-yl)piperidin-1-yl)-3-oxopropanenitrile Chemical compound C1C(C=23)=CNC3=NC=CC=2C(=O)N1C1(C)CCN(C(=O)CC#N)CC1 AWDLJJQJAVBHSC-UHFFFAOYSA-N 0.000 claims description 2
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Abstract
【選択図】なし
Description
G1は、NおよびCR8から成る基から選択され、
R1は、任意に置換されたC3−8シクロアルキル、任意に置換されたC3−6ヘテロシクロアルキル、任意に置換されたC4−14アリール、任意に置換されたC1−10ヘテロアリール、および任意に置換されたC1−6アルキルから成る基から選択され、
R2およびR3はそれぞれ、水素および任意に置換されたC1−4アルキルから成る基から独立して選択され、またはR2、R3、およびそれらが付着される炭素原子は、カルボニルを形成し、
R4は、水素、任意に置換されたC1−4アルキル、任意に置換されたC1−4アルコキシ、ハロ、ヒドロキシ、およびアミノから成る基から選択され、
R5は、水素、任意に置換されたC1−4アルキル、C3−8シクロアルキル、およびハロから成る基から選択され、
R6およびR7はそれぞれ、水素および任意に置換されたC1−4アルキルから成る基から独立して選択され、またはR6、R7、およびそれらが付着される炭素原子は、カルボニルを形成し、
R8は、水素、任意に置換されたC1−6アルキル、任意に置換されたC1−4アルコキシ、C1−9アミド、C1−5オキシカルボニル、シアノ、任意に置換されたC3−8シクロアルキル、任意に置換されたC4−14アリール、任意に置換されたC1−10ヘテロアリール、およびハロから成る基から選択され、
但し、2つ以上のカルボニルは、R2およびR3並びにR6およびR7から形成されない。
Claims (24)
-
R1は、任意に置換されたC3−8シクロアルキル、任意に置換されたC3−6ヘテロシクロアルキル、任意に置換されたC4−14アリール、任意に置換されたC1−10ヘテロアリール、および任意に置換されたC1−6アルキルから成る基から選択され、
R2およびR3はそれぞれ、水素および任意に置換されたC1−4アルキルから成る基から独立して選択される、またはR2、R3、およびそれらが付着される炭素原子は、カルボニルを形成し、
R4は、水素、任意に置換されたC1−4アルキル、任意に置換されたC1−4アルコキシ、ハロ、ヒドロキシ、およびアミノから成る基から選択され、
R5は、水素、任意に置換されたC1−4アルキル、C3−8シクロアルキル、およびハロから成る基から選択され、
R6およびR7はそれぞれ、水素および任意に置換されたC1−4アルキルから成る基から独立して選択され、またはR6、R7、およびそれらが付着される炭素原子は、カルボニルを形成し、
R8は、水素、任意に置換されたC1−6アルキル、任意に置換されたC1−4アルコキシ、C1−9アミド、C1−5オキシカルボニル、シアノ、任意に置換されたC3−8シクロアルキル、任意に置換されたC4−14アリール、任意に置換されたC1−10ヘテロアリール、およびハロから成る基から選択され、
但し、2つ以上のカルボニルは、R2およびR3並びにR6およびR7から形成されない、
化Iの化合物またはその薬学的に許容可能な塩。 - R4およびR5はそれぞれ、水素である、請求項1に記載の化合物または薬学的に許容可能な塩。
- Gは、CR8である、前記請求項のいずれかに記載の化合物または薬学的に許容可能な塩。
- Gは、CR8であって、R8は、水素、ハロ、および任意に置換されたC1−6アルキルから選択される、前記請求項のいずれかに記載の化合物または薬学的に許容可能な塩。
- Gは、CR8であって、R8は、水素、ハロ、およびC1−4アルキルから選択される、請求項4に記載の化合物または薬学的に許容可能な塩。
- Gは、Nである、請求項1から2のいずれかに記載の化合物または薬学的に許容可能な塩。
- R1は、任意に置換されたC3−8シクロアルキルである、請求項1から6のいずれかに記載の化合物または薬学的に許容可能な塩。
- R1は、任意に置換されたC3−6ヘテロシクロアルキルである、請求項1から6のいずれかに記載の化合物または薬学的に許容可能な塩。
- R1は、任意に置換されたC4−14アリールである、請求項1から6のいずれかに記載の化合物または薬学的に許容可能な塩。
- R1は、任意に置換されたC1−10ヘテロアリールである、請求項1から6のいずれかに記載の化合物または薬学的に許容可能な塩。
- R1は、任意に置換されたC1−6アルキルである、請求項1から6のいずれかに記載の化合物または薬学的に許容可能な塩。
- R2、R3、およびそれらが付着される炭素原子は、カルボニルを形成する、請求項1から11のいずれかに記載の化合物または薬学的に許容可能な塩。
- R6およびR7はそれぞれ、水素である、請求項12に記載の化合物または薬学的に許容可能な塩。
- R6、R7、およびそれらが付着される炭素原子は、カルボニルを形成する、請求項1から11のいずれかに記載の化合物または薬学的に許容可能な塩。
- R2およびR3はそれぞれ、水素である、請求項14に記載の化合物または薬学的に許容可能な塩。
- tert−ブチル4−(5−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ピペリジン−1−カルボキシレート、
4−(ピペリジン−4−イル)−3,4−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−5(1H)−オン、
3−オキソ−3−(4−(5−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ピペリジン−1−イル)プロパンニトリル、
tert−ブチル4−メチル−4−(5−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ピペリジン−1−カルボキシレート、
4−(4−メチルピペリジン−4−イル)−3,4−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−5(1H)−オン、
3−(4−メチル−4−(5−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ピペリジン−1−イル)−3−オキソプロパンニトリル、
tert−ブチル4−エチル−4−(5−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ピペリジン−1−カルボキシレート、
4−(4−エチルピペリジン−4−イル)−3,4−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−5(1H)−オン、
3−(4−エチル−4−(5−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ピペリジン−1−イル)−3−オキソプロパンニトリル、
4−(ペンタン−3−イル)−3,4−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−5(1H)−オン、
4−(1−シクロプロピル−3−ヒドロキシプロピル)−3,4−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−5(1H)−オン、
tert−ブチル3−((5−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)メチル)ピロリジン−1−カルボキシレート、
4−(ピロリジン−3−イルメチル)−3,4−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−5(1H)−オン、
tert−ブチル3−(5−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ピペリジン−1−カルボキシレート、
4−(ピペリジン−3−イル)−3,4−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−5(1H)−オン、
4−(4−エチル−1−プロピオニルピペリジン−4−イル)−3,4−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−5(1H)−オン、
4−(4−エチル−1−(ピリミジン−4−イル)ピペリジン−4−イル)−3,4−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−5(1H)−オン、
(S)−4−(1−オキソ−1−(ピロリジン−1−イル)ブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−4−(1−オキソ−1−(ピロリジン−1−イル)ブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−4−(3−メチル−1−オキソ−1−(ピロリジン−1−イル)ブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−4−(4−メチル−1−オキソ−1−(ピロリジン−1−イル)ペンタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−N−シクロペンチル−3−メチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(2R,3R)−N−シクロペンチル−3−メチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ペンタンアミド、
(2R,3S)−N−シクロペンチル−3−メチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ペンタンアミド、
(R)−N−シクロペンチル−2−シクロプロピル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)アセトアミド、
(R)−N−シクロペンチル−3,3−ジメチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(R)−N,2−ジシクロペンチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)アセトアミド、
(R)−N−シクロペンチル−4,4,4−トリフルオロ−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(R)−N−シクロペンチル−3−ヒドロキシ−3−メチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−シアノ−N−シクロペンチルプロパンアミド、
N−シクロペンチル−1−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)シクロペンタンカルボキサミド、
(R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−N−(シアノメチル)−3−メチルブタンアミド、
1−((R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタノイル)ピロリジン−3−カルボニトリル、
(R)−1−(2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタノイル)ピペリジン−4−カルボニトリル、
(R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−N−(4−シアノフェニル)−3−メチルブタンアミド、
(R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−N−(3−シアノフェニル)−3−メチルブタンアミド、
(R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−N−((S)−1−シアノブタン−2−イル)−3−メチルブタンアミド、
(R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−N−((R)−1−シアノブタン−2−イル)−3−メチルブタンアミド、
(R)−1−(2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタノイル)アゼチジン−3−カルボニトリル、
(R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−N−(2−シアノエチル)−3,3−ジメチルブタンアミド、
(R)−1−(2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3,3−ジメチルブタノイル)アゼチジン−3−カルボニトリル、
(R)−1−(2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタノイル)アゼチジン−3−カルボニトリル、
(R)−2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタン酸、
(2R)−2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチル−N−(テトラヒドロフラン−3−イル)ブタンアミド、
(R)−2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチル−N−(1,1−ジオキシドテトラヒドロチエン−3−イル)ブタンアミド、
(R)−2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチル−N−(2−(メチルスルホニル)エチル)ブタンアミド、
(R)−N−(1,1−ジオキソ−ヘキサヒドロ−6−チオピラン)−2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチル−N−4−イル)ブタンアミド、
4−{(1R)−1−[(1,1−ジオキシドチオモルホリン−4−イル)カルボニル]−2−メチルプロピル}−6−フルオロ−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−N−(シクロプロピルメトキシ)−2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタンアミド、
(2R)−N−(3,3−ジフルオロシクロペンチル)−2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタンアミド、
(R)−3−(フルオロメチル)−1−(3−メチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタノイル)アゼチジン−3−カルボニトリル、
(R)−1−(2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタノイル)−3−メチルアゼチジン−3−カルボニトリル、
(R)−3−メチル−1−(3−メチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタノイル)アゼチジン−3−カルボニトリル、
(R)−4−(1−モルホリノ−1−オキソブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−4−(1−(4−メチルピペラジン−1−イル)−1−オキソブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
4−((2R)−1−(3−ヒドロキシピロリジン−1−イル)−1−オキソブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−N−シクロペンチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
4−((2R)−1−(3−(4−フルオロフェニル)ピロリジン−1−イル)−1−オキソブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
4−((2R)−1−(3−(ジメチルアミノ)ピロリジン−1−イル)−1−オキソブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
4−((2R)−1−(3−(メトキシメチル)ピロリジン−1−イル)−1−オキソブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
4−((2R)−1−(3−メチルピペリジン−1−イル)−1−オキソブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−4−(1−(4−(2−ヒドロキシプロパン−2−イル)ピペリジン−1−イル)−1−オキソブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−4−(1−(4−(メチルスルホニル)ピペラジン−1−イル)−1−オキソブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−4−(1−オキソ−1−(4−(ピリジン−2−イル)ピペラジン−1−イル)ブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−N−シクロプロピル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(R)−N−(シクロプロピルメチル)−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(R)−N−イソブチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(R)−N−イソブチル−N−メチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(2R)−N−(1−ヒドロキシプロパン−2−イル)−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(R)−N−(2−ヒドロキシ−2−メチルプロピル)−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(R)−N−((S)−2,3−ジヒドロキシプロピル)−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(R)−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−N−フェニルブタンアミド、
(R)−N−(1−(メチルスルホニル)ピペリジン−4−イル)−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(2R)−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−N−((テトラヒドロフラン−2−イル)メチル)ブタンアミド、
(2R)−N−(1−シアノエチル)−2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタンアミド、
(R)−4−(1−(3,3−ジフルオロアゼチジン−1−イル)−3−メチル−1−オキソブタン−2−イル)−6−フルオロ−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−6−フルオロ−4−(3−メチル−1−オキソ−1−(チアゾリジン−3−イル−1,1−ジオキシド)ブタン−2−イル)−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−N,3−ジメチル−N−(2−(メチルスルホニル)エチル)ブタンアミド、
(R)−N−(シアノメチル)−2−(6−フルオロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−N,3−ジメチルブタンアミド、
(R)−4−(1−(3−(ジフルオロメチル)アゼチジン−1−イル)−3−メチル−1−オキソブタン−2−イル)−6−フルオロ−4,5−ジヒドロピロロ[4,3,2−de][2,6]ナフチリジン−3(1H)−オン、
(R)−1−(3−メチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタノイル)アゼチジン−3−カルボニトリル、
(R)−1−(3,3−ジメチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタノイル)アゼチジン−3−カルボニトリル、
(R)−N−(シアノメチル)−3,3−ジメチル−2−(3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタンアミド、
(S)−1−((R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタノイル)ピロリジン−2−カルボニトリル、
(R)−1−((R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタノイル)ピロリジン−2−カルボニトリル、
(2S,4S)−1−((R)−2−(6−クロロ−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)−3−メチルブタノイル)−4−フルオロピロリジン−2−カルボニトリル、
(R)−1−(3,3−ジメチル−2−(6−メチル−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタノイル)アゼチジン−3−カルボニトリル、
(R)−1−(3−メチル−2−(6−メチル−3−オキソピロロ[4,3,2−de][2,6]ナフチリジン−4(1H,3H,5H)−イル)ブタノイル)アゼチジン−3−カルボニトリル、
前記化合物のいずれかの立体異性体、および
前記立体異性体または化合物のいずれかの薬学的に許容可能な塩、
から選択される、請求項1に記載の化合物。 - 請求項1から16のいずれかに記載の化合物または薬学的に許容可能な塩と、薬学的に許容可能な賦形剤と、を含む、医薬組成物。
- 薬剤としての請求項1から16のいずれかに記載の化合物または薬学的に許容可能な塩の使用。
- JAKと関連付けられた疾患、障害、または病状の治療のための薬剤の製造のための請求項1から16のいずれかに記載の化合物または薬学的に許容可能な塩の使用。
- 対象において、JAKと関連付けられた疾患、障害、または病状を治療する方法であって、前記対象に有効量の請求項1から16のいずれかに記載の化合物または薬学的に許容可能な塩を投与するステップを含む、方法。
- 前記疾患、障害、または病状は、アレルギー性鼻炎、アレルギー性喘息、アトピー性皮膚炎、関節リウマチ、多発性硬化症、全身性紅斑性狼瘡、乾癬、免疫性血小板減少性紫斑病、慢性閉塞性肺疾患、および血栓症から選択される、請求項20に記載の方法。
- 有効量の請求項1から16のいずれかに記載の化合物または薬学的に許容可能な塩と、少なくとも1つの付加的薬理学的活性剤との組み合わせ。
- 前記付加的薬理学的活性剤は、DMARDである、請求項22に記載の組み合わせ。
- 前記DMARDは、メトトレキサートである、請求項23に記載の組み合わせ。
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US11561787B2 (en) | 2021-05-13 | 2023-01-24 | International Business Machines Corporation | Application invocation on specified operating system version |
Also Published As
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CN102459267B (zh) | 2014-11-26 |
HUE026518T2 (en) | 2016-06-28 |
SMT201500156B (it) | 2015-09-07 |
HRP20150701T1 (hr) | 2015-08-28 |
US20110136780A1 (en) | 2011-06-09 |
CN102459267A (zh) | 2012-05-16 |
EP2440558A1 (en) | 2012-04-18 |
US8420816B2 (en) | 2013-04-16 |
WO2010144486A1 (en) | 2010-12-16 |
CA2764885C (en) | 2018-05-15 |
EP2440558B1 (en) | 2015-04-01 |
JP5719840B2 (ja) | 2015-05-20 |
PL2440558T3 (pl) | 2015-10-30 |
DK2440558T3 (en) | 2015-07-06 |
ES2540964T3 (es) | 2015-07-15 |
SI2440558T1 (sl) | 2015-10-30 |
HK1167654A1 (en) | 2012-12-07 |
US8785429B2 (en) | 2014-07-22 |
CA2764885A1 (en) | 2010-12-16 |
PT2440558E (pt) | 2015-08-27 |
US20130184252A1 (en) | 2013-07-18 |
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